Strategies for mining fungal natural products

Distinct Amino Acids of Histone H3 Control Secondary Metabolism in Aspergillus nidulans

(2013) Hans-Wilhelm Nützmann et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Genome-wide analysis of the Zn(II)2Cys6 zinc cluster-encoding gene family in Aspergillus flavus

(2013) Perng-Kuang Chang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Bacterium Induces Cryptic Meroterpenoid Pathway in the Pathogenic FungusAspergillus fumigatus

(2013) Claudia C. König et al.   CHEMBIOCHEM

Fungus-Specific Sirtuin HstD Coordinates Secondary Metabolism and Development through Control of LaeA

(2013) Moriyuki Kawauchi et al.   EUKARYOTIC CELL

A Novel Automethylation Reaction in theAspergillus nidulansLaeA Protein GeneratesS-Methylmethionine

(2013) Alexander N. Patananan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Strain Improvement by Overexpression of the laeA Gene in Monascus pilosus for the Production of Monascus-Fermented Rice

(2013) Sang Sub Lee   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

The Fumagillin Biosynthetic Gene Cluster in Aspergillus fumigatus Encodes a Cryptic Terpene Cyclase Involved in the Formation of β-trans-Bergamotene

(2013) Hsiao-Ching Lin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An Efficient System for Heterologous Expression of Secondary Metabolite Genes in Aspergillus nidulans

(2013) Yi-Ming Chiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Nonribosomal Peptide Synthetase-Derived Iron(III) Complex from the Pathogenic Fungus Aspergillus fumigatus

(2013) Wen-Bing Yin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reconstruction of the biosynthetic pathway for the core fungal polyketide scaffold rubrofusarin in Saccharomyces cerevisiae

(2013) Peter Rugbjerg et al.   Microbial Cell Factories

Fragmentation of an aflatoxin-like gene cluster in a forest pathogen

(2013) Rosie E. Bradshaw et al.   NEW PHYTOLOGIST

antiSMASH 2.0—a versatile platform for genome mining of secondary metabolite producers

(2013) Kai Blin et al.   NUCLEIC ACIDS RESEARCH

Genome Mining of a Prenylated and Immunosuppressive Polyketide from Pathogenic Fungi

(2013) Yit-Heng Chooi et al.   ORGANIC LETTERS

Prototype of an intertwined secondary-metabolite supercluster

(2013) P. Wiemann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of Cryptic Polyketide Metabolites from Dermatophytes Using Heterologous Expression in Aspergillus nidulans

(2013) Wen-Bing Yin et al.   ACS Synthetic Biology

Plant-Symbiotic Fungi as Chemical Engineers: Multi-Genome Analysis of the Clavicipitaceae Reveals Dynamics of Alkaloid Loci

(2013) Christopher L. Schardl et al.   PLoS Genetics

Comparative Genome Structure, Secondary Metabolite, and Effector Coding Capacity across Cochliobolus Pathogens

(2013) Bradford J. Condon et al.   PLoS Genetics

Deciphering the Cryptic Genome: Genome-wide Analyses of the Rice Pathogen Fusarium fujikuroi Reveal Complex Regulation of Secondary Metabolism and Novel Metabolites

(2013) Philipp Wiemann et al.   PLoS Pathogens

Partial Reconstruction of the Ergot Alkaloid Pathway by Heterologous Gene Expression in Aspergillus nidulans

(2013) Katy Ryan et al.   Toxins

Insights to fungal biology through LaeA sleuthing

(2013) Sachin Jain et al.   Fungal Biology Reviews

Homologous NRPS-like Gene Clusters Mediate Redundant Small-Molecule Biosynthesis inAspergillus flavus

(2012) Ry R. Forseth et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Genome-Based Cluster Deletion Reveals an Endocrocin Biosynthetic Pathway in Aspergillus fumigatus

