Article
Multidisciplinary Sciences
Sook-Kyoung Heo, Eui-Kyu Noh, Hye Jin Seo, Yoo Jin Lee, SuJin Koh, Young Joo Min, Yunsuk Choi, Jae-Cheol Jo
Summary: Radotinib has been shown to induce apoptosis and inhibit cell proliferation in multiple myeloma cells by suppressing the activity and expression of STAT3 and JAK2 proteins. It also inhibits the growth of MM cells and related signaling proteins, making it a potential candidate for MM treatment.
Article
Biochemistry & Molecular Biology
Lan Yang, Le Ma, Qiang Gong, JiePing Chen, Qilin Huang
Summary: This study found that CARM1 is overexpressed in multiple myeloma (MM) and closely associated with poor prognosis. Knockdown of CARM1 inhibited the proliferation of MM cell lines and altered the cell cycle. RNA-seq analysis revealed the association of CARM1 with apoptosis and the p53 pathway. Knockdown of CARM1 also increased the sensitivity of MM cells to standard-of-care drugs.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Oncology
Fang Wang, Inge Oudaert, Chenggong Tu, Anke Maes, Arne Van Der Vreken, Philip Vlummens, Elke De Bruyne, Kim De Veirman, Yanmeng Wang, Rong Fan, Ann Massie, Karin Vanderkerken, Peng Shang, Eline Menu
Summary: Multiple myeloma cells obtain proliferative signals from the bone marrow microenvironment through exosomal crosstalk. This study reveals that the expression of system Xc(-) is increased in both bone marrow stromal cells and multiple myeloma cells, which is associated with bortezomib resistance. Glutamate released by system Xc(-) enhances exosome secretion, and the inhibitor of system Xc(-) can reduce bone marrow stromal cell-induced bortezomib resistance and enhance the anti-tumor effects of bortezomib on multiple myeloma cells.
Article
Cell Biology
Kazuya Ishiguro, Hiroshi Kitajima, Takeshi Niinuma, Reo Maruyama, Naotaka Nishiyama, Hitoshi Ohtani, Gota Sudo, Mutsumi Toyota, Hajime Sasaki, Eiichiro Yamamoto, Masahiro Kai, Hiroshi Nakase, Hiromu Suzuki
Summary: The study suggests that dual targeting of EZH2 and G9a in multiple myeloma can effectively inhibit tumor cell proliferation and xenograft formation, offering a promising therapeutic strategy.
CELL DEATH DISCOVERY
(2021)
Article
Cell & Tissue Engineering
Phoebe K. Mondala, Ashni A. Vora, Tianyuan Zhou, Elisa Lazzari, Luisa Ladel, Xiaolin Luo, Youngsoo Kim, Caitlin Costello, A. Robert MacLeod, Catriona H. M. Jamieson, Leslie A. Crews
Summary: In multiple myeloma, the inflammatory and anti-viral pathways play a role in disease progression and the generation of cancer stem cells. The inhibition of interferon regulatory factor 4 (IRF4) using antisense oligonucleotides (ASOs) shows promise in impairing myeloma cell survival and reducing tumor burden in pre-clinical models. Targeting IRF4 may offer a new strategy for preventing myeloma relapse driven by progenitor cells.
Article
Oncology
Aaron Waddell, Iqbal Mahmud, Haocheng Ding, Zhiguang Huo, Daiqing Liao
Summary: Breast cancer is the most common cancer in women globally, with estrogen receptor-positive breast cancer being the most prevalent type and often facing resistance to standard-of-care treatments. The study shows that CBP and p300 inhibitors effectively block estrogen receptor function, offering promising new therapeutic targets for breast cancer treatment by inhibiting ER signaling.
Article
Cell Biology
Zhigang Yi, Tao Ma, Jia Liu, Wenting Tie, Yanhong Li, Jun Bai, Lijuan Li, Liansheng Zhang
Summary: This study found that LGR4 expression was significantly upregulated in multiple myeloma (MM) tissues and cells. Knockdown of LGR4 inhibited MM cell proliferation, promoted apoptosis and cell cycle arrest in G1, while overexpression showed the opposite effect. Mechanistic studies revealed that LGR4 could interact with TGF-beta 1 and activate the TGF-beta 1/Smad signaling pathway, promoting MM progression. LGR4 may be a potential new target for MM diagnosis and treatment.
CELLULAR SIGNALLING
(2023)
Article
Oncology
Alejandra Ortiz-Ruiz, Yanira Ruiz-Heredia, Maria Luz Morales, Pedro Aguilar-Garrido, Almudena Garcia-Ortiz, Antonio Valeri, Carmen Barcena, Rosa Maria Garcia-Martin, Vanesa Garrido, Laura Moreno, Alicia Gimenez, Miguel Angel Navarro-Aguadero, Maria Velasco-Estevez, Eva Lospitao, Maria Teresa Cedena, Santiago Barrio, Joaquin Martinez-Lopez, Maria Linares, Miguel Gallardo
Summary: The study demonstrates the enhanced mitochondrial activity in multiple myeloma (MM) patients is linked to c-Myc expression. Through the mitochondrial inhibitor tigecycline, Myc functionality can be effectively inhibited to combat MM cell proliferation. Mitochondrial activity progressively increases as the disease progresses, and therapeutic targeting of mitochondria shows promising efficacy in overcoming MM growth.
Article
Pharmacology & Pharmacy
Yuxi Zhang, Yi Wang, Yanping Li, Cong Huang, Xiaoqian Xiao, Zhanqiong Zhong, Jingyi Tang, Haolan Lu, Yibei Tang, Jiahui Yang
Summary: In this study, it is shown that dihydroartemisinin (DHA) and artemisinin (AS) inhibit aerobic glycolysis in non-small cell lung cancer (NSCLC) cells through the ERK/c-Myc pathway, leading to the inhibition of tumor growth. This study expands our knowledge of artemisinin derivatives in regulating tumor glucose metabolism and provides a potential strategy for lung cancer therapy.
BIOCHEMICAL PHARMACOLOGY
(2022)
Editorial Material
Hematology
Antonio Sacco, Aldo M. Roccaro
Summary: In this study, it is shown that cyclin-dependent kinase-7 (CDK7) affects the oncogenic programming of multiple myeloma (MM) cells through modulation of MYC and E2F transcription factors. The authors demonstrate that inhibiting CDK7 counteracts E2F activity, resulting in reduced CDKs-retinoblastoma (Rb) axis and inhibition of MYC-regulated metabolic signatures. Therefore, CDK7 inhibition is a promising therapeutic target for MM.
Article
Multidisciplinary Sciences
Caojie Liu, Qiuchan Xiong, Qiwen Li, Weimin Lin, Shuang Jiang, Danting Zhang, Yuan Wang, Xiaobo Duan, Ping Gong, Ning Kang
Summary: This study demonstrates that knockout of CHD7 in bone marrow mesenchymal stem cells (MSCs) and pre-osteoblasts leads to skeletal system development disorder and upregulated PPAR signaling, disrupting the balance of osteogenic and adipogenic differentiation.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Rong Liu, Jie Liu, Ping Wu, Hong Yi, Bin Zhang, Wei Huang
Summary: The study found that FLOT2 can upregulate BCAT1 transcription by maintaining c-Myc expression levels, thereby promoting NPC cell proliferation. FLOT2 and BCAT1 expression in NPC tissues are positively correlated and associated with patient prognosis.
Article
Biochemistry & Molecular Biology
Xin Sun, Jia Yu, Xiaorong Cui, Yujie Tang, Yani Yu
Summary: The expression of USP21 is elevated in ovarian cancer tissues and promotes cell growth and tumor growth. Downregulating USP21 inhibits ovarian cancer growth, while overexpressing USP21 enhances cell proliferation and confers drug resistance.
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2023)
Article
Oncology
Frederic A. Vallejo, Anthony Sanchez, Branko Cuglievan, Winston M. Walters, Guillermo De Angulo, Steven Vanni, Regina M. Graham
Summary: NAMPT has been identified as a potential therapeutic target for high-risk neuroblastoma. Inhibition of NAMPT leads to decreased ATP levels, induced apoptosis, reduced stem cell self-renewal, and blocked tumor growth.
FRONTIERS IN ONCOLOGY
(2022)
Review
Pharmacology & Pharmacy
Omar Al-Odat, Max von Suskil, Robert Chitren, Weam Elbezanti, Sandeep Srivastava, Tulin Budak-Alpddogan, Subash Jonnalagadda, Bharat Aggarwal, Manoj Pandey
Summary: Mcl-1 protein plays a critical role in the progression of multiple myeloma and inhibiting this protein is considered a therapeutic strategy. Remarkable advancements have been made in the development of selective Mcl-1 inhibitors, which can be used as single agents or in combination therapy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Natsumi Suzuki, Masashi Idogawa, Shoichiro Tange, Tomoko Ohashi, Yasushi Sasaki, Hiroshi Nakase, Takashi Tokino
Article
Oncology
Takahiro Yokose, Minoru Kitago, Sachiko Matsuda, Yasushi Sasaki, Yohei Masugi, Yuki Nakamura, Masahiro Shinoda, Hiroshi Yagi, Yuta Abe, Go Oshima, Shutaro Hori, Fujita Yusuke, Yutaka Nakano, Yutaka Endo, Kodai Abe, Takashi Tokino, Yuko Kitagawa
Article
Dermatology
Tokimasa Hida, Masashi Idogawa, Masae Okura, Shintaro Sugita, Taro Sugawara, Yasushi Sasaki, Takashi Tokino, Toshiharu Yamashita, Hisashi Uhara
JOURNAL OF DERMATOLOGY
(2020)
Article
Oncology
Ryosuke Ota, Takeshi Sawada, Sho Tsuyama, Yasushi Sasaki, Hiromu Suzuki, Yasuharu Kaizaki, Kenkei Hasatani, Eiichiro Yamamoto, Hiroyoshi Nakanishi, Satoko Inagaki, Shigetsugu Tsuji, Naohiro Yoshida, Hisashi Doyama, Hiroshi Minato, Keishi Nakamura, Satomi Kasashima, Eiji Kubota, Hiromi Kataoka, Takashi Tokino, Takashi Yao, Toshinari Minamoto
JOURNAL OF PATHOLOGY
(2020)
Editorial Material
Gastroenterology & Hepatology
Takeshi Iwaya, Fumitaka Endo, Fumiaki Takahashi, Takashi Tokino, Yasushi Sasaki, Satoshi S. Nishizuka
Article
Medicine, General & Internal
Kazuya Ishiguro, Yasushi Sasaki, Yoshitake Takagi, Takeshi Niinuma, Hiromu Suzuki, Takashi Tokino, Toshiaki Hayashi, Tohru Takahashi, Tetsuyuki Igarashi, Yoshihiro Matsuno
Article
Multidisciplinary Sciences
Chihiro Udagawa, Yasushi Sasaki, Yasuhiro Tanizawa, Hiroshi Suemizu, Yasuyuki Ohnishi, Yasukazu Nakamura, Takashi Tokino, Hitoshi Zembutsu
Article
Multidisciplinary Sciences
Naoki Tanimizu, Norihisa Ichinohe, Yasushi Sasaki, Tohru Itoh, Ryo Sudo, Tomoko Yamaguchi, Takeshi Katsuda, Takafumi Ninomiya, Takashi Tokino, Takahiro Ochiya, Atsushi Miyajima, Toshihiro Mitaka
Summary: The study reports the generation of a hepatobiliary tubular organoid (HBTO) using mouse hepatocyte progenitors and cholangiocytes, which can reproduce the functional connection between hepatocytes and cholangiocytes in liver tissue.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Ryosuke Fujisawa, Takeshi Iwaya, Fumitaka Endo, Masashi Idogawa, Noriyuki Sasaki, Hayato Hiraki, Shoichiro Tange, Tomomi Hirano, Yuka Koizumi, Masakazu Abe, Tomoko Takahashi, Mizunori Yaegashi, Yuji Akiyama, Mari Masuda, Akira Sasaki, Fumiaki Takahashi, Yasushi Sasaki, Takashi Tokino, Satoshi S. Nishizuka
Summary: Early changes in circulating tumor DNA (ctDNA) following the first cycle of chemotherapy accurately predict later treatment responses in esophageal squamous cell cancer (ESCC) patients. The study shows that the dynamics of ctDNA can better predict total volume reductions and overall survival rates in ESCC patients.
