Malate and Fumarate Extend Lifespan in Caenorhabditis elegans

The free-radical theory of ageing - older, wiser and still alive

(2012) Thomas B. L. Kirkwood et al.   BIOESSAYS

Impaired Insulin/IGF1 Signaling Extends Life Span by Promoting Mitochondrial L-Proline Catabolism to Induce a Transient ROS Signal

(2012) Kim Zarse et al.   Cell Metabolism

Enhanced Energy Metabolism Contributes to the Extended Life Span of Calorie-restrictedCaenorhabditis elegans

(2012) Yiyuan Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dietary restriction increases skeletal muscle mitochondrial respiration but not mitochondrial content in C57BL/6 mice

(2012) Sarah Hempenstall et al.   MECHANISMS OF AGEING AND DEVELOPMENT

HIF-1 modulates longevity and healthspan in a temperature-dependent manner

(2011) Scott F. Leiser et al.   AGING CELL

GABA metabolism pathway genes, UGA1 and GAD1, regulate replicative lifespan in Saccharomyces cerevisiae

(2011) Yuka Kamei et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Antioxidant defense and aging inC. elegans: Is the oxidative damage theory of aging wrong?

(2011) David Gems et al.   CELL CYCLE

Deletion of the Mammalian INDY Homolog Mimics Aspects of Dietary Restriction and Protects against Adiposity and Insulin Resistance in Mice

(2011) Andreas L. Birkenfeld et al.   Cell Metabolism

Respiratory and TCA cycle activities affect S. cerevisiae lifespan, response to caloric restriction and mtDNA stability

(2011) Erich B. Tahara et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Increased longevity of some C. elegans mitochondrial mutants explained by activation of an alternative energy-producing pathway

(2011) Marco Gallo et al.   MECHANISMS OF AGEING AND DEVELOPMENT

ER stress and hormetic regulation of the aging process

(2010) Antero Salminen et al.   AGEING RESEARCH REVIEWS

Pyruvate imbalance mediates metabolic reprogramming and mimics lifespan extension by dietary restriction in Caenorhabditis elegans

(2010) Laurent Mouchiroud et al.   AGING CELL

The NADH-fumarate reductase system, a novel mitochondrial energy metabolism, is a new target for anticancer therapy in tumor microenvironments

(2010) Eriko Tomitsuka et al.   Annals of the New York Academy of Sciences

The effect of dichloroacetate on health- and lifespan in C. elegans

(2010) S. Schaffer et al.   BIOGERONTOLOGY

NAD+ and metabolic regulation of age-related proteoxicity: A possible role for methylglyoxal?

(2010) Alan R. Hipkiss   EXPERIMENTAL GERONTOLOGY

Gene regulatory changes in yeast during life extension by nutrient limitation

(2010) Jinqing Wang et al.   EXPERIMENTAL GERONTOLOGY

The sites and topology of mitochondrial superoxide production

(2010) Martin D. Brand   EXPERIMENTAL GERONTOLOGY

Flavin Adenine Dinucleotide Rescues the Phenotype of Frataxin Deficiency

(2010) Pilar Gonzalez-Cabo et al.   PLoS One

Acetylation of Metabolic Enzymes Coordinates Carbon Source Utilization and Metabolic Flux

(2010) Q. Wang et al.   SCIENCE

Oxaloacetate supplementation increases lifespan inCaenorhabditis elegansthrough an AMPK/FOXO-dependent pathway

(2009) David S. Williams et al.   AGING CELL

Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways inC. elegans

(2009) Eric L. Greer et al.   AGING CELL

Nicotinamide adenine dinucleotide extends the lifespan of Caenorhabditis elegans mediated by sir-2.1 and daf-16

(2009) Teppei Hashimoto et al.   BIOGERONTOLOGY

Origin and evolution of the free radical theory of aging: a brief personal history, 1954–2009

(2009) Denham Harman   BIOGERONTOLOGY

The lifespan-promoting effect of acetic acid and Reishi polysaccharide

(2009) Ming-Hong Chuang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A transfer-less, multi-well liquid culture feeding system for screening small molecules that affect the longevity of Caenorhabditis elegans

(2009) Vanessa K. Fitzgerald et al.   BIOTECHNIQUES

Protein Acetylation Microarray Reveals that NuA4 Controls Key Metabolic Target Regulating Gluconeogenesis

(2009) Yu-yi Lin et al.   CELL

Glucose Shortens the Life Span of C. elegans by Downregulating DAF-16/FOXO Activity and Aquaporin Gene Expression

(2009) Seung-Jae Lee et al.   Cell Metabolism

Decline in oxygen consumption correlates with lifespan in long-lived and short-lived mutants of Caenorhabditis elegans

(2009) Tetsuji Shoyama et al.   EXPERIMENTAL GERONTOLOGY

C. elegans longevity pathways converge to decrease mitochondrial membrane potential

(2009) Bernard D. Lemire et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Dual localization of fumarase is dependent on the integrity of the glyoxylate shunt

(2009) Neta Regev-Rudzki et al.   MOLECULAR MICROBIOLOGY

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Role of CBP and SATB-1 in Aging, Dietary Restriction, and Insulin-Like Signaling

(2009) Minhua Zhang et al.   PLOS BIOLOGY

HIF-1 Modulates Dietary Restriction-Mediated Lifespan Extension via IRE-1 in Caenorhabditis elegans

(2009) Di Chen et al.   PLoS Genetics

A Regulated Response to Impaired Respiration Slows Behavioral Rates and Increases Lifespan in Caenorhabditis elegans

(2009) David Cristina et al.   PLoS Genetics

Glyoxalase-1 prevents mitochondrial protein modification and enhances lifespan in Caenorhabditis elegans

(2008) Michael Morcos et al.   AGING CELL

Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans

(2008) Katherine A. Steinkraus et al.   AGING CELL

Tissue-specific regulation of SIRT1 by calorie restriction

(2008) D. Chen et al.   GENES & DEVELOPMENT