Article
Immunology
Chun-Han Hou, Po-Chun Chen, Ju-Fang Liu
Summary: This study provides novel insights into the role of CXCL1 in the pathogenesis of rheumatoid arthritis by promoting COX-II expression to regulate disease progression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Rheumatology
Raphael Micheroli, Muriel Elhai, Sam Edalat, Mojca Frank-Bertoncelj, Kristina Buerki, Adrian Ciurea, Lucy MacDonald, Mariola Kurowska-Stolarska, Myles J. Lewis, Katriona Goldmann, Cankut Cubuk, Tadeja Kuret, Oliver Distler, Costantino Pitzalis, Caroline Ospelt
Summary: This study integrated single-cell RNA sequencing data to assess the contribution of synovial fibroblast subsets to synovial pathotypes and clinical characteristics in treatment-naive early arthritis. The findings revealed a previously unexplored association between specific synovial pathologies and subtypes of synovial fibroblasts.
Article
Rheumatology
Tadashi Hosoya, Tetsuya Saito, Hiroyuki Baba, Nao Tanaka, Seiji Noda, Youji Komiya, Yasuhiro Tagawa, Akio Yamamoto, Fumitaka Mizoguchi, Kimito Kawahata, Nobuyuki Miyasaka, Hitoshi Kohsaka, Shinsuke Yasuda
Summary: This study reveals that inhibiting CDK4/6 activity can attenuate cartilage destruction and MMP-3 production, providing chondroprotective effects. These effects were achieved by impairing AP-1 transcriptional activity and destabilizing JUN.
Review
Rheumatology
Tamas Nemeth, Gyorgy Nagy, Thomas Pap
Summary: Fibroblast-like synoviocytes (FLS) are crucial cellular components in the synovial membrane of joints, contributing to normal joint function. However, under inflammatory conditions like rheumatoid arthritis (RA), FLS can become overactive and promote inflammation. Therefore, understanding the role of FLS in RA is essential for disease treatment.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Immunology
Valentina Pucino, Meriam Nefla, Vincent Gauthier, Ghada Alsaleh, Sally A. A. Clayton, Jennifer Marshall, Andrew Filer, Andy R. R. Clark, Karim Raza, Christopher D. D. Buckley
Summary: This study investigates how lactate regulates fibroblast and macrophage movement, IL-6 secretion, and metabolism via specific lactate transporters. The results show that lactate has opposite effects on the effector functions of these two cell types.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Yan Zhao, Xialin Sun, Jun Lin, Tingwen Zhang, Shuangli Liu, Zhaowei Yan
Summary: Panaxynol (PAL) can promote apoptosis and inhibit proliferation, migration, and invasion of fibroblast-like synovial cells in rheumatoid arthritis (RA). PAL can also reduce joint swelling and inflammatory infiltration in CIA rats, mainly through the TLR4/NF-kappa B signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Guliang Yang, Jie Sun, Kun Lu, Sijie Shan, Shiming Li, Chenglin Sun
Summary: The study showed that Pterostilbene combined with physical exercise has a significant preventive effect on rheumatoid arthritis, increasing the MaR1 content, reversing the abnormal expression of inflammatory signal pathways, and inhibiting the proliferation and apoptosis of synovial cells through promoting cell autophagy.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Jade Jaffar, Ian Glaspole, Karen Symons, Glen Westall
Summary: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with poor prognosis, and the transcription factor NF-ΚB is suggested as a potential therapeutic target. ACT001, an NF-ΚB inhibitor, showed inhibitory effects on fibroblast activity in primary lung fibroblasts from patients with and without IPF, indicating its potential as a therapeutic agent for IPF.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Rheumatology
Haruka Tsuchiya, Mineto Ota, Shuji Sumitomo, Kazuyoshi Ishigaki, Akari Suzuki, Toyonori Sakata, Yumi Tsuchida, Hiroshi Inui, Jun Hirose, Yuta Kochi, Yuho Kadono, Katsuhiko Shirahige, Sakae Tanaka, Kazuhiko Yamamoto, Keishi Fujio
Summary: Objectives: Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammation in the synovium, where synovial fibroblasts (SFs) play a major role. This study aimed to understand the genetic contribution to molecular regulatory networks in SFs under inflammatory conditions. Methods: SFs from RA and osteoarthritis (OA) patients were stimulated with various cytokines and immune cell subsets were analyzed. Integrative analyses including mRNA expression, histone modifications, 3D genome architecture, and genetic variations were performed. Results: Unstimulated SFs from RA patients showed differences in transcriptome and epigenome compared to OA SFs. Most responses to stimulations were shared between the diseases. SFs expressed pathogenic genes and chromatin remodeling in activated SFs revealed enrichment of RA risk loci in clusters of enhancers induced by proinflammatory cytokines. A RA risk SNP formed 3D contact with the promoter of a gene related to arthritis, and inhibition of this gene suppressed cytokine and chemokine production in SFs. Conclusions: This study identified potential therapeutic targets associated with genetic risk of RA and established a dynamic landscape of activated SFs.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Cell Biology
Chenyang Han, Yi Yang, Yongjia Sheng, Jin Wang, Xiaohong Zhou, Wenyan Li, Li Guo, Caiqun Zhang, Qiao Ye
Summary: The study found that Gla B can inhibit NF-kappa B signaling by regulating M1 polarization of SMG, thereby suppressing articular cartilage inflammation injury in RA. Additionally, Gla B can target the P65 protein and inhibit joint injury and inflammation in mice.