(2012) Fang Yun Lim et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Involvement of a Natural Fusion of a Cytochrome P450 and a Hydrolase in Mycophenolic Acid Biosynthesis

(2012) Bjarne Gram Hansen et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Increased Penicillin Production in Penicillium chrysogenum Production Strains via Balanced Overexpression of Isopenicillin N Acyltransferase

(2012) Stefan S. Weber et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Breaking the Silence: Protein Stabilization Uncovers Silenced Biosynthetic Gene Clusters in the Fungus Aspergillus nidulans

(2012) Jennifer Gerke et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Biosynthesis of Fusarubins Accounts for Pigmentation of Fusarium fujikuroi Perithecia

(2012) Lena Studt et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Molecular Diversity Sculpted by Fungal PKS-NRPS Hybrids

(2012) Daniela Boettger et al.   CHEMBIOCHEM

Characterization of a Silent Azaphilone Gene Cluster from Aspergillus niger ATCC 1015 Reveals a Hydroxylation-Mediated Pyran-Ring Formation

(2012) Angelica O. Zabala et al.   CHEMISTRY & BIOLOGY

Production of novel fusarielins by ectopic activation of the polyketide synthase 9 cluster in Fusarium graminearum

(2012) Jens Laurids Sørensen et al.   ENVIRONMENTAL MICROBIOLOGY

Synthetic Biology of secondary metabolite biosynthesis in actinomycetes: Engineering precursor supply as a way to optimize antibiotic production

(2012) Wolfgang Wohlleben et al.   FEBS LETTERS

Genome mining reveals the evolutionary origin and biosynthetic potential of basidiomycete polyketide synthases

(2012) Gerald Lackner et al.   FUNGAL GENETICS AND BIOLOGY

Lae1 regulates expression of multiple secondary metabolite gene clusters in Fusarium verticillioides

(2012) Robert A.E. Butchko et al.   FUNGAL GENETICS AND BIOLOGY

Identification of gene clusters associated with fusaric acid, fusarin, and perithecial pigment production in Fusarium verticillioides

(2012) Daren W. Brown et al.   FUNGAL GENETICS AND BIOLOGY

Thoughts and facts about antibiotics: Where we are now and where we are heading

(2012) János Bérdy   JOURNAL OF ANTIBIOTICS

Differential expression of silent polyketide biosynthesis gene clusters in chemostat cultures of Aspergillus nidulans

(2012) Anindita Sarkar et al.   JOURNAL OF BIOTECHNOLOGY

Discovery and Characterization of a Group of Fungal Polycyclic Polyketide Prenyltransferases

(2012) Yit-Heng Chooi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Two Separate Gene Clusters Encode the Biosynthetic Pathway for the Meroterpenoids Austinol and Dehydroaustinol in Aspergillus nidulans

(2012) Hsien-Chun Lo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Illuminating the Diversity of Aromatic Polyketide Synthases in Aspergillus nidulans

(2012) Manmeet Ahuja et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Overexpression of theAspergillus nidulanshistone 4 acetyltransferase EsaA increases activation of secondary metabolite production

(2012) Alexandra A. Soukup et al.   MOLECULAR MICROBIOLOGY

A fungal ketoreductase domain that displays substrate-dependent stereospecificity

(2012) Hui Zhou et al.   Nature Chemical Biology

Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses

(2012) Richard J O'Connell et al.   NATURE GENETICS

Regulation of fungal secondary metabolism

(2012) Axel A. Brakhage   NATURE REVIEWS MICROBIOLOGY

Identification and Characterization of a Novel Diterpene Gene Cluster in Aspergillus nidulans

(2012) Kirsi Bromann et al.   PLoS One

Accurate prediction of secondary metabolite gene clusters in filamentous fungi

(2012) M. R. Andersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparative Genome Analysis of Trichophyton rubrum and Related Dermatophytes Reveals Candidate Genes Involved in Infection

