Metabolomics of Human Brain Aging and Age-Related Neurodegenerative Diseases

Role of Oxidative Stress in the Progression of Alzheimer's Disease

(2017) Rukhsana Sultana et al.   JOURNAL OF ALZHEIMERS DISEASE

Amyloid Imaging in Aging and Dementia: Testing the Amyloid HypothesisIn Vivo

(2014) G. D. Rabinovici et al.   BEHAVIOURAL NEUROLOGY

Recent advances in metabolomics in neurological disease, and future perspectives

(2013) Ai-hua Zhang et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Toward ‘Omic Scale Metabolite Profiling: A Dual Separation–Mass Spectrometry Approach for Coverage of Lipid and Central Carbon Metabolism

(2013) Julijana Ivanisevic et al.   ANALYTICAL CHEMISTRY

Updating the Mitochondrial Free Radical Theory of Aging: An Integrated View, Key Aspects, and Confounding Concepts

(2013) Gustavo Barja   ANTIOXIDANTS & REDOX SIGNALING

DNA methylation map of mouse and human brain identifies target genes in Alzheimer’s disease

(2013) Jose V. Sanchez-Mut et al.   BRAIN

Metabolomics in Cerebrospinal Fluid of Patients with Amyotrophic Lateral Sclerosis: An Untargeted Approach via High-Resolution Mass Spectrometry

(2013) Hélène Blasco et al.   JOURNAL OF PROTEOME RESEARCH

Specific Lipidome Signatures in Central Nervous System from Methionine-Restricted Mice

(2013) Mariona Jové et al.   JOURNAL OF PROTEOME RESEARCH

3-hydroxykynurenine and other Parkinson's disease biomarkers discovered by metabolomic analysis

(2013) Peter A. LeWitt et al.   MOVEMENT DISORDERS

Human brain evolution: transcripts, metabolites and their regulators

(2013) Mehmet Somel et al.   NATURE REVIEWS NEUROSCIENCE

Redox Regulation in Amyotrophic Lateral Sclerosis

(2013) Sonam Parakh et al.   Oxidative Medicine and Cellular Longevity

Metabolomics and In-Silico Analysis Reveal Critical Energy Deregulations in Animal Models of Parkinson’s Disease

(2013) Pierre O. Poliquin et al.   PLoS One

Single-Cell Metabolomics: Analytical and Biological Perspectives

(2013) R. Zenobi   SCIENCE

Does variation in neurodegenerative disease susceptibility and phenotype reflect cerebral differences at the network level?

(2013) Andrew Eisen et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Exceptionally old mice are highly resistant to lipoxidation-derived molecular damage

(2012) Lorena Arranz et al.   AGE

NMR and pattern recognition methods in metabolomics: From data acquisition to biomarker discovery: A review

(2012) Agnieszka Smolinska et al.   ANALYTICA CHIMICA ACTA

Quantitative profiling of oxylipins through comprehensive LC-MS/MS analysis: application in cardiac surgery

(2012) Katrin Strassburg et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Toward a Predictive Model of Alzheimer’s Disease Progression Using Capillary Electrophoresis–Mass Spectrometry Metabolomics

(2012) Clara Ibáñez et al.   ANALYTICAL CHEMISTRY

Investigation of the Human Brain Metabolome to Identify Potential Markers for Early Diagnosis and Therapeutic Targets of Alzheimer’s Disease

(2012) Stewart F. Graham et al.   ANALYTICAL CHEMISTRY

Mitochondrial DNA Oxidative Damage and Repair in Aging and Alzheimer's Disease

(2012) Renato X. Santos et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial Energy Metabolism and Redox Signaling in Brain Aging and Neurodegeneration

(2012) Fei Yin et al.   ANTIOXIDANTS & REDOX SIGNALING

Antioxidant and bioenergetic coupling between neurons and astrocytes

(2012) Seila Fernandez-Fernandez et al.   BIOCHEMICAL JOURNAL

Caloric restriction improves basal redox parameters in hippocampus and cerebral cortex of Wistar rats

(2012) Leticia C. Ribeiro et al.   BRAIN RESEARCH

The role of metabolomics in neurological disease

(2012) Ghaniah Hassan-Smith et al.   JOURNAL OF NEUROIMMUNOLOGY

Accuracy of the Clinical Diagnosis of Alzheimer Disease at National Institute on Aging Alzheimer Disease Centers, 2005–2010

(2012) Thomas G. Beach et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

PINK1 parkinsonism and Parkinson disease: Distinguishable brain mitochondrial function and metabolomics

(2012) M. Rango et al.   MITOCHONDRION

An anatomically comprehensive atlas of the adult human brain transcriptome

(2012) Michael J. Hawrylycz et al.   NATURE

Metabolomics: the apogee of the omics trilogy

(2012) Gary J. Patti et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

HMDB 3.0—The Human Metabolome Database in 2013

(2012) David S. Wishart et al.   NUCLEIC ACIDS RESEARCH

Defining Alzheimer as a common age-related neurodegenerative process not inevitably leading to dementia

(2012) Isidro Ferrer   PROGRESS IN NEUROBIOLOGY

Human and rat brain lipofuscin proteome

(2012) Philipp Ottis et al.   PROTEOMICS

Multi-platform characterization of the human cerebrospinal fluid metabolome: a comprehensive and quantitative update

(2012) Rupasri Mandal et al.   Genome Medicine

Glucose metabolism in small subcortical structures in Parkinson’s disease

(2011) Per Borghammer et al.   ACTA NEUROLOGICA SCANDINAVICA

Cell stress induces TDP-43 pathological changes associated with ERK1/2 dysfunction: implications in ALS

(2011) Victòria Ayala et al.   ACTA NEUROPATHOLOGICA

Expression analysis of dopaminergic neurons in Parkinson’s disease and aging links transcriptional dysregulation of energy metabolism to cell death

(2011) Matthias Elstner et al.   ACTA NEUROPATHOLOGICA

Metabolic and functional differences between brain and spinal cord mitochondria underlie different predisposition to pathology

(2011) Alexander V. Panov et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Molecular and structural antioxidant defenses against oxidative stress in animals

(2011) Reinald Pamplona et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Biochemical alterations associated with ALS

(2011) Kay A. Lawton et al.   Amyotrophic Lateral Sclerosis

Redox Proteomics in Selected Neurodegenerative Disorders: From Its Infancy to Future Applications

(2011) D. Allan Butterfield et al.   ANTIOXIDANTS & REDOX SIGNALING

Brain aging, Alzheimer's disease, and mitochondria

(2011) Russell H. Swerdlow   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

An evolutionary comparative scan for longevity-related oxidative stress resistance mechanisms in homeotherms

(2011) Reinald Pamplona et al.   BIOGERONTOLOGY

Advanced lipoxidation end-products

(2011) Reinald Pamplona   CHEMICO-BIOLOGICAL INTERACTIONS

Relationship of electrophilic stress to aging

(2011) Piotr Zimniak   FREE RADICAL BIOLOGY AND MEDICINE

Early and Progressive Impairment of Spinal Blood Flow—Glucose Metabolism Coupling in Motor Neuron Degeneration of ALS Model Mice

(2011) Kazunori Miyazaki et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cerebral Glucose Metabolic Features of Parkinson Disease and Incident Dementia: Longitudinal Study

(2011) N. I. Bohnen et al.   JOURNAL OF NUCLEAR MEDICINE

Cerebral oxygen metabolism in patients with early Parkinson's disease

(2011) Per Borghammer et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Applications of mass spectrometry to metabolomics and metabonomics: Detection of biomarkers of aging and of age-related diseases

(2011) Robert J. Mishur et al.   MASS SPECTROMETRY REVIEWS

ALS patients with mutations in the SOD1 gene have an unique metabolomic profile in the cerebrospinal fluid compared with ALS patients without mutations

(2011) Anna Wuolikainen et al.   MOLECULAR GENETICS AND METABOLISM

Glutamate and glutathione interplay in a motor neuronal model of amyotrophic lateral sclerosis reveals altered energy metabolism

(2011) Giuseppina D'Alessandro et al.   NEUROBIOLOGY OF DISEASE

Neurochemistry and the non-motor aspects of PD

(2011) I. Ferrer et al.   NEUROBIOLOGY OF DISEASE

Increased Oxidative Damage and Decreased Antioxidant Function in Aging Human Substantia Nigra Compared to Striatum: Implications for Parkinson’s Disease

(2011) C. Venkateshappa et al.   NEUROCHEMICAL RESEARCH

Selective Neuronal Vulnerability in Neurodegenerative Diseases: from Stressor Thresholds to Degeneration

(2011) Smita Saxena et al.   NEURON

Disease-Related Changes in the Cerebrospinal Fluid Metabolome in Amyotrophic Lateral Sclerosis Detected by GC/TOFMS

(2011) Anna Wuolikainen et al.   PLoS One

Metabolomics in Early Alzheimer's Disease: Identification of Altered Plasma Sphingolipidome Using Shotgun Lipidomics

(2011) Xianlin Han et al.   PLoS One

Rapid metabolic evolution in human prefrontal cortex

(2011) X. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolome in progression to Alzheimer's disease

(2011) M Orešič et al.   Translational Psychiatry

Metabolomic changes in autopsy-confirmed Alzheimer's disease

(2010) Rima Kaddurah-Daouk et al.   Alzheimers & Dementia

Plasma Urate and Parkinson's Disease in Women

(2010) E. J. O'Reilly et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Cellular Stress Responses, The Hormesis Paradigm, and Vitagenes: Novel Targets for Therapeutic Intervention in Neurodegenerative Disorders

(2010) Vittorio Calabrese et al.   ANTIOXIDANTS & REDOX SIGNALING

Prefrontal cortex, caloric restriction and stress during aging: Studies on dopamine and acetylcholine release, BDNF and working memory

(2010) Alberto Del Arco et al.   BEHAVIOURAL BRAIN RESEARCH

Metabolomic analysis of serum by (1) H NMR spectroscopy in amyotrophic lateral sclerosis

(2010) Alok Kumar et al.   CLINICA CHIMICA ACTA

Functional Genomics of Brain Aging and Alzheimers Disease: Focus on Selective Neuronal Vulnerability

(2010) Xinkun Wang et al.   CURRENT GENOMICS

Targeting intrinsically disordered proteins in neurodegenerative and protein dysfunction diseases: another illustration of the D2concept

(2010) Vladimir N Uversky   Expert Review of Proteomics

Gene expression in the hippocampus: Regionally specific effects of aging and caloric restriction

(2010) Zane Zeier et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1

(2010) Jaime N. Guzman et al.   NATURE

A metabolomic study of the CRND8 transgenic mouse model of Alzheimer's disease

(2010) Reza M. Salek et al.   NEUROCHEMISTRY INTERNATIONAL

1H-NMR-Based Metabolomic Profiling of CSF in Early Amyotrophic Lateral Sclerosis

(2010) Hélène Blasco et al.   PLoS One

Cell Death and Learning Impairment in Mice Caused by in Vitro Modified Pro-NGF Can Be Related to Its Increased Oxidative Modifications in Alzheimer Disease

(2009) Anton Kichev et al.   AMERICAN JOURNAL OF PATHOLOGY

Urate as a Predictor of the Rate of Clinical Decline in Parkinson Disease

(2009) Alberto Ascherio   ARCHIVES OF NEUROLOGY

Mitochondrial dysfunction in Parkinson's disease

(2009) Konstanze F. Winklhofer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Phosphorus and proton magnetic resonance spectroscopy demonstrates mitochondrial dysfunction in early and advanced Parkinson's disease

(2009) Elke Hattingen et al.   BRAIN

Protein Targets of Oxidative Damage in Human Neurodegenerative Diseases with Abnormal Protein Aggregates

(2009) Anna Martínez et al.   BRAIN PATHOLOGY

Mitochondrial ATP-Synthase in the Entorhinal Cortex Is a Target of Oxidative Stress at Stages I/II of Alzheimer's Disease Pathology

(2009) Beatrice Terni et al.   BRAIN PATHOLOGY

Metabolic shifts due to long-term caloric restriction revealed in nonhuman primates

(2009) Serge Rezzi et al.   EXPERIMENTAL GERONTOLOGY

Human brain cortex: mitochondrial oxidative damage and adaptive response in Parkinson disease and in dementia with Lewy bodies

(2009) Ana Navarro et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial matters in Parkinson disease: introduction

(2009) George H. Sack   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Mitochondrial dysfunction in mouse models of Parkinson’s disease revealed by transcriptomics and proteomics

(2009) Desmond J. Smith   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Altered mitochondria, energy metabolism, voltage-dependent anion channel, and lipid rafts converge to exhaust neurons in Alzheimer’s disease

(2009) Isidre Ferrer   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Metabolomic Profiling in LRRK2-Related Parkinson's Disease

(2009) Krisztina K. Johansen et al.   PLoS One

Reactive oxygen species as universal constraints in life-history evolution

(2009) D. K. Dowling et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Early involvement of the cerebral cortex in Parkinson's disease: Convergence of multiple metabolic defects

(2009) Isidre Ferrer   PROGRESS IN NEUROBIOLOGY

Forty Percent Methionine Restriction Decreases Mitochondrial Oxygen Radical Production and Leak at Complex I During Forward Electron Flow and Lowers Oxidative Damage to Proteins and Mitochondrial DNA in Rat Kidney and Brain Mitochondria