Article
Immunology
Eva M. L. Philippon, Lisanne J. E. van Rooijen, Fatemeh Khodadust, Jan Piet van Hamburg, Conny J. van der Laken, Sander W. Tas
Summary: A spheroid-based model of RA synovial tissue was developed to mimic the 3D interactions between cells and pro-inflammatory mediators. It can be used to study the pathogenesis of rheumatoid arthritis, examine the effects of specific cell types and signaling pathways, and evaluate the efficacy of novel diagnostic and therapeutic compounds.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Rheumatology
Maximilian Kugler, Mirjam Dellinger, Felix Kartnig, Lena Mueller, Teresa Preglej, Leonhard X. Heinz, Elisabeth Simader, Lisa Goeschl, Stephan E. Puchner, Sebastian Weiss, Lisa E. Shaw, Matthias Farlik, Wolfgang Weninger, Giulio Superti-Furga, Josef S. Smolen, Guenter Steiner, Daniel Aletaha, Hans P. Kiener, Myles J. Lewis, Costantino Pitzalis, Anela Tosevska, Thomas Karonitsch, Michael Bonelli
Summary: Activated FLS play a critical role in synovial tissue remodeling and interaction with immune cells in rheumatoid arthritis (RA). Co-culture experiments demonstrated that cytokine-activated FLS enhance T cell activation, proliferation, and differentiation. Transcriptomic analysis revealed a correlation between FLS cytokine signatures and infiltrating CD4(+) T cells in RA synovial tissue. ICAM1 was identified as an important mediator in TNF-mediated FLS-T cell interaction.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Immunology
Anil K. Singh, Mahamudul Haque, Bhanupriya Madarampalli, Yuanyuan Shi, Benjamin J. Wildman, Abdul Basit, Sadik A. Khuder, Bhagwat Prasad, Quamarul Hassan, Salahuddin Ahmed, Madhu M. Ouseph
Summary: IL-6 trans-signaling induces molecular reprogramming of RASFs to osteoclast-like cells through the activation of transcription factor Ets2, leading to increased expression of osteoclast-specific proteins and markers of invasive phenotype.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Zixuan Xu, Wenting Hao, Daxiang Xu, Yan He, Ziyi Yan, Fenfen Sun, Xiangyang Li, Xiaoying Yang, Yinghua Yu, Renxian Tang, Kuiyang Zheng, Wei Pan
Summary: Polyene phosphatidylcholine (PPC) is a hepatoprotective agent that can alleviate synovial inflammation by inhibiting TLR-2-mediated MAPK and NF-kappa B pathways.
Article
Rheumatology
Li Zheng, Fanlei Hu, Wenjie Bian, Yingni Li, Linqi Zhang, Lianjie Shi, Xiaoxu Ma, Yanying Liu, Xuewu Zhang, Zhanguo Li
Summary: Dkk-1 exacerbates inflammation, cartilage erosion, and angiogenesis mediated by synovial fibroblasts in RA. Modulation of DKK-1 expression may facilitate the development of novel strategies to control RA.
CLINICAL RHEUMATOLOGY
(2021)
Correction
Multidisciplinary Sciences
Sophia Maschalidi, Parul Mehrotra, Burcu N. Keceli, Hannah K. L. De Cleene, Kim Lecomte, Renee Van der Cruyssen, Pauline Janssen, Jonathan Pinney, Geert van Loo, Dirk Elewaut, Ann Massie, Esther Hoste, Kodi S. Ravichandran
Article
Multidisciplinary Sciences
Annelore Beterams, Marta Calatayud Arroyo, Kim De Paepe, Ann-Sophie De Craemer, Dirk Elewaut, Koen Venken, Tom Van de Wiele
Summary: Spondyloarthritis is a chronic inflammatory disease that primarily affects joints and non-joint sites. This study explores the differential impact of gut microbiota from healthy individuals and spondyloarthritis patients on host cell response. The results show that there are differences in the composition of gut microbiota and host cell response between healthy individuals and spondyloarthritis patients.
