期刊
CURRENT OPINION IN GENETICS & DEVELOPMENT
卷 19, 期 4, 页码 329-337出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2009.06.005
关键词
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资金
- National Health and Medical Research council (NHMRC) [404805]
- Senior Research Fellowship
The components of the Notch signaling pathway and the mechanics of signal transduction have largely been established in Drosophila. Although essential for many developmental processes in invertebrates and vertebrates, this review focuses on Notch signaling in the vertebrate-specific process of somitogenesis. More specifically it describes that mutations in genes encoding Notch pathway components (DLL3, MESP2, LFNG and HES7) cause severe congenital vertebral defects in humans. Importantly, this review highlights studies demonstrating that DII3 is unique amongst DSL ligands acting as an inhibitor and not an activator of Notch signaling.
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