A 40-Year Journey in Search of Selective Antiviral Chemotherapy*

Effectiveness and Safety of Tenofovir Gel, an Antiretroviral Microbicide, for the Prevention of HIV Infection in Women

(2010) Q. Abdool Karim et al.   SCIENCE

TMC278, a Next-Generation Nonnucleoside Reverse Transcriptase Inhibitor (NNRTI), Active against Wild-Type and NNRTI-Resistant HIV-1

(2009) H. Azijn et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Alkoxyalkyl prodrugs of acyclic nucleoside phosphonates enhance oral antiviral activity and reduce toxicity: Current state of the art

(2009) Karl Y. Hostetler   ANTIVIRAL RESEARCH

Early nucleoside reverse transcriptase inhibitors for the treatment of HIV: A brief history of stavudine (D4T) and its comparison with other dideoxynucleosides

(2009) John C. Martin et al.   ANTIVIRAL RESEARCH

Nucleoside and nucleotide HIV reverse transcriptase inhibitors: 25 years after zidovudine

(2009) Tomas Cihlar et al.   ANTIVIRAL RESEARCH

The AMD3100 story: The path to the discovery of a stem cell mobilizer (Mozobil)

(2009) Erik De Clercq   BIOCHEMICAL PHARMACOLOGY

A new drug combination therapy for treatment-naive patients with HIV-1 infection, consisting of raltegravir, emtricitabine and tenofovir disoproxil fumarate

(2009) Erik De Clercq   EXPERT OPINION ON PHARMACOTHERAPY

Safety and efficacy of raltegravir-based versus efavirenz-based combination therapy in treatment-naive patients with HIV-1 infection: a multicentre, double-blind randomised controlled trial

(2009) Jeffrey L Lennox et al.   LANCET

Antiviral drug discovery: Ten more compounds, and ten more stories (part B)

(2009) Erik De Clercq   MEDICINAL RESEARCH REVIEWS

Another ten stories in antiviral drug discovery (part C): “Old” and “new” antivirals, strategies, and perspectives

(2009) Erik De Clercq   MEDICINAL RESEARCH REVIEWS

The next ten stories on antiviral drug discovery (part E): advents, advances, and adventures

(2009) Erik De Clercq   MEDICINAL RESEARCH REVIEWS

A preemptive strike against HIV

(2009) Cassandra Willyard   NATURE MEDICINE

The history of antiretrovirals: key discoveries over the past 25 years

(2009) Erik De Clercq   REVIEWS IN MEDICAL VIROLOGY

Novel Nucleotide Human Immunodeficiency Virus Reverse Transcriptase Inhibitor GS-9148 with a Low Nephrotoxic Potential: Characterization of Renal Transport and Accumulation

(2008) T. Cihlar et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Intracellular metabolism of the new antiviral compound 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine

(2008) Lieve Naesens et al.   BIOCHEMICAL PHARMACOLOGY

GS-9219--A Novel Acyclic Nucleotide Analogue with Potent Antineoplastic Activity in Dogs with Spontaneous Non-Hodgkin's Lymphoma

(2008) H. Reiser et al.   CLINICAL CANCER RESEARCH

Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV

(2008) Erik De Clercq   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Tetrazolium-based colorimetric assay for the detection of HIV replication inhibitors: revisited 20 years later

(2008) Christophe Pannecouque et al.   Nature Protocols

Tenofovir Disoproxil Fumarate versus Adefovir Dipivoxil for Chronic Hepatitis B

(2008) Patrick Marcellin et al.   NEW ENGLAND JOURNAL OF MEDICINE