期刊
NATURE CHEMICAL BIOLOGY
卷 8, 期 4, 页码 331-333出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NCHEMBIO.912
关键词
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资金
- US National Institutes of Health [1R01GM085128]
- Natural Sciences and Engineering Research Council of Canada
- Canada Research Chair in Bioorganic and Medicinal Chemistry
Iterative highly reducing polyketide synthases from filamentous fungi are the most complex and enigmatic type of polyketide synthase discovered to date. Here we uncover an unusual degree of programming by the hypothemycin highly reducing polyketide synthase, in which a single ketoreductase domain shows stereospecificity that is controlled by substrate length. Mapping of the structural domains responsible for this feature allowed for the biosynthesis of an unnatural diastereomer of the natural product dehydrozearalenol.
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