SCIENTIFIC REPORTS
(2022)
Article
Rheumatology
Simon Krabbe, Thomas Renson, Lennart Jans, Dirk Elewaut, Filip Van den Bosch, Philippe Carron, Mikkel Ostergaard
Summary: The study aims to investigate the reliability, validity, and sensitivity to change of a novel MRI scoring system in early peripheral SpA (pSpA). Results showed that the proposed MRI lower-extremity inflammation index demonstrated good reliability, validity, and sensitivity to change in patients with early pSpA, and was correlated with other measures of disease activity.
Article
Rheumatology
Desiree van der Heijde, Atul Deodhar, Xenofon Baraliakos, Matthew A. Brown, Hiroaki Dobashi, Maxime Dougados, Dirk Elewaut, Alicia M. Ellis, Carmen Fleurinck, Karl Gaffney, Lianne S. Gensler, Nigil Haroon, Marina Magrey, Walter P. Maksymowych, Alexander Marten, Ute Massow, Marga Oortgiesen, Denis Poddubnyy, Martin Rudwaleit, Julie Shepherd-Smith, Tetsuya Tomita, Filip van den Bosch, Thomas Vaux, Huji Xu
Summary: The BE MOBILE 1 and BE MOBILE 2 trials demonstrated that bimekizumab, a dual IL-17A and IL-17F inhibitor, improved efficacy outcomes in patients with axial spondyloarthritis (axSpA) and was well tolerated. These findings support the use of bimekizumab as a potential treatment option for axSpA.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Chemistry, Medicinal
Charlotte Courtens, Frits van Charante, Thibaut Quennesson, Martijn Risseeuw, Paul Cos, Guy Caljon, Tom Coenye, Serge Van Calenbergh
Summary: Fosmidomycin is a natural antibiotic that inhibits IspC. It is essential in bacterial and apicomplexan parasite biosynthesis pathways. However, its high polarity and inability to penetrate bacterial cell walls limit its effectiveness. By temporarily masking the phosphonate moiety as a prodrug, the researchers were able to discover derivatives with improved activity against Plasmodium and A. baumanii.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Muhammad Rishfi, Simon Krols, Fien Martens, Sarah-Lee Bekaert, Ellen Sanders, Aline Eggermont, Fanny De Vloed, Joshua Robert Goulding, Martijn Risseeuw, Jan Molenaar, Bram De Wilde, Serge Van Calenbergh, Kaat Durinck
Summary: We conducted a structure-activity relationship (SAR) study of MK-5108-derived PROTACs against AURKA in neuroblastoma. SK2188 showed the most potent AURKA degradation and excellent binding and degradation selectivity. It induced MYCN degradation, replication stress/DNA damage, and apoptosis in neuroblastoma cells.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Engineering, Biomedical
Roman V. V. Chernozem, Igor Pariy, Maria A. A. Surmeneva, Vladimir V. V. Shvartsman, Guillaume Planckaert, Joost Verduijn, Stef Ghysels, Anatolii Abalymov, Bogdan V. V. Parakhonskiy, Eric Gracey, Amanda Goncalves, Sanjay Mathur, Frederik Ronsse, Diederik Depla, Doru C. C. Lupascu, Dirk Elewaut, Roman A. A. Surmenev, Andre G. G. Skirtach
Summary: This study comprehensively examines the effects of biodegradation on the properties of poly(3-hydroxybutyrate) (PHB) scaffolds supplemented with reduced graphene oxide (rGO). The addition of 1.0 wt% rGO does not affect the enzymatic biodegradation rate of PHB scaffolds for 30 days. Biodegradation leads to depolymerization of the amorphous phase and an increase in crystallinity. The PHB-0.7rGO fibers exhibit the strongest piezoresponse, making them promising for tissue-engineering applications.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Anton De Spiegeleer, Amelie Descamps, Srinath Govindarajan, Julie Coudenys, Kevin van der Borght, Hannah Hirmz, Nele van den Noortgate, Dirk Elewaut, Bart De Spiegeleer, Evelien Wynendaele
Summary: This study discovered the potential of quorum-sensing peptides to modulate the immune system in microbiome-host interactions. Through screening 89 peptides, four of them were found to activate immune cells in vitro, and one of them was detected in human plasma. These findings are biologically significant and reveal the immunomodulatory potential of quorum-sensing peptides.
