A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer

POK/ZBTB proteins: an emerging family of proteins that regulate lymphoid development and function

(2012) Sung-Uk Lee et al.   IMMUNOLOGICAL REVIEWS

A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response

(2012) Zhao Chen et al.   NATURE

The mutational landscape of lethal castration-resistant prostate cancer

(2012) Catherine S. Grasso et al.   NATURE

Combination Therapy of Antiandrogen and XIAP Inhibitor for Treating Advanced Prostate Cancer

(2012) Michael Danquah et al.   PHARMACEUTICAL RESEARCH

Targeting X-linked inhibitor of apoptosis protein inhibits pancreatic cancer cell growth through p-Akt depletion

(2012) Chun Jiang   WORLD JOURNAL OF GASTROENTEROLOGY

Reciprocal Feedback Regulation of PI3K and Androgen Receptor Signaling in PTEN-Deficient Prostate Cancer

(2011) Brett S. Carver et al.   CANCER CELL

IAPS : More than just inhibitors of apoptosis proteins

(2011) Laurence Dubrez-Daloz et al.   CELL CYCLE

Novel Therapeutic Strategies for Castration Resistant Prostate Cancer: Inhibition of Persistent Androgen Production and Androgen Receptor Mediated Signaling

(2011) Arturo Molina et al.   JOURNAL OF UROLOGY

XIAP-associated factor 1 (XAF1), a novel target of p53, enhances p53-mediated apoptosis via post-translational modification

(2011) Bing Zou et al.   MOLECULAR CARCINOGENESIS

Exome sequencing identifies a spectrum of mutation frequencies in advanced and lethal prostate cancers

(2011) A. Kumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dihydrotestosterone synthesis bypasses testosterone to drive castration-resistant prostate cancer

(2011) K.-H. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular classification of prostate cancer using curated expression signatures

(2011) E. K. Markert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The APL Paradigm and the “Co-Clinical Trial” Project

(2011) Caterina Nardella et al.   Cancer Discovery

Integrative Genomic Profiling of Human Prostate Cancer

(2010) Barry S. Taylor et al.   CANCER CELL

Overcoming Persistent Dependency on Androgen Signaling after Progression to Castration-Resistant Prostate Cancer

(2010) M. Yamaoka et al.   CLINICAL CANCER RESEARCH

Characterizing the Contribution of Stem/Progenitor Cells to Tumorigenesis in the Pten−/−TP53−/− Prostate Cancer Model

(2010) Wassim G. Abou-Kheir et al.   STEM CELLS

Inhibition of Tumor Growth Progression by Antiandrogens and mTOR Inhibitor in a Pten-Deficient Mouse Model of Prostate Cancer

(2009) W. Zhang et al.   CANCER RESEARCH

XAF1 as a prognostic biomarker and therapeutic target in pancreatic cancer

(2009) Jia Huang et al.   CANCER SCIENCE

Phase II Study of Androgen Synthesis Inhibition with Ketoconazole, Hydrocortisone, and Dutasteride in Asymptomatic Castration-Resistant Prostate Cancer

(2009) M.-E. Taplin et al.   CLINICAL CANCER RESEARCH

Activity of Dutasteride Plus Ketoconazole in Castration-Refractory Prostate Cancer After Progression on Ketoconazole Alone

(2009) Oliver Sartor et al.   Clinical Genitourinary Cancer

LRF Is an Essential Downstream Target of GATA1 in Erythroid Development and Regulates BIM-Dependent Apoptosis

(2009) Takahiro Maeda et al.   DEVELOPMENTAL CELL

Restoration of XAF1 expression induces apoptosis and inhibits tumor growth in gastric cancer

(2009) Shui Ping Tu et al.   INTERNATIONAL JOURNAL OF CANCER

Adenovirus-mediated down-regulation of X-linked inhibitor of apoptosis protein inhibits colon cancer

(2009) Y. Dai et al.   MOLECULAR CANCER THERAPEUTICS

Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer

(2009) Wennuan Liu et al.   NATURE MEDICINE

Gene expression profile in colon cancer cells with respect to XIAP expression status

(2008) Liang Qiao et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

Clinical significance of p53 alterations in surgically treated prostate cancers

(2008) Thorsten Schlomm et al.   MODERN PATHOLOGY