Review
Biochemistry & Molecular Biology
Thiery De Serres-Berard, Siham Ait Benichou, Dominic Jauvin, Mohamed Boutjdir, Jack Puymirat, Mohamed Chahine
Summary: DM1 is a dominant genetic disease that can be treated by altering the chemical design of antisense oligonucleotides. Various strategies involving chemical modifications and conjugation with specific functional molecules have been shown to improve the potency in muscle and cardiac tissues. In addition, intrathecal administration can be used to treat central nervous system defects in DM1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Egidio Freitas, Melinda Gooderham, Tiago Torres
Summary: Atopic dermatitis is a common chronic inflammatory skin disease that is mainly treated with topical medications. However, long-term use of these medications may have safety concerns. Several new topical compounds are being developed and show promising results in treating mild to moderate disease. Further research is needed to evaluate their long-term efficacy and safety compared to current treatments.
Review
Biotechnology & Applied Microbiology
Giuseppe Pantaleo, Bruno Correia, Craig Fenwick, Victor S. Joo, Laurent Perez
Summary: Monoclonal antibodies are attractive as potential therapeutics and prophylactics for viral infections due to their high specificity and ability to enhance immune responses. Advances in antibody engineering and structural biology have led to the development of monoclonal antibodies targeting various viruses, and have implications for vaccine design.
NATURE REVIEWS DRUG DISCOVERY
(2022)
Review
Biochemistry & Molecular Biology
Pardis Mokhtary, Zeinab Pourhashem, Akram Abouei Mehrizi, Claudia Sala, Rino Rappuoli
Summary: Monoclonal antibodies are a revolutionary class of medications that can bind specific targets and receptors to combat various diseases. New technologies, such as gene delivery, have been developed to improve their efficacy and delivery routes, enabling them to be used in the treatment of viral infections and outbreaks.
Review
Biochemistry & Molecular Biology
Federica Sodano, Elena Gazzano, Roberta Fruttero, Loretta Lazzarato
Summary: Nitric oxide plays a crucial role in viral infections, particularly respiratory viral infections. By regulating nitric oxide synthesis, antiviral therapies based on nitric oxide can be developed. This review provides a comprehensive overview of the role of nitric oxide in viral infections and the development of nitric oxide-based antiviral strategies, with a particular focus on its clinical use in the prevention and treatment of COVID-19.
Review
Nanoscience & Nanotechnology
Pranav P. Kalelkar, Milan Riddick, Andres J. Garcia
Summary: This review discusses the use of antibacterial biomaterials and non-antibiotic therapies to improve the ability to combat antibiotic resistance and recurring infections. Utilizing biomaterials allows for targeted delivery of multiple agents while reducing systemic adverse effects, showing great potential for future development.
NATURE REVIEWS MATERIALS
(2022)
Review
Behavioral Sciences
Regine Sitruk-Ware, Brooke Bonsack, Roberta Brinton, Michael Schumacher, Narender Kumar, Jea-Young Lee, Vanessa Castelli, Sydney Corey, Alexandreya Coats, Nadia Sadanandan, Bella Gonzales-Portillo, Matt Heyck, Alex Shear, Cozene Blaise, Henry Zhang, Michael Sheyner, Julian Garcia-Sanchez, Lisset Navarro, Martine El-Etr, Alejandro F. De Nicola, Cesar Borlongan
Summary: Hormone therapy using progesterone and progestins for CNS disorders shows promise in regenerative medicine, with Nestorone emerging as a potential candidate for diseases such as MS, ALS, SCI, and stroke. Researchers are working to optimize drug regimens and identify suitable patient populations to advance Nestorone to clinical application.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Review
Virology
Isadora Zhang, Zoe Hsiao, Fenyong Liu
Summary: Herpes simplex virus 1 (HSV-1) can cause cold sores or keratitis in healthy individuals, but severe complications in immune-compromised or neonatal patients. Current therapies can block viral replication but have limited effect on viral latency, necessitating the development of new strategies. Genome editing methods like homing endonucleases and CRISPR/Cas systems show promise in inhibiting HSV-1 infection.
