Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases
出版年份 2013 全文链接
标题
Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases
作者
关键词
-
出版物
NATURE REVIEWS DRUG DISCOVERY
Volume 12, Issue 6, Pages 447-464
出版商
Springer Nature
发表日期
2013-05-31
DOI
10.1038/nrd4010
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- A phosphoramidate ProTide (NUC-1031) and acquired and intrinsic resistance to gemcitabine.
- (2017) C. McGuigan et al. JOURNAL OF CLINICAL ONCOLOGY
- Human Carboxylesterase-2 Hydrolyzes the Prodrug of Gemcitabine (LY2334737) and Confers Prodrug Sensitivity to Cancer Cells
- (2013) S. E. Pratt et al. CLINICAL CANCER RESEARCH
- Nucleotide Polymerase Inhibitor Sofosbuvir plus Ribavirin for Hepatitis C
- (2013) Edward J. Gane et al. NEW ENGLAND JOURNAL OF MEDICINE
- First Pharmacokinetic and Safety Study in Humans of the Novel Lipid Antiviral Conjugate CMX001, a Broad-Spectrum Oral Drug Active against Double-Stranded DNA Viruses
- (2012) Wendy Painter et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Genotype and Subtype Profiling of PSI-7977 as a Nucleotide Inhibitor of Hepatitis C Virus
- (2012) Angela M. Lam et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Anti-HIV-1 activity of resveratrol derivatives and synergistic inhibition of HIV-1 by the combination of resveratrol and decitabine
- (2012) Christine L. Clouser et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Elacytarabine has single-agent activity in patients with advanced acute myeloid leukaemia
- (2012) Susan O'Brien et al. BRITISH JOURNAL OF HAEMATOLOGY
- In vitro and in vivo studies of pharmacokinetics and antitumor efficacy of D07001-F4, an oral gemcitabine formulation
- (2012) Wei-Hua Hao et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Adenosine Transport Blockade Restores Attenuated Cardioprotective Effects of Adenosine Preconditioning in the Isolated Diabetic Rat Heart: Potential Crosstalk with Opioid Receptors
- (2012) Nidhi Krishan Sharma et al. Cardiovascular Toxicology
- HIV-1 Antiretroviral Resistance
- (2012) Michele W. Tang et al. DRUGS
- Pharmacogenetic determinants of mercaptopurine disposition in children with acute lymphoblastic leukemia
- (2012) Tiphaine Adam de Beaumais et al. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
- Stampidine as a promising antiretroviral drug candidate for pre-exposure prophylaxis against sexually transmitted HIV/AIDS
- (2012) Fatih M Uckun et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Levels of Gemcitabine Transport and Metabolism Proteins Predict Survival Times of Patients Treated With Gemcitabine for Pancreatic Adenocarcinoma
- (2012) Raphaël Maréchal et al. GASTROENTEROLOGY
- Effect of IL28B Genotype on Early Viral Kinetics During Interferon-Free Treatment of Patients With Chronic Hepatitis C
- (2012) Tom W. Chu et al. GASTROENTEROLOGY
- Gemcitabine is active against clinical multiresistant Staphylococcus aureus strains and is synergistic with gentamicin
- (2012) Lars Petter Jordheim et al. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- The HIVdb System for HIV-1 Genotypic Resistance Interpretation
- (2012) Michele W. Tang et al. INTERVIROLOGY
- Sofosbuvir (GS-7977) plus peginterferon/ribavirin in treatment-naïve patients with HCV genotype 1: A randomized, 28-day, dose-ranging trial
- (2012) Maribel Rodriguez-Torres et al. JOURNAL OF HEPATOLOGY
- Fluorocyclopentenyl-cytosine with Broad Spectrum and Potent Antitumor Activity
- (2012) Won Jun Choi et al. JOURNAL OF MEDICINAL CHEMISTRY
- Oral sapacitabine for the treatment of acute myeloid leukaemia in elderly patients: a randomised phase 2 study
- (2012) Hagop Kantarjian et al. LANCET ONCOLOGY
- TAS-102 monotherapy for pretreated metastatic colorectal cancer: a double-blind, randomised, placebo-controlled phase 2 trial
- (2012) Takayuki Yoshino et al. LANCET ONCOLOGY
- Elacytarabine, a novel 5′-elaidic acid derivative of cytarabine, and idarubicin combination is active in refractory acute myeloid leukemia
- (2012) Francis Giles et al. LEUKEMIA RESEARCH
- Role of Human Nucleoside Transporters in the Uptake and Cytotoxicity of Azacitidine and Decitabine
- (2012) Vijaya L. Damaraju et al. NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
- Henipavirus outbreaks to antivirals: the current status of potential therapeutics
- (2012) Christopher C Broder Current Opinion in Virology
- A 40-Year Journey in Search of Selective Antiviral Chemotherapy*
- (2011) Erik De Clercq Annual Review of Pharmacology and Toxicology
- Pharmacokinetics and Safety of FV-100, a Novel Oral Anti-Herpes Zoster Nucleoside Analogue, Administered in Single and Multiple Doses to Healthy Young Adult and Elderly Adult Volunteers
- (2011) Helen S. Pentikis et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- INX-08189, a Phosphoramidate Prodrug of 6-O-Methyl-2′-C-Methyl Guanosine, Is a Potent Inhibitor of Hepatitis C Virus Replication with Excellent Pharmacokinetic and Pharmacodynamic Properties
- (2011) John H. Vernachio et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Deoxycytidine kinase is overexpressed in poor outcome breast cancer and determines responsiveness to nucleoside analogs
- (2011) Ernst-Jan Geutjes et al. BREAST CANCER RESEARCH AND TREATMENT
- Phase I Study of Oral Gemcitabine Prodrug (LY2334737) Alone and in Combination with Erlotinib in Patients with Advanced Solid Tumors
- (2011) Stijn L.W. Koolen et al. CLINICAL CANCER RESEARCH
- Zidovudine (AZT) has a bactericidal effect on enterobacteria and induces genetic modifications in resistant strains
- (2011) A. Doléans-Jordheim et al. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
- Gemcitabine-loaded innovative nanocarriers vs GEMZAR: Biodistribution, pharmacokinetic features andin vivoantitumor activity
- (2011) Christian Celia et al. Expert Opinion on Drug Delivery
- Synthesis of n-squalenoyl cytarabine and evaluation of its affinity with phospholipid bilayers and monolayers
- (2011) Maria Grazia Sarpietro et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Metabolism and accumulation of the lipophilic deoxynucleoside analogs elacytarabine and CP-4126
- (2011) Auke D. Adema et al. INVESTIGATIONAL NEW DRUGS
- First-In-Man Study of CPX-351: A Liposomal Carrier Containing Cytarabine and Daunorubicin in a Fixed 5:1 Molar Ratio for the Treatment of Relapsed and Refractory Acute Myeloid Leukemia
- (2011) Eric J. Feldman et al. JOURNAL OF CLINICAL ONCOLOGY
- Stearoyl gemcitabine nanoparticles overcome resistance related to the over-expression of ribonucleotide reductase subunit M1
- (2011) Woon-Gye Chung et al. JOURNAL OF CONTROLLED RELEASE
- 1237 NO RESISTANCE TO IDX184 WAS DETECTED IN 3-DAY AND 14-DAY CLINICAL STUDIES OF IDX184 IN GENOTYPE 1-INFECTED HCV SUBJECTS
- (2011) J.F. McCarville et al. JOURNAL OF HEPATOLOGY
- 61 ONCE DAILY PSI-7977 PLUS PEGIFN/RBV IN A PHASE 2B TRIAL: RAPID VIROLOGIC SUPPRESSION IN TREATMENT-NAIVE PATIENTS WITH HCV GT2/GT3
- (2011) J. Lalezari et al. JOURNAL OF HEPATOLOGY
- In Vitro-Selected Drug-Resistant Varicella-Zoster Virus Mutants in the Thymidine Kinase and DNA Polymerase Genes Yield Novel Phenotype-Genotype Associations and Highlight Differences between Antiherpesvirus Drugs
- (2011) G. Andrei et al. JOURNAL OF VIROLOGY
- Transporters that translocate nucleosides and structural similar drugs: structural requirements for substrate recognition
- (2011) Pedro Cano-Soldado et al. MEDICINAL RESEARCH REVIEWS
- Squalenoyl gemcitabine nanomedicine overcomes the low efficacy of gemcitabine therapy in pancreatic cancer
- (2011) Soukaina Réjiba et al. Nanomedicine-Nanotechnology Biology and Medicine
- Integrating pharmacogenetics into gemcitabine dosing—time for a change?
- (2011) Joseph Ciccolini et al. Nature Reviews Clinical Oncology
- A Conjugate of Gemcitabine With Bisphosphonate (Gem/BP) Shows Potential as a Targeted Bone-Specific Therapeutic Agent in an Animal Model of Human Breast Cancer Bone Metastases
- (2011) A. A. El-Mabhouh et al. ONCOLOGY RESEARCH
- Drug uptake transporters in antiretroviral therapy
- (2011) Gerard Minuesa et al. PHARMACOLOGY & THERAPEUTICS
- Analysis of the Ex Vivo and In Vivo Antiretroviral Activity of Gemcitabine
- (2011) Christine L. Clouser et al. PLoS One
- Progress in the development of new therapies for herpesvirus infections
- (2011) Nathan B Price et al. Current Opinion in Virology
- Development of Hexadecyloxypropyl Tenofovir (CMX157) for Treatment of Infection Caused by Wild-Type and Nucleoside/Nucleotide-Resistant HIV
- (2010) E. R. Lanier et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Cytomegalovirus UL97 Mutations Affecting Cyclopropavir and Ganciclovir Susceptibility
- (2010) Sunwen Chou et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Superior Preclinical Efficacy of Gemcitabine Developed As Chitosan Nanoparticulate System
- (2010) José L. Arias et al. BIOMACROMOLECULES
- Deoxycitidine kinase is associated with prolonged survival after adjuvant gemcitabine for resected pancreatic adenocarcinoma
- (2010) Raphaël Maréchal et al. CANCER
- Liposomal cytarabine is effective and tolerable in the treatment of central nervous system relapse of acute lymphoblastic leukemia and very aggressive lymphoma
- (2010) N. Gokbuget et al. HAEMATOLOGICA
- Improved plasma stability and sustained release profile of gemcitabine via polypeptide conjugation
- (2010) Lik-Voon Kiew et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Antiproliferative activity, mechanism of action and oral antitumor activity of CP-4126, a fatty acid derivative of gemcitabine, in in vitro and in vivo tumor models
- (2010) Andries M. Bergman et al. INVESTIGATIONAL NEW DRUGS
- Thiopurine S-methyltransferase (TPMT) assessment prior to starting thiopurine drug treatment; a pharmacogenomic test whose time has come
- (2010) L. T. Ford et al. JOURNAL OF CLINICAL PATHOLOGY
- Transmembrane diffusion of gemcitabine by a nanoparticulate squalenoyl prodrug: An original drug delivery pathway
- (2010) L. Bildstein et al. JOURNAL OF CONTROLLED RELEASE
- RG7128 Alone or in Combination with Pegylated Interferon‐α2a and Ribavirin Prevents Hepatitis C Virus (HCV) Replication and Selection of Resistant Variants in HCV‐Infected Patients
- (2010) Sophie Le Pogam et al. JOURNAL OF INFECTIOUS DISEASES
- Improved Syntheses of 5′-S-(2-Aminoethyl)-6-N-(4-nitrobenzyl)-5′-thioadenosine (SAENTA), Analogues, and Fluorescent Probe Conjugates: Analysis of Cell-Surface Human Equilibrative Nucleoside Transporter 1 (hENT1) Levels for Prediction of the Antitumor Efficacy of Gemcitabine
- (2010) Morris J. Robins et al. JOURNAL OF MEDICINAL CHEMISTRY
- Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): a randomised, double-blind, placebo-controlled, dose-escalation trial
- (2010) Edward J Gane et al. LANCET
- The ribonucleotide reductase large subunit (RRM1) as a predictive factor in patients with cancer
- (2010) Lars Petter Jordheim et al. LANCET ONCOLOGY
- Nucleoside analog ARC targets Mcl-1 to induce apoptosis in leukemia cells
- (2010) U G Bhat et al. LEUKEMIA
- 8-Amino-Adenosine Inhibits Multiple Mechanisms of Transcription
- (2010) J. A. Frey et al. MOLECULAR CANCER THERAPEUTICS
- Delivery of 5-Azacytidine to Human Cancer Cells by Elaidic Acid Esterification Increases Therapeutic Drug Efficacy
- (2010) B. Brueckner et al. MOLECULAR CANCER THERAPEUTICS
- Trifluorothymidine Resistance Is Associated with Decreased Thymidine Kinase and Equilibrative Nucleoside Transporter Expression or Increased Secretory Phospholipase A2
- (2010) Olaf H. Temmink et al. MOLECULAR CANCER THERAPEUTICS
- S110, a 5-Aza-2'-Deoxycytidine-Containing Dinucleotide, Is an Effective DNA Methylation Inhibitor In vivo and Can Reduce Tumor Growth
- (2010) J. C. Chuang et al. MOLECULAR CANCER THERAPEUTICS
- A Placebo-Controlled Trial of Oral Cladribine for Relapsing Multiple Sclerosis
- (2010) Gavin Giovannoni et al. NEW ENGLAND JOURNAL OF MEDICINE
- Massively parallel pyrosequencing in HIV research
- (2009) Frederic D Bushman et al. AIDS
- Retention of Metabolites of 2',3'-Didehydro-3'-Deoxy-4'-Ethynylthymidine, a Novel Anti-Human Immunodeficiency Virus Type 1 Thymidine Analog, in Cells
- (2009) X. Wang et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Special feature of mixed phosphotriester derivatives of cytarabine
- (2009) Marie-Hélène Gouy et al. BIOORGANIC & MEDICINAL CHEMISTRY
- A unique RNA-directed nucleoside analog is cytotoxic to breast cancer cells and depletes cyclin E levels
- (2009) Christine M. Stellrecht et al. BREAST CANCER RESEARCH AND TREATMENT
- Assessment of GS-9219 in a Pet Dog Model of Non-Hodgkin's Lymphoma
- (2009) D. M. Vail et al. CLINICAL CANCER RESEARCH
- Targeting DNA Repair in Chronic Lymphocytic Leukemia Cells with a Novel Acyclic Nucleotide Analogue, GS-9219
- (2009) C.-Y. Tsai et al. CLINICAL CANCER RESEARCH
- Human Equilibrative Nucleoside Transporter 1 and Human Concentrative Nucleoside Transporter 3 Predict Survival after Adjuvant Gemcitabine Therapy in Resected Pancreatic Adenocarcinoma
- (2009) R. Marechal et al. CLINICAL CANCER RESEARCH
- Hepatitis B Virus Resistance to Nucleos(t)ide Analogues
- (2009) Fabien Zoulim et al. GASTROENTEROLOGY
- Resistance profile of the new nucleoside reverse transcriptase inhibitor apricitabine
- (2009) P. Cahn et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Cytidine Deaminase Residual Activity in Serum Is a Predictive Marker of Early Severe Toxicities in Adults After Gemcitabine-Based Chemotherapies
- (2009) Joseph Ciccolini et al. JOURNAL OF CLINICAL ONCOLOGY
- Phase I Clinical and Pharmacokinetic Study of Oral Sapacitabine in Patients With Acute Leukemia and Myelodysplastic Syndrome
