The role of molecular chaperones in human misfolding diseases

Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3

(2009) Martin Gamerdinger et al.   EMBO JOURNAL

Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS

(2009) J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1

(2009) S. D. Westerheide et al.   SCIENCE

Mitochondrial Hsp60 Chaperonopathy Causes an Autosomal-Recessive Neurodegenerative Disorder Linked to Brain Hypomyelination and Leukodystrophy

(2008) Daniella Magen et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Interactions between Hsp70 and the Hydrophobic Core of α-Synuclein Inhibit Fibril Assembly†

(2008) Kelvin C. Luk et al.   BIOCHEMISTRY

Polyglutamine gene function and dysfunction in the ageing brain

(2008) Sarah Hands et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

N-terminal polyglutamine-containing fragments inhibit androgen receptor transactivation function

(2008) Niclas W. Schiffer et al.   BIOLOGICAL CHEMISTRY

Structural Basis for the Cooperation of Hsp70 and Hsp110 Chaperones in Protein Folding

(2008) Sigrun Polier et al.   CELL

Phase II Trial of 17-Allylamino-17-Demethoxygeldanamycin in Patients with Metastatic Melanoma

(2008) D. B. Solit et al.   CLINICAL CANCER RESEARCH

Mutant Huntingtin reduces HSP70 expression through the sequestration of NF-Y transcription factor

(2008) Tomoyuki Yamanaka et al.   EMBO JOURNAL

Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity

(2008) M. L. Duennwald et al.   GENES & DEVELOPMENT

Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging

(2008) R. I. Morimoto   GENES & DEVELOPMENT

Heat Shock Transcription Factor 1-activating Compounds Suppress Polyglutamine-induced Neurodegeneration through Induction of Multiple Molecular Chaperones

(2008) Nobuhiro Fujikake et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CHIP Targets Toxic α-Synuclein Oligomers for Degradation

(2008) Julie E. Tetzlaff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Late stage treatment with arimoclomol delays disease progression and prevents protein aggregation in the SOD1G93A mouse model of ALS

(2008) Bernadett Kalmar et al.   JOURNAL OF NEUROCHEMISTRY

Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1

(2008) Janghoo Lim et al.   NATURE

Sirtuins — novel therapeutic targets to treat age-associated diseases

(2008) Siva Lavu et al.   NATURE REVIEWS DRUG DISCOVERY

Defining the TRiC/CCT interactome links chaperonin function to stabilization of newly made proteins with complex topologies

(2008) Alice Y Yam et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Heat shock treatment reduces beta amyloid toxicity in vivo by diminishing oligomers

(2008) Yanjue Wu et al.   NEUROBIOLOGY OF AGING

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE

Polyglutamine neurodegeneration: protein misfolding revisited

(2008) Aislinn J. Williams et al.   TRENDS IN NEUROSCIENCES