Review
Microbiology
Ali A. Rabaan, Amal H. Alfaraj, Amer Alshengeti, Abdulsalam Alawfi, Sara Alwarthan, Mashael Alhajri, Amal H. Al-Najjar, Mona A. Al Fares, Mustafa A. Najim, Souad A. Almuthree, Sultan T. AlShurbaji, Fadwa S. Alofi, Bashayer M. AlShehail, Buthina AlYuosof, Ahlam Alynbiawi, Suha A. Alzayer, Nawal Al Kaabi, Wesam A. Abduljabbar, Zakiyah A. Bukhary, Ahmed S. Bueid
Summary: The finding that certain monoclonal antibodies (mAbs) have antifungal properties suggests that antibody immunity may play a crucial role in the defense against fungal infections. This discovery is significant as it opens up possibilities for developing vaccines that can elicit protective antibody immunity. These vaccines could enhance the function of both non-specific (neutrophils, macrophages, NK cells) and specific (lymphocyte) cell-mediated immune responses and aid in eradicating or preventing fungal infections.
Review
Pediatrics
Suzanne Cuda, Marisa Censani
Summary: This review discusses new medical and surgical options for treating children and adolescents with obesity, and the impact of COVID-19 on this population, emphasizing the importance of screening tests for rare genetic causes of obesity. It also highlights the positive effects of new medications and surgical therapies in treating obesity, underscoring that obesity is a chronic disease that requires early intervention.
CURRENT OPINION IN PEDIATRICS
(2022)
Review
Cell Biology
Dragos-Bogdan Vlad, David-Ioan Dumitrascu, Alina-Laura Dumitrascu
Summary: The Golgi apparatus is an important organelle involved in the processing, sorting, and transportation of cellular components. It also plays a role in protein trafficking and post-translational modifications, which are significant in cancer development. Targeting the STING pathway, glycosylation, and Golgi trafficking are potential approaches for cancer treatment.
Article
Clinical Neurology
Nirosen Vijiaratnam, Tanya Simuni, Oliver Bandmann, Huw R. Morris, Thomas Foltynie
Summary: The development of disease-modifying treatments for Parkinson's disease remains a challenge, due in part to limitations in therapeutic candidate selection and clinical trial design. A better understanding of Parkinson's disease pathogenesis, the use of biomarkers, focus on safe drugs, and precision medicine approaches could greatly increase the likelihood of successful identification of disease-modifying treatments.
Review
Immunology
Kumari Asha, Neelam Sharma-Walia
Summary: Herpesviruses rely on various host factors to establish latent infection, survive, and spread diseases. Understanding these host factors can lead to the development of safe and effective antivirals. Targeting pro-inflammatory, anti-inflammatory, and resolution lipid metabolites of the arachidonic acid pathway can be a promising approach to combat herpesvirus infections. Anti-herpesvirus therapeutics include inhibitors blocking viral life cycle events, engineered anticancer agents, epigenome influencing factors, immunomodulators, and therapeutic compounds from natural extracts.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Maria Dolores Cima Cabal, Felipe Molina, Jose Ignacio Lopez-Sanchez, Efren Perez-Santin, Maria del Mar Garcia-Suarez
Summary: This systematic review evaluates pneumolysin (PLY) as a target for new treatments against pneumococcal infections. Forty-one articles were reviewed, and molecules that inhibit PLY were classified into three main groups: those exerting a direct effect, those acting indirectly, and those with unknown mechanisms. Some molecules have the potential for clinical implementation, while others require further research. These findings may contribute to the improvement of clinical management for patients with pneumococcal infections.
Article
Engineering, Biomedical
Siyoung A. Lim, Alysia Cox, Madelynn Tung, Eun Ji Chung
Summary: The clinical application of nanoparticles (NPs) for RNA delivery has shown promising results in extending the half-life of therapeutic RNA molecules. This review discusses the NP formulations used in clinical practice and provides examples of RNA-NPs currently under evaluation for human use, as well as failed NP formulations.
BIOACTIVE MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Gloria Komazin-Meredith, Steven C. Cardinale, Katelyn Comeau, Kevin J. Magalhaes, Caroll B. Hartline, John D. Williams, Timothy J. Opperman, Mark N. Prichard, Terry L. Bowlin
ANTIVIRAL RESEARCH
(2015)
Article
Medicine, General & Internal
D. W. Kimberlin, P. M. Jester, P. J. Sanchez, A. Ahmed, R. Arav-Boger, M. G. Michaels, N. Ashouri, J. A. Englund, B. Estrada, R. F. Jacobs, J. R. Romero, S. K. Sood, M. S. Whitworth, M. J. Abzug, M. T. Caserta, S. Fowler, J. Lujan-Zilbermann, G. A. Storch, R. L. DeBiasi, J. -Y. Han, A. Palmer, L. B. Weiner, J. A. Bocchini, P. H. Dennehy, A. Finn, P. D. Griffiths, S. Luck, K. Gutierrez, N. Halasa, J. Homans, A. L. Shane, M. Sharland, K. Simonsen, J. A. Vanchiere, C. R. Woods, D. L. Sabo, I. Aban, H. Kuo, S. H. James, M. N. Prichard, J. Griffin, D. Giles, E. P. Acosta, R. J. Whitley
NEW ENGLAND JOURNAL OF MEDICINE
(2015)
Article
Chemistry, Medicinal
Alexandra Manos-Turvey, Hiba A. Al-Ashtal, Patrick G. Needham, Caroll B. Hartline, Mark N. Prichard, Peter Wipf, Jeffrey L. Brodsky
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2016)
Article
Immunology
E. Randall Lanier, Scott Foster, Tom Brundage, Sunwen Chou, Mark N. Prichard, Steven Kleiboeker, Chad Wilson, Donella Colville, Herve Mommeja-Marin
JOURNAL OF INFECTIOUS DISEASES
(2016)
Article
Chemistry, Medicinal
James R. Beadle, Nadejda Valiaeva, Guang Yang, Jei-Hwa Yu, Thomas R. Broker, Kathy A. Aldern, Emma A. Harden, Kathy A. Keith, Mark N. Prichard, Tracy Hartman, Robert W. Buckheit, Louise T. Chow, Karl Y. Hostetler
JOURNAL OF MEDICINAL CHEMISTRY
(2016)
Article
Virology
Eve-Isabelle Pecheur, Viktoriya Borisevich, Peter Halfmann, John D. Morrey, Donald F. Smee, Mark Prichard, Chad E. Mire, Yoshihiro Kawaoka, Thomas W. Geisbert, Stephen J. Polyak
JOURNAL OF VIROLOGY
(2016)
Article
Immunology
K. M. Mullane, C. Nuss, J. Ridgeway, M. N. Prichard, C. B. Hartline, J. Theusch, H. Mommeja-Marin, R. A. Larson
TRANSPLANT INFECTIOUS DISEASE
(2016)
Article
Oncology
Kevin A. Cassady, David F. Bauer, Justin Roth, Melissa R. Chambers, Trent Shoeb, Jennifer Coleman, Mark Prichard, G. Yancey Gillespie, James M. Markert
MOLECULAR THERAPY-ONCOLYTICS
(2017)
Article
Pharmacology & Pharmacy
Karoly Toth, Jacqueline F. Spencer, Baoling Ying, Ann E. Tollefson, Caroll B. Hartline, Eric T. Richar, Jiajun Fan, Jinglei Lyu, Boris A. Kashemirov, Cheryl Harteg, Dawn Reyna, Elke Lipka, Mark N. Prichard, Charles E. McKenna, William S. M. Wold
ANTIVIRAL RESEARCH
(2018)
Article
Pharmacology & Pharmacy
Debra C. Quenelle, Alexander Birkmann, Thomas Goldner, Tamara Pfaff, Holger Zimmermann, Susanne Bonsmann, Deborah J. Collins, Terri L. Rice, Mark N. Prichard
ANTIVIRAL RESEARCH
(2018)
Article
Pharmacology & Pharmacy
William J. Britt, Mark N. Prichard
ANTIVIRAL RESEARCH
(2018)
Article
Medicine, Research & Experimental
Caroll B. Hartline, Ra'Shun L. Conner, Scott H. James, Jennifer Potter, Edward Gray, Jose Estrada, Mathew Tector, A. Joseph Tector, Mark N. Prichard
XENOTRANSPLANTATION
(2018)
Article
Pharmacology & Pharmacy
Caroll B. Hartline, Kathy A. Keith, Jessica Eagar, Emma A. Harden, Terry L. Bowlin, Mark N. Prichard
ANTIVIRAL RESEARCH
(2018)
Article
Pharmacology & Pharmacy
Kathy A. Keith, Caroll B. Hartline, Terry L. Bowlin, Mark N. Prichard
ANTIVIRAL RESEARCH
(2018)
Article
Pharmacology & Pharmacy
Donald F. Smee, Mark N. Prichard
ANTIVIRAL RESEARCH
(2017)