Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive review
出版年份 2015 全文链接
标题
Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive review
作者
关键词
Macrodomain, DLBCL, ARTD, PARP, DTX3L, NF-κB, STAT1, STAT3, Chemoresistance, ADP-ribosylation, Antibody drug conjugate, ABC-DLBCL, GCB-DLBCL, BCR, CAR-T cells
出版物
Molecular Cancer
Volume 14, Issue 1, Pages -
出版商
Springer Nature
发表日期
2015-12-12
DOI
10.1186/s12943-015-0474-2
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Randomized phase II study of R-CHOP plus enzastaurin versus R-CHOP in the first-line treatment of patients with intermediate- and high-risk diffuse large B-cell lymphoma (DLBCL): Preliminary analysis.
- (2017) J. D. Hainsworth et al. JOURNAL OF CLINICAL ONCOLOGY
- Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4
- (2015) Michael Zengerle et al. ACS Chemical Biology
- A comprehensive review of lenalidomide therapy for B-cell non-Hodgkin lymphoma
- (2015) T. E. Witzig et al. ANNALS OF ONCOLOGY
- Mechanistic overview of ADP-ribosylation reactions
- (2015) Vicky M.-H. Sung BIOCHIMIE
- Evolution: IMiDs to PPMs, revolution in DLBCL?
- (2015) G. S. Nowakowski BLOOD
- CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL
- (2015) P. R. Hagner et al. BLOOD
- Brentuximab vedotin demonstrates objective responses in a phase 2 study of relapsed/refractory DLBCL with variable CD30 expression
- (2015) E. D. Jacobsen et al. BLOOD
- Expression of programmed cell death ligand 1 is associated with poor overall survival in patients with diffuse large B-cell lymphoma
- (2015) J. Kiyasu et al. BLOOD
- Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4
- (2015) Jing Lu et al. CHEMISTRY & BIOLOGY
- The BET Bromodomain Inhibitor OTX015 Affects Pathogenetic Pathways in Preclinical B-cell Tumor Models and Synergizes with Targeted Drugs
- (2015) M. Boi et al. CLINICAL CANCER RESEARCH
- Digging deep into “dirty” drugs – modulation of the methylation machinery
- (2015) Lisa Pleyer et al. DRUG METABOLISM REVIEWS
- Towards small molecule inhibitors of mono-ADP-ribosyltransferases
- (2015) Torun Ekblad et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Diffuse Large B-Cell Lymphoma Classification System That Associates Normal B-Cell Subset Phenotypes With Prognosis
- (2015) Karen Dybkær et al. JOURNAL OF CLINICAL ONCOLOGY
- Lenalidomide Combined With R-CHOP Overcomes Negative Prognostic Impact of Non–Germinal Center B-Cell Phenotype in Newly Diagnosed Diffuse Large B-Cell Lymphoma: A Phase II Study
- (2015) Grzegorz S. Nowakowski et al. JOURNAL OF CLINICAL ONCOLOGY
- Chemotherapy-Refractory Diffuse Large B-Cell Lymphoma and Indolent B-Cell Malignancies Can Be Effectively Treated With Autologous T Cells Expressing an Anti-CD19 Chimeric Antigen Receptor
- (2015) James N. Kochenderfer et al. JOURNAL OF CLINICAL ONCOLOGY
- T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial
- (2015) Daniel W Lee et al. LANCET
- Safety and activity of the anti-CD79B antibody–drug conjugate polatuzumab vedotin in relapsed or refractory B-cell non-Hodgkin lymphoma and chronic lymphocytic leukaemia: a phase 1 study
- (2015) Maria Corinna A Palanca-Wessels et al. LANCET ONCOLOGY
- Anti-CD22 and anti-CD79B antibody drug conjugates are active in different molecular diffuse large B-cell lymphoma subtypes
- (2015) M Pfeifer et al. LEUKEMIA
- IL10 receptor is a novel therapeutic target in DLBCLs
- (2015) W Béguelin et al. LEUKEMIA
- Synergistic induction of apoptosis in high-risk DLBCL by BCL2 inhibition with ABT-199 combined with pharmacologic loss of MCL1
- (2015) L Li et al. LEUKEMIA
- Structural genomic alterations in primary mediastinal large B-cell lymphoma
- (2015) David D. W. Twa et al. LEUKEMIA & LYMPHOMA
- Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B-cell lymphoma
- (2015) Morihiro Higashi et al. LEUKEMIA & LYMPHOMA
- A phase 2 study of inotuzumab ozogamicin and rituximab, followed by autologous stem cell transplant in patients with relapsed/refractory diffuse large B-cell lymphoma
- (2015) Nina D. Wagner-Johnston et al. LEUKEMIA & LYMPHOMA
- Ibrutinib: from bench side to clinical implications
- (2015) Davide Grisafi et al. MEDICAL ONCOLOGY
- ARTD1 suppresses interleukin 6 expression by repressing MLL1-dependent histone H3 trimethylation
- (2015) Roberta Minotti et al. MOLECULAR AND CELLULAR BIOLOGY
- CC-223, a Potent and Selective Inhibitor of mTOR Kinase: In Vitro and In Vivo Characterization
- (2015) D. S. Mortensen et al. MOLECULAR CANCER THERAPEUTICS
- Preclinical and clinical development of inotuzumab-ozogamicin in hematological malignancies
- (2015) Boris Shor et al. MOLECULAR IMMUNOLOGY
- TET1 is a tumor suppressor of hematopoietic malignancy
- (2015) Luisa Cimmino et al. NATURE IMMUNOLOGY
- Targeting B cell receptor signaling with ibrutinib in diffuse large B cell lymphoma
- (2015) Wyndham H Wilson et al. NATURE MEDICINE
- A novel role for the mono-ADP-ribosyltransferase PARP14/ARTD8 in promoting homologous recombination and protecting against replication stress
- (2015) Claudia M. Nicolae et al. NUCLEIC ACIDS RESEARCH
- The tumor microenvironment shapes hallmarks of mature B-cell malignancies
- (2015) K H Shain et al. ONCOGENE
- Phthalimide conjugation as a strategy for in vivo target protein degradation
- (2015) G. E. Winter et al. SCIENCE
- FOXP1 potentiates Wnt/β-catenin signaling in diffuse large B cell lymphoma
- (2015) Matthew P. Walker et al. Science Signaling
- Treatment Approach to Newly Diagnosed Diffuse Large B-Cell Lymphoma
- (2015) Emmanuel Bachy et al. SEMINARS IN HEMATOLOGY
- MYC Alterations in Diffuse Large B-Cell Lymphomas
- (2015) Kennosuke Karube et al. SEMINARS IN HEMATOLOGY
- Cracking the Diverse Biologic Code of Diffuse Large B-Cell Lymphoma
- (2015) Mark Roschewski et al. SEMINARS IN HEMATOLOGY
- The Genetic Landscape of Diffuse Large B-Cell Lymphoma
- (2015) Laura Pasqualucci et al. SEMINARS IN HEMATOLOGY
- B-Cell Receptor Signaling in Diffuse Large B-Cell lymphoma
- (2015) Ryan M. Young et al. SEMINARS IN HEMATOLOGY
- Novel Targeted Therapies in Diffuse Large B-Cell Lymphoma
- (2015) Neha Mehta-Shah et al. SEMINARS IN HEMATOLOGY
- Emerging Biological Insights and Novel Treatment Strategies in Primary Mediastinal Large B-Cell Lymphoma
- (2015) Kieron Dunleavy et al. SEMINARS IN HEMATOLOGY
- Epigenomic evolution in diffuse large B-cell lymphomas
- (2015) Heng Pan et al. Nature Communications
- HDAC1,2 inhibition impairs EZH2- and BBAP- mediated DNA repair to overcome chemoresistance in EZH2 gain-of-function mutant diffuse large B-cell lymphoma
- (2015) Danielle P. Johnson et al. Oncotarget
- Deltex-3-like (DTX3L) stimulates metastasis of melanoma through FAK/PI3K/AKT but not MEK/ERK pathway
- (2015) Nguyen Dinh Thang et al. Oncotarget
- An Oncogenic Role for Alternative NF-κB Signaling in DLBCL Revealed upon Deregulated BCL6 Expression
- (2015) Baochun Zhang et al. Cell Reports
- FOXP1 potentiates Wnt/β-catenin signaling in diffuse large B cell lymphoma
- (2015) Matthew P. Walker et al. Science Signaling
- CDK9 inhibition by dinaciclib potently suppresses Mcl-1 to induce durable apoptotic responses in aggressive MYC-driven B-cell lymphoma in vivo
- (2015) G P Gregory et al. LEUKEMIA
- Recurrent targets of aberrant somatic hypermutation in lymphoma
- (2015) Alireza Hadj Khodabakhshi et al. Oncotarget
- Linked-In: Design and Efficacy of Antibody Drug Conjugates in Oncology
- (2015) Jonathan Feld et al. Oncotarget
- A potential therapeutic strategy for chronic lymphocytic leukemia by combining Idelalisib and GS-9973, a novel spleen tyrosine kinase (Syk) inhibitor
- (2015) Russell T Burke et al. Oncotarget
- Screening for E3-Ubiquitin ligase inhibitors: challenges and opportunities
- (2015) Vivien Landré et al. Oncotarget
- Synergistic induction of apoptosis by combination of BTK and dual mTORC1/2 inhibitors in diffuse large B cell lymphoma
- (2015) Scott A. Ezell et al. Oncotarget
- Novel inhibitors are cytotoxic for myeloma cells with NFkB inducing kinase-dependent activation of NFkB
- (2015) Yulia N. Demchenko et al. Oncotarget
- Linking off-target kinase pharmacology to the differential cellular effects observed among PARP inhibitors
- (2015) Albert A. Antolín et al. Oncotarget
- Constitutive activation of the DNA damage response pathway as a novel therapeutic target in diffuse large B-cell lymphoma
- (2015) Enrico Derenzini et al. Oncotarget
- Expression of Programmed Cell Death 1 Ligand 2 (PD-L2) Is a Distinguishing Feature of Primary Mediastinal (Thymic) Large B-cell Lymphoma and Associated With PDCD1LG2 Copy Gain
- (2014) Min Shi et al. AMERICAN JOURNAL OF SURGICAL PATHOLOGY
- PARP inhibitors for anticancer therapy
- (2014) Nicola Curtin BIOCHEMICAL SOCIETY TRANSACTIONS
- Inhibiting CARD11 translation during BCR activation by targeting the eIF4A RNA helicase
- (2014) J. J. Steinhardt et al. BLOOD
- Primary mediastinal B-cell lymphoma and mediastinal gray zone lymphoma: do they require a unique therapeutic approach?
- (2014) Kieron Dunleavy et al. BLOOD
- Genetic inactivation of TRAF3 in canine and human B-cell lymphoma
- (2014) K. R. Bushell et al. BLOOD
- FOXP1 directly represses transcription of proapoptotic genes and cooperates with NF- B to promote survival of human B cells
- (2014) M. van Keimpema et al. BLOOD
- An RCOR1 loss-associated gene expression signature identifies a prognostically significant DLBCL subgroup
- (2014) F. C. Chan et al. BLOOD
- Genomic rearrangements involving programmed death ligands are recurrent in primary mediastinal large B-cell lymphoma
- (2014) David D. W. Twa et al. BLOOD
- A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis
- (2014) T. Berg et al. BLOOD
- Exome sequencing reveals novel mutation targets in diffuse large B-cell lymphomas derived from Chinese patients
- (2014) N. F. C. C. de Miranda et al. BLOOD
- Addition of lenalidomide to rituximab, ifosfamide, carboplatin, etoposide (RICER) in first-relapse/primary refractory diffuse large B-cell lymphoma
- (2014) Tatyana Feldman et al. BRITISH JOURNAL OF HAEMATOLOGY
- CD30 expression inde novodiffuse large B-cell lymphoma: a population-based study from British Columbia
- (2014) Graham W. Slack et al. BRITISH JOURNAL OF HAEMATOLOGY
- MYC and BCL2 protein expression predicts survival in patients with diffuse large B-cell lymphoma treated with rituximab
- (2014) Anamarija M. Perry et al. BRITISH JOURNAL OF HAEMATOLOGY
- Protein and Nucleotide Biosynthesis Are Coupled by a Single Rate-Limiting Enzyme, PRPS2, to Drive Cancer
- (2014) John T. Cunningham et al. CELL
- NF-κB pathways in hematological malignancies
- (2014) Chiara Gasparini et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- EZH2 Inhibitor Efficacy in Non-Hodgkin’s Lymphoma Does Not Require Suppression of H3K27 Monomethylation
- (2014) William D. Bradley et al. CHEMISTRY & BIOLOGY
- Selective JAK2 Inhibition Specifically Decreases Hodgkin Lymphoma and Mediastinal Large B-cell Lymphoma Growth In Vitro and In Vivo
- (2014) Y. Hao et al. CLINICAL CANCER RESEARCH
- PI3K/mTOR Inhibition Markedly Potentiates HDAC Inhibitor Activity in NHL Cells through BIM- and MCL-1-Dependent Mechanisms In Vitro and In Vivo
- (2014) M. Rahmani et al. CLINICAL CANCER RESEARCH
- Inhibition of Bromodomain Proteins for the Treatment of Human Diffuse Large B-cell Lymphoma
- (2014) S. E. Trabucco et al. CLINICAL CANCER RESEARCH
- Effective response and delayed toxicities of refractory advanced diffuse large B-cell lymphoma treated by CD20-directed chimeric antigen receptor-modified T cells
- (2014) Yao Wang et al. CLINICAL IMMUNOLOGY
- 5LBA Results of a first-in-man phase I trial assessing OTX015, an orally available BET-bromodomain (BRD) inhibitor, in advanced hematologic malignancies
- (2014) A. Stathis et al. EUROPEAN JOURNAL OF CANCER
- Antibody-based therapies in B-cell lineage acute lymphoblastic leukaemia
- (2014) Caroline Le Jeune et al. EUROPEAN JOURNAL OF HAEMATOLOGY
- Human B-cell cancer cell lines as a preclinical model for studies of drug effect in diffuse large B-cell lymphoma and multiple myeloma
- (2014) Maria Bach Laursen et al. EXPERIMENTAL HEMATOLOGY
- Pidilizumab in the treatment of diffuse large B-cell lymphoma
- (2014) Locke J Bryan et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- Janus kinase inhibitors for the treatment of myeloproliferative neoplasms
- (2014) Allison Rosenthal et al. EXPERT OPINION ON PHARMACOTHERAPY
- Ibrutinib: a first in class covalent inhibitor of Bruton's tyrosine kinase
- (2014) Matthew S Davids et al. Future Oncology
- Going viral: chimeric antigen receptor T-cell therapy for hematological malignancies
- (2014) Saar Gill et al. IMMUNOLOGICAL REVIEWS
- Host STAT2/type I interferon axis controls tumor growth
- (2014) Chanyu Yue et al. INTERNATIONAL JOURNAL OF CANCER
- New and emerging HDAC inhibitors for cancer treatment
- (2014) Alison C. West et al. JOURNAL OF CLINICAL INVESTIGATION
- Randomized Comparison of Gemcitabine, Dexamethasone, and Cisplatin Versus Dexamethasone, Cytarabine, and Cisplatin Chemotherapy Before Autologous Stem-Cell Transplantation for Relapsed and Refractory Aggressive Lymphomas: NCIC-CTG LY.12
- (2014) Michael Crump et al. JOURNAL OF CLINICAL ONCOLOGY
- Combination of ibrutinib with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) for treatment-naive patients with CD20-positive B-cell non-Hodgkin lymphoma: a non-randomised, phase 1b study
- (2014) Anas Younes et al. LANCET ONCOLOGY
- Lenalidomide plus R-CHOP21 in elderly patients with untreated diffuse large B-cell lymphoma: results of the REAL07 open-label, multicentre, phase 2 trial
- (2014) Umberto Vitolo et al. LANCET ONCOLOGY
- Both leukaemic and normal peripheral B lymphoid cells are highly sensitive to the selective pharmacological inhibition of prosurvival Bcl-2 with ABT-199
- (2014) S L Khaw et al. LEUKEMIA
- MicroRNAs in B-cell lymphomas: how a complex biology gets more complex
- (2014) K Musilova et al. LEUKEMIA
- High level of soluble programmed cell death ligand 1 in blood impacts overall survival in aggressive diffuse large B-Cell lymphoma: results from a French multicenter clinical trial
- (2014) D Rossille et al. LEUKEMIA
- Relapsed/refractory diffuse large B-cell lymphoma: review of the management of transplant-eligible patients
- (2014) Joshua Lukenbill et al. LEUKEMIA & LYMPHOMA
- TP53mutations are frequent events in double-hit B-cell lymphomas withMYCandBCL2but notMYCandBCL6translocations
- (2014) Niklas Gebauer et al. LEUKEMIA & LYMPHOMA
- Differential Properties of Transcriptional Complexes Formed by the CoREST Family
- (2014) A. P. Barrios et al. MOLECULAR AND CELLULAR BIOLOGY
- STAT1 Is Not Dominant Negative and Is Capable of Contributing to Gamma Interferon-Dependent Innate Immunity
- (2014) C. Semper et al. MOLECULAR AND CELLULAR BIOLOGY
- DTX3L and ARTD9 inhibit IRF1 expression and mediate in cooperation with ARTD8 survival and proliferation of metastatic prostate cancer cells
- (2014) Samia B Bachmann et al. Molecular Cancer
- Abstract C244: Development of the BET bromodomain inhibitor OTX015.
- (2014) J. K. Noel et al. MOLECULAR CANCER THERAPEUTICS
- Selective Inhibition of EZH2 by EPZ-6438 Leads to Potent Antitumor Activity in EZH2-Mutant Non-Hodgkin Lymphoma
- (2014) S. K. Knutson et al. MOLECULAR CANCER THERAPEUTICS
- In Vitro and In Vivo Interactions between the HDAC6 Inhibitor Ricolinostat (ACY1215) and the Irreversible Proteasome Inhibitor Carfilzomib in Non-Hodgkin Lymphoma Cells
- (2014) G. Dasmahapatra et al. MOLECULAR CANCER THERAPEUTICS
- Highly Active Combination of BRD4 Antagonist and Histone Deacetylase Inhibitor against Human Acute Myelogenous Leukemia Cells
- (2014) W. Fiskus et al. MOLECULAR CANCER THERAPEUTICS
- A novel mechanism of skin tumor promotion involving interferon-gamma (IFNγ)/signal transducer and activator of transcription-1 (Stat1) signaling
- (2014) Ronald Bozeman et al. MOLECULAR CARCINOGENESIS
- Loss of signalling via Gα13 in germinal centre B-cell-derived lymphoma
- (2014) Jagan R. Muppidi et al. NATURE
- Precision therapy for lymphoma—current state and future directions
- (2014) Andrew M. Intlekofer et al. Nature Reviews Clinical Oncology
- Structure of the human Cereblon–DDB1–lenalidomide complex reveals basis for responsiveness to thalidomide analogs
- (2014) Philip P Chamberlain et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Resistance Mechanisms for the Bruton's Tyrosine Kinase Inhibitor Ibrutinib
- (2014) Jennifer A. Woyach et al. NEW ENGLAND JOURNAL OF MEDICINE
- Circumvention of Mcl-1-Dependent Drug Resistance by Simultaneous Chk1 and MEK1/2 Inhibition in Human Multiple Myeloma Cells
- (2014) Xin-Yan Pei et al. PLoS One
- Resistance to mTOR Kinase Inhibitors in Lymphoma Cells Lacking 4EBP1
- (2014) Sharmila Mallya et al. PLoS One
- Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas
- (2014) Sarah K. Knutson et al. PLoS One
- High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell–like diffuse large B-cell lymphoma cells
- (2014) Lesley A. Mathews Griner et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Blockade of oncogenic I B kinase activity in diffuse large B-cell lymphoma by bromodomain and extraterminal domain protein inhibitors
- (2014) M. Ceribelli et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Postulated Mechanisms of Resistance of B-Cell Non-Hodgkin Lymphoma to Rituximab Treatment Regimens: Strategies to Overcome Resistance
- (2014) Benjamin Bonavida SEMINARS IN ONCOLOGY
- ALDH1A1 mediates resistance of diffuse large B cell lymphoma to the CHOP regimen
- (2014) Ying-hui Song et al. TUMOR BIOLOGY
- Double-hit lymphomas: current paradigms and novel treatment approaches
- (2014) K. Dunleavy Hematology-American Society of Hematology Education Program
- Double-hit B-cell Lymphomas With BCL6 and MYC Translocations Are Aggressive, Frequently Extranodal Lymphomas Distinct From BCL2 Double-hit B-cell Lymphomas
- (2013) Raju K. Pillai et al. AMERICAN JOURNAL OF SURGICAL PATHOLOGY
- Accelerated therapeutic progress in diffuse large B cell lymphoma
- (2013) Qingqing Cai et al. ANNALS OF HEMATOLOGY
- Combined inhibition of PI3K-related DNA damage response kinases and mTORC1 induces apoptosis in MYC-driven B-cell lymphomas
- (2013) J. Shortt et al. BLOOD
- The Myc-miR-17-92 axis amplifies B-cell receptor signaling via inhibition of ITIM proteins: a novel lymphomagenic feed-forward loop
- (2013) J. N. Psathas et al. BLOOD
- ABT-199, a new Bcl-2-specific BH3 mimetic, has in vivo efficacy against aggressive Myc-driven mouse lymphomas without provoking thrombocytopenia
- (2013) C. J. Vandenberg et al. BLOOD
- Sirtuin and pan-class I/II deacetylase (DAC) inhibition is synergistic in preclinical models and clinical studies of lymphoma
- (2013) J. E. Amengual et al. BLOOD
- MYC status in concert with BCL2 and BCL6 expression predicts outcome in diffuse large B-cell lymphoma
- (2013) H. Horn et al. BLOOD
- MicroRNA-155 controls RB phosphorylation in normal and malignant B lymphocytes via the noncanonical TGF- 1/SMAD5 signaling module
- (2013) D. Jiang et al. BLOOD
- I B- controls the constitutive NF- B target gene network and survival of ABC DLBCL
- (2013) H. Nogai et al. BLOOD
- CD30 expression defines a novel subgroup of diffuse large B-cell lymphoma with favorable prognosis and distinct gene expression signature: a report from the International DLBCL Rituximab-CHOP Consortium Program Study
- (2013) S. Hu et al. BLOOD
- Potent antimyeloma activity of the novel bromodomain inhibitors I-BET151 and I-BET762
- (2013) A. Chaidos et al. BLOOD
- Mutational and structural analysis of diffuse large B-cell lymphoma using whole-genome sequencing
- (2013) R. D. Morin et al. BLOOD
- Donor-derived CD19-targeted T cells cause regression of malignancy persisting after allogeneic hematopoietic stem cell transplantation
- (2013) J. N. Kochenderfer et al. BLOOD
- A phase I/II trial to evaluate the safety, feasibility and activity of salvage therapy consisting of the mTOR inhibitor Temsirolimus added to standard therapy of Rituximab and DHAP for the treatment of patients with relapsed or refractory diffuse large cell B-Cell lymphoma – the STORM trial
- (2013) Mathias Witzens-Harig et al. BMC CANCER
- Acquired resistance to temsirolimus in human renal cell carcinoma cells is mediated by the constitutive activation of signal transduction pathways through mTORC2
- (2013) K Harada et al. BRITISH JOURNAL OF CANCER
- Single-agent lenalidomide is active in patients with relapsed or refractory aggressive non-Hodgkin lymphoma who received prior stem cell transplantation
- (2013) Julie M. Vose et al. BRITISH JOURNAL OF HAEMATOLOGY
- ABT-199 selectively inhibits BCL2 but not BCL2L1 and efficiently induces apoptosis of chronic lymphocytic leukaemic cells but not platelets
- (2013) Meike Vogler et al. BRITISH JOURNAL OF HAEMATOLOGY
- The Bruton tyrosine kinase (BTK) inhibitor PCI-32765 synergistically increases proteasome inhibitor activity in diffuse large-B cell lymphoma (DLBCL) and mantle cell lymphoma (MCL) cells sensitive or resistant to bortezomib
- (2013) Girija Dasmahapatra et al. BRITISH JOURNAL OF HAEMATOLOGY
- EZH2 Is Required for Germinal Center Formation and Somatic EZH2 Mutations Promote Lymphoid Transformation
- (2013) Wendy Béguelin et al. CANCER CELL
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- (2013) Linfeng Chen et al. CANCER CELL
- Discovery and Characterization of Super-Enhancer-Associated Dependencies in Diffuse Large B Cell Lymphoma
- (2013) Bjoern Chapuy et al. CANCER CELL
- A Novel Inhibitor of STAT3 Homodimerization Selectively Suppresses STAT3 Activity and Malignant Transformation
- (2013) X. Zhang et al. CANCER RESEARCH
- PFI-1, a Highly Selective Protein Interaction Inhibitor, Targeting BET Bromodomains
- (2013) S. Picaud et al. CANCER RESEARCH
- Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers
- (2013) Jakob Lovén et al. CELL
- PI3K/AKT addiction in subsets of diffuse large B-cell lymphoma
- (2013) Matthias Pfeifer et al. CELL CYCLE
- Molecular Pathways: Targeting MALT1 Paracaspase Activity in Lymphoma
- (2013) L. Fontan et al. CLINICAL CANCER RESEARCH
- PAK1 Mediates Resistance to PI3K Inhibition in Lymphomas
- (2013) K. Walsh et al. CLINICAL CANCER RESEARCH
- A Dose-Escalation Study of SAR3419, an Anti-CD19 Antibody Maytansinoid Conjugate, Administered by Intravenous Infusion Once Weekly in Patients with Relapsed/Refractory B-cell Non-Hodgkin Lymphoma
- (2013) V. Ribrag et al. CLINICAL CANCER RESEARCH
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- (2013) B. J. Chen et al. CLINICAL CANCER RESEARCH
- Diffuse large B-cell lymphoma
- (2013) Maurizio Martelli et al. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
- Identification of a novel BET bromodomain inhibitor-sensitive, gene regulatory circuit that controls Rituximab response and tumour growth in aggressive lymphoid cancers
- (2013) Anouk Emadali et al. EMBO Molecular Medicine
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- (2013) Holger H H Erb et al. ENDOCRINE-RELATED CANCER
- In silico simulations of STAT1 and STAT3 inhibitors predict SH2 domain cross-binding specificity
- (2013) Malgorzata Szelag et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Targeting the JAK-STAT pathway in lymphoma: a focus on pacritinib
- (2013) Enrico Derenzini et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- AKT signalling is required for ribosomal RNA synthesis and progression of Eμ-MycB-cell lymphomain vivo
- (2013) Jennifer R. Devlin et al. FEBS Journal
- Lenalidomide plus cyclophosphamide, doxorubicin, vincristine, prednisone and rituximab is safe and effective in untreated, elderly patients with diffuse large B-cell lymphoma: a phase I study by the Fondazione Italiana Linfomi
- (2013) A. Chiappella et al. HAEMATOLOGICA
- Reprogramming cell death: BCL2 family inhibition in hematological malignancies
- (2013) Lydia Scarfò et al. IMMUNOLOGY LETTERS
- BAL1/ARTD9 represses the anti-proliferative and pro-apoptotic IFN -STAT1-IRF1-p53 axis in diffuse large B-cell lymphoma
- (2013) R. Camicia et al. JOURNAL OF CELL SCIENCE
- Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis
- (2013) Marieta Caganova et al. JOURNAL OF CLINICAL INVESTIGATION
- Phase III Randomized Study of Rituximab/Carmustine, Etoposide, Cytarabine, and Melphalan (BEAM) Compared With Iodine-131 Tositumomab/BEAM With Autologous Hematopoietic Cell Transplantation for Relapsed Diffuse Large B-Cell Lymphoma: Results From the BMT CTN 0401 Trial
- (2013) Julie M. Vose et al. JOURNAL OF CLINICAL ONCOLOGY
- Safety and Clinical Activity of a Combination Therapy Comprising Two Antibody-Based Targeting Agents for the Treatment of Non-Hodgkin Lymphoma: Results of a Phase I/II Study Evaluating the Immunoconjugate Inotuzumab Ozogamicin With Rituximab
- (2013) Luis Fayad et al. JOURNAL OF CLINICAL ONCOLOGY
- Disabling Immune Tolerance by Programmed Death-1 Blockade With Pidilizumab After Autologous Hematopoietic Stem-Cell Transplantation for Diffuse Large B-Cell Lymphoma: Results of an International Phase II Trial
- (2013) Philippe Armand et al. JOURNAL OF CLINICAL ONCOLOGY
- Activation of the STAT3 Signaling Pathway Is Associated With Poor Survival in Diffuse Large B-Cell Lymphoma Treated With R-CHOP
- (2013) Xin Huang et al. JOURNAL OF CLINICAL ONCOLOGY
- DNA repair genes are selectively mutated in diffuse large B cell lymphomas
- (2013) Noel FCC de Miranda et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Replenishment of the B cell compartment after doxorubicin-induced hematopoietic toxicity is facilitated by STAT1
- (2013) Sebak Datta et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Inhibiting Aberrant Signal Transducer and Activator of Transcription Protein Activation with Tetrapodal, Small Molecule Src Homology 2 Domain Binders: Promising Agents against Multiple Myeloma
- (2013) Brent D. G. Page et al. JOURNAL OF MEDICINAL CHEMISTRY
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- (2013) David Cunningham et al. LANCET
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- (2013) C C Bjorklund et al. LEUKEMIA
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- (2013) M Wang et al. LEUKEMIA
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- (2013) Chuanbing Zang et al. LEUKEMIA & LYMPHOMA
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- (2013) Ben-Zion Katz et al. LEUKEMIA & LYMPHOMA
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- (2013) Jennifer R. Brown LEUKEMIA & LYMPHOMA
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- (2013) Hans Erik Johnsen et al. LEUKEMIA & LYMPHOMA
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- (2013) Tobias Karlberg et al. MOLECULAR ASPECTS OF MEDICINE
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- (2013) C. Billard MOLECULAR CANCER THERAPEUTICS
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- (2013) Dennis E K Tan et al. NATURE GENETICS
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- (2013) Carol Y Ying et al. NATURE IMMUNOLOGY
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- (2013) Andrew J Souers et al. NATURE MEDICINE
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- (2013) Mark Roschewski et al. Nature Reviews Clinical Oncology
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- (2013) James N. Kochenderfer et al. Nature Reviews Clinical Oncology
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- (2013) Ryan M. Young et al. NATURE REVIEWS DRUG DISCOVERY
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- (2013) Karla L. H. Feijs et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
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- (2013) Michael L. Wang et al. NEW ENGLAND JOURNAL OF MEDICINE
- Targeting BTK with Ibrutinib in Relapsed Chronic Lymphocytic Leukemia
- (2013) John C. Byrd et al. NEW ENGLAND JOURNAL OF MEDICINE
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- (2013) K H Shain et al. ONCOGENE
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- (2013) Roland M. Huber et al. PLoS One
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- (2013) Guangzhen Hu et al. PLoS One
- Suppression of Molecular Inflammatory Pathways by Toll-Like Receptor 7, 8, and 9 Antagonists in a Model of IL-23-Induced Skin Inflammation
- (2013) Mayte Suárez-Fariñas et al. PLoS One
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- (2013) Sylvia Hartmann et al. PLoS One
- Genetic heterogeneity of diffuse large B-cell lymphoma
- (2013) Jenny Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PTEN loss defines a PI3K/AKT pathway-dependent germinal center subtype of diffuse large B-cell lymphoma
- (2013) M. Pfeifer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2013) G. Lu et al. SCIENCE
- B-cell receptor signaling as a driver of lymphoma development and evolution
- (2013) Carsten U. Niemann et al. SEMINARS IN CANCER BIOLOGY
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- (2013) Ryan D. Morin et al. SEMINARS IN HEMATOLOGY
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- (2013) Robert Z. Orlowski SEMINARS IN ONCOLOGY
- Recognition of Mono-ADP-Ribosylated ARTD10 Substrates by ARTD8 Macrodomains
- (2013) Alexandra H. Forst et al. STRUCTURE
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- (2013) Leandro Cerchietti et al. Expert Review of Hematology
- TYK2–STAT1–BCL2 Pathway Dependence in T-cell Acute Lymphoblastic Leukemia
- (2013) Takaomi Sanda et al. Cancer Discovery
- Mechanism-Based Epigenetic Chemosensitization Therapy of Diffuse Large B-Cell Lymphoma
- (2013) T. Clozel et al. Cancer Discovery
- Targeting the epigenome and other new strategies in diffuse large B-cell lymphoma: beyond R-CHOP
- (2013) L. Cerchietti et al. Hematology-American Society of Hematology Education Program
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- (2013) George W. Small et al. PeerJ
- Beyond DNA Repair: Additional Functions of PARP-1 in Cancer
- (2013) Alice N. Weaver et al. Frontiers in Oncology
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- (2012) Albert A. Antolín et al. ACS Chemical Biology
- Pathogenesis of Human B Cell Lymphomas
- (2012) Arthur L. Shaffer et al. Annual Review of Immunology
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- (2012) Paul Warrener et al. APOPTOSIS
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- (2012) Nicolas Mounier et al. BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY
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- (2012) Z. Y. Xu-Monette et al. BLOOD
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- (2012) Z. Y. Xu-Monette et al. BLOOD
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- (2012) W. Cuccuini et al. BLOOD
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- (2012) M. Gupta et al. BLOOD
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- (2012) G. D. Victora et al. BLOOD
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- (2012) C. J. Ott et al. BLOOD
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- (2012) Hsiao-Ching Chuang et al. BREAST CANCER RESEARCH AND TREATMENT
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- (2012) Julio García-Suárez et al. BRITISH JOURNAL OF HAEMATOLOGY
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- (2012) Ling-Hua Zhang et al. BRITISH JOURNAL OF HAEMATOLOGY
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- (2012) Pilar Caro et al. CANCER CELL
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- (2012) Lorena Fontan et al. CANCER CELL
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- (2012) Yibin Yang et al. CANCER CELL
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- (2012) Stefano Monti et al. CANCER CELL
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- (2012) Chuanbing Zang et al. CANCER LETTERS
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- (2012) Chaitali Dutta et al. CANCER RESEARCH
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- (2012) M. A. Zimmerman et al. CANCER RESEARCH
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- (2012) M. R. Green et al. CLINICAL CANCER RESEARCH
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- (2012) S. Kummar et al. CLINICAL CANCER RESEARCH
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- (2012) N. N. Khodarev et al. CLINICAL CANCER RESEARCH
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- (2012) C. Fabre et al. CLINICAL CANCER RESEARCH
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- (2012) Gerrit M Daubner et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
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- (2012) Fahu He et al. FEBS LETTERS
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- (2012) Z. Wang et al. GENES & DEVELOPMENT
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- (2012) Suzan Guney et al. GENES CHROMOSOMES & CANCER
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- (2012) J. A. Barnes et al. HAEMATOLOGICA
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- (2012) Pier Luigi Zinzani et al. HEMATOLOGICAL ONCOLOGY
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- (2012) Burkhard Hirsch et al. HISTOPATHOLOGY
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- (2012) Christina Magkou et al. HISTOPATHOLOGY
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- (2012) George R. Stark et al. IMMUNITY
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- (2012) Mark Roschewski et al. INTERNATIONAL JOURNAL OF HEMATOLOGY
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- (2012) Anas Younes et al. JOURNAL OF CLINICAL ONCOLOGY
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- (2012) Anas Younes et al. JOURNAL OF CLINICAL ONCOLOGY
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- (2012) Tina Marie Green et al. JOURNAL OF CLINICAL ONCOLOGY
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- (2012) Nathalie A. Johnson et al. JOURNAL OF CLINICAL ONCOLOGY
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- (2012) Christian Gisselbrecht et al. JOURNAL OF CLINICAL ONCOLOGY
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- (2012) Pasquale Sansone et al. JOURNAL OF CLINICAL ONCOLOGY
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- (2012) Akihiro Tamiya et al. JOURNAL OF CLINICAL ONCOLOGY
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- (2012) Ranjana H. Advani et al. JOURNAL OF CLINICAL ONCOLOGY
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- (2012) C. David Andersson et al. JOURNAL OF MEDICINAL CHEMISTRY
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- (2012) Ambrogio Fassina et al. LABORATORY INVESTIGATION
- MCL1 is deregulated in subgroups of diffuse large B-cell lymphoma
- (2012) S-S Wenzel et al. LEUKEMIA
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- (2012) H Tilly et al. LEUKEMIA
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- (2012) Lucile Couronné et al. LEUKEMIA & LYMPHOMA
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- (2012) Q. Yan et al. MOLECULAR AND CELLULAR BIOLOGY
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- (2012) G. Dasmahapatra et al. MOLECULAR CANCER THERAPEUTICS
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- (2012) Süheda Erener et al. MOLECULAR CELL
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- (2012) Michael T. McCabe et al. NATURE
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- (2012) Jun Cui et al. NATURE IMMUNOLOGY
- Poly(ADP-ribose) polymerase family member 14 (PARP14) is a novel effector of the JNK2-dependent pro-survival signal in multiple myeloma
- (2012) A Barbarulo et al. ONCOGENE
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- (2012) Michael J. Kluk et al. PLoS One
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- (2012) Bhuvanesh Dave et al. PLoS One
- Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing
- (2012) J. G. Lohr et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2012) Josiah Obiero et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
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- (2012) Andrew P. South et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
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- (2012) Yesid Alvarado et al. Expert Review of Hematology
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- (2011) Graham W. Slack et al. ADVANCES IN ANATOMIC PATHOLOGY
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- (2011) T. E. Witzig et al. ANNALS OF ONCOLOGY
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- (2011) Juraj Bodo et al. APOPTOSIS
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- (2011) I. N. M. Micallef et al. BLOOD
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- (2011) M. Gupta et al. BLOOD
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- (2011) C. Steidl et al. BLOOD
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- (2011) J. N. Kochenderfer et al. BLOOD
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- (2011) S. Kannan et al. BLOOD
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- (2011) S. Cheng et al. BLOOD
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- (2011) E. Campo et al. BLOOD
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- (2011) Y. X. Zhu et al. BLOOD
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- (2011) Wen-Yong Wu et al. BMC CANCER
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- (2011) A Smith et al. BRITISH JOURNAL OF CANCER
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- (2011) Francisco J. Hernandez-Ilizaliturri et al. CANCER
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- (2011) Ning Chen et al. CANCER BIOLOGY & THERAPY
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- (2011) Madhavi Challa-Malladi et al. CANCER CELL
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- (2011) E. A. Stronach et al. CANCER RESEARCH
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- (2011) T. L. Naylor et al. CANCER RESEARCH
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- (2011) S. Kummar et al. CANCER RESEARCH
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- (2011) A. Scuto et al. CANCER RESEARCH
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- (2011) B. A. Teicher et al. CLINICAL CANCER RESEARCH
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- (2011) D. J. Andorsky et al. CLINICAL CANCER RESEARCH
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- (2011) J. Iqbal et al. CLINICAL CANCER RESEARCH
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- (2011) Pier Luigi Zinzani et al. Clinical Lymphoma Myeloma & Leukemia
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- (2011) Krzysztof Sikorski et al. CYTOKINE & GROWTH FACTOR REVIEWS
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- (2011) Loic Ysebaert et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
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- (2011) Monica Civallero et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- The Y641C mutation of EZH2 alters substrate specificity for histone H3 lysine 27 methylation states
- (2011) Tim J. Wigle et al. FEBS LETTERS
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- (2011) Davide Schiavone et al. FEBS LETTERS
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- (2011) V. Biberacher et al. HAEMATOLOGICA
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- (2011) W. H. Wilson et al. HAEMATOLOGICA
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- (2011) T. M. Cardesa-Salzmann et al. HAEMATOLOGICA
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- (2011) Eve Roman et al. HISTOPATHOLOGY
- The Germinal Center/Activated B-Cell Subclassification Has a Prognostic Impact for Response to Salvage Therapy in Relapsed/Refractory Diffuse Large B-Cell Lymphoma: A Bio-CORAL Study
- (2011) Catherine Thieblemont et al. JOURNAL OF CLINICAL ONCOLOGY
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- (2011) Wu ZL et al. Journal of Hematology & Oncology
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- (2011) Anthony D. William et al. JOURNAL OF MEDICINAL CHEMISTRY
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- (2011) P Ruminy et al. LEUKEMIA
- Lenalidomide can be safely combined with R-CHOP (R2CHOP) in the initial chemotherapy for aggressive B-cell lymphomas: phase I study
- (2011) G S Nowakowski et al. LEUKEMIA
- Regulation of STAT3 by histone deacetylase-3 in diffuse large B-cell lymphoma: implications for therapy
- (2011) M Gupta et al. LEUKEMIA
- SB1518, a novel macrocyclic pyrimidine-based JAK2 inhibitor for the treatment of myeloid and lymphoid malignancies
- (2011) S Hart et al. LEUKEMIA
- Interleukin-6 plasma levels are modulated by a polymorphism in theNF-κB1gene and are associated with outcome following rituximab-combined chemotherapy in diffuse large B-cell non-Hodgkin lymphoma
- (2011) Manuela Giachelia et al. LEUKEMIA & LYMPHOMA
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- (2011) Shaoying Li et al. MODERN PATHOLOGY
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- (2011) L. Novikov et al. MOLECULAR AND CELLULAR BIOLOGY
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- (2011) Thomas Helleday Molecular Oncology
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- (2011) Laura Pasqualucci et al. NATURE
- Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma
- (2011) Ryan D. Morin et al. NATURE
- MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers
- (2011) Christian Steidl et al. NATURE
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- (2011) Laura Pasqualucci et al. NATURE GENETICS
- ABCG2 is a direct transcriptional target of hedgehog signaling and involved in stroma-induced drug tolerance in diffuse large B-cell lymphoma
- (2011) R R Singh et al. ONCOGENE
- Glycolytic rate and lymphomagenesis depend on PARP14, an ADP ribosyltransferase of the B aggressive lymphoma (BAL) family
- (2011) S. H. Cho et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeting MYC dependence in cancer by inhibiting BET bromodomains
- (2011) J. A. Mertz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Malt1-dependent RelB cleavage promotes canonical NF- B activation in lymphocytes and lymphoma cell lines
- (2011) S. Hailfinger et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Progress in the Function and Regulation of ADP-Ribosylation
- (2011) M. O. Hottiger et al. Science Signaling
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- (2011) Christof Schneider et al. SEMINARS IN DIAGNOSTIC PATHOLOGY
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- (2011) Thomas Tousseyn et al. VIRCHOWS ARCHIV
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- (2011) Cancer Discovery
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- (2011) T. E. Witzig et al. Hematology-American Society of Hematology Education Program
- Relapsed/Refractory Diffuse Large B-Cell Lymphoma
- (2011) J. W. Friedberg Hematology-American Society of Hematology Education Program
- B-cell Lymphomas With Concurrent IGH-BCL2 and MYC Rearrangements Are Aggressive Neoplasms With Clinical and Pathologic Features Distinct From Burkitt Lymphoma and Diffuse Large B-cell Lymphoma
- (2010) Matija Snuderl et al. AMERICAN JOURNAL OF SURGICAL PATHOLOGY
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- (2010) Rebecca L. Lamason et al. BIOCHEMISTRY
- Antitransgene Rejection Responses Contribute to Attenuated Persistence of Adoptively Transferred CD20/CD19-Specific Chimeric Antigen Receptor Redirected T Cells in Humans
- (2010) Michael C. Jensen et al. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
- The Role of Cytotoxic Therapy with Hematopoietic Stem Cell Transplantation in the Treatment of Diffuse Large B Cell Lymphoma: Update of the 2001 Evidence-Based Review
- (2010) Denise M. Oliansky et al. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
- The Hsp90 inhibitor IPI-504 overcomes bortezomib resistance in mantle cell lymphoma in vitro and in vivo by down-regulation of the prosurvival ER chaperone BiP/Grp78
- (2010) G. Roue et al. BLOOD
- The PARP inhibitor olaparib induces significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo
- (2010) V. J. Weston et al. BLOOD
- Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation
- (2010) D. B. Yap et al. BLOOD
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- (2010) M. R. Green et al. BLOOD
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- (2010) J. N. Kochenderfer et al. BLOOD
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- (2010) D. Yecies et al. BLOOD
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- (2010) J. N. Kochenderfer et al. BLOOD
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- (2010) L. V. Pham et al. BLOOD
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- (2010) F. Jardin et al. BLOOD
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- (2010) B. Coiffier et al. BLOOD
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- (2010) G. Dasmahapatra et al. BLOOD
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- (2010) S. M. Aukema et al. BLOOD
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- (2010) Sonali M. Smith et al. BLOOD CELLS MOLECULES AND DISEASES
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- (2010) Lixin Rui et al. CANCER CELL
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- (2010) Jonathan Mandelbaum et al. CANCER CELL
- A Small-Molecule Inhibitor of BCL6 Kills DLBCL Cells In Vitro and In Vivo
- (2010) Leandro C. Cerchietti et al. CANCER CELL
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- (2010) Scott Ackler et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
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- (2010) Maribel Cotto et al. Clinical & Translational Oncology
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- (2010) Julie Lignon et al. Clinical Lymphoma Myeloma & Leukemia
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- (2010) J. A. Martinez-Climent et al. HAEMATOLOGICA
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- (2010) Roel G. J. Klein Wolterink et al. IMMUNOLOGICAL REVIEWS
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- (2010) Purvi Mehrotra et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2010) Leandro C. Cerchietti et al. JOURNAL OF CLINICAL INVESTIGATION
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- (2010) Sharon Barrans et al. JOURNAL OF CLINICAL ONCOLOGY
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- (2010) Christian Gisselbrecht et al. JOURNAL OF CLINICAL ONCOLOGY
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- (2010) Jia Ruan et al. JOURNAL OF CLINICAL ONCOLOGY
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- (2010) T E Witzig et al. LEUKEMIA
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- (2010) Ajay K. Gopal et al. LEUKEMIA & LYMPHOMA
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- (2010) Sari Riihijärvi et al. MODERN PATHOLOGY
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- (2010) Seong-Su Han et al. Molecular Cancer
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- (2010) A. L. Romero-Weaver et al. MOLECULAR CANCER RESEARCH
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- (2010) Wioleta Luszczek et al. MOLECULAR CANCER THERAPEUTICS
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- (2010) R. Eric Davis et al. NATURE
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- (2010) Ryan D Morin et al. NATURE GENETICS
- Aggressive Lymphomas
- (2010) Georg Lenz et al. NEW ENGLAND JOURNAL OF MEDICINE
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- (2010) B. Kloo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2010) L. A. Honigberg et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2010) D. Rai et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2010) Michael O. Hottiger et al. TRENDS IN BIOCHEMICAL SCIENCES
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- (2010) Chao Dai et al. TRENDS IN MOLECULAR MEDICINE
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- (2010) L. M. Staudt Cold Spring Harbor Perspectives in Biology
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- (2009) S. H. Cho et al. BLOOD
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- (2009) O. Ritz et al. BLOOD
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- (2009) J. Hiraga et al. BLOOD
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- (2009) M. Gupta et al. BLOOD
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- (2009) K. Dunleavy et al. BLOOD
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- (2009) N. A. Johnson et al. BLOOD
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- (2009) A. Mottok et al. BLOOD
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- (2009) K. J. Savage et al. BLOOD
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- (2009) J. W. Friedberg et al. BLOOD
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- (2009) Sean P Pitroda et al. BMC Medicine
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- (2009) Shigeo Masuda et al. CANCER SCIENCE
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- (2009) Suk-young Lee et al. CANCER SCIENCE
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- (2009) Lakshmi Srinivasan et al. CELL
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- (2009) Ji Luo et al. CELL
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- (2009) Y. Terui et al. CLINICAL CANCER RESEARCH
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- (2009) M. Y. Zhao et al. CLINICAL CANCER RESEARCH
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- (2009) Brian Ruffell et al. CYTOKINE & GROWTH FACTOR REVIEWS
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- (2009) Paul et al. Frontiers in Bioscience-Landmark
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- (2009) N. A. Johnson et al. HAEMATOLOGICA
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- (2009) P. Van Loo et al. HAEMATOLOGICA
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- (2009) Elena V. Efimova et al. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
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- (2009) Ziyun Du et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2009) Uta Ferch et al. JOURNAL OF EXPERIMENTAL MEDICINE
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- (2009) James N. Kochenderfer et al. JOURNAL OF IMMUNOTHERAPY
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- (2009) N Niitsu et al. LEUKEMIA
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- (2009) Douglas A. Stewart et al. LEUKEMIA & LYMPHOMA
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- (2009) Claudia Stolz et al. LEUKEMIA & LYMPHOMA
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- (2009) Kritika Chaiwatanatorn et al. LEUKEMIA & LYMPHOMA
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- (2009) Dilek Dincol et al. MEDICAL ONCOLOGY
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- (2009) Wai M. Liu et al. MOLECULAR BIOLOGY REPORTS
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- (2009) Qingsheng Yan et al. MOLECULAR CELL
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- (2009) Mara Compagno et al. NATURE
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- (2009) Yongzhan Nie et al. NATURE CELL BIOLOGY
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- (2009) Leandro C Cerchietti et al. NATURE MEDICINE
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- (2009) Gyula Timinszky et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
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- (2009) Nikolai N. Khodarev et al. PLoS One
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- (2009) S. Hailfinger et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2009) M. Saito et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2009) E. S. Jaffe Hematology-American Society of Hematology Education Program
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- (2008) M. Crump et al. ANNALS OF ONCOLOGY
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- (2008) Mary E. Keir et al. Annual Review of Immunology
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- (2008) Przemysław Juszczyński et al. ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
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- (2008) X. Lu et al. BLOOD
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- (2008) L. C. Cerchietti et al. BLOOD
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- (2008) K. H. Young et al. BLOOD
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- (2008) B. Chetaille et al. BLOOD
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- (2008) C. Tse et al. CANCER RESEARCH
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- (2008) Leonardo Salmena et al. CELL
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- (2008) S. H. Olejniczak et al. CLINICAL CANCER RESEARCH
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- (2008) M. B. Meads et al. CLINICAL CANCER RESEARCH
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- (2008) Maurizio Martelli et al. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
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- (2008) Luca Costantino et al. CURRENT MEDICINAL CHEMISTRY
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- (2008) A. Martin et al. HAEMATOLOGICA
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- (2008) S O Yoon et al. HISTOPATHOLOGY
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- (2008) Wyndham H. Wilson et al. JOURNAL OF CLINICAL ONCOLOGY
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- (2008) Imen Najjar et al. JOURNAL OF LEUKOCYTE BIOLOGY
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- (2008) Michael Pfreundschuh et al. LANCET ONCOLOGY
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- (2008) O Ritz et al. LEUKEMIA
- Structural aberrations affecting the MYC locus indicate a poor prognosis independent of clinical risk factors in diffuse large B-cell lymphomas treated within randomized trials of the German High-Grade Non-Hodgkin's Lymphoma Study Group (DSHNHL)
- (2008) W Klapper et al. LEUKEMIA
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- (2008) Jane Houldsworth et al. LEUKEMIA & LYMPHOMA
- Mutation or polymorphism of the CD20 gene is not associated with the response to R-CHOP in diffuse large B cell lymphoma patients
- (2008) Aylin Sar et al. LEUKEMIA RESEARCH
- ABT-263 and rapamycin act cooperatively to kill lymphoma cells in vitro and in vivo
- (2008) Scott Ackler et al. MOLECULAR CANCER THERAPEUTICS
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- (2008) Dana M. Gwinn et al. MOLECULAR CELL
- The chromatin-remodeling enzyme BRG1 coordinates CIITA induction through many interdependent distal enhancers
- (2008) Zuyao Ni et al. NATURE IMMUNOLOGY
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- (2008) G. Lenz et al. NEW ENGLAND JOURNAL OF MEDICINE
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- (2008) R. R. Weichselbaum et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways
- (2008) G. Lenz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1)
- (2008) M. Marzec et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2008) G. Lenz et al. SCIENCE
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- (2008) Gabriella Regis et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
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- (2008) S WANG et al. TRENDS IN PHARMACOLOGICAL SCIENCES
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- (2007) L. T. Lam et al. BLOOD
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- (2007) E. Vellenga et al. BLOOD
- The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases
- (2007) Paul et al. Frontiers in Bioscience-Landmark
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