The self-obsession of T cells: how TCR signaling thresholds affect fate 'decisions' and effector function

Signals and pathways controlling regulatory T cells

(2014) Alexandria Huynh et al.   IMMUNOLOGICAL REVIEWS

Overlapping and Asymmetric Functions of TCR Signaling during Thymic Selection of CD4 and CD8 Lineages

(2014) C. Sinclair et al.   JOURNAL OF IMMUNOLOGY

Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development

(2014) Byron B Au-Yeung et al.   NATURE IMMUNOLOGY

Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells

(2014) Shawn A Mahmud et al.   NATURE IMMUNOLOGY

Intrinsic CD4+ T cell sensitivity and response to a pathogen are set and sustained by avidity for thymic and peripheral complexes of self peptide and MHC

(2014) Stephen P Persaud et al.   NATURE IMMUNOLOGY

Thymocyte apoptosis drives the intrathymic generation of regulatory T cells

(2014) J. E. Konkel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T cell immunodominance is dictated by the positively selecting self-peptide

(2014) Wan-Lin Lo et al.   eLife

T Cell-Positive Selection Uses Self-Ligand Binding Strength to Optimize Repertoire Recognition of Foreign Antigens

(2013) Judith N. Mandl et al.   IMMUNITY

Agonist-Selected T Cell Development Requires Strong T Cell Receptor Signaling and Store-Operated Calcium Entry

(2013) Masatsugu Oh-hora et al.   IMMUNITY

The thymic medulla is required for Foxp3+regulatory but not conventional CD4+thymocyte development

(2013) Jennifer E. Cowan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Coreceptor affinity for MHC defines peptide specificity requirements for TCR interaction with coagonist peptide–MHC

(2013) John A.H. Hoerter et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Helios marks strongly autoreactive CD4+T cells in two major waves of thymic deletion distinguished by induction of PD-1 or NF-κB

(2013) Stephen R. Daley et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Type 1 Diabetes Occurs despite Robust Anergy among Endogenous Insulin-Specific CD4 T Cells in NOD Mice

(2013) K. E. Pauken et al.   JOURNAL OF IMMUNOLOGY

Themis sets the signal threshold for positive and negative selection in T-cell development

(2013) Guo Fu et al.   NATURE

Thymoproteasome subunit- 5T generates peptide-MHC complexes specialized for positive selection

(2013) Y. Xing et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effective functional maturation of invariant natural killer T cells is constrained by negative selection and T-cell antigen receptor affinity

(2013) R. Bedel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Murine thymic selection quantified using a unique method to capture deleted T cells

(2013) G. L. Stritesky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Critical role for miR-181a/b-1 in agonist selection of invariant natural killer T cells

(2013) N. Zietara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Asymmetric thymocyte death underlies the CD4:CD8 T-cell ratio in the adaptive immune system

(2013) C. Sinclair et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aire-Dependent Thymic Development of Tumor-Associated Regulatory T Cells

(2013) S. Malchow et al.   SCIENCE

Distinct Temporal Patterns of T Cell Receptor Signaling During Positive Versus Negative Selection in Situ

(2013) H. J. Melichar et al.   Science Signaling

Elimination of Self-Reactive T Cells in the Thymus: A Timeline for Negative Selection

(2013) Ivan Lilyanov Dzhagalov et al.   PLOS BIOLOGY

Models of Self-Peptide Sampling by Developing T Cells Identify Candidate Mechanisms of Thymic Selection

(2013) Iren Bains et al.   PLoS Computational Biology

Selection of Self-Reactive T Cells in the Thymus

(2012) Gretta L. Stritesky et al.   Annual Review of Immunology

A Closer Look at TCR Germline Recognition

(2012) K. Christopher Garcia et al.   IMMUNITY

A Broad Range of Self-Reactivity Drives Thymic Regulatory T Cell Selection to Limit Responses to Self

(2012) Hyang-Mi Lee et al.   IMMUNITY

The BH3-Only Proteins Bim and Puma Cooperate to Impose Deletional Tolerance of Organ-Specific Antigens

(2012) Daniel H.D. Gray et al.   IMMUNITY

Self-awareness: How self-peptide/MHC complexes are essential in the development of T cells

(2012) Wan-Lin Lo et al.   MOLECULAR IMMUNOLOGY

Elevated and sustained expression of the transcription factors Egr1 and Egr2 controls NKT lineage differentiation in response to TCR signaling

(2012) Michael P Seiler et al.   NATURE IMMUNOLOGY

A voltage-gated sodium channel is essential for the positive selection of CD4+ T cells

(2012) Wan-Lin Lo et al.   NATURE IMMUNOLOGY

Clonal deletion and the fate of autoreactive thymocytes that survive negative selection

(2012) Leonid A Pobezinsky et al.   NATURE IMMUNOLOGY

Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling

(2012) Di Wang et al.   NATURE IMMUNOLOGY

Distinct CD4+ helper T cells involved in primary and secondary responses to infection

(2012) K. S. Weber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Detection of an autoreactive T-cell population within the polyclonal repertoire that undergoes distinct autoimmune regulator (Aire)-mediated selection

(2012) R. T. Taniguchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proapoptotic protein Bim is differentially required during thymic clonal deletion to ubiquitous versus tissue-restricted antigens

(2012) A. Y. W. Suen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signaling in thymic selection

(2011) Nicholas RJ Gascoigne et al.   CURRENT OPINION IN IMMUNOLOGY

αβ T Cell Receptors that Do Not Undergo Major Histocompatibility Complex-Specific Thymic Selection Possess Antibody-like Recognition Specificities

(2011) Anastasia N. Tikhonova et al.   IMMUNITY

Signaling thresholds govern heterogeneity in IL-7-receptor-mediated responses of naïve CD8+ T cells

(2011) Megan J Palmer et al.   IMMUNOLOGY AND CELL BIOLOGY

T cell receptor signal strength in Tregand iNKT cell development demonstrated by a novel fluorescent reporter mouse

(2011) Amy E. Moran et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dampening of death pathways by schnurri-2 is essential for T-cell development

(2011) Tracy L. Staton et al.   NATURE

Control of the development of CD8αα+ intestinal intraepithelial lymphocytes by TGF-β

(2011) Joanne E Konkel et al.   NATURE IMMUNOLOGY

Quantitative impact of thymic selection on Foxp3+ and Foxp3- subsets of self-peptide/MHC class II-specific CD4+ T cells

(2011) J. J. Moon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T Cell Receptor-Dependent Regulation of Lipid Rafts Controls Naive CD8+ T Cell Homeostasis

(2010) Jae-Ho Cho et al.   IMMUNITY

Thymoproteasome Shapes Immunocompetent Repertoire of CD8+ T Cells

(2010) Takeshi Nitta et al.   IMMUNITY

Invariant NKT Cell Development Requires a Full Complement of Functional CD3   Immunoreceptor Tyrosine-Based Activation Motifs

(2010) A. M. Becker et al.   JOURNAL OF IMMUNOLOGY

Self-Specific CD8+ T Cells Maintain a Semi-Naive State Following Lymphopenia-Induced Proliferation

(2010) L. D. S. Johnson et al.   JOURNAL OF IMMUNOLOGY

Negative Selection and Peptide Chemistry Determine the Size of Naive Foreign Peptide-MHC Class II-Specific CD4+ T Cell Populations

(2010) H. H. Chu et al.   JOURNAL OF IMMUNOLOGY

Regulation of Zap70 Expression During Thymocyte Development Enables Temporal Separation of CD4 and CD8 Repertoire Selection at Different Signaling Thresholds

(2010) M. Saini et al.   Science Signaling

Aire

(2009) Diane Mathis et al.   Annual Review of Immunology

Evolution of Genetic Networks Underlying the Emergence of Thymopoiesis in Vertebrates

(2009) Baubak Bajoghli et al.   CELL

Self–class I MHC molecules support survival of naive CD8 T cells, but depress their functional sensitivity through regulation of CD8 expression levels

(2009) Kensuke Takada et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bim-Mediated Apoptosis Is Not Necessary for Thymic Negative Selection to Ubiquitous Self-Antigens

(2009) Q. Hu et al.   JOURNAL OF IMMUNOLOGY

An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a

(2009) Peter J R Ebert et al.   NATURE IMMUNOLOGY

Intraclonal competition limits the fate determination of regulatory T cells in the thymus

(2009) Jhoanne L Bautista et al.   NATURE IMMUNOLOGY

Regulatory T cell differentiation of thymocytes does not require a dedicated antigen-presenting cell but is under T cell-intrinsic developmental control

(2009) G. Wirnsberger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Homeostasis of Naive and Memory T Cells

(2008) Charles D. Surh et al.   IMMUNITY

Memory T-lymphocyte survival does not require T-cell receptor expression

(2008) J. Leignadier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA