期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 216, 期 1-2, 页码 59-65出版社
ELSEVIER
DOI: 10.1016/j.jneuroim.2009.09.010
关键词
Experimental autoimmune neuritis; Inflammatory demyelinating polyradiculoneuropathy; AUY954; Sphingosine-1-phosphate receptor 1; Lymphocytes; Macrophages
Experimental autoimmune neuritis (EAN) is a T cell-mediated autoimmune inflammatory demyelinating disease of the peripheral nervous system and an animal model of human inflammatory demyelinating polyradiculoneuropathy. AUY954, which targets selectively the sphingosine-1-phosphate receptor 1 (SIP1), is known to sequester lymphocytes into secondary lymphoid tissues. In EAN rats, AUY954 greatly prevented paraparesis if administrated from the day of immunization. T cell, B cell, and macrophage infiltration, inflammatory demyelination, and local expression of interleukine-17 and matrix metalloproteinase-9 in sciatic nerves of EAN rats were significantly decreased by AUY954 treatment Therefore, S1P(1) modulation might be a potential treatment option for inflammatory neuropathies. (C) 2009 Elsevier B.V. All rights reserved.
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