2019年发表

Nucleic acid medicines as green novel anticancer drugs

作者: -

发表期刊: Nucleic Acids as Gene Anticancer Drug Delivery Therapy

2018年发表

Applications of gold nanoparticles in medicine and therapy

gold nanoparticles medicine therapy Applications

作者: Loutfy H Madkour

发表期刊: Pharmacy & Pharmacology International Journal

论文简介:

The stability and dispersity of AuNMs in solution play a key role for the many applications. Most inorganic nanomaterials are not well dispersed in physiological buffers and require function-alization by thiols or surfactants to offer the stabilization forces. Furthermore, suficient blood circulation time is critical for both imaging and in vivo drug delivery. Localized surface Plasmon resonance (LSPR) is one of the most signiicant features of AuNMs. The AuNMs as reporters have been broadly applied into lateral low immunechromatographicalassay (LFICA) and enzyme-linked immunosorbent assay (ELISA), which is a well-established technology for analysis of the target analytes in food safety, clinical diagnosis, environmental monitoring, and medical science and so on. Au based nanomaterials (AuNMs) are known to possess many attractive features such as unique electrical, optical and catalytic properties as well as excellent biocompatibility. In this review, we summarize the current advancement on application of AuNMs in analytical sciences based on their local surface plasmon resonance, luorescence and electrochemistry properties. AuNMs based imaging and therapy in biomolecules is explained. As one of the most reliable imaging modes, computed tomography (CT), X-ray and SERS imaging has been widely used owing to its high spatial and density resolution. We end the review by a discussion of the conjugation between gold nanoparticles with other kinds of nanoparticles such as other metals and carbon nano structures. Finally, future development in this research area is also prospected.

2018年发表

Biogenic– Biosynthesis Metallic Nanoparticles (MNPs) for Pharmacological, Biomedical and Environmental Nanobiotechnological Applications

Biogenic– Biosynthesis Metallic Nanoparticles Pharmacological Nanobiotechnological Applications

作者: Loutfy H. Madkour

发表期刊: Chronicles of Pharmaceutical Science

论文简介:

Abstract In future, the biogenic– biosynthesis MNPs have wide perspective synthesis in healthcare, sustainable and renewable energy and other commercial products. MNPs produced by nanotechnology have received global attention due to their extensive applications in the biomedical and physiochemical fields. Biomolecules present in live plants, plant extracts and microorganisms such as: bacteria, fungi, seaweeds, actinomycetes, algae and microalgae can be used to reduce metal ions to MNPs in a single-step and green synthesis process. Biological green synthesis of MNPs has been always beneficial, more economical, energy efficient and eco-friendly approach, which is free of toxic contaminates as required in therapeutic applications. The biosynthesis reduction of metal ion to base metal is quite rapid, readily conducted at room temperature, pressure and easily scaled up. The reducing agents involved include the various water-soluble plant metabolites (e.g. alkaloids, phenolic compounds, terpenoids, flavonoids, saponins, steroids, tannins and other nutritional compounds) and co-enzymes. The polysaccharides, proteins and lipids present in the algal membranes act as capping agents and thus limit the use of non-biodegradable commercial surfactants, which are difficult to remove after the synthesis of MNPs. Metallic nanoparticles viz. cobalt, copper, silver, gold, platinum, zirconium, palladium, iron, cadmium and metal oxides such as titanium oxide, zinc oxide, magnetite, etc. have been the particular focus of green biosynthesis. Here we review the methods of making MNPs using plants extracts and microorganisms. Methods of particle characterization, biomedical and environmental applications of MNPs are reviewed. In the near future, the application of clean, non-toxic, and ecofriendly nanostructured material will be possible in industry and biomedicine. Volume 2 • Issue 1 • 2018 Page 384 to 444 Keywords: Biogenic–Biosynthesis; MNPs; Plant extracts; Microorganisms; Pharmacological; Biomedical; Commercial applications

2018年发表

Toxic Effects of Environmental Heavy Metals on Cardiovascular Pathophysiology and Heart Health Function: Chelation Therapeutics

Toxic Effects Heavy Metals Cardiovascular Pathophysiology Heart Health Function

作者: Loutfy H. Madkour

发表期刊: LAMBART Academic Publishing

论文简介:

