Review
Cell Biology
Seham A. Abd El-Aleem, Entesar Ali Saber, Neven M. Aziz, Hani El-Sherif, Asmaa M. Abdelraof, Laiche Djouhri
Summary: Follicular dendritic cells (FDCs) are essential for immune regulation and can contribute to immune disorders when antigens are retained for extended periods. Understanding FDC biology is crucial for controlling humoral immunity and managing FDC-mediated immune disorders.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Immunology
Paula Grskovic, Suzana Hancic, Snjezana Dotlic, Maja Matulic, Slobodanka Ostojic Kolonic, Slavko Gasparov, Mara Dominis, Petra Korac
Summary: Follicular lymphoma is a common type of non-Hodgkin's lymphoma, which is difficult to treat and has a fast disease progression. Our research found that specific components of the tumor microenvironment are associated with tumor behavior and patient survival.
Article
Immunology
Frederic Mourcin, Lea Verdiere, David Roulois, Rada Amin, Claire Lamaison, Vonick Sibut, Brice Thamphya, Celine Pangault, Celine Monvoisin, Sarah Huet, Marine Seffals, Sylvain Baulande, Fatima Mechta-Grigoriou, Patricia Legoix, Delphine Rossille, Marion Guirriec, Simon Leonard, Guillaume Cartron, Gilles Salles, Thierry Fest, Karin Tarte
Summary: The study identified three distinct human lymphoid stromal cell (LSC) subsets with different functions in healthy tissue. In lymphoma, LSCs can be reprogrammed in response to cytokines like tumor necrosis factor and transforming growth factor beta, leading to increased expression of chemokines. This bidirectional crosstalk between LSCs and malignant B cells may be a targetable axis in lymphoma.
Review
Oncology
Rosario Munguia-Fuentes, Raul Antonio Maqueda-Alfaro, Rommel Chacon-Salinas, Leopoldo Flores-Romo, Juan Carlos Yam-Puc
Summary: Understanding the malignant aspects of the three main cells involved in the GC reaction can provide insights into better treatments. Poorly studied neoplasms of Tfh cells and FDCs are clinically significant due to their aggressive behavior and metastatic potential. Better molecular and genetic characterization of these malignancies will lead to improved diagnosis and treatment.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Liang Ma, Liwen Zhang, Yun Zhuang, Yanbo Ding, Jianping Chen
Summary: This study found that the combination of gut microbiota and prednisone therapy has an impact on Tfh cell response in AIH patients, and Lactobacillus plays a positive role in these effects.
CELL COMMUNICATION AND SIGNALING
(2022)
Review
Health Care Sciences & Services
Karthik Nath, Maher K. Gandhi
Summary: Follicular lymphoma, the most common indolent B-cell lymphoma, has different prognoses, but the emergence of novel targeted agents offers hope for future treatment options.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Cell Biology
Xiaowei Qin, Wenqing Dang, Xiaofeng Yang, Kai Wang, Ermias Kebreab, Lihua Lyu
Summary: The inactivation of protein neddylation has been found to play an important role in regulating the proliferation of sheep follicular granulosa cells. Inhibition of neddylation significantly attenuated cell proliferation and induced apoptosis in sheep follicular granulosa cells. Furthermore, neddylation inactivation affected multiple signaling pathways and mitochondrial functions, leading to changes in cell physiology.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Immunology
Yin Yao, Zhian Chen, Hao Zhang, Cailing Chen, Ming Zeng, Joseph Yunis, Yunbo Wei, Yanmin Wan, Naiqi Wang, Mingzhe Zhou, Chao Qiu, Qunxiong Zeng, Hong Sheng Ong, Hao Wang, Fadzai Victor Makota, Yang Yang, Zhaohui Yang, Nan Wang, Jun Deng, Chao Shen, Yan Xia, Lin Yuan, Zhaoqin Lian, Yike Deng, Cuilian Guo, Ao Huang, Pengcheng Zhou, Haibo Shi, Weitian Zhang, Hongliang Yi, Dongmei Li, Ming Xia, Jing Fu, Ning Wu, Judy B. de Haan, Nan Shen, Wenhong Zhang, Zheng Liu, Di Yu
Summary: Researchers found that T follicular helper (T-FH) cells are highly sensitive to ferroptosis, and this process is regulated by the activity of the selenoenzyme GPX4. Selenium supplementation can increase GPX4 expression, leading to an increase in T-FH cell numbers and antibody responses.
Editorial Material
Hematology
James D. Phelan, Elaine S. Jaffe
Summary: In this study, the authors used whole genome sequencing to investigate the basis of follicular lymphoma (FL) transformation. They identified two genetically distinct subgroups of FL, dFL and cFL, which showed a significant difference in time to transformation.
Editorial Material
Immunology
Krystal S. A. Lianos, Anne L. Fletcher
Summary: Fibroblasts play a crucial role in shaping the immune landscape of lymph nodes, and understanding their interactions with T and B cells could uncover potential clinical targets in follicular lymphoma.
Article
Multidisciplinary Sciences
Johanne T. Jacobsen, Wei Hu, Tiago B. R. Castro, Sigrid Solem, Alice Galante, Zeran Lin, Samuel J. Allon, Luka Mesin, Angelina M. Bilate, Arien Schiepers, Alex K. Shalek, Alexander Y. Rudensky, Gabriel D. Victora
Summary: Research shows that contraction of immunization-induced germinal centers is associated with an acute surge in GC-resident Foxp3(+) T cells, attributed to the up-regulation of Foxp3 by T follicular helper cells. This natural up-regulation of Foxp3 in T-FH cells may play a role in regulating GC lifetimes.
Article
Oncology
Fen Zhang, Wenyu Li, Qian Cui, Yu Chen, Yanhui Liu
Summary: We report a case of Angioimmunoblastic T-cell lymphoma (AITL) with extensive spindle cell meshwork that can be misdiagnosed as follicular dendritic cell sarcoma (FDCS) due to its unusual morphologic features. Next-generation sequencing revealed common mutations associated with AITL, while mutations related to FDCS were not detected. This study highlights the importance of careful morphological observation and immunohistochemical and molecular examinations in accurately diagnosing such cases.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Takashi Watanabe
Summary: In the follicular lymphoma microenvironment, follicular helper T cells play a major role in supporting FL by closely correlating with FL B cells. Inhibition of HVEM and PI3K delta may impact T cells and regulatory T cells, while TIGIT blockade could invigorate cytotoxic T cells against FL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Evelina Rogges, Sabrina Pelliccia, Gianluca Lopez, Sabina Barresi, Agostino Tafuri, Rita Alaggio, Arianna Di Napoli
Summary: In this study, we reported a case of AITL with coexisting SARS-CoV-2 infection and exuberant CD30-positive FDC proliferation. Genetic analysis identified mutations commonly involved in AITL but not in FDC sarcoma, supporting the reactive nature of the CD30-positive FDC expansion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Yanan Li, Yan Zhang, Wei Wang, Chong Wei, Danqing Zhao, Wei Zhang
Summary: This study aims to evaluate prognostic predictors of follicular lymphoma among Chinese patients. The study found that LMR is a new independent predictor that has better predictive ability compared to FLIPI.
