标题
Cancer Systems Biology: a peek into the future of patient care?
作者
关键词
-
出版物
Nature Reviews Clinical Oncology
Volume 11, Issue 3, Pages 167-176
出版商
Springer Nature
发表日期
2014-02-04
DOI
10.1038/nrclinonc.2014.6
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4
- (2013) Alfred Csibi et al. CELL
- An Interactive Resource to Identify Cancer Genetic and Lineage Dependencies Targeted by Small Molecules
- (2013) Amrita Basu et al. CELL
- Characteristics and Clinical Impacts of the Immune Environments in Colorectal and Renal Cell Carcinoma Lung Metastases: Influence of Tumor Origin
- (2013) R. Remark et al. CLINICAL CANCER RESEARCH
- Integrated genomic characterization of endometrial carcinoma
- (2013) Gad Getz et al. NATURE
- Mutational heterogeneity in cancer and the search for new cancer-associated genes
- (2013) Michael S. Lawrence et al. NATURE
- Heterogeneity of tumor-induced gene expression changes in the human metabolic network
- (2013) Jie Hu et al. NATURE BIOTECHNOLOGY
- Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples
- (2013) Kristian Cibulskis et al. NATURE BIOTECHNOLOGY
- Lineage analysis of basal epithelial cells reveals their unexpected plasticity and supports a cell-of-origin model for prostate cancer heterogeneity
- (2013) Zhu A. Wang et al. NATURE CELL BIOLOGY
- A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer
- (2013) Andrea Lunardi et al. NATURE GENETICS
- A colorectal cancer classification system that associates cellular phenotype and responses to therapy
- (2013) Anguraj Sadanandam et al. NATURE MEDICINE
- Systematic Identification of Combinatorial Drivers and Targets in Cancer Cell Lines
- (2013) Adel Tabchy et al. PLoS One
- Mechanistic patient-specific predictive correlation of tumor drug response with microenvironment and perfusion measurements
- (2013) J. Pascal et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Receptor Tyrosine Kinases Fall into Distinct Classes Based on Their Inferred Signaling Networks
- (2013) J. P. Wagner et al. Science Signaling
- Computational Modeling of ERBB2-Amplified Breast Cancer Identifies Combined ErbB2/3 Blockade as Superior to the Combination of MEK and AKT Inhibitors
- (2013) D. C. Kirouac et al. Science Signaling
- Clinically Relevant Modeling of Tumor Growth and Treatment Response
- (2013) T. E. Yankeelov et al. Science Translational Medicine
- Systematic Analysis of Challenge-Driven Improvements in Molecular Prognostic Models for Breast Cancer
- (2013) A. A. Margolin et al. Science Translational Medicine
- Linking Proteomic and Transcriptional Data through the Interactome and Epigenome Reveals a Map of Oncogene-induced Signaling
- (2013) Shao-shan Carol Huang et al. PLoS Computational Biology
- Improving Breast Cancer Survival Analysis through Competition-Based Multidimensional Modeling
- (2013) Erhan Bilal et al. PLoS Computational Biology
- Bayesian Inference of Signaling Network Topology in a Cancer Cell Line
- (2012) Steven M. Hill et al. BIOINFORMATICS
- What does the concept of the stem cell niche really mean today?
