Cortistatin A is a High-Affinity Ligand of Protein Kinases ROCK, CDK8, and CDK11

Inhibition of Rho-dependent kinases ROCK I/II activates VEGF-driven retinal neovascularization and sprouting angiogenesis

(2009) Jens Kroll et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Stereodivergent Synthesis of 17-α and 17-β-Aryl Steroids: Application and Biological Evaluation of D-Ring Cortistatin Analogues

(2009) Jun Shi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An Oxidative Dearomatization Cyclization Model for Cortistatin A

(2009) Samuel J. Danishefsky et al.   HETEROCYCLES

Discovery of 6-Aryl-7-alkoxyisoquinoline Inhibitors of IκB Kinase-β (IKK-β)

(2009) John A. Christopher et al.   JOURNAL OF MEDICINAL CHEMISTRY

Total Synthesis and Biological Evaluation of Cortistatins A and J and Analogues Thereof

(2009) K. C. Nicolaou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Discovery of Potent and Practical Antiangiogenic Agents Inspired by Cortistatin A

(2009) Barbara Czakó et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Intramolecular Cyclopropene-Furan [2 + 4] Cycloaddition followed by a Cyclopropylcarbinyl Rearrangement to Synthesize the BCD Rings of Cortistatin A

(2009) Philip Magnus et al.   ORGANIC LETTERS

Efficient and stereoselective installation of isoquinoline: formal total synthesis of cortistatin A

(2009) Shuji Yamashita et al.   TETRAHEDRON LETTERS

Total Synthesis of (+)-Cortistatin A

(2008) K. C. Nicolaou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rapid Construction of the Cortistatin Pentacyclic Core

(2008) Eric M. Simmons et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highlights in Steroid Chemistry: Total Synthesis versus Semisynthesis

(2008) Carl F. Nising et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis and Anti-Angiogenic Activity of Cortistatin Analogs

(2008) Yuuki SATO et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

A model study for the concise construction of the oxapentacyclic core of cortistatins through intramolecular Diels–Alder and oxidative dearomatization–cyclization reactions

(2008) Lianzhu Liu et al.   CHEMICAL COMMUNICATIONS

Applications for ROCK kinase inhibition

(2008) Michael F Olson   CURRENT OPINION IN CELL BIOLOGY

Antiangiogenic properties of fasudil, a potent Rho-Kinase inhibitor

(2008) Yasuaki Hata et al.   JAPANESE JOURNAL OF OPHTHALMOLOGY

Discovery of Substituted 4-(Pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as Potent and Highly Selective Rho Kinase (ROCK-II) Inhibitors

(2008) Yangbo Feng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of (+)-Cortistatin A

(2008) Ryan A. Shenvi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Synthesis of (+)-Cortistatin A, a Potent and Selective Inhibitor of Endothelial Cell Proliferation

(2008) Hong Myung Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

CDK8 is a colorectal cancer oncogene that regulates β-catenin activity

(2008) Ron Firestein et al.   NATURE

A quantitative analysis of kinase inhibitor selectivity

(2008) Mazen W Karaman et al.   NATURE BIOTECHNOLOGY

A Short, Scalable Synthesis of the Carbocyclic Core of the Anti-Angiogenic Cortistatins from (+)-Estrone by B-Ring Expansion

(2008) László Kürti et al.   ORGANIC LETTERS

A Concise Synthesis of the Pentacyclic Framework of Cortistatins

(2008) Shuji Yamashita et al.   ORGANIC LETTERS

The first transannular [4+3] cycloaddition reaction: synthesis of the ABCD ring structure of cortistatins

(2008) Derek T. Craft et al.   TETRAHEDRON LETTERS

Synthesis of CD-ring structure of cortistatin A, an anti-angiogenic steroidal alkaloid from marine sponge

(2008) Naoyuki Kotoku et al.   TETRAHEDRON LETTERS

A concise synthesis of the cortistatin core

(2008) Mingji Dai et al.   TETRAHEDRON LETTERS

A novel α,β-unsaturated nitrone-aryne [3+2] cycloaddition and its application in the synthesis of the cortistatin core

(2008) Mingji Dai et al.   TETRAHEDRON LETTERS