2023年发表

Anticorrosive Carbon-Based Polymer and Epoxy Nanocomposite Coatings

Anticorrosive Carbon-Based Polymer and Epoxy Nanocomposite Coatings

作者: Loutfy Madkour

发表期刊: Handbook of Research on Corrosion Sciences and Engineering

论文简介:

Carbon is used as a reinforcing phase in carbon-fiber reinforced polymer composites employed in aeronautical and other technological applications. Degradation of composite occurs under polarization in aqueous media. Epoxy-based coatings have gained significant research interest owing to sufficient hydrophobicity, conductivity, water transport behaviour, and corrosion resistance. Furthermore, the anti-corrosive polymer coatings with low nanotube content have shown enhanced surface hydrophobicity and anti-rusting properties in addition to strength, conductivity, and thermal resistance. Also, polymer base coatings assessing the strength of bonding of the coating to the substrate, and salt spray test are common. This book chapter highlights the potential corrosion challenges in multi-material combinations containing carbon-fiber reinforced polymers, the surface chemistry of carbon, its plausible effects on the electrochemical activity of carbon, and consequently the degradation processes on carbon-fiber reinforced polymers.

2023年发表

Graphitic Carbon Nitride Quantum Dots (g-C3N4): Fundamentals and Applications

g-C3N4) Graphitic Carbon Nitride Quantum Dots Fundamentals and Applications

作者: Loutfy H. Madkour

发表期刊: International Research Journal of Basic and Clinical Studies Vol. 8(4) pp. 1-14, August, 2023

论文简介:

As a novel C and N based two-dimensional material, graphitic carbon nitride quantum dots (g-C3N4) QDsis regarded as a new generation of photocatalyst and has been widely used in the field of environmentalphotocatalysis. In recent years, graphitic carbon nitride has become one of the very exciting sustainablematerials, due to its unusual properties and promising applications as a heterogeneous catalyst in water splittingand organic contaminant degradation. A variety of modifications have been reported for this nanostructuredmaterial with the use of carbonaceous materials to enhance its potential applications. Carbon nitrides (C3N4)are renowned organic semiconductors with a band gap of 2.7 eV, which are connected via tri-s-triazine-basedforms. Graphitic carbon nitride (g-C3N4) is considered as an attractive, efficient and newly generated promisingvisible light–driven photocatalyst ascribable material owing to its distinct properties such as metal free, suitableband gap, chemical inertness and high physicochemical stability. Nevertheless, the photocatalytic activity ofpure g-C3N4 was limited by the fast recombination rate of photoinduced electron–hole pairs, poor photoexcitedcharge separation, limited range of visible light absorption and relatively low specific surface area. Enhancedphotocatalytic activity is achievable by the construction of homojunction nanocomposites to reduce the undesiredrecombination of photogenerated charge carriers. The formed g-C3N4 isotype heterojunction photocatalystmanifested significant improvement photocatalytic hydrogen production than the single and pure g-C3N4 sample.This significant enhanced photocatalytic performance is mainly ascribed to inhibited recombination, enrichedactive site and enlarged specific surface area. Hence, current chapter on g-C3N4 mainly focuses on basics,properties, and fundamentals of its synthesis and its applications with an aim to improving its photocatalyticperformance. In this chapter, the background of photocatalysis, mechanism of photocatalysis, and the severalresearches on the heterostructure graphitic carbon nitride (g-C3N4) semiconductor are discussed. This researchgives a useful knowledge on the heterostructure g-C3N4 and their photocatalytic mechanisms and applications.Finally, the challenges and future research directions of g-C3N4 photocatalysts are summarized to promotetheir environmental applications. The advantages of the heterostructure g-C3N4 over their precursors are alsodiscussed. The conclusion and future perspectives on this emerging research direction are given (12) (PDF) Graphitic Carbon Nitride Quantum Dots (g-C3N4): Fundamentals and Applications. Available from: https://www.researchgate.net/publication/373598474_Graphitic_Carbon_Nitride_Quantum_Dots_g-C3N4_Fundamentals_and_Applications?fbclid=IwAR2viFWw99PN-mzYhtx6GWDWFk4klA5nBKs5WhkCQgX9G98kwomA-iCn_6c [accessed Sep 14 2023].

2022年发表

Nanoparticle-Based Drug Delivery in Cancer Treatment

Nanoparticles Drug Delivery Cancer Treatment

作者: Loutfy H. Madkour

发表期刊: Journal Taylor & Francis eBooks

论文简介:

The careful choice of nanoparticles as targets and in drug delivery routes enhances therapeutic efficacy in cancer. Nanoparticle-Based Drug Delivery in Cancer Treatment discusses nanotechnological developments of interfering RNA-based nanoparticles, delivery vehicles, and validated therapeutic RNAi–molecular target interactions and explains the results of clinical and preclinical trials. The book also gives strategies for universal methods of constructing hybrid organic–inorganic nanomaterials that can be widely applied in the biomedical field. Key Features: Reviews recent advances of nanoparticle-mediated siRNA delivery systems and their application in clinical trials for cancer therapy Focuses on material platforms that establish NPs and both localized and controlled gene silencing Emphasizes the most promising systems for clinical application Surveys progress in nanoparticle-based nanomedicine in cancer treatment Describes the most advanced of the nonviral nanocarriers for delivery of oligonucleotides to malignant blood cancer cells This book is a valuable resource for researchers, professors, and students researching drug delivery, gene carriers, cancer therapy, nanotechnology, and nanomaterials.

2022年发表

RNA Delivery Function for Anticancer Therapeutics

RNA Delivery Function Anticancer Therapeutics

作者: Loutfy H. Madkour

发表期刊: Journal Taylor & Francis eBooks

论文简介:

This book presents an overview of the current status of translating the RNAi cancer therapeutics in the clinic, a brief description of the biological barriers in drug delivery, and the roles of imaging in aspects of administration route, systemic circulation, and cellular barriers for the clinical translation of RNAi cancer therapeutics, and with partial content for discussing the safety concerns. It then focuses on imaging-guided delivery of RNAi therapeutics in preclinical development, including the basic principles of different imaging modalities, and their advantages and limitations for biological imaging. With growing number of RNAi therapeutics entering the clinic, various imaging methods will play an important role in facilitating the translation of RNAi cancer therapeutics from bench to bedside. RNAi technique has become a powerful tool for basic research to selectively knock down gene expression in vitro and in vivo. Our scientific and industrial communities have started to develop RNAi therapeutics as the next class of drugs for treating a variety of genetic disorders, such as cancer and other diseases that are particularly hard to address with current treatment strategies. Key Features Provides insight into the current advances and hurdles of RNAi therapeutics. Accelerates RNAi, miRNAs, and siRNA drug development for cancer therapy from bench to bedside. Addresses various modifications and novel delivery strategies for miRNAs, piRNAs and siRNA delivery in anticancer therapeutics. Explores the need for the interaction of hematologists, cell biologists, immunologists, and material scientists in the development of novel cancer therapies. Describes the …

2022年发表

RNA Delivery Function for Anticancer Therapeutics (Nanotechnology for Drugs, Vaccines and Smart Delivery Systems)

RNA Delivery Function Anticancer Therapeutics Nanotechnology for Drugs Vaccines and Smart

作者: Loutfy H. Madkour

发表期刊: Publisher ‏ : ‎ CRC Press; 1st edition (25 Jan. 2022)

论文简介:

This book presents an overview of the current status of translating the RNAi cancer therapeutics in the clinic, a brief description of the biological barriers in drug delivery, and the roles of imaging in aspects of administration route, systemic circulation, and cellular barriers for the clinical translation of RNAi cancer therapeutics, and with partial content for discussing the safety concerns. It then focuses on imaging-guided delivery of RNAi therapeutics in preclinical development, including the basic principles of different imaging modalities, and their advantages and limitations for biological imaging. With growing number of RNAi therapeutics entering the clinic, various imaging methods will play an important role in facilitating the translation of RNAi cancer therapeutics from bench to bedside. RNAi technique has become a powerful tool for basic research to selectively knock down gene expression in vitro and in vivo. Our scientific and industrial communities have started to develop RNAi therapeutics as the next class of drugs for treating a variety of genetic disorders, such as cancer and other diseases that are particularly hard to address with current treatment strategies. Key Features　 Provides　insight　into　the　current　advances　and　hurdles　of　RNAi　therapeutics.　　 Accelerates　RNAi,　miRNAs, and siRNA　drug　development　for cancer therapy　from　bench　to　bedside.　 Addresses　various modifications and　novel　delivery　strategies for miRNAs,　piRNAs　and siRNA delivery　in　anticancer therapeutics.　　 Explores the need for the interaction　of　hematologists,cell　biologists,　immunologists, and material　scientists　in the development of 　novel　cancer therapies. Describes the　current status　of clinical trials related to miRNA and siRNA-based cancer therapy　 Presents　remaining issues that need to be overcome to establish　successful therapies.　

2022年发表

Nanoparticle-Based Drug Delivery in Cancer Treatment (Nanotechnology for Drugs, Vaccines and Smart Delivery Systems)

Nanoparticles Drug Delivery Cancer Treatment Nanotechnology

作者: Loutfy H. Madkour

发表期刊: Publisher CRC Press

论文简介:

The careful choice of nanoparticles as targets and in drug delivery routes enhances therapeutic efficacy in cancer. Nanoparticle-Based Drug Delivery in Cancer Treatment discusses nanotechnological developments of interfering RNA-based nanoparticles, delivery vehicles, and validated therapeutic RNAi–molecular target interactions and explains the results of clinical and preclinical trials. The book also gives strategies for universal methods of constructing hybrid organic–inorganic nanomaterials that can be widely applied in the biomedical field. Key Features: Reviews recent advances of nanoparticle-mediated siRNA delivery systems and their application in clinical trials for cancer therapy Focuses on material platforms that establish NPs and both localized and controlled gene silencing Emphasizes the most promising systems for clinical application Surveys progress in nanoparticle-based nanomedicine in cancer treatment Describes the most advanced of the nonviral nanocarriers for delivery of oligonucleotides to malignant blood cancer cells This book is a valuable resource for researchers, professors, and students researching drug delivery, gene carriers, cancer therapy, nanotechnology, and nanomaterials.