- (2012) Arthur D Lander et al. BMC BIOLOGY
- A reaction–diffusion mechanism influences cell lineage progression as a basis for formation, regeneration, and stability of intestinal crypts
- (2012) Lei Zhang et al. BMC Systems Biology
- TGF-β signalling and its role in cancer progression and metastasis
- (2012) Yvette Drabsch et al. CANCER AND METASTASIS REVIEWS
- Tumor Microenvironment Complexity: Emerging Roles in Cancer Therapy
- (2012) M. A. Swartz et al. CANCER RESEARCH
- Computational Modeling of Pancreatic Cancer Reveals Kinetics of Metastasis Suggesting Optimum Treatment Strategies
- (2012) Hiroshi Haeno et al. CELL
- Sequential Application of Anticancer Drugs Enhances Cell Death by Rewiring Apoptotic Signaling Networks
- (2012) Michael J. Lee et al. CELL
- Understanding resistance to targeted cancer drugs through loss of function genetic screens
- (2012) Katrien Berns et al. DRUG RESISTANCE UPDATES
- An emerging toolkit for targeted cancer therapies
- (2012) G. B. Mills GENOME RESEARCH
- Whole-exome sequencing combined with functional genomics reveals novel candidate driver cancer genes in endometrial cancer
- (2012) H. Liang et al. GENOME RESEARCH
- Systematic analysis of genotype-specific drug responses in cancer
- (2012) Nayoung Kim et al. INTERNATIONAL JOURNAL OF CANCER
- PI3K/AKT/mTOR Inhibitors in Patients With Breast and Gynecologic Malignancies HarboringPIK3CAMutations
- (2012) Filip Janku et al. JOURNAL OF CLINICAL ONCOLOGY
- Multispecies model of cell lineages and feedback control in solid tumors
- (2012) H. Youssefpour et al. JOURNAL OF THEORETICAL BIOLOGY
- Antitumor Activity of a Novel Bispecific Antibody That Targets the ErbB2/ErbB3 Oncogenic Unit and Inhibits Heregulin-Induced Activation of ErbB3
- (2012) C. F. McDonagh et al. MOLECULAR CANCER THERAPEUTICS
- Frequency-Modulated Pulses of ERK Activity Transmit Quantitative Proliferation Signals
- (2012) John G. Albeck et al. MOLECULAR CELL
- Model-driven multi-omic data analysis elucidates metabolic immunomodulators of macrophage activation
- (2012) Aarash Bordbar et al. Molecular Systems Biology
- Combined experimental and computational analysis of DNA damage signaling reveals context-dependent roles for Erk in apoptosis and G1/S arrest after genotoxic stress
- (2012) Andrea R Tentner et al. Molecular Systems Biology
- The glucose-deprivation network counteracts lapatinib-induced toxicity in resistant ErbB2-positive breast cancer cells
- (2012) Kakajan Komurov et al. Molecular Systems Biology
- Comprehensive molecular portraits of human breast tumours
- (2012) Daniel C. Koboldt et al. NATURE
- Multiplexed mass cytometry profiling of cellular states perturbed by small-molecule regulators
- (2012) Bernd Bodenmiller et al. NATURE BIOTECHNOLOGY
- Developing predictive molecular maps of human disease through community-based modeling
- (2012) Jonathan M J Derry et al. NATURE GENETICS
- Fractional proliferation: a method to deconvolve cell population dynamics from single-cell data
- (2012) Darren R Tyson et al. NATURE METHODS
- STK38 is a critical upstream regulator of MYC’s oncogenic activity in human B-cell lymphoma
- (2012) B C Bisikirska et al. ONCOGENE
- Genome-Wide Gene Expression Analysis in Cancer Cells Reveals 3D Growth to Affect ECM and Processes Associated with Cell Adhesion but Not DNA Repair
- (2012) Oliver Zschenker et al. PLoS One
- Defining principles of combination drug mechanisms of action
- (2012) J. R. Pritchard et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Impact of genetic dynamics and single-cell heterogeneity on development of nonstandard personalized medicine strategies for cancer
- (2012) R. A. Beckman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Reverse-engineering human regulatory networks
- (2012) Celine Lefebvre et al. Wiley Interdisciplinary Reviews-Systems Biology and Medicine
- Challenges and opportunities for converting renal cell carcinoma into a chronic disease with targeted therapies
- (2011) M E Gore et al. BRITISH JOURNAL OF CANCER
- Systems Biology: Confronting the Complexity of Cancer
- (2011) A. J. Gentles et al. CANCER RESEARCH
- Quantifying the Role of Angiogenesis in Malignant Progression of Gliomas: In Silico Modeling Integrates Imaging and Histology
- (2011) K. R. Swanson et al. CANCER RESEARCH
- Comparing Signaling Networks between Normal and Transformed Hepatocytes Using Discrete Logical Models
- (2011) J. Saez-Rodriguez et al. CANCER RESEARCH
- Cancer Stem Cells in Squamous Cell Carcinoma Switch between Two Distinct Phenotypes That Are Preferentially Migratory or Proliferative
- (2011) A. Biddle et al. CANCER RESEARCH
- An Extensive MicroRNA-Mediated Network of RNA-RNA Interactions Regulates Established Oncogenic Pathways in Glioblastoma
- (2011) Pavel Sumazin et al. CELL
