期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 22, 期 6, 页码 544-550出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2011.03.009
关键词
Ubiquitin; Anapahase-promoting complex; APC/C; Ube2C; Ube2S; Processivity
资金
- NIH [5R01GM083064-03, 1DP2OD003088]
- March of Dimes Foundation
Progression through mitosis requires the sequential ubiquitination of cell cycle regulators by the anaphase-promoting complex, resulting in their proteasomal degradation. Although several mechanisms contribute to APC/C regulation during mitosis, the APC/C is able to discriminate between its many substrates by exploiting differences in the processivity of ubiquitin chain assembly. Here, we discuss how the APC/C achieves processive ubiquitin chain formation to trigger the sequential degradation of cell cycle regulators during mitosis. (C) 2011 Elsevier Ltd. All rights reserved.
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