Review
Pharmacology & Pharmacy
Jillian M. Doyle, Roger P. Croll
Summary: Zebrafish has been widely used as a model for various human diseases, including cancer, cardiovascular diseases, and neurodegenerative diseases. This review critically evaluates the available models of Parkinson's Disease in zebrafish and compares them with other animal models. Zebrafish has unique advantages, such as a wide range of behavioral assays and high-throughput screens, as well as the ability for genetic manipulation and in vivo visualization. This makes zebrafish a versatile model for investigating disease states.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Nathalie Van Den Berge, Ayse Ulusoy
Summary: Alpha-synuclein aggregates are the hallmark of Parkinson's disease and can propagate along the brain-body axis in a stereotypical pattern. The heterogeneity of symptoms and pathology in Parkinson's disease patients may be explained by the variable onset site, either in the brain or body. Animal models have been developed to reproduce Parkinson's disease pathology in order to study the site of disease onset.
NEUROBIOLOGY OF DISEASE
(2022)
Review
Geriatrics & Gerontology
Minjing Ke, Cheong-Meng Chong, Qi Zhu, Ke Zhang, Cui-Zan Cai, Jia-Hong Lu, Dajiang Qin, Huanxing Su
Summary: Parkinson's disease research utilizes various preclinical models, including cellular and animal models, each with its own strengths and limitations. The selection of models depends on the research interest, and none of the current models can fully replicate all features of PD.
Review
Clinical Neurology
Mattia Volta
Summary: The discovery of mutations in LRRK2 and GBA1 has provided evidence for the involvement of autophagy and lysosome pathways in Parkinson's disease. These mutations slow down the degradation of alpha-synuclein, leading to dysfunction in the neuropathology of the disease. The development of genetic rodent models holds promise for studying pathogenic processes and validating drugs.
Review
Clinical Neurology
Mattia Volta
Summary: The discovery of mutations in LRRK2 and GBA1 that are linked to Parkinson's disease provides further evidence of the involvement of autophagy and lysosomal pathways in the disease's pathology. The development of genetic rodent models for LRRK2 and GBA1 has the potential to enhance our understanding of lysosome alterations in Parkinson's disease and provide new insights. Further research is needed to exploit these rodent models in the fight against the disease.
Review
Pharmacology & Pharmacy
Cheng-Fu Su, Li Jiang, Xiao-Wen Zhang, Ashok Iyaswamy, Min Li
Summary: Parkinson's disease (PD) is a common neurodegenerative disease characterized by the progressive degeneration of nigrostriatal dopaminergic neurons and motor function impairment. Resveratrol, a polyphenol found in plants and fruits, has shown potent neuroprotective efficacy in various PD animal models through antioxidation, anti-inflammation, ameliorating mitochondrial dysfunction, and improving motor function. The systematic analysis of 18 studies reveals significant neuroprotective effects of resveratrol on PD models and highlights the importance of methodological quality assessment in preclinical research.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Peter A. LeWitt, Jia Li, Kuan-Han Wu, Mei Lu
Summary: Comprehensive metabolomic profiling of biochemicals in CSF and serum identified diagnostic biomarkers for Parkinson's disease. Twenty-one CSF compounds showed significantly different concentrations between PD and healthy controls. Logistic LASSO regression selected 23 biochemicals that accurately distinguished PD from controls with high sensitivity and specificity. This study provides further evidence for the involvement of polyamine pathways in the neurodegeneration of PD.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Nicola D'Ascenzo, Emanuele Antonecchia, Antonella Angiolillo, Victor Bender, Marco Camerlenghi, Qingguo Xie, Alfonso Di Costanzo
Summary: This study identified PD blood metabolites and metabolic pathways significantly correlated with age, and proposed a personalized age-dependent approach to early PD diagnosis.
CELL AND BIOSCIENCE
(2022)
Review
Cell Biology
Isaac Deng, Larisa Bobrovskaya
Summary: Parkinson's disease, a common movement disorder, is strongly associated with neuroinflammation. The administration of lipopolysaccharide can be used to study the neuroinflammatory aspects of Parkinson's disease. Lipopolysaccharide mouse models are useful tools for future research in this field.
NEURAL REGENERATION RESEARCH
(2022)
Article
Behavioral Sciences
Ruiqing Ni
Summary: Animal models of α-synucleinopathies have greatly contributed to the understanding of the disease and the development of therapeutics. Recent advances in positron emission tomography have allowed the noninvasive visualization of molecular alterations and behavioral dysfunctions in these animal models. This review focuses on the development of new PET tracers and studies of α-synuclein and neurotransmitter receptor deficits in Parkinson's disease animal models.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Review
Neurosciences
Ninuo Xia, Deborah E. Cabin, Fang Fang, Renee A. Reijo Pera
Summary: Parkinson's disease is a common neurodegenerative disorder with limited understanding of its genetic basis and disease mechanisms. Despite progress in diagnosis and clinical management, there is still limited ability to alter the trajectory of the disease.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Medicine, General & Internal
Katherine Muksuris, David M. Scarisbrick, James J. Mahoney, Mariya V. Cherkasova
Summary: The main treatments for Parkinson's Disease (PD) have been limited to medication and deep brain stimulation, but new research is exploring noninvasive neuromodulation methods as potential treatments. Some promising methods include transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), electroconvulsive therapy (ECT), and focused ultrasound (FUS). This rapid review assesses the available animal literature on these noninvasive techniques and discusses the possible mechanisms behind their therapeutic effects.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Nicholas J. Fiore, Yosif M. Ganat, Kapil Devkota, Rebecca Batorsky, Ming Lei, Kyongbum Lee, Lenore J. Cowen, Gist Croft, Scott A. Noggle, Thomas J. F. Nieland, David L. Kaplan
Summary: This article introduces a three-dimensional culture system using hiPSCs to study the biology of Parkinson's disease. The results show that this 3D system can mimic the molecular mechanisms of Parkinson's disease and provide insights into novel molecular interactions.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Geriatrics & Gerontology
Ida Hyllen Klaestrup, Mie Kristine Just, Karina Lassen Holm, Aage Kristian Olsen Alstrup, Marina Romero-Ramos, Per Borghammer, Nathalie van den Berge
Summary: Aging is a major risk factor for PD, but most studies use young animals and overlook age-related mechanisms. Recent research shows that aged PD animal models have higher pathological risk and accelerated disease progression. Therefore, using aged animals in PD research can better represent clinical disease, increase research value, and reduce the risk of therapy failure.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Neurosciences
Axelle Dovonou, Cyril Bolduc, Victoria Soto Linan, Charles Gora, Modesto R. R. Peralta, Martin Levesque
Summary: Parkinson's disease (PD) is a progressive neurodegenerative disorder with motor and non-motor symptoms. Despite its long history and extensive research, there is still no cure or disease-modifying therapy available. Animal models have been developed to study PD, providing valuable insights into the disease. This review comprehensively summarizes the different animal models used in PD research, their characteristics, and ability to replicate PD-like phenotypes, aiming to assist researchers in selecting appropriate models for their research questions.
