Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas
出版年份 2014 全文链接
标题
Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas
作者
关键词
Cancer treatment, Lymphoma cells, Lymphomas, B cells, Gene expression, Chromatin, Cyclophosphamide, Drug therapy
出版物
PLoS One
Volume 9, Issue 12, Pages e111840
出版商
Public Library of Science (PLoS)
发表日期
2014-12-11
DOI
10.1371/journal.pone.0111840
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Selective Inhibition of EZH2 by EPZ-6438 Leads to Potent Antitumor Activity in EZH2-Mutant Non-Hodgkin Lymphoma
- (2014) S. K. Knutson et al. MOLECULAR CANCER THERAPEUTICS
- An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1
- (2013) Kyle D. Konze et al. ACS Chemical Biology
- EZH2 Is Required for Germinal Center Formation and Somatic EZH2 Mutations Promote Lymphoid Transformation
- (2013) Wendy Béguelin et al. CANCER CELL
- Discovery and Characterization of Super-Enhancer-Associated Dependencies in Diffuse Large B Cell Lymphoma
- (2013) Bjoern Chapuy et al. CANCER CELL
- Identification of EZH2 and EZH1 Small Molecule Inhibitors with Selective Impact on Diffuse Large B Cell Lymphoma Cell Growth
- (2013) Shivani Garapaty-Rao et al. CHEMISTRY & BIOLOGY
- Drugging the human methylome: an emerging modality for reversible control of aberrant gene transcription
- (2013) Tim J Wigle et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Non-Hodgkin’s B-cell lymphoma: Advances in molecular strategies targeting drug resistance
- (2013) Steve A Maxwell et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- The biology of the glucocorticoid receptor: New signaling mechanisms in health and disease
- (2013) Robert H. Oakley et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Target identification and mechanism of action in chemical biology and drug discovery
- (2013) Monica Schenone et al. Nature Chemical Biology
- Emerging roles for chromatin as a signal integration and storage platform
- (2013) Aimee I. Badeaux et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2
- (2013) S. K. Knutson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations
- (2012) Michael T. McCabe et al. NATURE
- Targeting genetic alterations in protein methyltransferases for personalized cancer therapeutics
- (2012) R A Copeland et al. ONCOGENE
- Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation
- (2012) W. Qi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing
- (2012) J. G. Lohr et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Dynamical-Systems View of Stem Cell Biology
- (2012) C. Furusawa et al. SCIENCE
- Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor
- (2011) Scott R. Daigle et al. CANCER CELL
- Glucocorticoid receptor-mediated apoptosis: mechanisms of resistance in cancer cells
- (2011) George Schlossmacher et al. JOURNAL OF ENDOCRINOLOGY
- Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma
- (2011) Ryan D. Morin et al. NATURE
- Crosstalk between TNF and glucocorticoid receptor signaling pathways
- (2010) Tom Van Bogaert et al. CYTOKINE & GROWTH FACTOR REVIEWS
- Current treatment strategy of diffuse large B-cell lymphomas
- (2010) Nozomi Niitsu INTERNATIONAL JOURNAL OF HEMATOLOGY
- Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
- (2010) Ryan D Morin et al. NATURE GENETICS
- Expert opinion on the use of anthracyclines in patients with advanced breast cancer at cardiac risk
- (2009) P. J. Barrett-Lee et al. ANNALS OF ONCOLOGY
- A New Immunostain Algorithm Classifies Diffuse Large B-Cell Lymphoma into Molecular Subtypes with High Accuracy
- (2009) W. W.L. Choi et al. CLINICAL CANCER RESEARCH
- Glucocorticoid-induced leucine zipper (GILZ): a new important mediator of glucocorticoid action
- (2009) Emira Ayroldi et al. FASEB JOURNAL
- Protein methyltransferases as a target class for drug discovery
- (2009) Robert A. Copeland et al. NATURE REVIEWS DRUG DISCOVERY
- p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling
- (2008) Andrei V. Budanov et al. CELL
- Dynamic access of the glucocorticoid receptor to response elements in chromatin
- (2008) Anuja A. George et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Interaction of the Glucocorticoid Receptor with the Chromatin Landscape
- (2008) Sam John et al. MOLECULAR CELL
- Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways
- (2008) G. Lenz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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