(2009) Pilar Caro et al.   REJUVENATION RESEARCH

The conservation and evolutionary modularity of metabolism

(2009) José M Peregrín-Alvarez et al.   GENOME BIOLOGY

Management of a twenty-first century brain bank: experience in the BrainNet Europe consortium

(2008) Jeanne E. Bell et al.   ACTA NEUROPATHOLOGICA

Pro-oxidant shift in glutathione redox state during aging☆

(2008) Igor Rebrin et al.   ADVANCED DRUG DELIVERY REVIEWS

Self-Modeling Curve Resolution Recovery of Temporal Metabolite Signal Modulation in NMR Spectroscopic Data Sets: Application to a Life-Long Caloric Restriction Study in Dogs

(2008) Selena E. Richards et al.   ANALYTICAL CHEMISTRY

Maillard Reaction versus Other Nonenzymatic Modifications in Neurodegenerative Processes

(2008) Reinald Pamplona et al.   Annals of the New York Academy of Sciences

The Nrf2/ARE Pathway as a Potential Therapeutic Target in Neurodegenerative Disease

(2008) Marcus J. Calkins et al.   ANTIOXIDANTS & REDOX SIGNALING

Serum Urate as a Predictor of Clinical and Radiographic Progression in Parkinson Disease

(2008) Michael A. Schwarzschild   ARCHIVES OF NEUROLOGY

Membrane phospholipids, lipoxidative damage and molecular integrity: A causal role in aging and longevity

(2008) Reinald Pamplona   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Metabolomic profiling to develop blood biomarkers for Parkinson's disease

(2008) M. Bogdanov et al.   BRAIN

Brain banks: benefits, limitations and cautions concerning the use of post-mortem brain tissue for molecular studies

(2008) Isidre Ferrer et al.   CELL AND TISSUE BANKING

High- and low-calcium-dependent mechanisms of mitochondrial calcium signalling

(2008) A SPAT et al.   CELL CALCIUM

Brain mitochondrial dysfunction in aging

(2008) Alberto Boveris et al.   IUBMB LIFE

The human cerebrospinal fluid metabolome

(2008) David S. Wishart et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Multicenter Standardized 18F-FDG PET Diagnosis of Mild Cognitive Impairment, Alzheimer's Disease, and Other Dementias

(2008) L. Mosconi et al.   JOURNAL OF NUCLEAR MEDICINE

Mitochondria in the aetiology and pathogenesis of Parkinson's disease

(2008) Anthony HV Schapira   LANCET NEUROLOGY

Molecular Bases of Caloric Restriction Regulation of Neuronal Synaptic Plasticity

(2008) Ángela Fontán-Lozano et al.   MOLECULAR NEUROBIOLOGY

Uric acid in Parkinson's disease

(2008) Ilana Schlesinger et al.   MOVEMENT DISORDERS

Differential age-related changes in mitochondrial DNA repair activities in mouse brain regions

(2008) Ricardo Gredilla et al.   NEUROBIOLOGY OF AGING

Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosis

(2008) Julie D. Atkin et al.   NEUROBIOLOGY OF DISEASE

Paths of Convergence: Sirtuins in Aging and Neurodegeneration

(2008) Li Gan et al.   NEURON

Metabolomics: A Global Biochemical Approach to the Study of Central Nervous System Diseases

(2008) Rima Kaddurah-Daouk et al.   NEUROPSYCHOPHARMACOLOGY

HMDB: a knowledgebase for the human metabolome

(2008) D. S. Wishart et al.   NUCLEIC ACIDS RESEARCH

The PINK1/Parkin pathway regulates mitochondrial morphology

(2008) A. C. Poole et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic changes in schizophrenia and human brain evolution

(2008) Philipp Khaitovich et al.   GENOME BIOLOGY

From prebiotic chemistry to cellular metabolism—The chemical evolution of metabolism before Darwinian natural selection

(2007) Enrique Meléndez-Hevia et al.   JOURNAL OF THEORETICAL BIOLOGY

Early α-synuclein lipoxidation in neocortex in Lewy body diseases

(2006) Esther Dalfó et al.   NEUROBIOLOGY OF AGING

BMCP1: a mitochondrial uncoupling protein in neurons which regulates mitochondrial function and oxidant production

(2003) Jeong Sook Kim-Han et al.   JOURNAL OF NEUROCHEMISTRY