Generation of functional liver organoids on combining hepatocytes and cholangiocytes with hepatobiliary connections ex vivo

Human Pluripotent Stem Cell-Derived Organoids as Models of Liver Disease

(2020) Muhammad Nadzim Bin Ramli et al.   GASTROENTEROLOGY

Generation of hepato-biliary organoids from human induced pluripotent stem cells

(2019) Fenfang Wu et al.   JOURNAL OF HEPATOLOGY

Spatial heterogeneity in the mammalian liver

(2019) Shani Ben-Moshe et al.   Nature Reviews Gastroenterology & Hepatology

Generation of human hepatic progenitor cells with regenerative and metabolic capacities from primary hepatocytes

(2019) Takeshi Katsuda et al.   eLife

Self-assembled liver organoids recapitulate hepatobiliary organogenesis in vitro

(2018) Dipen Vyas et al.   HEPATOLOGY

Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids

(2018) Huili Hu et al.   CELL

Inflammatory Cytokine TNFα Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture

(2018) Weng Chuan Peng et al.   CELL

Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration

(2017) Alexander Raven et al.   NATURE

Massive and Reproducible Production of Liver Buds Entirely from Human Pluripotent Stem Cells

(2017) Takanori Takebe et al.   Cell Reports

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

Intrahepatic bile ducts are developed through formation of homogeneous continuous luminal network and its dynamic rearrangement in mice

(2016) Naoki Tanimizu et al.   HEPATOLOGY

Liver Progenitors Isolated from Adult Healthy Mouse Liver Efficiently Differentiate to Functional Hepatocytes In Vitro and Repopulate Liver Tissue

(2016) Naoki Tanimizu et al.   STEM CELLS

Mfsd2a+ hepatocytes repopulate the liver during injury and regeneration

(2016) Wenjuan Pu et al.   Nature Communications

Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer

(2015) Joan Font-Burgada et al.   CELL

Self-renewing diploid Axin2+ cells fuel homeostatic renewal of the liver

(2015) Bruce Wang et al.   NATURE

Generation of stomach tissue from mouse embryonic stem cells

(2015) Taka-aki K. Noguchi et al.   NATURE CELL BIOLOGY

Bipotential Adult Liver Progenitors Are Derived from Chronically Injured Mature Hepatocytes

(2014) Branden D. Tarlow et al.   Cell Stem Cell

Sry HMG Box Protein 9-positive (Sox9+) Epithelial Cell Adhesion Molecule-negative (EpCAM−) Biphenotypic Cells Derived from Hepatocytes Are Involved in Mouse Liver Regeneration

(2014) Naoki Tanimizu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Robust cellular reprogramming occurs spontaneously during liver regeneration

(2013) K. Yanger et al.   GENES & DEVELOPMENT

Vascularized and functional human liver from an iPSC-derived organ bud transplant

(2013) Takanori Takebe et al.   NATURE

Isolation, culture and genetic manipulation of mouse pancreatic ductal cells

(2013) Maximilian Reichert et al.   Nature Protocols

Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell

(2012) Shiro Yui et al.   NATURE MEDICINE

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Ductular Network Formation by Rat Biliary Epithelial Cells in the Dynamical Culture with Collagen Gel and Dimethylsulfoxide Stimulation

(2008) Wataru Hashimoto et al.   AMERICAN JOURNAL OF PATHOLOGY