2022年发表

Pharmacogenomics-Synergistic Strategies Using a Chimerical Peptide for Enhanced Chemotherapy Based on ROS and DNA Nanosystem

positive feedback strategy ROS-responsive drug delivery mesoporous silica nanoparticle

作者: Loutfy H. Madkour

发表期刊: Biotechnology and Bioprocessing. 3(2): DOI: 10.31579/2766-2314/071

论文简介:

Co-delivery of gene and drug for synergistic therapy has provided a promising strategy to cure devastating diseases. The use of genomic predictors of response to cisplatin and pemetrexed can be incorporated into strategies to optimize therapy for advanced solid tumors. Here, a positive feedback strategy was utilized to amplify the concentration of intracellular reactive oxygen species (ROS) and a ROS-triggered self-accelerating drug release nanosystem (defined as T/D@RSMSNs) was demonstrated for enhanced tumor chemotherapy. It was found that in human breast cancer (MCF-7) cells, T/D@RSMSNs could not only release DOX and a-TOS initiatively, but also lead to increased concentration of intracellular ROS, which could be used as new trigger to cut away TK linkage and then in turn facilitate the further release of DOX for enhanced chemotherapy. Standard treatment for advanced non–small-cell lung cancer (NSCLC) includes the use of a platinum-based chemotherapy regimen. This novel ROS triggered self-accelerating drug release nanosystem with remarkably improved therapeutic effects could provide a general strategy to branch out the applications of existing ROS-responsive drug delivery systems (DDSs).

2022年发表

BOOK: RNA Delivery Function for Anticancer Therapeutics ByLoutfy H. Madkour

Cancer Epigenetic Mechanisms Circulating MiRNAs Therapeutic Targets and Novel DNA-Damaging Cancer Therapies

作者: Loutfy H. Madkour

发表期刊: CRC Press

论文简介:

This book presents an overview of the current status of translating the RNAi cancer therapeutics in the clinic, a brief description of the biological barriers in drug delivery, and the roles of imaging in aspects of administration route, systemic circulation, and cellular barriers for the clinical translation of RNAi cancer therapeutics, and with partial content for discussing the safety concerns. It then focuses on imaging-guided delivery of RNAi therapeutics in preclinical development, including the basic principles of different imaging modalities, and their advantages and limitations for biological imaging. With growing number of RNAi therapeutics entering the clinic, various imaging methods will play an important role in facilitating the translation of RNAi cancer therapeutics from bench to bedside. RNAi technique has become a powerful tool for basic research to selectively knock down gene expression in vitro and in vivo. Our scientific and industrial communities have started to develop RNAi therapeutics as the next class of drugs for treating a variety of genetic disorders, such as cancer and other diseases that are particularly hard to address with current treatment strategies. Key Features　 Provides　insight　into　the　current　advances　and　hurdles　of　RNAi　therapeutics.　　 Accelerates　RNAi,　miRNAs, and siRNA　drug　development　for cancer therapy　from　bench　to　bedside.　 Addresses　various modifications and　novel　delivery　strategies for miRNAs,　piRNAs　and siRNA delivery　in　anticancer therapeutics.　　 Explores the need for the interaction　of　hematologists,cell　biologists,　immunologists, and material　scientists　in the development of 　novel　cancer therapies. 　 Describes the　current status　of clinical trials related to miRNA and siRNA-based cancer therapy　 Presents　remaining issues that need to be overcome to establish　successful therapies.　

2022年发表

BOOK: Nanoparticle-Based Drug Delivery in Cancer Treatment

Bioscience Engineering Technology Cancer

作者: Loutfy H. Madkour

发表期刊: CRC Press

论文简介:

The careful choice of nanoparticles as targets and in drug delivery routes enhances therapeutic efficacy in cancer. Nanoparticle-Based Drug Delivery in Cancer Treatment discusses nanotechnological developments of interfering RNA-based nanoparticles, delivery vehicles, and validated therapeutic RNAi–molecular target interactions and explains the results of clinical and preclinical trials. The book also gives strategies for universal methods of constructing hybrid organic–inorganic nanomaterials that can be widely applied in the biomedical field.

2022年发表

Auranofin and Baicalin Inhibit Clostridioides difficile Growth and Sporulation: An In vitro Study

作者: Lamiaa A. Madkour

发表期刊: Journal of Pure and Applied Microbiology