BAG6/BAT3: emerging roles in quality control for nascent polypeptides

The complex process of GETting tail-anchored membrane proteins to the ER

(2012) Justin W Chartron et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Bat3 facilitates H3K79 dimethylation by DOT1L and promotes DNA damage-induced 53BP1 foci at G1/G2 cell-cycle phases

(2012) Timothy P Wakeman et al.   EMBO JOURNAL

Scythe cleavage during Fas (APO-1)-and staurosporine-mediated apoptosis

(2012) Giulio Preta et al.   FEBS LETTERS

Get5 Carboxyl-terminal Domain Is a Novel Dimerization Motif That Tethers an Extended Get4/Get5 Complex

(2012) Justin W. Chartron et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of apoptosis by Bat3-enhanced YWK-II/APLP2 protein stability

(2012) W. Wu et al.   JOURNAL OF CELL SCIENCE

Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion

(2012) Manu Rangachari et al.   NATURE MEDICINE

A Novel BAT3 Sequence Generated by Alternative RNA Splicing of Exon 11B Displays Cell Type-Specific Expression and Impacts on Subcellular Localization

(2012) Nadine Kämper et al.   PLoS One

A Novel, Non-Apoptotic Role for Scythe/BAT3: A Functional Switch between the Pro- and Anti-Proliferative Roles of p21 during the Cell Cycle

(2012) Sheila T. Yong et al.   PLoS One

BAT3 Regulates Mycobacterium tuberculosis Protein ESAT-6-Mediated Apoptosis of Macrophages

(2012) Ajay Grover et al.   PLoS One

SGTA antagonizes BAG6-mediated protein triage

(2012) P. Leznicki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydrophobicity as a driver of MHC class I antigen processing

(2011) Lan Huang et al.   EMBO JOURNAL

γ-Interferon-regulated chaperone governs human lymphocyte antigen class II expression

(2011) Nadine Kämper et al.   FASEB JOURNAL

Interaction Surface and Topology of Get3-Get4-Get5 Protein Complex, Involved in Targeting Tail-anchored Proteins to Endoplasmic Reticulum

(2011) Yi-Wei Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Structural Model of the Sgt2 Protein and Its Interactions with Chaperones and the Get4/Get5 Complex

(2011) Justin W. Chartron et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

WRB is the receptor for TRC40/Asna1-mediated insertion of tail-anchored proteins into the ER membrane

(2011) F. Vilardi et al.   JOURNAL OF CELL SCIENCE

Exposed hydrophobicity is a key determinant of nuclear quality control degradation

(2011) Eric K. Fredrickson et al.   MOLECULAR BIOLOGY OF THE CELL

A Ubiquitin Ligase-Associated Chaperone Holdase Maintains Polypeptides in Soluble States for Proteasome Degradation

(2011) Qiuyan Wang et al.   MOLECULAR CELL

Protein targeting and degradation are coupled for elimination of mislocalized proteins

(2011) Tara Hessa et al.   NATURE

The mechanism of membrane-associated steps in tail-anchored protein insertion

(2011) Malaiyalam Mariappan et al.   NATURE

Tail-anchored membrane protein insertion into the endoplasmic reticulum

(2011) Ramanujan S. Hegde et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death

(2011) Domagoj Vucic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

BAT3 Guides Misfolded Glycoproteins Out of the Endoplasmic Reticulum

(2011) Jasper H. L. Claessen et al.   PLoS One

Road to Ruin: Targeting Proteins for Degradation in the Endoplasmic Reticulum

(2011) M. H. Smith et al.   SCIENCE

DRiPs solidify: progress in understanding endogenous MHC class I antigen processing

(2011) Jonathan W. Yewdell   TRENDS IN IMMUNOLOGY

Emerging Tim-3 functions in antimicrobial and tumor immunity

(2011) Kaori Sakuishi et al.   TRENDS IN IMMUNOLOGY

HLA-B-associated transcript 3 (Bat3/Scythe) negatively regulates Smad phosphorylation in BMP signaling

(2011) K Goto et al.   Cell Death & Disease

Enzymatic Blockade of the Ubiquitin-Proteasome Pathway

(2011) Robert Ernst et al.   PLOS BIOLOGY

ERAD ubiquitin ligases

(2010) Martin Mehnert et al.   BIOESSAYS

Immunoproteasomes Preserve Protein Homeostasis upon Interferon-Induced Oxidative Stress

(2010) Ulrike Seifert et al.   CELL

The structure of Get4 reveals an α-solenoid fold adapted for multiple interactions in tail-anchored protein biogenesis

(2010) Gunes Bozkurt et al.   FEBS LETTERS

Crystal Structure of Get4-Get5 Complex and Its Interactions with Sgt2, Get3, and Ydj1

(2010) Yi-Wei Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BAG-6 is essential for selective elimination of defective proteasomal substrates

(2010) Ryosuke Minami et al.   JOURNAL OF CELL BIOLOGY

Asna1/TRC40-mediated membrane insertion of tail-anchored proteins

(2010) V. Favaloro et al.   JOURNAL OF CELL SCIENCE

Bat3 promotes the membrane integration of tail-anchored proteins

(2010) P. Leznicki et al.   JOURNAL OF CELL SCIENCE

A Chaperone Cascade Sorts Proteins for Posttranslational Membrane Insertion into the Endoplasmic Reticulum

(2010) Fei Wang et al.   MOLECULAR CELL

A ribosome-associating factor chaperones tail-anchored membrane proteins

(2010) Malaiyalam Mariappan et al.   NATURE

Structural characterization of the Get4/Get5 complex and its interaction with Get3

(2010) J. W. Chartron et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of Get3, Get4, and Get5 Provide New Models for TA Membrane Protein Targeting

(2010) Peter J. Simpson et al.   STRUCTURE

Cell death: protein misfolding and neurodegenerative diseases

(2009) Tomohiro Nakamura et al.   APOPTOSIS

Scythe/BAT3 regulates apoptotic cell death induced by papillomavirus binding factor in human osteosarcoma

(2009) Tomohide Tsukahara et al.   CANCER SCIENCE

Sequential interplay between BAG6 and HSP70 upon heat shock

(2009) A. Corduan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The role of molecular chaperones in human misfolding diseases

(2009) Sarah A. Broadley et al.   FEBS LETTERS

Biogenesis of tail-anchored proteins: the beginning for the end?

(2009) C. Rabu et al.   JOURNAL OF CELL SCIENCE

The ubiquitylation machinery of the endoplasmic reticulum

(2009) Christian Hirsch et al.   NATURE

The GET Complex Mediates Insertion of Tail-Anchored Proteins into the ER Membrane

(2008) Maya Schuldiner et al.   CELL

The BAG proteins: a ubiquitous family of chaperone regulators

(2008) M. Kabbage et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Thymoproteasome: probable role in generating positively selecting peptides

(2008) Shigeo Murata et al.   CURRENT OPINION IN IMMUNOLOGY

BAT3 Interacts with Transforming Growth Factor-β (TGF-β) Receptors and Enhances TGF-β1-induced Type I Collagen Expression in Mesangial Cells

(2008) Joon Hyeok Kwak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Degradation of a Cytosolic Protein Requires Endoplasmic Reticulum-associated Degradation Machinery

(2008) Meredith Boyle Metzger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BAT3 and SET1A Form a Complex with CTCFL/BORIS To Modulate H3K4 Histone Dimethylation and Gene Expression

(2008) P. Nguyen et al.   MOLECULAR AND CELLULAR BIOLOGY

Common 5p15.33 and 6p21.33 variants influence lung cancer risk

(2008) Yufei Wang et al.   NATURE GENETICS