NF-κB pathways in hematological malignancies

A critical role for the NFkB pathway in multiple myeloma

(2015)   Oncotarget

CD40 Ligand Protects from TRAIL-Induced Apoptosis in Follicular Lymphomas through NF- B Activation and Up-Regulation of c-FLIP and Bcl-xL

(2014) M. Travert et al.   JOURNAL OF IMMUNOLOGY

Developments in the immunophenotypic analysis of haematological malignancies

(2013) Kathy Heel et al.   BLOOD REVIEWS

p53 dysfunction precedes the activation of nuclear factor-κB during disease progression in mice expressing Tax, a human T-cell leukemia virus type 1 oncoprotein

(2013) Takeo Ohsugi et al.   CARCINOGENESIS

TRAIL-Based Therapeutic Approaches for the Treatment of Pediatric Malignancies

(2013) C. Gasparini et al.   CURRENT MEDICINAL CHEMISTRY

RelB/p50 regulates TNF production in LPS-stimulated dendritic cells and macrophages

(2013) Chiara Gasparini et al.   CYTOKINE

NF-κB: roles and regulation in different CD4+T-cell subsets

(2013) Hyunju Oh et al.   IMMUNOLOGICAL REVIEWS

Leukaemias into the 21st century - part 2: the chronic leukaemias

(2013) J. Gibson et al.   INTERNAL MEDICINE JOURNAL

Leveraging Cancer Genome Information in Hematologic Malignancies

(2013) Raajit Rampal et al.   JOURNAL OF CLINICAL ONCOLOGY

A Structural Basis for Selective Dimerization by NF-κB RelB

(2013) Don Vu et al.   JOURNAL OF MOLECULAR BIOLOGY

Targeting pathological B cell receptor signalling in lymphoid malignancies

(2013) Ryan M. Young et al.   NATURE REVIEWS DRUG DISCOVERY

Frequent Engagement of RelB Activation Is Critical for Cell Survival in Multiple Myeloma

(2013) Françoise Cormier et al.   PLoS One

Lessons from next-generation sequencing analysis in hematological malignancies

(2013) E Braggio et al.   Blood Cancer Journal

Pathogenesis of Human B Cell Lymphomas

(2012) Arthur L. Shaffer et al.   Annual Review of Immunology

Germinal Centers

(2012) Gabriel D. Victora et al.   Annual Review of Immunology

Hodgkin lymphoma requires stabilized NIK and constitutive RelB expression for survival

(2012) S. M. Ranuncolo et al.   BLOOD

NF-κB as a Target for Modulating Inflammatory Responses

(2012) Chiara Gasparini et al.   CURRENT PHARMACEUTICAL DESIGN

The MDM2 inhibitor Nutlin-3 modulates dendritic cell–induced T cell proliferation

(2012) Chiara Gasparini et al.   HUMAN IMMUNOLOGY

NF-κB function in B lymphocytes

(2012) Mary Kaileh et al.   IMMUNOLOGICAL REVIEWS

NF-κB subunit specificity in hemopoiesis

(2012) Steve Gerondakis et al.   IMMUNOLOGICAL REVIEWS

Regulation of cell death and autophagy by IKK and NF-κB: critical mechanisms in immune function and cancer

(2012) Albert S. Baldwin   IMMUNOLOGICAL REVIEWS

Leukaemias into the 21st century: part 1: the acute leukaemias

(2012) C. M. S. Brown et al.   INTERNAL MEDICINE JOURNAL

RelB inhibits cell proliferation and tumor growth through p53 transcriptional activation

(2012) E Jacque et al.   ONCOGENE

Distinct Motifs in the Intracellular Domain of Human CD30 Differentially Activate Canonical and Alternative Transcription Factor NF-κB Signaling

(2012) Sarah L. Buchan et al.   PLoS One

T cell receptor/CARMA1/NF- B signaling controls T-helper (Th) 17 differentiation

(2012) L. L. Molinero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear factor-κB, p53, and mitochondria: regulation of cellular metabolism and the Warburg effect

(2012) Renée F. Johnson et al.   TRENDS IN BIOCHEMICAL SCIENCES

The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications

(2011) E. Campo et al.   BLOOD

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

A Noncanonical Flt3ITD/NF- B Signaling Pathway Represses DAPK1 in Acute Myeloid Leukemia

(2011) R. Shanmugam et al.   CLINICAL CANCER RESEARCH

Recent Advances in the Therapeutic Perspectives of Nutlin-3

(2011) Paola Secchiero et al.   CURRENT PHARMACEUTICAL DESIGN

Pathogenesis of Non-Hodgkin's Lymphoma

(2011) Hendrik Nogai et al.   JOURNAL OF CLINICAL ONCOLOGY

Notch is an essential upstream regulator of NF-κB and is relevant for survival of Hodgkin and Reed–Sternberg cells

(2011) R Schwarzer et al.   LEUKEMIA

STAT-3 Activates NF- B in Chronic Lymphocytic Leukemia Cells

(2011) Z. Liu et al.   MOLECULAR CANCER RESEARCH

Malignant pirates of the immune system

(2011) Lixin Rui et al.   NATURE IMMUNOLOGY

Inflammation meets cancer, with NF-κB as the matchmaker

(2011) Yinon Ben-Neriah et al.   NATURE IMMUNOLOGY

c-Rel Controls Multiple Discrete Steps in the Thymic Development of Foxp3+ CD4 Regulatory T Cells

(2011) George Grigoriadis et al.   PLoS One

Malt1-dependent RelB cleavage promotes canonical NF- B activation in lymphocytes and lymphoma cell lines

(2011) S. Hailfinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signalling to drug resistance in CLL

(2010) Erin Hertlein et al.   BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY

The lymph node microenvironment promotes B-cell receptor signaling, NF- B activation, and tumor proliferation in chronic lymphocytic leukemia

(2010) Y. Herishanu et al.   BLOOD

Classical and/or alternative NF- B pathway activation in multiple myeloma

(2010) Y. N. Demchenko et al.   BLOOD

MDM2 antagonist nutlin plus proteasome inhibitor velcade combination displays a synergistic anti-myeloma activity

(2010) Manujendra N. Saha et al.   CANCER BIOLOGY & THERAPY

Constitutive Canonical NF-κB Activation Cooperates with Disruption of BLIMP1 in the Pathogenesis of Activated B Cell-like Diffuse Large Cell Lymphoma

(2010) Dinis Pedro Calado et al.   CANCER CELL

MDM2 antagonist Nutlin-3 enhances bortezomib-mediated mitochondrial apoptosis in TP53-mutated mantle cell lymphoma

(2010) Linhua Jin et al.   CANCER LETTERS

Non-canonical NF-κB signaling pathway

(2010) Shao-Cong Sun   CELL RESEARCH

Nutlin-3 up-regulates the expression of Notch1 in both myeloid and lymphoid leukemic cells, as part of a negative feedback antiapoptotic mechanism

(2009) P. Secchiero et al.   BLOOD

The IKK2/NF- B pathway suppresses MYC-induced lymphomagenesis

(2009) K. Klapproth et al.   BLOOD

Interactions of the Hdm2/p53 and Proteasome Pathways May Enhance the Antitumor Activity of Bortezomib

(2009) M. G. Ooi et al.   CLINICAL CANCER RESEARCH

Tumor necrosis factor-related apoptosis-inducing ligand and the regulation of hematopoiesis

(2009) Paola Secchiero et al.   CURRENT OPINION IN HEMATOLOGY

Multiple Myeloma

(2009) S. Vincent Rajkumar   CURRENT PROBLEMS IN CANCER

Bortezomib restores stroma-mediated APO2L/TRAIL apoptosis resistance in multiple myeloma

(2009) Lia E. Perez et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

RelB/p50 regulates CCL19 production, but fails to promote human DC maturation

(2009) Chiara Gasparini et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Nuclear Factor-κB Modulates Regulatory T Cell Development by Directly Regulating Expression of Foxp3 Transcription Factor

(2009) Meixiao Long et al.   IMMUNITY

Membrane Tumor Necrosis Factor (TNF) Induces p100 Processing via TNF Receptor-2 (TNFR2)

(2009) Hilka Rauert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

B Cell Receptor-Mediated Sustained c-Rel Activation Facilitates Late Transitional B Cell Survival through Control of B Cell Activating Factor Receptor and NF- B2

(2009) I. Castro et al.   JOURNAL OF IMMUNOLOGY

Multiple myeloma

(2009) Marc S Raab et al.   LANCET

TRAF1 is involved in the classical NF-κB activation and CD30-induced alternative activity in Hodgkin's lymphoma cells

(2009) Feng Guo et al.   MOLECULAR IMMUNOLOGY

Development of immunoglobulin λ-chain–positive B cells, but not editing of immunoglobulin κ-chain, depends on NF-κB signals

(2009) Emmanuel Derudder et al.   NATURE IMMUNOLOGY

The 2008 WHO classification of lymphomas: implications for clinical practice and translational research

(2009) E. S. Jaffe   Hematology-American Society of Hematology Education Program

Antitumor Activity of Bortezomib Alone and in Combination with Trail in Human Acute Myeloid Leukemia

(2008) Concetta Conticello et al.   ACTA HAEMATOLOGICA

Constitutively activated Notch signaling is involved in survival and apoptosis resistance of B-CLL cells

(2008) E. Rosati et al.   BLOOD

Rearranged NF-κB2 gene in an adult T-cell leukemia cell line

(2008) Masato Isogawa et al.   CANCER SCIENCE

Role of full-length osteoprotegerin in tumor cell biology

(2008) G. Zauli et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

NF-??B in the pathogenesis and treatment of multiple myeloma

(2008) Zhi-Wei Li et al.   CURRENT OPINION IN HEMATOLOGY

The MDM2 Inhibitor Nutlins as an Innovative Therapeutic Tool for the Treatment of Haematological Malignancies

(2008) Paola Secchiero et al.   CURRENT PHARMACEUTICAL DESIGN

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-κB signaling

(2008) Sivakumar Vallabhapurapu et al.   NATURE IMMUNOLOGY

Is NF-κB a good target for cancer therapy? Hopes and pitfalls

(2008) Véronique Baud et al.   NATURE REVIEWS DRUG DISCOVERY

RelB-Dependent Stromal Cells Promote T-Cell Leukemogenesis

(2008) Nuno R. dos Santos et al.   PLoS One

Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Promotes Migration of Human Bone Marrow Multipotent Stromal Cells

(2008) Paola Secchiero et al.   STEM CELLS