标题
A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease
作者
关键词
-
出版物
Nature Chemical Biology
Volume 11, Issue 12, Pages 973-980
出版商
Springer Nature
发表日期
2015-10-26
DOI
10.1038/nchembio.1952
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Linifanib Versus Sorafenib in Patients With Advanced Hepatocellular Carcinoma: Results of a Randomized Phase III Trial
- (2015) Calin Cainap et al. JOURNAL OF CLINICAL ONCOLOGY
- Discovery of Potent, Orally Bioavailable, Small-Molecule Inhibitors of WNT Signaling from a Cell-Based Pathway Screen
- (2015) Aurélie Mallinger et al. JOURNAL OF MEDICINAL CHEMISTRY
- Comparative efficacy of tyrosine kinase inhibitor treatments in the third-line setting, for chronic-phase chronic myelogenous leukemia after failure of second-generation tyrosine kinase inhibitors
- (2015) J.H. Lipton et al. LEUKEMIA RESEARCH
- The Mediator complex: a central integrator of transcription
- (2015) Benjamin L. Allen et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The roles of Mediator complex in cardiovascular diseases
- (2014) Concetta Schiano et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- Chemical biology approaches to target validation in cancer
- (2014) Julian Blagg et al. CURRENT OPINION IN PHARMACOLOGY
- Can we safely target the WNT pathway?
- (2014) Michael Kahn NATURE REVIEWS DRUG DISCOVERY
- The two faces of Cdk8, a positive/negative regulator of transcription
- (2013) Josipa Nemet et al. BIOCHIMIE
- HIF1A Employs CDK8-Mediator to Stimulate RNAPII Elongation in Response to Hypoxia
- (2013) Matthew D. Galbraith et al. CELL
- CDK8 Kinase Phosphorylates Transcription Factor STAT1 to Selectively Regulate the Interferon Response
- (2013) Joanna Bancerek et al. IMMUNITY
- The why and how of phenotypic small-molecule screens
- (2013) Ulrike S Eggert Nature Chemical Biology
- Structure-kinetic relationship study of CDK8/CycC specific compounds
- (2013) E. V. Schneider et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974
- (2013) J. Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay
- (2013) D. M. Molina et al. SCIENCE
- The multitalented Mediator complex
- (2013) Jonas O.P. Carlsten et al. TRENDS IN BIOCHEMICAL SCIENCES
- CDK8 Maintains Tumor Dedifferentiation and Embryonic Stem Cell Pluripotency
- (2012) A. S. Adler et al. CANCER RESEARCH
- Mammary Tumor Regression Elicited by Wnt Signaling Inhibitor Requires IGFBP5
- (2012) B. Y. Liu et al. CANCER RESEARCH
- Ponatinib (AP24534), a Multitargeted Pan-FGFR Inhibitor with Activity in Multiple FGFR-Amplified or Mutated Cancer Models
- (2012) J. M. Gozgit et al. MOLECULAR CANCER THERAPEUTICS
- In vivo and in vitro models for the therapeutic targeting of Wnt signaling using a Tet-OΔN89β-catenin system
- (2012) T Jardé et al. ONCOGENE
- Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities
- (2012) D. C. Porter et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Chemoproteomic approaches to drug target identification and drug profiling
- (2011) Marcus Bantscheff et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Function and regulation of the Mediator complex
- (2011) Ronald C Conaway et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- The Structure of CDK8/CycC Implicates Specificity in the CDK/Cyclin Family and Reveals Interaction with a Deep Pocket Binder
- (2011) E.V. Schneider et al. JOURNAL OF MOLECULAR BIOLOGY
- How were new medicines discovered?
- (2011) David C. Swinney et al. NATURE REVIEWS DRUG DISCOVERY
- Integrated genome-wide analysis of transcription factor occupancy, RNA polymerase II binding and steady-state RNA levels identify differentially regulated functional gene classes
- (2011) Michal Mokry et al. NUCLEIC ACIDS RESEARCH
- Guidelines for the welfare and use of animals in cancer research
- (2010) P Workman et al. BRITISH JOURNAL OF CANCER
- Probing the Probes: Fitness Factors For Small Molecule Tools
- (2010) Paul Workman et al. CHEMISTRY & BIOLOGY
- Non-ATP Competitive Protein Kinase Inhibitors
- (2010) L. Garuti et al. CURRENT MEDICINAL CHEMISTRY
- The Embryonic Transcription Cofactor LBH Is a Direct Target of the Wnt Signaling Pathway in Epithelial Development and in Aggressive Basal Subtype Breast Cancers
- (2010) M. E. Rieger et al. MOLECULAR AND CELLULAR BIOLOGY
- The histone variant macroH2A suppresses melanoma progression through regulation of CDK8
- (2010) Avnish Kapoor et al. NATURE
- The art of the chemical probe
- (2010) Stephen V Frye Nature Chemical Biology
- CDK8 is a positive regulator of transcriptional elongation within the serum response network
- (2010) Aaron J Donner et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Cortistatin A is a High-Affinity Ligand of Protein Kinases ROCK, CDK8, and CDK11
- (2009) Victor J. Cee et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Kinase selectivity potential for inhibitors targeting the ATP binding site: a network analysis
- (2009) Danzhi Huang et al. BIOINFORMATICS
- Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways
- (2009) Claudio Alarcón et al. CELL
- Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
- (2009) Shih-Min A. Huang et al. NATURE
- Proteomics strategy for quantitative protein interaction profiling in cell extracts
- (2009) Kirti Sharma et al. NATURE METHODS
- Proximal events in Wnt signal transduction
- (2009) Stephane Angers et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Identifying the proteins to which small-molecule probes and drugs bind in cells
- (2009) S.-E. Ong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- E2F1 represses β-catenin transcription and is antagonized by both pRB and CDK8
- (2008) Erick J. Morris et al. NATURE
- CDK8 is a colorectal cancer oncogene that regulates β-catenin activity
- (2008) Ron Firestein et al. NATURE
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search