Resistance to mTOR Kinase Inhibitors in Lymphoma Cells Lacking 4EBP1

mTOR inhibitor efficacy is determined by the eIF4E/4E-BP ratio

(2015) Tommy Alain et al.   Oncotarget

Incomplete inhibition of phosphorylation of 4E-BP1 as a mechanism of primary resistance to ATP-competitive mTOR inhibitors

(2013) G S Ducker et al.   ONCOGENE

Pancreatic tumours escape from translational control through 4E-BP1 loss

(2013) Y Martineau et al.   ONCOGENE

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Dual mTORC1/2 and HER2 Blockade Results in Antitumor Activity in Preclinical Models of Breast Cancer Resistant to Anti-HER2 Therapy

(2012) C. Garcia-Garcia et al.   CLINICAL CANCER RESEARCH

Efficacy of the investigational mTOR kinase inhibitor MLN0128/INK128 in models of B-cell acute lymphoblastic leukemia

(2012) M R Janes et al.   LEUKEMIA

The translational landscape of mTOR signalling steers cancer initiation and metastasis

(2012) Andrew C. Hsieh et al.   NATURE

Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy

(2011) Seth A. Wander et al.   JOURNAL OF CLINICAL INVESTIGATION

Rapamycin passes the torch: a new generation of mTOR inhibitors

(2011) Don Benjamin et al.   NATURE REVIEWS DRUG DISCOVERY

Targeting the translational machinery as a novel treatment strategy for hematologic malignancies

(2010) P. R. Hagner et al.   BLOOD

CAL-101, a p110  selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability

(2010) B. J. Lannutti et al.   BLOOD

Target of Rapamycin Signaling in Leukemia and Lymphoma

(2010) C. Vu et al.   CLINICAL CANCER RESEARCH

The dual PI3K/mTOR inhibitor, NVP-BEZ235, is efficacious against follicular lymphoma

(2010) P M Bhende et al.   LEUKEMIA

Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor

(2010) Matthew R Janes et al.   NATURE MEDICINE

Inhibition of histone deacetylase overcomes rapamycin-mediated resistance in diffuse large B-cell lymphoma by inhibiting Akt signaling through mTORC2

(2009) M. Gupta et al.   BLOOD

Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

(2009) Nahum Sonenberg et al.   CELL

The Pharmacology of mTOR Inhibition

(2009) D. A. Guertin et al.   Science Signaling

Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation

(2008) A. Y. Choo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA