Breaking the Silence: Protein Stabilization Uncovers Silenced Biosynthetic Gene Clusters in the Fungus Aspergillus nidulans

Illuminating the Diversity of Aromatic Polyketide Synthases in Aspergillus nidulans

(2012) Manmeet Ahuja et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reengineering an Azaphilone Biosynthesis Pathway in Aspergillus nidulans To Create Lipoxygenase Inhibitors

(2012) Amber D. Somoza et al.   ORGANIC LETTERS

The Aspergillus nidulans MAPK Module AnSte11-Ste50-Ste7-Fus3 Controls Development and Secondary Metabolism

(2012) Özgür Bayram et al.   PLoS Genetics

Cytotoxic Pheofungins from an Engineered Fungus Impaired in Posttranslational Protein Modification

(2011) Kirstin Scherlach et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

FIMO: scanning for occurrences of a given motif

(2011) Charles E. Grant et al.   BIOINFORMATICS

A Single Cluster of Coregulated Genes Encodes the Biosynthesis of the Mycotoxins Roquefortine C and Meleagrin in Penicillium chrysogenum

(2011) Carlos García-Estrada et al.   CHEMISTRY & BIOLOGY

A genome-wide polyketide synthase deletion library uncovers novel genetic links to polyketides and meroterpenoids in Aspergillus nidulans

(2011) Michael L. Nielsen et al.   FEMS MICROBIOLOGY LETTERS

Engineering of an “Unnatural” Natural Product by Swapping Polyketide Synthase Domains inAspergillus nidulans

(2011) Ting Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fix the antibiotics pipeline

(2011) Matthew A. Cooper et al.   NATURE

Bacteria-induced natural product formation in the fungus Aspergillus nidulans requires Saga/Ada-mediated histone acetylation

(2011) H.-W. Nutzmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of a Silent Fungal Polyketide Biosynthesis Pathway through Regulatory Cross Talk with a Cryptic Nonribosomal Peptide Synthetase Gene Cluster

(2010) S. Bergmann et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Aspergilones A and B, two benzylazaphilones with an unprecedented carbon skeleton from the gorgonian-derived fungus Aspergillus sp.

(2010) Chang-Lun Shao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Recent advances in awakening silent biosynthetic gene clusters and linking orphan clusters to natural products in microorganisms

(2010) Yi-Ming Chiang et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Fungal development and the COP9 signalosome

(2010) Gerhard H Braus et al.   CURRENT OPINION IN MICROBIOLOGY

Suppressor Mutagenesis Identifies a Velvet Complex Remediator of Aspergillus nidulans Secondary Metabolism

(2010) Mona I. Shaaban et al.   EUKARYOTIC CELL

Fungal secondary metabolites – Strategies to activate silent gene clusters

(2010) Axel A. Brakhage et al.   FUNGAL GENETICS AND BIOLOGY

The COP9 signalosome mediates transcriptional and metabolic response to hormones, oxidative stress protection and cell wall rearrangement during fungal development

(2010) Krystyna Nahlik et al.   MOLECULAR MICROBIOLOGY

Methods and options for the heterologous production of complex natural products

(2010) Haoran Zhang et al.   NATURAL PRODUCT REPORTS

Azaphilones: a class of fungal metabolites with diverse biological activities

(2010) Natalia Osmanova et al.   PHYTOCHEMISTRY REVIEWS

Fungal polyketide azaphilone pigments as future natural food colorants?

(2010) Sameer A.S. Mapari et al.   TRENDS IN BIOTECHNOLOGY

LaeA Control of Velvet Family Regulatory Proteins for Light-Dependent Development and Fungal Cell-Type Specificity

(2010) Özlem Sarikaya Bayram et al.   PLoS Genetics

Strategies for the Discovery of New Natural Products by Genome Mining

(2009) Malek Zerikly et al.   CHEMBIOCHEM

A novel polyketide biosynthesis gene cluster is involved in fruiting body morphogenesis in the filamentous fungi Sordaria macrospora and Neurospora crassa

(2009) Minou Nowrousian   CURRENT GENETICS

Sch 1385568, a new azaphilone from Aspergillus sp.

(2009) Shu-Wei Yang et al.   JOURNAL OF ANTIBIOTICS

A Gene Cluster Containing Two Fungal Polyketide Synthases Encodes the Biosynthetic Pathway for a Polyketide, Asperfuranone, inAspergillus nidulans

(2009) Yi-Ming Chiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular genetic analysis of the orsellinic acid/F9775 genecluster of Aspergillus nidulans

(2009) James F. Sanchez et al.   Molecular BioSystems

Antibacterial discovery in actinomycetes strains with mutations in RNA polymerase or ribosomal protein S12

(2009) Takeshi Hosaka et al.   NATURE BIOTECHNOLOGY

Chromatin-level regulation of biosynthetic gene clusters

(2009) Jin Woo Bok et al.   Nature Chemical Biology

Hidden biosynthetic treasures brought to light

(2009) Christian Hertweck   Nature Chemical Biology

Triggering cryptic natural product biosynthesis in microorganisms

(2009) Kirstin Scherlach et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Intimate bacterial-fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans

(2009) V. Schroeckh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolite-based clustering and visualization of mass spectrometry data using one-dimensional self-organizing maps

(2008) Peter Meinicke et al.   Algorithms for Molecular Biology

Identification and Characterization of the Asperthecin Gene Cluster of Aspergillus nidulans

(2008) E. Szewczyk et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

A survey of nonribosomal peptide synthetase (NRPS) genes in Aspergillus nidulans

(2008) Hans von Döhren   FUNGAL GENETICS AND BIOLOGY

Construction of a Citrinin Gene Cluster Expression System in Heterologous Aspergillus oryzae

(2008) Kanae Sakai et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Epigenetic remodeling of the fungal secondary metabolome

(2008) Russell B. Williams et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A chemical epigenetics approach for engineering the in situbiosynthesis of a cryptic natural product from Aspergillus niger

(2008) Jon C. Henrikson et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

VelB/VeA/LaeA Complex Coordinates Light Signal with Fungal Development and Secondary Metabolism

(2008) O. Bayram et al.   SCIENCE

Bis-spiro-azaphilones and azaphilones from the fungi Chaetomium cochliodes VTh01 and C. cochliodes CTh05

(2008) Nutchanat Phonkerd et al.   TETRAHEDRON

The COP9 signalosome: more than a protease

(2008) N WEI et al.   TRENDS IN BIOCHEMICAL SCIENCES