Article
Oncology
Rui-huan Gan, Li-song Lin, Dan-ping Zheng, Yong Zhao, Lin-can Ding, Da-li Zheng, You-guang Lu
Summary: Abnormal expression of Notch2 is associated with proliferation, invasion, and migration of tongue squamous cell carcinoma. Inhibition of Notch2 can suppress the malignant behavior of TSCC cells, while overexpression of Notch2 has a promoting effect on tongue cancer cells.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Dan Yang, Dan Yang, Yuqing He, Jiaxin Liu, Yansong Song, Yu Zhou, Lu Jiang, Xin Zeng, Xiaoping Xu, Hao Xu, Jing Li, Hongxia Dan
Summary: The overexpression of MRTF-A/SRF was found to inhibit the proliferation, migration, and invasion of oral squamous cell carcinoma (OSCC) cells in vitro. High expression of SRF and its co-activator MRTF-A was associated with better prognosis in OSCC patients on the hard palate, alveolar ridge, and oral tongue. It was also observed that overexpression of MRTF-A/SRF inhibited the epithelial-mesenchymal transformation (EMT) of OSCC cells.
Article
Oncology
Zhonghui Sun, Yunyi Guo, Danlu Zhang, Guolong Zhang, Ying Zhang, Xiuli Wang
Summary: The expression of FABP7 is reduced in CSCC and overexpression of FABP7 can inhibit the proliferation and invasion of CSCC cells. This suggests that FABP7 may have an inhibitory effect on CSCC cells through the Notch signaling pathway.
Article
Oncology
Xiaoguang Li, Fengshuo Zhu, Zhonglong Liu, Xiao Tang, Yu Han, Junjian Jiang, Chunyue Ma, Yue He
Summary: The dysregulation of Rab proteins has been implicated in various cancers, with Rab31 playing a role in the development and progression of cancer, particularly in oral squamous cell carcinoma (OSCC). High expression of Rab31 was associated with poor prognosis in OSCC patients. Knocking down Rab31 suppressed cell proliferation, induced apoptosis, and inhibited invasion, potentially through the regulation of gene expression.
Article
Oncology
Jiali Li, Zhenhua Li, Yanzhao Xu, Chao Huang, Baoen Shan
Summary: METTL3 is found to be significantly increased in ESCC tissues and associated with poor prognosis. METTL3 promotes cell proliferation, migration, and invasion in ESCC and achieves this through upregulating the expression of COL12A1 and phosphorylation of RAF/MRK/ERK. Additionally, COL12A1 can counteract the siMETTL3-mediated inhibition of proliferation, migration, and invasion in ESCC.
Article
Biochemistry & Molecular Biology
Xiaoyu Hu, Xin Shen, Jiangxue Tian
Summary: The research found that periodontitis positive correlated microbiota promotes the development of oral squamous cell carcinoma, while periodontitis negative correlated microbiota inhibits its development.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Oncology
Qiusheng Shan, Kiyofumi Takabatake, Haruka Omori, Hotaka Kawai, May Wathone Oo, Keisuke Nakano, Soichiro Ibaragi, Akira Sasaki, Hitoshi Nagatsuka
Summary: The study demonstrates that both VSCC-SCs and SCC-SCs may promote the progression of OSCC, with SCC-SCs showing a more prominent effect, indicating a potential regulatory mechanism for OSCC progression.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Liang Li, Lihui Chen, Zhangwei Li, Shiqin Huang, Yaoyao Chen, Zhiyong Li, Wenkuan Chen
Summary: This study found that FSCN1 is significantly upregulated in OSCC tissues and cell lines, and silencing FSCN1 can inhibit OSCC growth and invasion, as well as reduce glycolysis. Mechanistic studies showed that FSCN1 achieves its function by activating the IRF4 and AKT pathways. Therefore, FSCN1 may serve as a biomarker and therapeutic target for OSCC.
