Sphingosine kinase type 1 inhibition reveals rapid turnover of circulating sphingosine 1-phosphate

A rapid assay for assessment of sphingosine kinase inhibitors and substrates

(2011) Yugesh Kharel et al.   ANALYTICAL BIOCHEMISTRY

Development of Amidine-Based Sphingosine Kinase 1 Nanomolar Inhibitors and Reduction of Sphingosine 1-Phosphate in Human Leukemia Cells

(2011) Andrew J. Kennedy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibitors of the Sphingosine Kinase Pathway as Potential Therapeutics

(2010) M.R. Pitman et al.   CURRENT CANCER DRUG TARGETS

Discovery, Biological Evaluation, and Structure−Activity Relationship of Amidine Based Sphingosine Kinase Inhibitors

(2010) Thomas P. Mathews et al.   JOURNAL OF MEDICINAL CHEMISTRY

Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation

(2010) H. M. H. G. Albers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SphK1 Regulates Proinflammatory Responses Associated with Endotoxin and Polymicrobial Sepsis

(2010) P. Puneet et al.   SCIENCE

Lipid phosphate phosphohydrolase type 1 (LPP1) degrades extracellular lysophosphatidic acidin vivo

(2009) Jose L. Tomsig et al.   BIOCHEMICAL JOURNAL

Discovery of novel sphingosine kinase 1 inhibitors

(2009) Yibin Xiang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

FTY720 (fingolimod) in Multiple Sclerosis: therapeutic effects in the immune and the central nervous system

(2009) Volker Brinkmann   BRITISH JOURNAL OF PHARMACOLOGY

When the Sphingosine Kinase 1/Sphingosine 1-Phosphate Pathway Meets Hypoxia Signaling: New Targets for Cancer Therapy

(2009) I. Ader et al.   CANCER RESEARCH

Targeting Sphingosine Kinase 1 Inhibits Akt Signaling, Induces Apoptosis, and Suppresses Growth of Human Glioblastoma Cells and Xenografts

(2009) D. Kapitonov et al.   CANCER RESEARCH

Sphingosine kinase 1 inhibition sensitizes hormone-resistant prostate cancer to docetaxel

(2009) Lysann Sauer et al.   INTERNATIONAL JOURNAL OF CANCER

Sphingosine kinase 2 deficient tumor xenografts show impaired growth and fail to polarize macrophages towards an anti-inflammatory phenotype

(2009) Andreas Weigert et al.   INTERNATIONAL JOURNAL OF CANCER

Synthesis and Evaluation of Sphingosine Analogues as Inhibitors of Sphingosine Kinases

(2009) Lingkai Wong et al.   JOURNAL OF MEDICINAL CHEMISTRY

Sphingosine-1-Phosphate Regulates Glioblastoma Cell Invasiveness through the Urokinase Plasminogen Activator System and CCN1/Cyr61

(2009) Nicholas Young et al.   MOLECULAR CANCER RESEARCH

Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis

(2009) Masaru Ishii et al.   NATURE

Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

(2009) N. C. Hait et al.   SCIENCE

Molecular profiling of LGL leukemia reveals role of sphingolipid signaling in survival of cytotoxic lymphocytes

(2008) M. V. Shah et al.   BLOOD

A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia

(2008) S. W. Paugh et al.   BLOOD

The lysophospholipid mediator sphingosine-1-phosphate promotes angiogenesis in vivo in ischaemic hindlimbs of mice

(2008) O. Oyama et al.   CARDIOVASCULAR RESEARCH

Vascular Endothelium As a Contributor of Plasma Sphingosine 1-Phosphate

(2008) Krishnan Venkataraman et al.   CIRCULATION RESEARCH

Sphingosine-1-phosphate receptors regulate individual cell behaviours underlying the directed migration of prechordal plate progenitor cells during zebrafish gastrulation

(2008) M. Kai et al.   DEVELOPMENT

Quantitative analysis of sphingolipids for lipidomics using triple quadrupole and quadrupole linear ion trap mass spectrometers

(2008) Rebecca L. Shaner et al.   JOURNAL OF LIPID RESEARCH

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Characterization of N,N,-dimethyl-d-erythro-sphingosine-induced apoptosis and signaling in U937 cells: Independence of sphingosine kinase inhibition

(2008) Hyo-Lim Kim et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS