Mechanistic insights into bacterial AAA+ proteases and protein-remodelling machines

Escherichia coliClpB is a non-processive polypeptide translocase

(2015) Tao Li et al.   BIOCHEMICAL JOURNAL

Mitochondrial ClpX Activates a Key Enzyme for Heme Biosynthesis and Erythropoiesis

(2015) Julia R. Kardon et al.   CELL

Deciphering the Roles of Multicomponent Recognition Signals by the AAA + Unfoldase ClpX

(2015) Lorraine Ling et al.   JOURNAL OF MOLECULAR BIOLOGY

Mechanistic insights into the recycling machine of the SNARE complex

(2015) Minglei Zhao et al.   NATURE

Coordinated gripping of substrate by subunits of a AAA+ proteolytic machine

(2015) Ohad Iosefson et al.   Nature Chemical Biology

Mechanisms of ribosome rescue in bacteria

(2015) Kenneth C. Keiler   NATURE REVIEWS MICROBIOLOGY

Assaying the kinetics of protein denaturation catalyzed by AAA+ unfolding machines and proteases

(2015) Vladimir Baytshtok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spring-loaded unraveling of a single SNARE complex by NSF in one round of ATP turnover

(2015) J.-K. Ryu et al.   SCIENCE

Dissection of Axial-Pore Loop Function during Unfolding and Translocation by a AAA+ Proteolytic Machine

(2015) Ohad Iosefson et al.   Cell Reports

Intrinsically Disordered Proteins and Intrinsically Disordered Protein Regions

(2014) Christopher J. Oldfield et al.   Annual Review of Biochemistry

Stochastic but Highly Coordinated Protein Unfolding and Translocation by the ClpXP Proteolytic Machine

(2014) Juan Carlos Cordova et al.   CELL

Lassomycin, a Ribosomally Synthesized Cyclic Peptide, Kills Mycobacterium tuberculosis by Targeting the ATP-Dependent Protease ClpC1P1P2

(2014) Ekaterina Gavrish et al.   CHEMISTRY & BIOLOGY

Survival of mycobacteria depends on proteasome-mediated amino acid recycling under nutrient limitation

(2014) Y. Elharar et al.   EMBO JOURNAL

Restriction of the Conformational Dynamics of the Cyclic Acyldepsipeptide Antibiotics Improves Their Antibacterial Activity

(2014) Daniel W. Carney et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Substrate delivery by the AAA+ ClpX and ClpC1 unfoldases activates the mycobacterial ClpP1P2 peptidase

(2014) Karl R. Schmitz et al.   MOLECULAR MICROBIOLOGY

Mechanochemical basis of protein degradation by a double-ring AAA+ machine

(2014) Adrian O Olivares et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Location of Dual Sites in E. coli FtsZ Important for Degradation by ClpXP; One at the C-Terminus and One in the Disordered Linker

(2014) Jodi L. Camberg et al.   PLoS One

Crystal structure of Mycobacterium tuberculosis ClpP1P2 suggests a model for peptidase activation by AAA+ partner binding and substrate delivery

(2014) K. R. Schmitz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibacterial Activity of and Resistance to Small Molecule Inhibitors of the ClpP Peptidase

(2013) Corey L. Compton et al.   ACS Chemical Biology

Pupylation as a signal for proteasomal degradation in bacteria

(2013) Frank Striebel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The ClpXP Protease Unfolds Substrates Using a Constant Rate of Pulling but Different Gears

(2013) Maya Sen et al.   CELL

Nucleotide Binding and Conformational Switching in the Hexameric Ring of a AAA+ Machine

(2013) Benjamin M. Stinson et al.   CELL

Structural Basis of Mycobacterial Inhibition by Cyclomarin A

(2013) Dileep Vasudevan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ClpV recycles VipA/VipB tubules and prevents non-productive tubule formation to ensure efficient type VI protein secretion

(2013) Nicole Kapitein et al.   MOLECULAR MICROBIOLOGY

Activated ClpP kills persisters and eradicates a chronic biofilm infection

(2013) B. P. Conlon et al.   NATURE

Conformational switching of the 26S proteasome enables substrate degradation

(2013) Mary E Matyskiela et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Critical clamp loader processing by an essential AAA+ protease in Caulobacter crescentus

(2013) R. H. Vass et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct quaternary structures of the AAA+ Lon protease control substrate degradation

(2013) E. F. Vieux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The active ClpP protease fromM. tuberculosisis a complex composed of a heptameric ClpP1 and a ClpP2 ring

(2012) Tatos Akopian et al.   EMBO JOURNAL

RpoS proteolysis is controlled directly by ATP levels in Escherichia coli

(2012) C. N. Peterson et al.   GENES & DEVELOPMENT

Design Principles of a Universal Protein Degradation Machine

(2012) Mary E. Matyskiela et al.   JOURNAL OF MOLECULAR BIOLOGY

ClpP: A structurally dynamic protease regulated by AAA+ proteins

(2012) John A. Alexopoulos et al.   JOURNAL OF STRUCTURAL BIOLOGY

Chaperone networks in protein disaggregation and prion propagation

(2012) Juliane Winkler et al.   JOURNAL OF STRUCTURAL BIOLOGY

Dynamic and static components power unfolding in topologically closed rings of a AAA+ proteolytic machine

(2012) Steven E Glynn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Identification of the Cdc48bullet20S Proteasome as an Ancient AAA+ Proteolytic Machine

(2012) D. Barthelme et al.   SCIENCE

Adaptor-Dependent Degradation of a Cell-Cycle Regulator Uses a Unique Substrate Architecture

(2012) Keith L. Rood et al.   STRUCTURE

Mycobacterium tuberculosis ClpP1 and ClpP2 Function Together in Protein Degradation and Are Required for Viability in vitro and During Infection

(2012) Ravikiran M. Raju et al.   PLoS Pathogens

The Natural Product Cyclomarin Kills Mycobacterium Tuberculosis by Targeting the ClpC1 Subunit of the Caseinolytic Protease

(2011) Esther K. Schmitt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

AAA+ Proteases: ATP-Fueled Machines of Protein Destruction

(2011) Robert T. Sauer et al.   Annual Review of Biochemistry

Mitochondrial AAA proteases — Towards a molecular understanding of membrane-bound proteolytic machines

(2011) Florian Gerdes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

ClpXP, an ATP-powered unfolding and protein-degradation machine

(2011) Tania A. Baker et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Development and characterization of improved β-lactone-based anti-virulence drugs targeting ClpP

(2011) Evelyn Zeiler et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Single-Molecule Protein Unfolding and Translocation by an ATP-Fueled Proteolytic Machine

(2011) Marie-Eve Aubin-Tam et al.   CELL

ATP Binds to Proteasomal ATPases in Pairs with Distinct Functional Effects, Implying an Ordered Reaction Cycle

(2011) David M. Smith et al.   CELL

ClpX(P) Generates Mechanical Force to Unfold and Translocate Its Protein Substrates

(2011) Rodrigo A. Maillard et al.   CELL

Proteolysis in the Escherichia coli heat shock response: a player at many levels

(2011) Anne S Meyer et al.   CURRENT OPINION IN MICROBIOLOGY

Stepwise Unfolding of a β Barrel Protein by the AAA+ ClpXP Protease

(2011) Andrew R. Nager et al.   JOURNAL OF MOLECULAR BIOLOGY

Regulatory Cohesion of Cell Cycle and Cell Differentiation through Interlinked Phosphorylation and Second Messenger Networks

(2011) Sören Abel et al.   MOLECULAR CELL

Subunit Stoichiometry, Evolution, and Functional Implications of an Asymmetric Plant Plastid ClpP/R Protease Complex inArabidopsis

(2011) Paul Dominic B. Olinares et al.   PLANT CELL

Acyldepsipeptide Antibiotics Induce the Formation of a Structured Axial Channel in ClpP: A Model for the ClpX/ClpA-Bound State of ClpP

(2010) Dominic Him Shun Li et al.   CHEMISTRY & BIOLOGY

Control of Substrate Gating and Translocation into ClpP by Channel Residues and ClpX Binding

(2010) Mary E. Lee et al.   JOURNAL OF MOLECULAR BIOLOGY

Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism

(2010) Byung-Gil Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Recognition and Processing of Ubiquitin-Protein Conjugates by the Proteasome

(2009) Daniel Finley   Annual Review of Biochemistry

Structures of Asymmetric ClpX Hexamers Reveal Nucleotide-Dependent Motions in a AAA+ Protein-Unfolding Machine

(2009) Steven E. Glynn et al.   CELL

Polypeptide Translocation by the AAA+ ClpXP Protease Machine

(2009) Sarah R. Barkow et al.   CHEMISTRY & BIOLOGY

Microtubule-severing enzymes

(2009) Antonina Roll-Mecak et al.   CURRENT OPINION IN CELL BIOLOGY

Controlled destruction: AAA+ ATPases in protein degradation from bacteria to eukaryotes

(2009) Frank Striebel et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The antibiotic ADEP reprogrammes ClpP, switching it from a regulated to an uncontrolled protease

(2009) Janine Kirstein et al.   EMBO Molecular Medicine

ATP-dependent Proteases Differ Substantially in Their Ability to Unfold Globular Proteins

(2009) Prakash Koodathingal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Both ATPase Domains of ClpA Are Critical for Processing of Stable Protein Structures

(2009) Wolfgang Kress et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Co-evolution of multipartite interactions between an extended tmRNA tag and a robust Lon protease inMycoplasma

(2009) Zhiyun Ge et al.   MOLECULAR MICROBIOLOGY

Targeting proteins for degradation

(2009) Erin K Schrader et al.   Nature Chemical Biology

Degrons in protein substrates program the speed and operating efficiency of the AAA+ Lon proteolytic machine

(2009) E. Gur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteases in bacterial pathogenesis

(2009) Hanne Ingmer et al.   RESEARCH IN MICROBIOLOGY

ClpP Hydrolyzes a Protein Substrate Processively in the Absence of the ClpA ATPase: Mechanistic Studies of ATP-Independent Proteolysis†

(2008) Laura D. Jennings et al.   BIOCHEMISTRY

Diverse Pore Loops of the AAA+ ClpX Machine Mediate Unassisted and Adaptor-Dependent Recognition of ssrA-Tagged Substrates

(2008) Andreas Martin et al.   MOLECULAR CELL

Multiple pathways for regulation of σS (RpoS) stability in Escherichia coli via the action of multiple anti-adaptors

(2008) Alexandre Bougdour et al.   MOLECULAR MICROBIOLOGY

Pore loops of the AAA+ ClpX machine grip substrates to drive translocation and unfolding

(2008) Andreas Martin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Protein unfolding by a AAA+ protease is dependent on ATP-hydrolysis rates and substrate energy landscapes

(2008) Andreas Martin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Evolution of the ssrA degradation tag in Mycoplasma: Specificity switch to a different protease

(2008) E. Gur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA