Themis sets the signal threshold for positive and negative selection in T-cell development

Shp1 regulates T cell homeostasis by limiting IL-4 signals

(2013) Dylan J. Johnson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

GRB2-Mediated Recruitment of THEMIS to LAT Is Essential for Thymocyte Development

(2013) W. Paster et al.   JOURNAL OF IMMUNOLOGY

Selection of Self-Reactive T Cells in the Thymus

(2012) Gretta L. Stritesky et al.   Annual Review of Immunology

Interchangeability of Themis1 and Themis2 in Thymocyte Development Reveals Two Related Proteins with Conserved Molecular Function

(2012) R. Lesourne et al.   JOURNAL OF IMMUNOLOGY

How the TCR balances sensitivity and specificity for the recognition of self and pathogens

(2012) Gerald P Morris et al.   NATURE IMMUNOLOGY

Negative Selection Assay Based on Stimulation of T Cell Receptor Transgenic Thymocytes with Peptide-MHC Tetramers

(2012) Vasily Rybakin et al.   PLoS One

T cell receptor signal strength in Tregand iNKT cell development demonstrated by a novel fluorescent reporter mouse

(2011) Amy E. Moran et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

(2011) Stephen Sawcer et al.   NATURE

Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease

(2011) Gosia Trynka et al.   NATURE GENETICS

Protein Kinase C   Is Required for T Cell Activation and Homeostatic Proliferation

(2011) G. Fu et al.   Science Signaling

T Cell Receptor (TCR)-induced Tyrosine Phosphorylation Dynamics Identifies THEMIS as a New TCR Signalosome Component

(2010) Claudia Brockmeyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selection

(2010) Jeremy Juang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness

(2010) Jun Huang et al.   NATURE

Multiple common variants for celiac disease influencing immune gene expression

(2010) Patrick C A Dubois et al.   NATURE GENETICS

SHP-1 and SHP-2 in T cells: two phosphatases functioning at many levels

(2009) Ulrike Lorenz   IMMUNOLOGICAL REVIEWS

Multiplexed labeling of samples with cell tracking dyes facilitates rapid and accurate internally controlled calcium flux measurement by flow cytometry

(2009) Guo Fu et al.   JOURNAL OF IMMUNOLOGICAL METHODS

A Novel Gene Essential for the Development of Single Positive Thymocytes

(2009) K. Kakugawa et al.   MOLECULAR AND CELLULAR BIOLOGY

Themis, a T cell–specific protein important for late thymocyte development

(2009) Renaud Lesourne et al.   NATURE IMMUNOLOGY

Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection

(2009) Andy L Johnson et al.   NATURE IMMUNOLOGY

Themis controls thymocyte selection through regulation of T cell antigen receptor–mediated signaling

(2009) Guo Fu et al.   NATURE IMMUNOLOGY

Gasp, a Grb2-associating protein, is critical for positive selection of thymocytes

(2009) M. S. Patrick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The thymus chapter in the life of gut-specific intra epithelial lymphocytes

(2008) Hilde Cheroutre et al.   CURRENT OPINION IN IMMUNOLOGY

Activation of Cdk2 Stimulates Proteasome-dependent Truncation of Tyrosine Phosphatase SHP-1 in Human Proliferating Intestinal Epithelial Cells

(2008) Mélanie Simoneau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance

(2008) Masatsugu Oh-hora et al.   NATURE IMMUNOLOGY