Spatiotemporal regulation of the anaphase-promoting complex in mitosis

Enhanced Protein Degradation by Branched Ubiquitin Chains

(2014) Hermann-Josef Meyer et al.   CELL

Activation of the APC/C Ubiquitin Ligase by Enhanced E2 Efficiency

(2014) Vanessa A. Van Voorhis et al.   CURRENT BIOLOGY

Insights into the anaphase-promoting complex: a molecular machine that regulates mitosis

(2014) Leifu Chang et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

PP2A delays APC/C-dependent degradation of separase-associated but not free securin

(2014) S. Hellmuth et al.   EMBO JOURNAL

Multiple mechanisms determine the order of APC/C substrate degradation in mitosis

(2014) Dan Lu et al.   JOURNAL OF CELL BIOLOGY

The spindle and kinetochore–associated (Ska) complex enhances binding of the anaphase-promoting complex/cyclosome (APC/C) to chromosomes and promotes mitotic exit

(2014) Sushama Sivakumar et al.   MOLECULAR BIOLOGY OF THE CELL

Microtubule-Dependent Regulation of Mitotic Protein Degradation

(2014) Ling Song et al.   MOLECULAR CELL

Ubiquitin Chain Elongation Requires E3-Dependent Tracking of the Emerging Conjugate

(2014) Aileen Kelly et al.   MOLECULAR CELL

Mechanism of Polyubiquitination by Human Anaphase-Promoting Complex: RING Repurposing for Ubiquitin Chain Assembly

(2014) Nicholas G. Brown et al.   MOLECULAR CELL

Molecular architecture and mechanism of the anaphase-promoting complex

(2014) Leifu Chang et al.   NATURE

Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C

(2014) Katharine L. Sackton et al.   NATURE

Signalling dynamics in the spindle checkpoint response

(2014) Nitobe London et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Disassembly of mitotic checkpoint complexes by the joint action of the AAA-ATPase TRIP13 and p31comet

(2014) E. Eytan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emi2 mediates meiotic MII arrest by competitively inhibiting the binding of Ube2S to the APC/C

(2014) Kosuke Sako et al.   Nature Communications

Co-activator independent differences in how the metaphase and anaphase APC/C recognise the same substrate

(2014) T. Matsusaka et al.   Biology Open

The ubiquitin proteasome system — Implications for cell cycle control and the targeted treatment of cancer

(2013) Florian Bassermann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mechanisms controlling the temporal degradation of Nek2A and Kif18A by the APC/C–Cdc20 complex

(2013) Garry G Sedgwick et al.   EMBO JOURNAL

Sequestration of CDH1 by MAD2L2 prevents premature APC/C activation prior to anaphase onset

(2013) Tamar Listovsky et al.   JOURNAL OF CELL BIOLOGY

Panta rhei: The APC/C at steady state

(2013) Ivana Primorac et al.   JOURNAL OF CELL BIOLOGY

The Four Canonical TPR Subunits of Human APC/C Form Related Homo-Dimeric Structures and Stack in Parallel to Form a TPR Suprahelix

(2013) Ziguo Zhang et al.   JOURNAL OF MOLECULAR BIOLOGY

Insights into Degron Recognition by APC/C Coactivators from the Structure of an Acm1-Cdh1 Complex

(2013) Jun He et al.   MOLECULAR CELL

Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase-promoting complex

(2013) Weiping Wang et al.   NATURE CELL BIOLOGY

Kinetic framework of spindle assembly checkpoint signalling

(2013) Amalie E. Dick et al.   NATURE CELL BIOLOGY

The spindle assembly checkpoint works like a rheostat rather than a toggle switch

(2013) Philippe Collin et al.   NATURE CELL BIOLOGY

Electron microscopy structure of human APC/CCDH1–EMI1 reveals multimodal mechanism of E3 ligase shutdown

(2013) Jeremiah J Frye et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Roles of different pools of the mitotic checkpoint complex and the mechanisms of their disassembly

(2013) E. Eytan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Spindle Assembly Checkpoint

(2012) Pablo Lara-Gonzalez et al.   CURRENT BIOLOGY

Separase Sensor Reveals Dual Roles for Separase Coordinating Cohesin Cleavage and Cdk1 Inhibition

(2012) Norihisa Shindo et al.   DEVELOPMENTAL CELL

Separase Biosensor Reveals that Cohesin Cleavage Timing Depends on Phosphatase PP2ACdc55 Regulation

(2012) Gilad Yaakov et al.   DEVELOPMENTAL CELL

Dephosphorylation of Cdc20 is required for its C-box-dependent activation of the APC/C

(2012) Helene Labit et al.   EMBO JOURNAL

Depletion of p31cometProtein Promotes Sensitivity to Antimitotic Drugs

(2012) Hoi Tang Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mad2 and the APC/C compete for the same site on Cdc20 to ensure proper chromosome segregation

(2012) Daisuke Izawa et al.   JOURNAL OF CELL BIOLOGY

Emerging regulatory mechanisms in ubiquitin-dependent cell cycle control

(2012) A. Mocciaro et al.   JOURNAL OF CELL SCIENCE

The APC/C Subunit Mnd2/Apc15 Promotes Cdc20 Autoubiquitination and Spindle Assembly Checkpoint Inactivation

(2012) Scott A. Foster et al.   MOLECULAR CELL

Structure of the mitotic checkpoint complex

(2012) William C. H. Chao et al.   NATURE

Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore

(2012) Emily A. Foley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The spindle-assembly checkpoint and the beauty of self-destruction

(2012) Andrea Musacchio et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

APC15 mediates CDC20 autoubiquitylation by APC/CMCC and disassembly of the mitotic checkpoint complex

(2012) Kristina Uzunova et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cohesion Fatigue Explains Why Pharmacological Inhibition of the APC/C Induces a Spindle Checkpoint-Dependent Mitotic Arrest

(2012) Pablo Lara-Gonzalez et al.   PLoS One

Structural analysis of human Cdc20 supports multisite degron recognition by APC/C

(2012) W. Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The APC/C Inhibitor XErp1/Emi2 Is Essential for Xenopus Early Embryonic Divisions

(2012) T. Tischer et al.   SCIENCE

Cdc20 control of cell fate during prolonged mitotic arrest

(2011) Jakob Nilsson   BIOESSAYS

Spindle Checkpoint Silencing: PP1 Tips the Balance

(2011) Bart Lesage et al.   CURRENT BIOLOGY

Cohesion Fatigue Induces Chromatid Separation in Cells Delayed at Metaphase

(2011) John R. Daum et al.   CURRENT BIOLOGY

Evidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction

(2011) Stefano Santaguida et al.   EMBO JOURNAL

Cdk1 promotes kinetochore bi-orientation and regulates Cdc20 expression during recovery from spindle checkpoint arrest

(2011) Hongqing Liang et al.   EMBO JOURNAL

Regulation of the Action of Early Mitotic Inhibitor 1 on the Anaphase-promoting Complex/Cyclosome by Cyclin-dependent Kinases

(2011) Yakir Moshe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p31comet-mediated extraction of Mad2 from the MCC promotes efficient mitotic exit

(2011) F. G. Westhorpe et al.   JOURNAL OF CELL SCIENCE

BubR1 blocks substrate recruitment to the APC/C in a KEN-box-dependent manner

(2011) Pablo Lara-Gonzalez et al.   JOURNAL OF CELL SCIENCE

Defining pathways of spindle checkpoint silencing: functional redundancy between Cdc20 ubiquitination and p31comet

(2011) Luying Jia et al.   MOLECULAR BIOLOGY OF THE CELL

p31comet acts to ensure timely spindle checkpoint silencing subsequent to kinetochore attachment

(2011) Robert S. Hagan et al.   MOLECULAR BIOLOGY OF THE CELL

Mitotic progression becomes irreversible in prometaphase and collapses when Wee1 and Cdc25 are inhibited

(2011) Tamara A. Potapova et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation of Ubiquitin Chain Initiation to Control the Timing of Substrate Degradation

(2011) Adam Williamson et al.   MOLECULAR CELL

Homeostatic Control of Mitotic Arrest

(2011) Gianluca Varetti et al.   MOLECULAR CELL

Deubiquitinase USP37 Is Activated by CDK2 to Antagonize APCCDH1 and Promote S Phase Entry

(2011) XiaoDong Huang et al.   MOLECULAR CELL

Structural basis for the subunit assembly of the anaphase-promoting complex

(2011) Anne Schreiber et al.   NATURE

Cdk1-phosphorylated CUEDC2 promotes spindle checkpoint inactivation and chromosomal instability

(2011) Yan-Fei Gao et al.   NATURE CELL BIOLOGY

APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment

(2011) Jörg Mansfeld et al.   NATURE CELL BIOLOGY

Cubism and the cell cycle: the many faces of the APC/C

(2011) Jonathon Pines   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Uncoordinated Loss of Chromatid Cohesion Is a Common Outcome of Extended Metaphase Arrest

(2011) Deanna Stevens et al.   PLoS One

p31comet promotes disassembly of the mitotic checkpoint complex in an ATP-dependent process

(2011) A. Teichner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Processive ubiquitin chain formation by the anaphase-promoting complex

(2011) Hermann-Josef Meyer et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Cyclin A and Nek2A: APC/C–Cdc20 substrates invisible to the mitotic spindle checkpoint

(2010) Wouter van Zon et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Pharmacologic Inhibition of the Anaphase-Promoting Complex Induces A Spindle Checkpoint-Dependent Mitotic Arrest in the Absence of Spindle Damage

(2010) Xing Zeng et al.   CANCER CELL

The APC/C subunit Cdc16/Cut9 is a contiguous tetratricopeptide repeat superhelix with a homo-dimer interface similar to Cdc27

(2010) Ziguo Zhang et al.   EMBO JOURNAL

How cyclin A destruction escapes the spindle assembly checkpoint

(2010) Barbara Di Fiore et al.   JOURNAL OF CELL BIOLOGY

Emi2 Inhibition of the Anaphase-promoting Complex/Cyclosome Absolutely Requires Emi2 Binding via the C-Terminal RL Tail

(2010) Munemichi Ohe et al.   MOLECULAR BIOLOGY OF THE CELL

A Specific Form of Phospho Protein Phosphatase 2 Regulates Anaphase-promoting Complex/Cyclosome Association with Spindle Poles

(2010) Jorge Z. Torres et al.   MOLECULAR BIOLOGY OF THE CELL

K11-Linked Polyubiquitination in Cell Cycle Control Revealed by a K11 Linkage-Specific Antibody

(2010) Marissa L. Matsumoto et al.   MOLECULAR CELL

Structures of APC/CCdh1 with substrates identify Cdh1 and Apc10 as the D-box co-receptor

(2010) Paula C. A. da Fonseca et al.   NATURE

Substrate binding on the APC/C occurs between the coactivator Cdh1 and the processivity factor Doc1

(2010) Bettina A Buschhorn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Sustained Spindle-Assembly Checkpoint Response Requires De Novo Transcription and Translation of Cyclin B1

(2010) Ana Lúcia Mena et al.   PLoS One

ATP is required for the release of the anaphase-promoting complex/cyclosome from inhibition by the mitotic checkpoint

(2010) S. Miniowitz-Shemtov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

UBE2S drives elongation of K11-linked ubiquitin chains by the Anaphase-Promoting Complex

(2010) T. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynein at the kinetochore: Timing, Interactions and Functions

(2010) Jason R. Bader et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Ska3 Is Required for Spindle Checkpoint Silencing and the Maintenance of Chromosome Cohesion in Mitosis

(2009) John R. Daum et al.   CURRENT BIOLOGY

The Human Kinetochore Ska1 Complex Facilitates Microtubule Depolymerization-Coupled Motility

(2009) Julie P.I. Welburn et al.   DEVELOPMENTAL CELL

Unattached Kinetochores Catalyze Production of an Anaphase Inhibitor that Requires a Mad2 Template to Prime Cdc20 for BubR1 Binding

(2009) Anita Kulukian et al.   DEVELOPMENTAL CELL

Stable kinetochore–microtubule interactions depend on the Ska complex and its new component Ska3/C13Orf3

(2009) Thomas N Gaitanos et al.   EMBO JOURNAL

BubR1 acetylation at prometaphase is required for modulating APC/C activity and timing of mitosis

(2009) Eunhee Choi et al.   EMBO JOURNAL

Loss of the mammalian APC/C activator FZR1 shortens G1 and lengthens S phase but has little effect on exit from mitosis

(2009) R. Sigl et al.   JOURNAL OF CELL SCIENCE

Analysis of Activator-Binding Sites on the APC/C Supports a Cooperative Substrate-Binding Mechanism

(2009) Mary E. Matyskiela et al.   MOLECULAR CELL

UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit

(2009) Mathew J. Garnett et al.   NATURE CELL BIOLOGY

Building ubiquitin chains: E2 enzymes at work

(2009) Yihong Ye et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Insights into anaphase promoting complex TPR subdomain assembly from a CDC26–APC6 structure

(2009) Jing Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms

(2009) A Satyanarayana et al.   ONCOGENE

The emerging role of APC/CCdh1 in controlling differentiation, genomic stability and tumor suppression

(2009) R Wäsch et al.   ONCOGENE

Identification of a physiological E2 module for the human anaphase-promoting complex

(2009) A. Williamson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the Anaphase-Promoting Complex/Cyclosome Interacting with a Mitotic Checkpoint Complex

(2009) F. Herzog et al.   SCIENCE

Cancer Cells Display Profound Intra- and Interline Variation following Prolonged Exposure to Antimitotic Drugs

(2008) Karen E. Gascoigne et al.   CANCER CELL

Mechanism of Ubiquitin-Chain Formation by the Human Anaphase-Promoting Complex

(2008) Lingyan Jin et al.   CELL

APC/CCdh1 Targets Aurora Kinase to Control Reorganization of the Mitotic Spindle at Anaphase

(2008) Suzanne Floyd et al.   CURRENT BIOLOGY

Phosphorylation of Skp2 regulated by CDK2 and Cdc14B protects it from degradation by APCCdh1 in G1 phase

(2008) Geneviève Rodier et al.   EMBO JOURNAL

Pseudosubstrate Inhibition of the Anaphase-Promoting Complex by Acm1: Regulation by Proteolysis and Cdc28 Phosphorylation

(2008) D. Ostapenko et al.   MOLECULAR AND CELLULAR BIOLOGY

Modulation of the Mitotic Regulatory Network by APC-Dependent Destruction of the Cdh1 Inhibitor Acm1

(2008) Maria Enquist-Newman et al.   MOLECULAR CELL

Cdc20 and Cks Direct the Spindle Checkpoint-Independent Destruction of Cyclin A

(2008) Rob Wolthuis et al.   MOLECULAR CELL

A Role for the Fizzy/Cdc20 Family of Proteins in Activation of the APC/C Distinct from Substrate Recruitment

(2008) Yuu Kimata et al.   MOLECULAR CELL

Genomic stability and tumour suppression by the APC/C cofactor Cdh1

(2008) Irene García-Higuera et al.   NATURE CELL BIOLOGY

The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction

(2008) Jakob Nilsson et al.   NATURE CELL BIOLOGY