(2012) D. A. Martinez et al.   mBio

ChLae1 and ChVel1 Regulate T-toxin Production, Virulence, Oxidative Stress Response, and Development of the Maize Pathogen Cochliobolus heterostrophus

(2012) Dongliang Wu et al.   PLoS Pathogens

Synthesis and assembly of fungal melanin

(2011) Helene C. Eisenman et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Total Biosynthesis of Diterpene Aphidicolin, a Specific Inhibitor of DNA Polymerase α: Heterologous Expression of Four Biosynthetic Genes inAspergillus oryzae

(2011) Ryuya FUJII et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

Two Induced Fungal Polyketide Pathways Converge into Antiproliferative Spiroanthrones

(2011) Kirstin Scherlach et al.   CHEMBIOCHEM

The Role of Glutathione S-Transferase GliG in Gliotoxin Biosynthesis in Aspergillus fumigatus

(2011) Carol Davis et al.   CHEMISTRY & BIOLOGY

Multifactorial Induction of an Orphan PKS-NRPS Gene Cluster in Aspergillus terreus

(2011) Markus Gressler et al.   CHEMISTRY & BIOLOGY

Identification and characterization of Penicillium citrinum VeA and LaeA as global regulators for ML-236B production

(2011) Satoshi Baba et al.   CURRENT GENETICS

Heterochromatin influences the secondary metabolite profile in the plant pathogen Fusarium graminearum

(2011) Yazmid Reyes-Dominguez et al.   FUNGAL GENETICS AND BIOLOGY

Strain improvement in actinomycetes in the postgenomic era

(2011) Richard H. Baltz   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Transcriptional regulatory elements in fungal secondary metabolism

(2011) Wenbing Yin et al.   JOURNAL OF MICROBIOLOGY

Rational Domain Swaps Decipher Programming in Fungal Highly Reducing Polyketide Synthases and Resurrect an Extinct Metabolite

(2011) Katja M. Fisch et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Genome-Based Deletion Analysis Reveals the Prenyl Xanthone Biosynthesis Pathway inAspergillus nidulans

(2011) James F. Sanchez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Dedicated GlutathioneS-Transferase Mediates Carbon–Sulfur Bond Formation in Gliotoxin Biosynthesis

(2011) Daniel H. Scharf et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Engineering of an “Unnatural” Natural Product by Swapping Polyketide Synthase Domains inAspergillus nidulans

(2011) Ting Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identification of Cryptic Products of the Gliotoxin Gene Cluster Using NMR-Based Comparative Metabolomics and a Model for Gliotoxin Biosynthesis

(2011) Ry R. Forseth et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A genetic and molecular toolbox for analyzing histone ubiquitylation and sumoylation in yeast

(2011) Kelly M. Trujillo et al.   METHODS

The Genome Portal of the Department of Energy Joint Genome Institute

(2011) I. V. Grigoriev et al.   NUCLEIC ACIDS RESEARCH

antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences

(2011) Marnix H. Medema et al.   NUCLEIC ACIDS RESEARCH

Bacteria-induced natural product formation in the fungus Aspergillus nidulans requires Saga/Ada-mediated histone acetylation

(2011) H.-W. Nutzmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fusarin C acts like an estrogenic agonist and stimulates breast cancer cells in vitro

(2011) T.E. Sondergaard et al.   TOXICOLOGY LETTERS

Genomic Analysis of the Necrotrophic Fungal Pathogens Sclerotinia sclerotiorum and Botrytis cinerea

(2011) Joelle Amselem et al.   PLoS Genetics

Genome Sequencing and Comparative Transcriptomics of the Model Entomopathogenic Fungi Metarhizium anisopliae and M. acridum

(2011) Qiang Gao et al.   PLoS Genetics

Comparative genome sequence analysis underscores mycoparasitism as the ancestral life style of Trichoderma

(2011) Christian P Kubicek et al.   GENOME BIOLOGY

Characterization of the Aspergillus nidulans Monodictyphenone Gene Cluster

(2010) Y.-M. Chiang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

First Heterologous Reconstruction of a Complete Functional Fungal Biosynthetic Multigene Cluster

(2010) Mary N. Heneghan et al.   CHEMBIOCHEM

Secondary metabolism in fungi: does chromosomal location matter?

(2010) Jonathan M Palmer et al.   CURRENT OPINION IN MICROBIOLOGY

Global Burden of Aflatoxin-Induced Hepatocellular Carcinoma: A Risk Assessment

(2010) Yan Liu et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Two Components of avelvet-Like Complex Control Hyphal Morphogenesis, Conidiophore Development, and Penicillin Biosynthesis in Penicillium chrysogenum

(2010) Birgit Hoff et al.   EUKARYOTIC CELL

SMURF: Genomic mapping of fungal secondary metabolite clusters

(2010) Nora Khaldi et al.   FUNGAL GENETICS AND BIOLOGY

Fungal secondary metabolites as modulators of interactions with insects and other arthropods

(2010) Marko Rohlfs et al.   FUNGAL GENETICS AND BIOLOGY

Regulation of secondary metabolism by chromatin structure and epigenetic codes

(2010) Joseph Strauss et al.   FUNGAL GENETICS AND BIOLOGY

Aspernidine A and B, prenylated isoindolinone alkaloids from the model fungus Aspergillus nidulans

(2010) Kirstin Scherlach et al.   JOURNAL OF ANTIBIOTICS

Penicillin biosynthesis in Aspergillus oryzae and its overproduction by genetic engineering

(2010) Junichiro Marui et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Streptomyces and Saccharopolyspora hosts for heterologous expression of secondary metabolite gene clusters

(2010) Richard H. Baltz   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Chemical Epigenetics Alters the Secondary Metabolite Composition of Guttate Excreted by an Atlantic-Forest-Soil-DerivedPenicillium citreonigrum

(2010) Xiaoru Wang et al.   JOURNAL OF NATURAL PRODUCTS

Heterochromatic marks are associated with the repression of secondary metabolism clusters in Aspergillus nidulans

(2010) Yazmid Reyes-Dominguez et al.   MOLECULAR MICROBIOLOGY

Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium

(2010) Li-Jun Ma et al.   NATURE

De novo Assembly of a 40 Mb Eukaryotic Genome from Short Sequence Reads: Sordaria macrospora, a Model Organism for Fungal Morphogenesis

(2010) Minou Nowrousian et al.   PLoS Genetics

Exploring and dissecting genome-wide gene expression responses of Penicillium chrysogenum to phenylacetic acid consumption and penicillinG production

(2009) Diana M Harris et al.   BMC GENOMICS

Distinct Roles for VeA and LaeA in Development and Pathogenesis ofAspergillus flavus

(2009) Saori Amaike et al.   EUKARYOTIC CELL

Sphingoid base levels in humans consuming fumonisin-contaminated maize in rural areas of the former Transkei, South Africa: a cross-sectional study

(2009) L. van der Westhuizen et al.   Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment

HdaA, a class 2 histone deacetylase of Aspergillus fumigatus, affects germination and secondary metabolite production

(2009) Inhyung Lee et al.   FUNGAL GENETICS AND BIOLOGY

Improved tryprostatin B production by heterologous gene expression in Aspergillus nidulans

(2009) Shubha Maiya et al.   FUNGAL GENETICS AND BIOLOGY

Rapid Cloning and Heterologous Expression of the Meridamycin Biosynthetic Gene Cluster Using a VersatileEscherichia coli−StreptomycesArtificial Chromosome Vector, pSBAC⊥

(2009) Hongbo Liu et al.   JOURNAL OF NATURAL PRODUCTS

A Gene Cluster Containing Two Fungal Polyketide Synthases Encodes the Biosynthetic Pathway for a Polyketide, Asperfuranone, inAspergillus nidulans

(2009) Yi-Ming Chiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biosynthesis of the red pigment bikaverin inFusarium fujikuroi: genes, their function and regulation

(2009) Philipp Wiemann et al.   MOLECULAR MICROBIOLOGY

Ergot: from witchcraft to biotechnology

(2009) THOMAS HAARMANN et al.   MOLECULAR PLANT PATHOLOGY

Beyond aflatoxin: four distinct expression patterns and functional roles associated withAspergillus flavussecondary metabolism gene clusters

(2009) D. RYAN GEORGIANNA et al.   MOLECULAR PLANT PATHOLOGY

Genomic basis for natural product biosynthetic diversity in the actinomycetes

(2009) Markus Nett et al.   NATURAL PRODUCT REPORTS

Epigenome manipulation as a pathway to new natural product scaffolds and their congeners

(2009) Robert H. Cichewicz   NATURAL PRODUCT REPORTS

Chromatin-level regulation of biosynthetic gene clusters

(2009) Jin Woo Bok et al.   Nature Chemical Biology

FtmOx1, a non-heme Fe(ii) and α-ketoglutarate-dependent dioxygenase, catalyses the endoperoxide formation of verruculogen in Aspergillus fumigatus

(2009) Nicola Steffan et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Aspects on evolution of fungal β-lactam biosynthesis gene clusters and recruitment of trans-acting factors

(2009) Axel A. Brakhage et al.   PHYTOCHEMISTRY

Diversity, regulation, and evolution of the gibberellin biosynthetic pathway in fungi compared to plants and bacteria

(2009) Christiane Bömke et al.   PHYTOCHEMISTRY

Intimate bacterial-fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans

(2009) V. Schroeckh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification and Characterization of the Asperthecin Gene Cluster of Aspergillus nidulans

(2008) E. Szewczyk et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

FtmPT2, anN-Prenyltransferase fromAspergillus fumigatus, Catalyses the Last Step in the Biosynthesis of Fumitremorgin B

(2008) Alexander Grundmann et al.   CHEMBIOCHEM

Molecular Genetic Mining of the Aspergillus Secondary Metabolome: Discovery of the Emericellamide Biosynthetic Pathway

(2008) Yi-Ming Chiang et al.   CHEMISTRY & BIOLOGY

H3K9 Methylation Regulates Growth and Development inAspergillus fumigatus

(2008) Jonathan M. Palmer et al.   EUKARYOTIC CELL

Genome Sequence of the Streptomycin-Producing Microorganism Streptomyces griseus IFO 13350

(2008) Y. Ohnishi et al.   JOURNAL OF BACTERIOLOGY

Construction of a Citrinin Gene Cluster Expression System in Heterologous Aspergillus oryzae

(2008) Kanae Sakai et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

An orally delivered small-molecule formulation with antiangiogenic and anticancer activity

(2008) Ofra Benny et al.   NATURE BIOTECHNOLOGY

Genome sequencing and analysis of the filamentous fungus Penicillium chrysogenum

(2008) Marco A van den Berg et al.   NATURE BIOTECHNOLOGY

Epigenetic remodeling of the fungal secondary metabolome

(2008) Russell B. Williams et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A chemical epigenetics approach for engineering the in situbiosynthesis of a cryptic natural product from Aspergillus niger

(2008) Jon C. Henrikson et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

VelB/VeA/LaeA Complex Coordinates Light Signal with Fungal Development and Secondary Metabolism

(2008) O. Bayram et al.   SCIENCE

The COP9 signalosome: more than a protease

(2008) N WEI et al.   TRENDS IN BIOCHEMICAL SCIENCES

A Zn(II)2Cys6 DNA binding protein regulates the sirodesmin PL biosynthetic gene cluster in Leptosphaeria maculans

(2007) Ellen M. Fox et al.   FUNGAL GENETICS AND BIOLOGY