The impact of food intake on the luminal environment and performance of oral drug products with a view to in vitro and in silico simulations: a PEARRL review
出版年份 2018 全文链接
标题
The impact of food intake on the luminal environment and performance of oral drug products with a view to in vitro
and in silico
simulations: a PEARRL review
作者
关键词
-
出版物
JOURNAL OF PHARMACY AND PHARMACOLOGY
Volume -, Issue -, Pages -
出版商
Wiley
发表日期
2018-09-11
DOI
10.1111/jphp.12999
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Influence of Postprandial Intragastric Pressures on Drug Release from Gastroretentive Dosage Forms
- (2018) Felix Schneider et al. AAPS PHARMSCITECH
- Food Effect Projections via Physiologically Based Pharmacokinetic Modeling: Predictive Case Studies
- (2018) Christophe Tistaert et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Food for thought: formulating away the food effect - a PEARRL review
- (2018) Joseph P. O'Shea et al. JOURNAL OF PHARMACY AND PHARMACOLOGY
- Lipids in the Stomach – Implications for the Evaluation of Food Effects on Oral Drug Absorption
- (2018) Mirko Koziolek et al. PHARMACEUTICAL RESEARCH
- Mechanistic investigation of the negative food effect of modified release zolpidem
- (2017) Cord J. Andreas et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Magnetic Resonance Imaging Quantification of Fasted State Colonic Liquid Pockets in Healthy Humans
- (2017) Kathryn Murray et al. MOLECULAR PHARMACEUTICS
- Low Buffer Capacity and Alternating Motility along the Human Gastrointestinal Tract: Implications for in Vivo Dissolution and Absorption of Ionizable Drugs
- (2017) Bart Hens et al. MOLECULAR PHARMACEUTICS
- Gastric Water Emptying under Fed State Clinical Trial Conditions Is as Fast as under Fasted Conditions
- (2017) Michael Grimm et al. MOLECULAR PHARMACEUTICS
- In Vivo Dissolution and Systemic Absorption of Immediate Release Ibuprofen in Human Gastrointestinal Tract under Fed and Fasted Conditions
- (2017) Mark J. Koenigsknecht et al. MOLECULAR PHARMACEUTICS
- In Vivo Predictive Dissolution (IPD) and Biopharmaceutical Modeling and Simulation: Future Use of Modern Approaches and Methodologies in a Regulatory Context
- (2017) H. Lennernäs et al. MOLECULAR PHARMACEUTICS
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- (2017) Danai Georgaka et al. MOLECULAR PHARMACEUTICS
- Gastrointestinal and Systemic Disposition of Diclofenac under Fasted and Fed State Conditions Supporting the Evaluation of in Vitro Predictive Tools
- (2017) Jens Van Den Abeele et al. MOLECULAR PHARMACEUTICS
- Navigating the human gastrointestinal tract for oral drug delivery: Uncharted waters and new frontiers
- (2016) Mirko Koziolek et al. ADVANCED DRUG DELIVERY REVIEWS
- An in vitro biorelevant gastrointestinal transfer (BioGIT) system for forecasting concentrations in the fasted upper small intestine: Design, implementation, and evaluation
- (2016) Alexandros Kourentas et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Supersaturation of zafirlukast in fasted and fed state intestinal media with and without precipitation inhibitors
- (2016) Cecilie Maria Madsen et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Resolving the physiological conditions in bioavailability and bioequivalence studies: Comparison of fasted and fed state
- (2016) Felix Schneider et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Can dosage form-dependent food effects be predicted using biorelevant dissolution tests? Case example extended release nifedipine
- (2016) Cord J. Andreas et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Gastrointestinal dissolution, supersaturation and precipitation of the weak base indinavir in healthy volunteers
- (2016) Jari Rubbens et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Evaluation of two dynamic in vitro models simulating fasted and fed state conditions in the upper gastrointestinal tract (TIM-1 and tiny-TIM) for investigating the bioaccessibility of pharmaceutical compounds from oral dosage forms
- (2016) Miriam Verwei et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Physiologically Based Absorption Modeling to Impact Biopharmaceutics and Formulation Strategies in Drug Development—Industry Case Studies
- (2016) Filippos Kesisoglou et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Gastrointestinal and Systemic Monitoring of Posaconazole in Humans After Fasted and Fed State Administration of a Solid Dispersion
- (2016) Bart Hens et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Differences in Food Effects for 2 Weak Bases With Similar BCS Drug-Related Properties: What Is Happening in the Intestinal Lumen?
- (2016) Rodrigo Cristofoletti et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- The Effect of Food on the Intraluminal Behavior of Abiraterone Acetate in Man
- (2016) Sophie Geboers et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Characterization of Human Duodenal Fluids in Fasted and Fed State Conditions
- (2016) Danny Riethorst et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Characteristics of the Human Upper Gastrointestinal Contents in the Fasted State Under Hypo- and A-chlorhydric Gastric Conditions Under Conditions of Typical Drug – Drug Interaction Studies
- (2016) Chara Litou et al. PHARMACEUTICAL RESEARCH
- Food Effect in Humans: Predicting the Risk Through In Vitro Dissolution and In Vivo Pharmacokinetic Models
- (2015) Neil Mathias et al. AAPS Journal
- Analysis of small intestinal transit and colon arrival times of non-disintegrating tablets administered in the fasted state
- (2015) Mitja Pišlar et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
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- (2015) Bart Hens et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
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- (2015) Cord J. Andreas et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
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- (2014) Preetanshu Pandey et al. AAPS PHARMSCITECH
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- (2013) Binfeng Xia et al. AAPS PHARMSCITECH
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- (2013) Stephen Timothy Buckley et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
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- (2013) Erik Sjögren et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
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- (2013) Nikunjkumar Patel et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
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- (2013) Mirko Koziolek et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Early pharmaceutical profiling to predict oral drug absorption: Current status and unmet needs
- (2013) Christel A.S. Bergström et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Interaction between fed gastric media (Ensure Plus®) and different hypromellose based caffeine controlled release tablets: Comparison and mechanistic study of caffeine release in fed and fasted media versus water using the USP dissolution apparatus 3
- (2013) Frans Franek et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Application of permeability‐limited physiologically-based pharmacokinetic models: Part II-prediction of p‐glycoprotein mediated drug–drug interactions with digoxin
- (2013) Sibylle Neuhoff et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- In Vitro and Ex Vivo Investigation of the Impact of Luminal Lipid Phases on Passive Permeability of Lipophilic Small Molecules Using PAMPA
- (2013) Constantinos Markopoulos et al. PHARMACEUTICAL RESEARCH
- The Use of Modeling Tools to Drive Efficient Oral Product Design
- (2012) Neil R. Mathias et al. AAPS Journal
- Mechanistic investigation of food effect on disintegration and dissolution of BCS class III compound solid formulations: the importance of viscosity
- (2012) Asma Radwan et al. BIOPHARMACEUTICS & DRUG DISPOSITION
- Absolute abundance and function of intestinal drug transporters: a prerequisite for fully mechanisticin vitro-in vivoextrapolation of oral drug absorption
- (2012) M. D. Harwood et al. BIOPHARMACEUTICS & DRUG DISPOSITION
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- (2012) Avital Beig et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Predicting the oral absorption of a poorly soluble, poorly permeable weak base using biorelevant dissolution and transfer model tests coupled with a physiologically based pharmacokinetic model
- (2012) Christian Wagner et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Integration of dissolution into physiologically-based pharmacokinetic models III: PK-Sim®
- (2012) Stefan Willmann et al. JOURNAL OF PHARMACY AND PHARMACOLOGY
- Luminal Lipid Phases after Administration of a Triglyceride Solution of Danazol in the Fed State and Their Contribution to the Flux of Danazol Across Caco-2 Cell Monolayers
- (2012) Maria Vertzoni et al. MOLECULAR PHARMACEUTICS
- Differences in bioavailability between 60 mg of nifedipine osmotic push-pull systems after fasted and fed administration
- (2011) M. Anschütz et al. INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
- Predicting the human in vivo performance of different oral capsule shell types using a novel in vitro dynamic gastric model
- (2011) M. Vardakou et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1: Oral solutions