Article
Biochemistry & Molecular Biology
Tae Oike, Yoshihito Sekiguchi, Yuya Yoshimoto, Takahiro Oike, Ken Ando, Wenchao Gu, Yasushi Sasaki, Takashi Tokino, Akira Iwase, Tatsuya Ohno
Summary: Simultaneous mutations in KRAS and SMAD4 may be associated with radioresistance in cervical cancer, and carbon ion radiotherapy could be a potential treatment option for these cases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Yui Hatanaka, Takeshi Niinuma, Hiroshi Kitajima, Koyo Nishiyama, Reo Maruyama, Kazuya Ishiguro, Mutsumi Toyota, Eiichiro Yamamoto, Masahiro Kai, Akira Yorozu, Shohei Sekiguchi, Kazuhiro Ogi, Hironari Dehari, Masashi Idogawa, Yasushi Sasaki, Takashi Tokino, Akihiro Miyazaki, Hiromu Suzuki
Summary: DLEU1, an overexpressed lncRNA, exerts oncogenic effects in oral squamous cell carcinoma by activating a series of interferon-stimulated genes (ISGs).
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Ryunosuke Kogo, Tomomi Manako, Takeshi Iwaya, Satoshi Nishizuka, Hayato Hiraki, Yasushi Sasaki, Masashi Idogawa, Takashi Tokino, Ayaka Koide, Noritaka Komune, Ryuji Yasumatsu, Takashi Nakagawa
Summary: This study investigates the role of individualized ctDNA analysis in monitoring treatment response and relapse in HNSCC patients. Mutation analysis of tumor and peripheral blood DNA reveals TP53 as the most frequently mutated gene, and the persistence of ctDNA positivity or reversion to positivity is associated with relapse. Patients who remain ctDNA negative have a better prognosis compared to those who become ctDNA positive.
Article
Gastroenterology & Hepatology
Yoshiharu Masaki, Noriyuki Akutsu, Yasushi Adachi, Keisuike Ishigami, Norikazu Iwata, Takao Endo, Yoshifumi Ishii, Yasushi Sasaki, Minoru Nagayama, Yasutoshi Kimura, Hiroshi Nakase
Summary: Intrahepatic mucinous cholangiocarcinoma (IHMC) is a rare and aggressive tumor. This study presents the clinicopathological characteristics, treatment, disease progression, and autopsy findings of a 70-year-old male patient with IHMC. The molecular carcinogenesis of IHMC may differ from that of ordinary cholangiocarcinoma and requires further investigation.
CLINICAL JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Oncology
Yasush Adachi, Masanori Nojima, Mitsuru Mori, Toshiyuki Kubo, Noriyuki Akutsu, Yasushi Sasaki, Hiroshi Nakase, Yingsong Lin, Youichi Kurozawa, Kenji Wakai, Akiko Tamakoshi
Summary: This study analyzed the association between serum sFas levels and the incidence of liver cancer. The results showed that high levels of sFas were associated with an increased risk of liver cancer. These findings suggest that sFas may serve as a biomarker for assessing liver cancer risk.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Oncology
Yuya Yoshimoto, Yasushi Sasaki, Kazutoshi Murata, Shin-ei Noda, Yuhei Miyasaka, Junko Hamamoto, Mio Furuya, Junko Hirato, Yoshiyuki Suzuki, Tatsuya Ohno, Takashi Tokino, Takahiro Oike, Takashi Nakano
GYNECOLOGIC ONCOLOGY
(2020)