CANCER MANAGEMENT AND RESEARCH
(2022)
Article
Respiratory System
Konstantinos Evangelou, Dimitris Veroutis, Koralia Paschalaki, Periklis G. Foukas, Nefeli Lagopati, Marios Dimitriou, Angelos Papaspyropoulos, Bindu Konda, Orsalia Hazapis, Aikaterini Polyzou, Sophia Havaki, Athanassios Kotsinas, Christos Kittas, Athanasios G. Tzioufas, Laurence De Leval, Demetris Vassilakos, Sotirios Tsiodras, Barry R. Stripp, Argyris Papantonis, Giovanni Blandino, Ioannis Karakasiliotis, Peter J. Barnes, Vassilis G. Gorgoulis
Summary: This study found that SARS-CoV-2 infection in severe COVID-19 patients leads to cellular senescence and a proinflammatory phenotype in AT2 cells. In vitro experiments showed that SARS-CoV-2 infection induces cell senescence and inflammation. Infected senescent cells may contribute to SARS-CoV-2 mutagenesis mediated by APOBEC enzymes.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Oncology
Emmanuel Bachy, Vincent Camus, Catherine Thieblemont, David Sibon, Rene-Olivier Casasnovas, Loic Ysebaert, Gandhi Damaj, Stephanie Guidez, Gian Matteo Pica, Won Seog Kim, Soon Thye Lim, Marc Andre, Alejandro Martin Garcia-Sancho, Maria Jesus Penarrubia, Philipp B. Staber, Judith Trotman, Andreas Huettmann, Vittorio Stefoni, Alessandro Re, Philippe Gaulard, Marie-Helene Delfau-Larue, Laurence de Leval, Michel Meignan, Ju Li, Franck Morschhauser, Richard Delarue
Summary: This study is a randomized phase III study comparing Ro-CHOP with CHOP in previously untreated adult PTCL patients. The study results showed that the addition of romidepsin to CHOP did not improve PFS, response rates, nor overall survival and increased the frequency of grade >= 3 treatment-emergent adverse events.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Jeremy Di Domizio, Muhammet F. Gulen, Fanny Saidoune, Vivek V. Thacker, Ahmad Yatim, Kunal Sharma, Theo Nass, Emmanuella Guenova, Martin Schaller, Curdin Conrad, Christine Goepfert, Laurence de Leval, Christophe von Garnier, Sabina Berezowska, Anaelle Dubois, Michel Gilliet, Andrea Ablasser
Summary: This study reveals the mechanism behind aberrant type I interferon responses in COVID-19 through the cGAS-STING pathway and demonstrates its importance in severe cases. By using animal and lung-on-chip models, the study provides insights into host-directed therapeutic strategies for COVID-19.
Article
Medicine, General & Internal
Francesco Fortarezza, Federica Pezzuto, Paul Hofman, Izidor Kern, Angel Panizo, Jan von der Thuesen, Sergei Timofeev, Gregor Gorkiewicz, Sabina Berezowska, Laurence de Leval, Cristian Ortiz-Villalon, Francesca Lunardi, Fiorella Calabrese
Summary: Autoptic studies of patients who died from COVID-19 are crucial for improving our understanding of the disease and its impact on patient management and treatment.
Review
Pathology
Andrew L. Feldman, Camille Laurent, Marina Narbaitz, Shigeo Nakamura, Wing C. Chan, Laurence de Leval, Philippe Gaulard
Summary: This article discusses the classification and diagnostic evaluation of nodal T- and NK-cell lymphomas based on the 2022 International Consensus Classification of Mature Lymphoid Neoplasms (2022 ICC). It highlights the grouping of T-follicular helper cell lymphoma into a single entity with three subtypes, as well as the genetic subtype of ALK-negative anaplastic large cell lymphoma (ALCL) associated with DUSP22 rearrangement. The introduction of a new provisional entity, primary nodal EBV-positive T-/NK-cell lymphoma, is also mentioned, along with evolving molecular data indicating distinct subgroups within PTCL, NOS.
Article
Pathology
Come Sesboue, Jean Galtier, Marie Jeanneau, Annick Chauvel, Elodie Laharanne, Samuel Amintas, Jean-Philippe Merlio, Krimo Bouabdallah, Francois-Xavier Gros, Laurence de Leval, Audrey Gros, Marie Parrens
Summary: Distinguishing FL from NMZL can be difficult in cases with unusual morphologic and phenotypic features and without characteristic cytogenetic rearrangements. Ancillary techniques, such as FISH, RT-MLPA, and NGS, can provide diagnostic contributions for unclassified tumors. In this study, FISH detected 1p36 deletion in some FLs and unclassified tumors, while RT-MLPA signatures were associated with FL and NMZL subtypes. Combining RT-MLPA and NGS findings successfully discriminated most unclassified tumors towards FL or NMZL diagnosis.
Article
Pathology
Rita Sarkis, Olivier Burri, Claire Royer-Chardon, Frederica Schyrr, Sophie Blum, Mariangela Costanza, Stephane Cherix, Nathalie Piazzon, Carmen Barcena, Bettina Bisig, Valentina Nardi, Rossella Sarro, Giovanna Ambrosini, Martin Weigert, Olivier Spertini, Sabine Blum, Bart Deplancke, Arne Seitz, Laurence de Leval, Olaia Naveiras
Summary: Bone marrow cellularity assessment is crucial in evaluating bone marrow biopsies for hematologic and nonhematologic disorders. MarrowQuant 2.0 is an efficient digital hematopathology workflow that accurately quantifies the cellularity of human bone marrow biopsies by segmenting different compartments. This tool can be used for clinical research to explore biomarkers related to bone marrow stromal components.
Review
Pathology
Laurence de Leval, Andrew L. Feldman, Stefano Pileri, Shigeo Nakamura, Philippe Gaulard
Summary: Non-cutaneous extranodal NK/T cell lymphoproliferations are a rare group of tumors that primarily occur in the gastrointestinal tract, nasal area, spleen, and liver. Accurate diagnosis is crucial due to the diverse clinical presentations and similarities with other diseases.
Review
Pathology
Leticia Quintanilla-Martinez, Camille Laurent, Lorinda Soma, Siok-Bian Ng, Fina Climent, Sarah L. L. Ondrejka, Alberto Zamo, Andrew Wotherspoon, Laurence de Leval, Stefan Dirnhofer, Lorenzo Leoncini
Summary: The 2022 European Association for Haematopathology/Society for Hematopathology workshop in Florence, Italy discussed emerging entities and molecular subgroups in large B-cell lymphomas (LBCLs). The session focused on newly recognized diseases and their diagnostic challenges. Topics included high-grade/large B-cell lymphoma with 11q aberration (HG/LBCL-11q), LBCL with IRF4 rearrangement (LBCL-IRF4), primary bone diffuse large B-cell lymphoma (PB-DLBCL), and B-acute lymphoblastic leukemia (B-ALL) with IGH::MYC translocation.
Review
Pathology
Alberto Zamo, Michiel van den Brand, Fina Climent, Laurence de Leval, Stefan Dirnhofer, Lorenzo Leoncini, Siok-Bian Ng, Sarah L. Ondrejka, Leticia Quintanilla-Martinez, Lorinda Soma, Andrew Wotherspoon
Summary: Session 3 of the lymphoma workshop at the joint meeting of the European Association for Haematopathology and the Society for Hematopathology discussed splenic and nodal marginal zone lymphomas, transformation in marginal zone lymphomas, and pediatric nodal marginal zone lymphomas. The case review emphasized the challenges in diagnosing marginal zone lymphomas, including distinguishing between different types and the need for molecular studies to establish a final diagnosis. The workshop also addressed the overlapping spectrum between pediatric nodal marginal zone lymphoma and pediatric-type follicular lymphoma.
Correction
Pathology
Alberto Zamo, Michiel van den Brand, Fina Climent, Laurence de Leval, Stefan Dirnhofer, Lorenzo Leoncini, Siok-Bian Ng, Sarah L. Ondrejka, Leticia Quintanilla-Martinez, Lorinda Soma, Andrew Wotherspoon
Review
Pathology
Fina Climent, Alina Nicolae, Laurence de Leval, Stefan Dirnhofer, Lorenzo Leoncini, Sarah L. Ondrejka, Lorinda Soma, Andrew Wotherspoon, Alberto Zamo, Leticia Quintanilla-Martinez, Siok-Bian Ng
Summary: The 2022 European Association for Haematopathology/Society for Hematopathology lymphoma workshop discussed cytotoxic peripheral T-cell lymphomas and EBV-positive T/NK-cell lymphoproliferative diseases. Primary nodal-EBV-TNKL is a newly recognized entity associated with underlying immune deficiency/immune dysregulation. cPTCL-NOS demonstrates the TBX21 phenotype and shows an unexpected association with TFH lymphomas/LPDs.
Meeting Abstract
Oncology
O. Pavlova, G. Blanchard, M. Vernez, L. De Leval, E. Guenova
EUROPEAN JOURNAL OF CANCER
(2022)
Meeting Abstract
Oncology
Norbert Schmitz, Bettina Altmann, Birte Friedrichs, Krimo Bouabdallah, Guillaume Cartron, Maike Nickelsen, Gerald Wulf, Mathieu Leclerc, Alban Vilatte, Pascal Turlure, Roch Houot, Laurence De Leval, Philippe Gaulard, German Ott, Gandhi Laurent Damaj, Peter Reimer, Georg Lenz, Lorenz H. Trumper, Marita Ziepert, Olivier Tournilhac
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Pathology
K. Ioannidou, D. Comte, A. Clottu, L. de Leval, C. Petrovas