- (2011) Kirstin Thelen et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Drug release from HPMC matrices in milk and fat‐rich emulsions
- (2011) Hywel D. Williams et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Evolution of a Detailed Physiological Model to Simulate the Gastrointestinal Transit and Absorption Process in Humans, Part II: Extension to Describe Performance of Solid Dosage Forms
- (2011) Kirstin Thelen et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Application of Dissolution/Permeation System for Evaluation of Formulation Effect on Oral Absorption of Poorly Water-Soluble Drugs in Drug Development
- (2011) Makoto Kataoka et al. PHARMACEUTICAL RESEARCH
- Precipitation in and Supersaturation of Contents of the Upper Small Intestine After Administration of Two Weak Bases to Fasted Adults
- (2011) Dimitrios Psachoulias et al. PHARMACEUTICAL RESEARCH
- Food-dependent disintegration of immediate release fosamprenavir tablets: In vitro evaluation using magnetic resonance imaging and a dynamic gastrointestinal system
- (2010) Joachim Brouwers et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- A biorelevant dissolution stress test device – background and experiences
- (2010) Grzegorz Garbacz et al. Expert Opinion on Drug Delivery
- The transit of dosage forms through the colon
- (2010) Clive G. Wilson INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Gastric emptying of multi-particulate dosage forms
- (2010) J. Michael Newton INTERNATIONAL JOURNAL OF PHARMACEUTICS
- In-vitro and in-vivo erosion profiles of hydroxypropylmethylcellulose (HPMC) matrix tablets
- (2010) Manish Ghimire et al. JOURNAL OF CONTROLLED RELEASE
- Characterising the behaviour of poorly water soluble drugs in the intestine: application of biorelevant media for solubility, dissolution and transport studies
- (2010) Karen Kleberg et al. JOURNAL OF PHARMACY AND PHARMACOLOGY
- Leakiness and Size Exclusion of Paracellular Channels in Cultured Epithelial Cell Monolayers–Interlaboratory Comparison
- (2010) Alex Avdeef PHARMACEUTICAL RESEARCH
- Characterization of the Ascending Colon Fluids in Ulcerative Colitis
- (2010) Maria Vertzoni et al. PHARMACEUTICAL RESEARCH
- Population-Based Mechanistic Prediction of Oral Drug Absorption
- (2009) Masoud Jamei et al. AAPS Journal
- A Framework for Assessing Inter-individual Variability in Pharmacokinetics Using Virtual Human Populations and Integrating General Knowledge of Physical Chemistry, Biology, Anatomy, Physiology and Genetics: A Tale of ‘Bottom-Up’ vs ‘Top-Down’ Recognition of Covariates
- (2009) Masoud Jamei et al. Drug Metabolism and Pharmacokinetics
- Comparison of dissolution profiles obtained from nifedipine extended release once a day products using different dissolution test apparatuses
- (2009) Grzegorz Garbacz et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Simulation of gastric lipolysis and prediction of felodipine release from a matrix tablet in the fed stomach
- (2009) A. Diakidou et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Magnetic Marker Monitoring: High resolution real-time tracking of oral solid dosage forms in the gastrointestinal tract
- (2009) Werner Weitschies et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Colonic treatments and targets: issues and opportunities
- (2009) Emma L. McConnell et al. JOURNAL OF DRUG TARGETING
- In vitro digestion methods for assessing the effect of food structure on allergen breakdown
- (2009) Martin Wickham et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Characterization of the Contents of Ascending Colon to Which Drugs are Exposed After Oral Administration to Healthy Adults
- (2009) Amalia Diakidou et al. PHARMACEUTICAL RESEARCH
- Pharmacokinetics and Absorption of Posaconazole Oral Suspension under Various Gastric Conditions in Healthy Volunteers
- (2008) G. Krishna et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- In vitro methods can forecast the effects of intragastric residence on dosage form performance
- (2008) Lida Kalantzi et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Scintigraphic evaluation of colon targeting pectin–HPMC tablets in healthy volunteers
- (2008) L.A. Hodges et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Postprandial Evolution in Composition and Characteristics of Human Duodenal Fluids in Different Nutritional States
- (2008) S. Clarysse et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Scintigraphic Study to Investigate the Effect of Food on a HPMC Modified Release Formulation of UK-294,315
- (2008) J. Davis et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Meal-Induced Acceleration of Tablet Transit Through the Human Small Intestine
- (2008) Hala M. Fadda et al. PHARMACEUTICAL RESEARCH
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