The mobilization of heavy metals by man through extraction from ores and processing for different applications has led to the release of these elements into the environment. Since heavy metals are non-biodegradable, they accumulate in the environment and subsequently contaminate the food chain. This contamination poses a risk to environmental and human health. Heavy metals are strongly implicated in atherosclerotic heart disease. There is many evidence supporting toxic xenobiotic heavy metals as an emerging cardiovascular risk factor. In this review, we will summarize the evidence for the four toxic xenobiotic heavy metals such as lead, cadmium, mercury and arsenic that are chelated most effectively by edentate (EDTA) disodium and that have convincing published reports documenting their cardiovascular toxicity ranked priority, as environmental chemicals of concern by the Agency for Toxic Substances and Disease Registry. The metabolic effects of heavy metals and hypothetical mechanisms of metal toxicity are discussed. Standard therapies involving treatment with EDTA and curcumin as chelating agent for heavy metals are given. EDTA normalizes the distribution of most metallic elements in the body. There is a relationship between heavy metals to the blood pressure and cholesterol level as a risk factor of myocardial infraction, coronary or cardiovascular disease. Xenobiotic heavy metals (Pb, As, Hg and Cd deplete glutathione and protein-bound sulfhydryl groups, resulting in the production of reactive oxygen species as superoxide ion, hydrogen peroxide and hydroxyl radical (O2.-, H2O2,. OH, OH-), consequence, enhanced lipid …

2018年发表

Understanding the corrosion behavior of amorphous multiple-layer carbon coating

Understanding corrosion behavior amorphous multiple carbon coating

作者: Loutfy H Madkour

发表期刊: AIP Conference Proceedings Volume 1955 Issue 1 Pages 020001

论文简介:

The corrosion behavior of multiple-layer carbon coating that contained hydrogen, fluorine and silicon, possessed dual amorphous structure with sutured interfaces was investigated using potentiodynamic polarization and electrochemical impedances (ETS) in 3.5 wt.% NaCl solution. The coating exhibited good resistance to corrosion in 3.5 wt.% NaCl solution due to its amorphous and dense structures. REFERENCES 1.N.W. Khun, E. Liu, and X.T. Zeng. Corrosion behavior of nitrogen doped diamond-like carbon thin films in NaCl solutions. Corros. Sci. 51 (2009) 9, 2158–2164.https://doi.org/10.1016/j.corsci.2009.05.050 Google ScholarCrossref 2.K. Enke, H. Dimigen, and H. Hübsch. Frictional properties of diamondlike carbon layers. Appl. Phys. Lett. 36 (1980) 4, 291–292.https://doi.org/10.1063/1.91465 Google ScholarCrossref 3.L.X. Liu and E. Liu. Nitrogenated diamond-like carbon films for metal tracing. Surf. Coat. Technol. 198 (2005) 1, 189–193.https://doi.org/10.1016/j.surfcoat.2004.10.031 Google ScholarCrossref 4.A. Zeng, E. Liu, T.F. Annergren, et al ETS capacitance diagnosis of nanoporosity effect on the corrosion protection of DLC films. Diamond Relat. Mater. 11 (2002) 2, 160–168.https://doi.org/10.1016/S0925-9635(01)00568-4 Google ScholarCrossref 5.J. Choi, M. Kawaguchi, T. Kato, et al Deposition of Si-DLC film and its microstructural, tribological and corrosion properties. Mcrosys. Technol. 13 (2007) 8, 1353–1358.https://doi.org/10.1007/s00542-006-0368-8 Google ScholarCrossref 6.R. Sharma, P.K. Barhai, and N. Kumari. Corrosion resistant behaviour of DLC films. Thin Solid Films 516 (2008) 16, 5397–5403.https://doi.org/10.1016/j.tsf.2007.07.099 Google ScholarCrossref 7.R.H. Zhang, J. Liang, and Q. Wang. Preparation and characterization of graphite-dispersed styrene-acrylic emulsion composite coating on magnesium alloy. Appl. Surf. Sci. 258 (2012) 10, 4360–4364.https://doi.org/10.1016/j.apsusc.2011.12.113 Google ScholarCrossref 8.N. Zulfareen, K. Kannan, T. Venugopal, et al Synthesis, characterization and corrosion inhibition efficiency of N-(4-(Morpholinomethyl Carbamoyl Phenyl) Furan-2-Carboxamide for brass in HCl medium. Arab. J. Chem. 9 (2016) 1, 121–135.https://doi.org/10.1016/j.arabjc.2015.08.023 Google ScholarCrossref

2018年发表

Computational, Monte Carlo simulation and experimental studies of some arylazotriazoles (AATR) and their copper complexes in corrosion inhibition process

Monte Carlo simulation corrosion experimental studies arylazotriazoles (AATR) copper complexes

作者: Loutfy H. Madkour

发表期刊: Journal of Molecular Liquids Volume 260, 15 June 2018, Pages 351-374

论文简介:

The inhibition properties of three synthesized 3-(-arylazo)-l, 2, 4-triazole (AATR) derivatives were investigated for copper corrosion in aerated 0.5 M HNO3 acid using potentiodynamic polarization, cyclic voltammetry, and spectrophotometric measurements. DFT calculations and Monte Carlo simulation are applied to further explain the anti-corrosion mechanism. Quantum chemical indexes, are performed using DFT/B3LYP methods with SDD, 6-31++G (d,p) and 6-31 G basis sets in gas and aqueous phase. The inhibitors can be adsorbed onto surfaces by both physical and chemical means obeys Langmuir and that of El-Awady adsorption isotherm. Potentiodynamic polarization curves revealed that AATRs behave as mixed-type inhibitors. Both thermodynamic and kinetic: (Kads, ∆G°ads, A, 1/y, Ea, ∆H°a and ∆S°a) parameters were determined and discussed. The adsorption behaviour of the AATR derivatives on Cu (111) surface was investigated by Monte Carlo simulation in the presence of water to verify their corrosion inhibition efficacies. The results showed that AATRs were good inhibitors and the inhibition efficiency increased with increasing of their concentration but decreased with rising temperature. The high IE (%) is due primarily to the adsorption behaviour of both free ligand inhibitor, together with overlapping chelate [Cu (I) and Cu (II)-AATR] complex molecules in the ratio (1:1) and/or (1:2) depending on concentration. DFT calculations and Monte Carlo simulation indicate that the order of IE (%) is: AATR_3 ≅ AATR_2 > AATR_1. The theoretical results were found to be consistent with the experimental data reported.

2018年发表

Experimental and Theoretical Investigation of Thiazolyl Blue as a Corrosion Inhibitor for Copper in Neutral Sodium Chloride Solution

Thiazolyl Blue Corrosion Inhibitor Copper Sodium Chloride

作者: Loutfy H. Madkour

发表期刊: Materials 2018, 11(6), 1042; https://doi.org/10.3390/ma11061042

论文简介:

The anticorrosion effect of thiazolyl blue (MTT) for copper in 3% NaCl at 298 K was researched by electrochemical methods, scanning electron-microscopy (SEM), and atomic force microscopy (AFM). The results reveal that MTT can protect copper efficiently, with a maximum efficiency of 95.7%. The corrosion inhibition mechanism was investigated by X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectral (FT-IR), and theoretical calculation. The results suggest that the MTT molecules are adsorbed on metal surface forming a hydrophobic protective film to prevent copper corrosion. It also indicates that the MTT and copper form covalent bonds. The molecular dynamic simulation further gives the evidence for adsorption. The adsorption isotherm studies demonstrate that a spontaneous, mixed physical and chemical adsorption occurs, which obeys Langmuir adsorption isotherm. The present research can help us better understand the corrosion inhibition process and improve it. Keywords: corrosion; copper; electrochemistry; XPS; molecular simulation

2018年发表

"Toxic Effects of Environmental Heavy Metals on Cardiovascular Pathophysiology and Heart Health Function: Chelation Therapeutics Loutfy H. Madkour"

作者: Loutfy H. Madkour

发表期刊: LAP Lambert Academic Publishing ( 2018-10-15 )

论文简介:

Thirty-five metals pose a threat to human health, 23 of which are heavy metals [1]. Studies report various effects of heavy metals in drinking water [2,3]. According to the International Agency for Research on Cancer (IARC), inorganic As and Cd are classified as human carcinogens [4]. Heavy metal toxicity is an important consideration in medical workups, at very high levels, most heavy metals can cause health problems for which no cause or solution has been found. Heavy metals are continuously released into the terrestrial environment by natural sources and human activities, accumulate in the environment and subsequently contaminate the food chain. Book Details: ISBN-13: 978-613-9-92290-1 ISBN-10: 6139922909 EAN: 9786139922901 Book language: English By (author) : Loutfy H. Madkour Number of pages: 84 Published on: 2018-10-15 Category: Medicine

2018年发表

Toxic Effects of Environmental Heavy Metals on Cardiovascular Pathophy Paperback – 15 Oct. 2018 by Loutfy H. Madkour (Author)

Toxic Effects Heavy Metals Cardiovascular Pathophy

作者: Loutfy H. Madkour

发表期刊: Publisher ‏ : ‎ LAP LAMBERT Academic Publishing (15 Oct. 2018)

论文简介:

Thirty-five metals pose a threat to human health, 23 of which are heavy metals [1]. Studies report various effects of heavy metals in drinking water [2,3]. According to the International Agency for Research on Cancer (IARC), inorganic As and Cd are classified as human carcinogens [4]. Heavy metal toxicity is an important consideration in medical workups, at very high levels, most heavy metals can cause health problems for which no cause or solution has been found. Heavy metals are continuously released into the terrestrial environment by natural sources and human activities, accumulate in the environment and subsequently contaminate the food chain.

2018年发表

Experimental and theoretical investigations of some pyrazolo-pyrimidine derivatives as corrosion inhibitors on copper in sulfuric acid solution

作者: Yue Xu, Shengtao Zhang, Wenpo Li, Lei Guo, Shenying Xu, Li Feng, Loutfy H. Madkour

发表期刊: Applied Surface Science