标题
Targeting pathological B cell receptor signalling in lymphoid malignancies
作者
关键词
-
出版物
NATURE REVIEWS DRUG DISCOVERY
Volume 12, Issue 3, Pages 229-243
出版商
Springer Nature
发表日期
2013-03-01
DOI
10.1038/nrd3937
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Phase I study of CAL-101, an isoform-selective inhibitor of phosphatidylinositol 3‐kinase P110d, in patients with previously treated chronic lymphocytic leukemia.
- (2017) S. E. Coutre et al. JOURNAL OF CLINICAL ONCOLOGY
- Pathogenesis of Human B Cell Lymphomas
- (2012) Arthur L. Shaffer et al. Annual Review of Immunology
- Germinal Centers
- (2012) Gabriel D. Victora et al. Annual Review of Immunology
- PI3K signalling in B- and T-lymphocytes: new developments and therapeutic advances
- (2012) Lomon So et al. BIOCHEMICAL JOURNAL
- Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapies
- (2012) A. Agathangelidis et al. BLOOD
- Self-antigen recognition by follicular lymphoma B-cell receptors
- (2012) K. L. Sachen et al. BLOOD
- The clinically active BTK inhibitor PCI-32765 targets B-cell receptor- and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia
- (2012) M. F. M. de Rooij et al. BLOOD
- MYD88 somatic mutations in MALT lymphomas
- (2012) Zhi-Ming Li et al. BRITISH JOURNAL OF HAEMATOLOGY
- Synergy between PI3K Signaling and MYC in Burkitt Lymphomagenesis
- (2012) Sandrine Sander et al. CANCER CELL
- Exploiting Synthetic Lethality for the Therapy of ABC Diffuse Large B Cell Lymphoma
- (2012) Yibin Yang et al. CANCER CELL
- mTOR Signaling in Growth Control and Disease
- (2012) Mathieu Laplante et al. CELL
- A multicenter phase II trial (SAKK 36/06) of single-agent everolimus (RAD001) in patients with relapsed or refractory mantle cell lymphoma
- (2012) C. Renner et al. HAEMATOLOGICA
- Bruton Tyrosine Kinase Inhibitor Ibrutinib (PCI-32765) Has Significant Activity in Patients With Relapsed/Refractory B-Cell Malignancies
- (2012) Ranjana H. Advani et al. JOURNAL OF CLINICAL ONCOLOGY
- MYD88 Somatic Mutation Is a Genetic Feature of Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type
- (2012) Anne Pham-Ledard et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling
- (2012) Marcus Dühren-von Minden et al. NATURE
- Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics
- (2012) Roland Schmitz et al. NATURE
- MYD88 L265P Somatic Mutation in Waldenström's Macroglobulinemia
- (2012) Steven P. Treon et al. NEW ENGLAND JOURNAL OF MEDICINE
- Activating L265P mutations of the MYD88 gene are common in primary central nervous system lymphoma
- (2011) Manuel Montesinos-Rongen et al. ACTA NEUROPATHOLOGICA
- Is there a role for antigen selection in mantle cell lymphoma? Immunogenetic support from a series of 807 cases
- (2011) A. Hadzidimitriou et al. BLOOD
- SYK inhibition and response prediction in diffuse large B-cell lymphoma
- (2011) S. Cheng et al. BLOOD
- Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765
- (2011) S. E. M. Herman et al. BLOOD
- The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications
- (2011) E. Campo et al. BLOOD
- The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo
- (2011) S. Ponader et al. BLOOD
- The phosphoinositide 3'-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia
- (2011) J. Hoellenriegel et al. BLOOD
- Higher response to lenalidomide in relapsed/refractory diffuse large B-cell lymphoma in nongerminal center B-cell-like than in germinal center B-cell-like phenotype
- (2011) Francisco J. Hernandez-Ilizaliturri et al. CANCER
- Protein Kinase C Inhibitor Sotrastaurin Selectively Inhibits the Growth of CD79 Mutant Diffuse Large B-Cell Lymphomas
- (2011) T. L. Naylor et al. CANCER RESEARCH
- Phase II Study of Dasatinib in Relapsed or Refractory Chronic Lymphocytic Leukemia
- (2011) P. C. Amrein et al. CLINICAL CANCER RESEARCH
- The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85
- (2011) Thomas Oellerich et al. EMBO JOURNAL
- Inhibition of Akt with small molecules and biologics: historical perspective and current status of the patent landscape
- (2011) Margrith E Mattmann et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- BCR and TLR signaling pathways are recurrently targeted by genetic changes in splenic marginal zone lymphomas
- (2011) Q. Yan et al. HAEMATOLOGICA
- Monophosphorylation of CD79a and CD79b ITAM Motifs Initiates a SHIP-1 Phosphatase-Mediated Inhibitory Signaling Cascade Required for B Cell Anergy
- (2011) Shannon K. O'Neill et al. IMMUNITY
- Selective Utilization of Toll-like Receptor and MyD88 Signaling in B Cells for Enhancement of the Antiviral Germinal Center Response
- (2011) Baidong Hou et al. IMMUNITY
- Anergic Responses Characterize a Large Fraction of Human Autoreactive Naive B Cells Expressing Low Levels of Surface IgM
- (2011) T. D. Quach et al. JOURNAL OF IMMUNOLOGY
- The isotype of the BCR as a surrogate for the GCB and ABC molecular subtypes in diffuse large B-cell lymphoma
- (2011) P Ruminy et al. LEUKEMIA
- Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
- (2011) Xose S. Puente et al. NATURE
- Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia
- (2011) Víctor Quesada et al. NATURE GENETICS
- Malignant pirates of the immune system
- (2011) Lixin Rui et al. NATURE IMMUNOLOGY
- SF3B1and Other Novel Cancer Genes in Chronic Lymphocytic Leukemia
- (2011) Lili Wang et al. NEW ENGLAND JOURNAL OF MEDICINE
- Malt1-dependent RelB cleavage promotes canonical NF- B activation in lymphocytes and lymphoma cell lines
- (2011) S. Hailfinger et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The lymph node microenvironment promotes B-cell receptor signaling, NF- B activation, and tumor proliferation in chronic lymphocytic leukemia
- (2010) Y. Herishanu et al. BLOOD
- The Syk inhibitor fostamatinib disodium (R788) inhibits tumor growth in the E - TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell receptor signaling
- (2010) M. Suljagic et al. BLOOD
- PI3K/p110 is a novel therapeutic target in multiple myeloma
- (2010) H. Ikeda et al. BLOOD
- Hepatitis viruses and non-Hodgkin lymphoma: epidemiology, mechanisms of tumorigenesis, and therapeutic opportunities
- (2010) F. Marcucci et al. BLOOD
- Many chronic lymphocytic leukemia antibodies recognize apoptotic cells with exposed nonmuscle myosin heavy chain IIA: implications for patient outcome and cell of origin
- (2010) C. C. Chu et al. BLOOD
- CAL-101, a p110 selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability
- (2010) B. J. Lannutti et al. BLOOD
- Phosphatidylinositol 3-kinase- inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals
- (2010) S. E. M. Herman et al. BLOOD
- Origin of Chromosomal Translocations in Lymphoid Cancer
- (2010) André Nussenzweig et al. CELL
- Molecular underpinning of B-cell anergy
- (2010) Yuval Yarkoni et al. IMMUNOLOGICAL REVIEWS
- Ig gene diversification and selection in follicular lymphoma, diffuse large B cell lymphoma and primary central nervous system lymphoma revealed by lineage tree and mutation analyses
- (2010) N. S. Zuckerman et al. INTERNATIONAL IMMUNOLOGY
- A phase II trial of the oral mTOR inhibitor everolimus in relapsed aggressive lymphoma
- (2010) T E Witzig et al. LEUKEMIA
- Receptors, subcellular compartments and the regulation of peripheral B cell responses: The illuminating state of anergy
- (2010) Marcus R. Clark et al. MOLECULAR IMMUNOLOGY
- Oncogenically active MYD88 mutations in human lymphoma
- (2010) Vu N. Ngo et al. NATURE
- Oligomeric organization of the B-cell antigen receptor on resting cells
- (2010) Jianying Yang et al. NATURE
- Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma
- (2010) R. Eric Davis et al. NATURE
- Critical role of PI3K signaling for NF- B-dependent survival in a subset of activated B-cell-like diffuse large B-cell lymphoma cells
- (2010) B. Kloo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Glycosylation of surface Ig creates a functional bridge between human follicular lymphoma and microenvironmental lectins
- (2010) V. Coelho et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy
- (2010) L. A. Honigberg et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- B-cell signaling networks reveal a negative prognostic human lymphoma cell subset that emerges during tumor progression
- (2010) J. M. Irish et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The PI3K Isoforms p110 and p110 Are Essential for Pre-B Cell Receptor Signaling and B Cell Development
- (2010) F. Ramadani et al. Science Signaling
- PKC is essential for the development of chronic lymphocytic leukemia in the TCL1 transgenic mouse model: validation of PKC as a therapeutic target in chronic lymphocytic leukemia
- (2009) C. Holler et al. BLOOD
- B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: specific targeting with a novel spleen tyrosine kinase inhibitor, R406
- (2009) M. P. Quiroga et al. BLOOD
- Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia
- (2009) J. W. Friedberg et al. BLOOD
- PI3 Kinase Signals BCR-Dependent Mature B Cell Survival
- (2009) Lakshmi Srinivasan et al. CELL
- Suppression of Phosphatidylinositol 3,4,5-Trisphosphate Production Is a Key Determinant of B Cell Anergy
- (2009) Cecille D. Browne et al. IMMUNITY
- The molecular assembly and organization of signaling active B-cell receptor oligomers
- (2009) Pavel Tolar et al. IMMUNOLOGICAL REVIEWS
- Tyrosine kinases and their substrates in B lymphocytes
- (2009) Tomohiro Kurosaki et al. IMMUNOLOGICAL REVIEWS
- Bruton’s tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain
- (2009) Abdalla J. Mohamed et al. IMMUNOLOGICAL REVIEWS
- Multiple layers of B cell memory with different effector functions
- (2009) Ismail Dogan et al. NATURE IMMUNOLOGY
- Essential function for the GTPase TC21 in homeostatic antigen receptor signaling
- (2009) Pilar Delgado et al. NATURE IMMUNOLOGY
- Essential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma
- (2009) S. Hailfinger et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Developmental toxicity associated with receptor tyrosine kinase Ret inhibition in reproductive toxicity testing
- (2008) George R. Clemens et al. BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY
- Mouse models of non-Hodgkin lymphoma reveal Syk as an important therapeutic target
- (2008) R. M. Young et al. BLOOD
- Inhibition of constitutive and BCR-induced Syk activation downregulates Mcl-1 and induces apoptosis in chronic lymphocytic leukemia B cells
- (2008) S Gobessi et al. LEUKEMIA
- Unknown
- (2008) Rosa Catera et al. MOLECULAR MEDICINE
- T cell antigen receptor stimulation induces MALT1 paracaspase–mediated cleavage of the NF-κB inhibitor A20
- (2008) Beatrice Coornaert et al. NATURE IMMUNOLOGY
- The proteolytic activity of the paracaspase MALT1 is key in T cell activation
- (2008) Fabien Rebeaud et al. NATURE IMMUNOLOGY
- Is NF-κB a good target for cancer therapy? Hopes and pitfalls
- (2008) Véronique Baud et al. NATURE REVIEWS DRUG DISCOVERY
- PI3K pathway alterations in cancer: variations on a theme
- (2008) T L Yuan et al. ONCOGENE
- Oncogenic CARD11 Mutations in Human Diffuse Large B Cell Lymphoma
- (2008) G. Lenz et al. SCIENCE
- A phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory mantle cell lymphoma
- (2007) F. Morschhauser et al. ANNALS OF ONCOLOGY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search