TRANSLATIONAL NEURODEGENERATION
(2023)
Article
Biochemistry & Molecular Biology
Guillaume M. Fortin, Charles Ducrot, Nicolas Giguere, Willemieke M. Kouwenhoven, Marie-Josee Bourque, Consiglia Pacelli, Rafael Koerich Varaschin, Marion Brill, Sherdeep Singh, Paul W. Wiseman, Louis-Eric Trudeau
Article
Nanoscience & Nanotechnology
Hu Zhu, Falix Lussier, Charles Ducrot, Marie-Josee Bourque, Joachim P. Spatz, Wenli Cui, Li Yu, Wei Peng, Louis-Eric Trudeau, C. Geraldine Bazuin, Jean-Francois Masson
ACS APPLIED MATERIALS & INTERFACES
(2019)
Editorial Material
Neurosciences
John Apergis-Schoute, Geoffrey Burnstock, Michael P. Nusbaum, David Parker, Miguel A. Morales, Louis-Eric Trudeau, Erik Svensson
FRONTIERS IN NEURAL CIRCUITS
(2019)
Article
Clinical Neurology
Yvette C. Wong, Kelvin Luk, Kerry Purtell, Samuel Burke Nanni, A. Jon Stoessl, Louis-Eric Trudeau, Zhenyu Yue, Dimitri Krainc, Wolfgang Oertel, Jose A. Obeso, Laura A. Volpicelli-Daley
MOVEMENT DISORDERS
(2019)
Article
Genetics & Heredity
Nicolas Giguere, Benoit Delignat-Lavaud, Freja Herborg, Aurore Voisin, Yuan Li, Vincent Jacquemet, Madhu Anand-Srivastava, Ulrik Gether, Bruno Giros, Louis-Eric Trudeau
Article
Cell Biology
Ujval Anilkumar, Mireille Khacho, Alexanne Cuillerier, Richard Harris, David A. Patten, Maria Bilen, Mohamed Ariff Iqbal, Ding Yuan Guo, Louis-Eric Trudeau, David S. Park, Mary-Ellen Harper, Yan Burelle, Ruth S. Slack
CELL DEATH & DISEASE
(2020)
Article
Neurosciences
Florence Allain, Benoit Delignat-Lavaud, Marie-Pierre Beaudoin, Vincent Jacquemet, Terry E. Robinson, Louis-Eric Trudeau, Anne-Noel Samaha
Summary: D-amphetamine maintenance therapy shows promise in reducing cocaine use by preventing sensitization-related changes in cocaine potency at the dopamine transporter (DAT).
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Chemistry, Physical
Gregory Q. Wallace, Benoit Delignat-Lavaud, Xingjuan Zhao, Louis-Eric Trudeau, Jean-Francois Masson
JOURNAL OF CHEMICAL PHYSICS
(2020)
Article
Gastroenterology & Hepatology
Tyler Cannon, Anshul Sinha, Louis-Eric Trudeau, Corinne F. Maurice, Samantha Gruenheid
Editorial Material
Neurosciences
Charles Ducrot, Louis-Eric Trudeau
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
William Tanguay, Charles Ducrot, Nicolas Giguere, Marie-Josee Bourque, Louis-Eric Trudeau
Summary: In Parkinson's disease, dopamine neurons in the substantia nigra pars compacta show unique vulnerability due to their large axonal arbors. By inducing partial SNc lesions in neonatal mice, researchers found that adult mice exhibited compensatory axonal sprouting in SNc DA neurons after neuronal loss.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Benoit Delignat-Lavaud, Charles Ducrot, Willemieke Kouwenhoven, Nina Feller, Louis-Eric Trudeau
Summary: This study uncovers clear differences in the mechanisms of somatodendritic (STD) and axonal dopamine release. STD dopamine release has low capacity and differs from axonal release in terms of molecular mechanisms.
Article
Neurosciences
Samuel Burke, Louis-Eric Trudeau
NPJ PARKINSONS DISEASE
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
S. B. Nanni, M. -J. Bourque, L. -E. Trudeau
JOURNAL OF NEUROCHEMISTRY
(2019)
Meeting Abstract
Biochemistry & Molecular Biology
B. Delignat-Lavaud, L. -E. Trudeau
JOURNAL OF NEUROCHEMISTRY
(2019)