- Stochastic State Transitions Give Rise to Phenotypic Equilibrium in Populations of Cancer Cells
- (2011) Piyush B. Gupta et al. CELL
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Making sense of cancer genomic data
- (2011) Lynda Chin et al. GENES & DEVELOPMENT
- Chemical Genetic Screen for AMPKα2 Substrates Uncovers a Network of Proteins Involved in Mitosis
- (2011) Max R. Banko et al. MOLECULAR CELL
- Integrated genomic analyses of ovarian carcinoma
- (2011) D. Bell et al. NATURE
- Extracting a cellular hierarchy from high-dimensional cytometry data with SPADE
- (2011) Peng Qiu et al. NATURE BIOTECHNOLOGY
- Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy
- (2011) Eric A Collisson et al. NATURE MEDICINE
- Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth
- (2011) Kristin M Nieman et al. NATURE MEDICINE
- Emerging therapeutic targets in endometrial cancer
- (2011) Konstantin J. Dedes et al. Nature Reviews Clinical Oncology
- Kinome siRNA-phosphoproteomic screen identifies networks regulating AKT signaling
- (2011) Y Lu et al. ONCOGENE
- Integrated molecular profiles of invasive breast tumors and ductal carcinoma in situ (DCIS) reveal differential vascular and interleukin signaling
- (2011) V. N. Kristensen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Subtype and pathway specific responses to anticancer compounds in breast cancer
- (2011) L. M. Heiser et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cross-species hybridization of microarrays for studying tumor transcriptome of brain metastasis
- (2011) E. S. Park et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state
- (2011) C. L. Chaffer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identification of Optimal Drug Combinations Targeting Cellular Networks: Integrating Phospho-Proteomics and Computational Network Analysis
- (2010) S. Iadevaia et al. CANCER RESEARCH
- Three-Dimensional Cell Growth Confers Radioresistance by Chromatin Density Modification
- (2010) K. Storch et al. CANCER RESEARCH
- Transforming growth factor-β and the hallmarks of cancer
- (2010) Maozhen Tian et al. CELLULAR SIGNALLING
- Mathematical modeling of cancer cell invasion of tissue: biological insight from mathematical analysis and computational simulation
- (2010) Vivi Andasari et al. JOURNAL OF MATHEMATICAL BIOLOGY
- Networks Inferred from Biochemical Data Reveal Profound Differences in Toll-like Receptor and Inflammatory Signaling between Normal and Transformed Hepatocytes
- (2010) Leonidas G. Alexopoulos et al. MOLECULAR & CELLULAR PROTEOMICS
- The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models
- (2010) NATURE BIOTECHNOLOGY
- A mammalian functional-genetic approach to characterizing cancer therapeutics
- (2010) Hai Jiang et al. Nature Chemical Biology
- EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer
- (2010) A Singh et al. ONCOGENE
- Accumulation of driver and passenger mutations during tumor progression
- (2010) I. Bozic et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Linking Changes in Epithelial Morphogenesis to Cancer Mutations Using Computational Modeling
- (2010) Katarzyna A. Rejniak et al. PLoS Computational Biology
- Drug Off-Target Effects Predicted Using Structural Analysis in the Context of a Metabolic Network Model
- (2010) Roger L. Chang et al. PLoS Computational Biology
- A Technical Assessment of the Utility of Reverse Phase Protein Arrays for the Study of the Functional Proteome in Non-microdissected Human Breast Cancers
- (2010) Bryan T. Hennessy et al. Clinical Proteomics
- Paradoxical Dependencies of Tumor Dormancy and Progression on Basic Cell Kinetics
- (2009) H. Enderling et al. CANCER RESEARCH
- Cross-Talk between Integrins and Oncogenes Modulates Chemosensitivity
- (2009) J. C. Puigvert et al. MOLECULAR PHARMACOLOGY
- The transcriptional network for mesenchymal transformation of brain tumours
- (2009) Maria Stella Carro et al. NATURE
- Therapeutically Targeting ErbB3: A Key Node in Ligand-Induced Activation of the ErbB Receptor-PI3K Axis
- (2009) B. Schoeberl et al. Science Signaling
- Cell Lineages and the Logic of Proliferative Control
- (2009) Arthur D Lander et al. PLOS BIOLOGY
- Integrated analysis of breast cancer cell lines reveals unique signaling pathways
- (2009) Laura M Heiser et al. GENOME BIOLOGY
- Survival of the Fittest: Cancer Stem Cells in Therapeutic Resistance and Angiogenesis
- (2008) Christine E. Eyler et al. JOURNAL OF CLINICAL ONCOLOGY
- Models from experiments: combinatorial drug perturbations of cancer cells
- (2008) Sven Nelander et al. Molecular Systems Biology
- Stromal gene expression predicts clinical outcome in breast cancer
- (2008) Greg Finak et al. NATURE MEDICINE
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