Article
Oncology
Yuanyuan Kang, Ying Zhang, Yan Sun
Summary: miR-198 downregulation in OSCC tissues and cell lines is associated with poor overall survival and disease-free survival. Overexpression of miR-198 significantly inhibits proliferation, invasion, and EMT of OSCC cells. Luciferase assay results demonstrate that miR-198 interacts with CDK4 by directly targeting its binding site in the CDK4 sequence.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sarai Pongjantarasatian, Nunthawan Nowwarote, Varumporn Rotchanakitamnuai, Watcharee Srirodjanakul, Ritmongkol Saehun, Kajohnkiart Janebodin, Jeeranan Manokawinchoke, Benjamin P. J. Fournier, Thanaphum Osathanon
Summary: Notch signaling plays an important regulatory role in oral squamous cell carcinoma (OSCC), promoting cell growth, cell cycle progression, cell migration, and invasion. Blocking Notch signaling can significantly inhibit the proliferation and progression of OSCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Kana Hasegawa, Shinsuke Fujii, Shinji Matsumoto, Yudai Tajiri, Akira Kikuchi, Tamotsu Kiyoshima
Summary: The study demonstrates that the YAP signaling pathway promotes oral squamous cell carcinoma (OSCC) cell proliferation through the PIEZO1 channel, indicating a crucial role of YAP/PIEZO1 axis in tumorigenesis. These findings provide important insights into the understanding of cellular behavior changes during tumor growth.
JOURNAL OF PATHOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Yue Xiao, Yanjun Duan, Yongjie Wang, Xiaojia Yin
Summary: The study demonstrated that resveratrol inhibits the growth and promotes apoptosis of CAL-27 oral squamous cell carcinoma cells by regulating the ZNF750/RAC1 signaling pathway. Resveratrol also suppresses malignant progression by modulating the expression of angiogenin, cell adhesion molecules, and vascular markers.
Article
Medicine, Research & Experimental
Peng Shen, Tian-Yang Zhang, Shu-Yan Wang
Summary: TRIB3 promotes OSCC cell proliferation by activating the AKT signaling pathway. Therefore, TRIB3 may serve as a potential target for the diagnosis and treatment of OSCC.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Lei Yang, Qiqiong Zhang, Qiuye Yang
Summary: This study reveals the role of KDM3A in regulating proliferation and invasion of OSCC cells by eliminating H3K9me2 to upregulate DCLK1 expression levels.
Article
Oncology
Mengmeng Wang, Mingjun Gao, Yong Chen, Jun Wu, Xiaolin Wang, Yusheng Shu
Summary: This study found that PLCD3 is highly expressed in ESCC tissues and cell lines, and its expression is correlated with pathological stage and lymphatic metastasis. PLCD3 knockdown inhibits cell proliferation, migration, and invasion, promotes apoptosis, and arrests the cell cycle in the G1 phase. PLCD3 overexpression, on the other hand, promotes cell proliferation, migration, and invasion. Xenograft models also suggest that PLCD3 promotes tumorigenesis in ESCC. Finally, overexpression of PLCD3 activates the PI3K/AKT/P21 signaling pathway.
Article
Medicine, Research & Experimental
Marijn A. Scheijde-Vermeulen, Lennart A. Kester, Liset Westera, Bastiaan B. J. Tops, Friederike A. G. Meyer-Wentrup
Summary: This study aimed to evaluate the feasibility of integrating state-of-the-art sequencing techniques and flow cytometry into the diagnostic workup of pediatric lymphoma. The results showed that this integration is not only feasible but also provides additional diagnostic information.
LABORATORY INVESTIGATION
(2024)
Article
Medicine, Research & Experimental
Enrico Berrino, Sara Erika Bellomo, Anita Chesta, Paolo Detillo, Alberto Bragoni, Amedeo Gagliardi, Alessio Naccarati, Matteo Cereda, Gianluca Witel, Anna Sapino, Benedetta Bussolati, Gianni Bussolati, Caterina Marchi
Summary: Formalin-fixed paraffin-embedded (FFPE) samples are crucial for tissue-based analysis in precision medicine, but the quality of these samples can affect the reliability of sequencing data. The use of acid-deprived fixatives guarantees the highest DNA preservation and sequencing performance, enabling more complex molecular profiling of tissue samples.
LABORATORY INVESTIGATION
(2024)
Article
Medicine, Research & Experimental
Roope A. Kallionpaa, Sirkku Peltonen, Kim My Le, Eija Martikkala, Mira Jaaskelainen, Elnaz Fazeli, Pilvi Riihila, Pekka Haapaniemi, Anne Rokka, Marko Salmi, Ilmo Leivo, Juha Peltonen
Summary: This study investigated the immune microenvironment of cutaneous neurofibromas (cNFs) in patients with neurofibromatosis 1 (NF1). The results showed that cNFs have substantial populations of T cells and macrophages, which may be tumor-specific. T cell populations in cNFs were found to be different from those in the skin, and cNFs exhibited lower expression of proteins related to T cell-mediated immunity compared to the skin.
LABORATORY INVESTIGATION
(2024)