Article
Biochemistry & Molecular Biology
Marzuq A. Ungogo, Mustafa M. Aldfer, Manal J. Natto, Hainan Zhuang, Robyn Chisholm, Katy Walsh, MarieClaire McGee, Kayhan Ilbeigi, Jamal Ibrahim Asseri, Richard J. S. Burchmore, Guy Caljon, Serge Van Calenbergh, Harry P. De Koning
Summary: African Animal Trypanosomiasis (AAT) is a fatal livestock disease in Sub-Saharan Africa caused by Trypanosoma brucei brucei, T. vivax, and T. congolense. Limited treatment options and resistance threaten the control of this disease. In this study, the adenosine transporters of T. vivax (TvxNT3) and T. congolense (TcoAT1/NT10) were characterized and their functional expression was demonstrated. The findings suggest that nucleoside chemotherapy for AAT is viable based on the similarities in nucleoside sensitivity among different parasite species and the interactions with nucleoside transporters.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Rheumatology
Manouk de Hooge, Alla Ishchenko, Ann-Sophie De Craemer, Serge Steinfeld, Adrien Nzeusseu, Dirk Elewaut, Rik Lories, Kurt de Vlam, Filip van den Bosch
Summary: This study aimed to examine radiographic axial damage of the sacroiliac joints and spine in patients with psoriatic arthritis (PsA) and spondyloarthritis (SpA) in private and academic Belgian practices. The data comparison between the two patient groups found that patients with SpA tend to have more severe spinal damage compared to those with PsA. In patients with PsA, the cervical spine is more often affected, while in patients with SpA, the location of syndesmophytes is more evenly distributed.
Article
Rheumatology
Manouk de Hooge, Alla Ischenko, Serge Steinfeld, Adrien Nzeusseu, Dirk Elewaut, Rik Lories, Filip van den Bosch, Kurt De Vlam
Summary: This study investigates the association between different definitions of axial involvement and syndesmophytes development in patients with Psoriatic Arthritis (PsA). The results show that the probability of developing syndesmophytes is much higher when axial involvement is determined radiographically rather than clinically, particularly in the context of high CRP.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Thomas Van den Berghe, Danilo Babin, Min Chen, Martijn Callens, Denim Brack, Helena Maes, Jan Lievens, Marie Lammens, Maxime Van Sumere, Lieve Morbee, Simon Hautekeete, Stijn Schatteman, Tom Jacobs, Willem-Jan Thooft, Nele Herregods, Wouter Huysse, Jacob L. Jaremko, Robert Lambert, Walter Maksymowych, Frederiek Laloo, Xenofon Baraliakos, Ann-Sophie De Craemer, Philippe Carron, Filip van den Bosch, Dirk Elewaut, Lennart Jans
Summary: This study aimed to evaluate the feasibility and diagnostic accuracy of a deep learning network for detection of structural lesions of sacroiliitis on multicenter pelvic CT scans. The results showed that the optimized deep learning pipeline, including an explainability analysis, can detect structural lesions of sacroiliitis on pelvic CT scans with excellent statistical performance on a slice-by-slice and patient level.
EUROPEAN RADIOLOGY
(2023)
Article
Immunology
Koen Venken, Tine Decruy, Tim Sparwasser, Dirk Elewaut
Summary: Regulatory T cells (Tregs) and invariant natural killer T (iNKT) cells play a crucial role in controlling autoimmune diseases. The study reveals that Treg depletion enhances iNKT cell responses and leads to severe liver and gut pathology in preclinical models of autoimmunity.
Meeting Abstract
Clinical Neurology
R. Raedt, E. Craey, J. Spanoghe, L. E. Larsen, K. Vonck, E. Carrette, J. Delbeke, M. Sprengers, S. Van Calenbergh, W. J. Wadman, P. Boon
Article
Chemistry, Multidisciplinary
Silke Geurs, Dorien Clarisse, Freya Baele, Jorick Franceus, Tom Desmet, Karolien De Bosscher, Matthias D'hooghe
Summary: In this study, a set of HDAC6-selective inhibitors with low side effects and significant inhibitory activity in the nanomolar range were successfully synthesized using a lean inhibitor strategy.
CHEMICAL COMMUNICATIONS
(2022)