- (2009) Hagop Kantarjian et al. JOURNAL OF CLINICAL ONCOLOGY
- Synthesis, Crystallization, and Biological Evaluation of an Orally Active Prodrug of Gemcitabine
- (2009) David M. Bender et al. JOURNAL OF MEDICINAL CHEMISTRY
- Anticancer Efficacy of Squalenoyl Gemcitabine Nanomedicine on 60 Human Tumor Cell Panel and on Experimental Tumor
- (2009) L. Harivardhan Reddy et al. MOLECULAR PHARMACEUTICS
- Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
- (2009) Dongliang Ge et al. NATURE
- Molecular strategies to inhibit the replication of RNA viruses
- (2008) Pieter Leyssen et al. ANTIVIRAL RESEARCH
- Inhibition of topoisomerase II by 8-chloro-adenosine triphosphate induces DNA double-stranded breaks in 8-chloro-adenosine-exposed human myelocytic leukemia K562 cells
- (2008) Sheng-Yong Yang et al. BIOCHEMICAL PHARMACOLOGY
- CP-4055 and CP-4126 are active in ara-C and gemcitabine-resistant lymphoma cell lines
- (2008) Carlos M. Galmarini et al. BRITISH JOURNAL OF HAEMATOLOGY
- Oral Administration of Gemcitabine in Patients with Refractory Tumors: A Clinical and Pharmacologic Study
- (2008) S. A. Veltkamp et al. CLINICAL CANCER RESEARCH
- 188Re-labelled gemcitabine/bisphosphonate (Gem/BP): a multi-functional, bone-specific agent as a potential treatment for bone metastases
- (2008) Amal A. El-Mabhouh et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- The value of oral cytarabine ocfosfate and etoposide in the treatment of refractory and elderly AML patients
- (2008) Akira Horikoshi et al. INTERNATIONAL JOURNAL OF HEMATOLOGY
- Antitumoral activity of PEG–gemcitabine prodrugs targeted by folic acid
- (2008) Gianfranco Pasut et al. JOURNAL OF CONTROLLED RELEASE
- 588 IN VITRO ANTIVIRAL ACTIVITY AND PHARMACOLOGY OF IDX184, A NOVEL AND POTENT INHIBITOR OF HCV REPLICATION
- (2008) E. Cretton-Scott et al. JOURNAL OF HEPATOLOGY
- Pradefovir: A Prodrug That Targets Adefovir to the Liver for the Treatment of Hepatitis B
- (2008) K. Raja Reddy et al. JOURNAL OF MEDICINAL CHEMISTRY
- Activation ofp16Gene Silenced by DNA Methylation in Cancer Cells by Phosphoramidate Derivatives of 2′-Deoxyzebularine
- (2008) Christine B. Yoo et al. JOURNAL OF MEDICINAL CHEMISTRY
- Use of Massively Parallel Ultradeep Pyrosequencing To Characterize the Genetic Diversity of Hepatitis B Virus in Drug-Resistant and Drug-Naive Patients and To Detect Minor Variants in Reverse Transcriptase and Hepatitis B S Antigen
- (2008) M. Solmone et al. JOURNAL OF VIROLOGY
- Nucleoside analogs: molecular mechanisms signaling cell death
- (2008) B Ewald et al. ONCOGENE
- Discovery of New Hexagonal Supramolecular Nanostructures Formed by Squalenoylation of an Anticancer Nucleoside Analogue
- (2008) Patrick Couvreur et al. Small
- Liposomal Coencapsulated Fludarabine and Mitoxantrone for Lymphoproliferative Disorder Treatment**Xiaobin Zhao and Jianmei Wu contributed equally to this study.
- (2007) Xiaobin Zhao et al. JOURNAL OF PHARMACEUTICAL SCIENCES
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started