Review
Biotechnology & Applied Microbiology
Minjeong Kim, Nakjun Choi, Eunna Choi, Eun-Jin Lee
Summary: Pathogenic bacteria in the human intestinal tract have developed strategies to overcome acidic conditions. Amino acid-mediated acid resistance systems play a crucial role in surviving in the stomach. The ClC chloride antiporter is responsible for eliminating intracellular chloride ions, preventing hyperpolarization in the inner membrane.
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Peripheral Vascular Disease
Min Gao, Ming-Ming Ma, Feng-Ting Lu, Cheng-Cui Huang, Lu Sun, Xiao-Fei Lv, Bin Zhang, Guan-Lei Wang, Yong-Yuan Guan
Summary: The study revealed that ClC-5 plays a key role in low extracellular Cl-induced Cl- currents, with upregulated expression in arterial tissues of hypertensive rats and patients. ClC-5 expression positively correlated with basilar artery remodeling during hypertension, and it promotes hypertension-induced cerebrovascular remodeling via the WNK1/AKT signaling pathway.
Review
Biochemistry & Molecular Biology
Oscar Brenes, Michael Pusch, Fernando Morales
Summary: Myotonia congenita is a hereditary muscle disease caused by mutations in the CLCN1 gene, leading to abnormal function of the chloride ion channel and resulting in muscle hyperexcitability and other symptoms. This review examines over 350 reported mutations and analyzes their effects on the structure and function of the chloride ion channel.
Article
Medicine, Research & Experimental
Jiezhu Feng, Zihan Peng, Lvfen Gao, Xiurou Yang, Zele Sun, Xiuying Hou, Enze Li, Linyan Zhu, Haifeng Yang
Summary: Over-expression of ClC-3 protein in PTX-resistant ovarian cancer cells promotes the combination of ClC-3 and beta-tubulin, reducing sensitivity to PTX.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Immunology
Ting Liu, Yu Liu, Chen-xi Liu, Yong-mei Jiang
Summary: This study investigates the role of CXCL13 in the pathogenesis of inflammatory bowel disease (IBD) using clinical specimens and animal models. The findings show that CXCL13 concentration is significantly higher in IBD patients and correlates with inflammatory markers. In mice models, CXCL13 deficiency leads to a milder form of the disease. The study suggests that CXCL13 plays a critical role in the pathogenesis of IBD and may be a potential target for adjunctive therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Yucan Chen, Min Liu, Weidi Wang, Wenxiang Cai, WeiChen Song, Li Li, Guan Ning Lin
Summary: Both SETD2-mediated H3K36me3 and miRNAs are crucial in IBD and its related dysfunctional intestinal barrier. Integrative analysis of ChIP-seq, miRNA expression profiles, and RNA-seq data revealed a significant inverse correlation between H3K36me3 modification and the expression of 171 peak-covered miRNAs, with enrichment in cell-cell junction and signaling pathways. Ten hub miRNAs, including six H3K36me3-associated ones, were identified as potential therapeutic targets for IBD patients with SETD2 deficiency.
Article
Pharmacology & Pharmacy
Concetta Altamura, Elena Conte, Carmen Campanale, Paola Laghetti, Ilaria Saltarella, Giulia Maria Camerino, Paola Imbrici, Jean-Francois Desaphy
Summary: This study found that niflumic acid (NFA) can act as a pharmacological chaperone and has therapeutic effects on patients with specific ClC-1 channel mutations in myotonia congenita (MC). NFA can improve the expression of ClC-1 protein on the plasma membrane to restore normal chloride ion channel function.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Bing Zhang, Sensen Zhang, Maya M. Polovitskaya, Jingbo Yi, Binglu Ye, Ruochong Li, Xueying Huang, Jian Yin, Sebastian Neuens, Tom Balfroid, Julie Soblet, Daphne Vens, Alec Aeby, Xiaoling Li, Jinjin Cai, Yingcai Song, Yuanxi Li, Marco Tartaglia, Yang Li, Thomas J. Jentsch, Maojun Yang, Zhiqiang Liu
Summary: The study reveals that ClC-6 is an ion exchanger protein expressed in the nervous system and associated with severe neurological diseases. The researchers used cryo-EM structures and functional studies to uncover the structure, function, and regulation of ClC-6, as well as identifying hotspots for disease-causing mutations.
Article
Cell Biology
Oscar Brenes, Raffaella Barbieri, Melissa Vasquez, Rebeca Vindas-Smith, Jeffrey Roig, Adarli Romero, Gerardo del Valle, Luis Bermudez-Guzman, Sara Bertelli, Michael Pusch, Fernando Morales
Summary: Non-dystrophic myotonias are associated with loss-of-function mutations in the ClC-1 chloride channel or gain-of-function mutations in the Na(v)1.4 sodium channel. A family with members diagnosed with Thomsen's disease was found to have novel mutations in CLCN1 and SCN4A genes, leading to myotonia. The study highlights the importance of deep genetic analysis in accurate genetic counseling and patient management.
Article
Medicine, Research & Experimental
Meng-Hsuan Lin, Jen-Chi Chen, Xuejiao Tian, Chia-Ming Lee, I-Shing Yu, Yi-Fen Lo, Shinichi Uchida, Chou-Long Huang, Bi-Chang Chen, Chih-Jen Cheng
Summary: The study revealed that both ClC-Ka and ClC-Kb are broadly expressed and colocalized in perinatal mouse kidneys, with both participating in NaCl reabsorption in neonatal kidneys. Deletion of ClC-K2 causes tubular injury and salt wasting, while ClC-K1 and ClC-K2 together play a role in salt reabsorption in TAL and DCT in neonates.
Article
Immunology
Dominik Eichin, Alberto Pessia, Akira Takeda, Joni Laakkonen, Lydia Bellmann, Matti Kankainen, Beat A. Imhof, Patrizia Stoitzner, Jing Tang, Marko Salmi, Sirpa Jalkanen
Summary: CD73 plays an unknown role in dampening immune responses on afferent lymphatics, as revealed by this study. Knocking out or suppressing CD73 leads to upregulation of inflammation-associated genes on lymphatic endothelial cells and a more pro-inflammatory phenotype of interacting dendritic cells in vitro and in vivo. Anti-CD73 antibodies have negligible effects on gene expression of lymphatic- and blood-endothelial cells, indicating a low likelihood of endothelial cell-related adverse effects with CD73 targeting therapeutic antibodies.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Dun Niu, Lanfang Li, Zhizhong Xie
Summary: ClC-3, a chloride antiporter, is a key mediator in various diseases, especially in the process of atherosclerosis. Studies have shown that ClC-3 may participate in atherosclerotic plaque formation through regulating inflammation-related signaling pathways, lipoprotein levels, and cell functions.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS
(2021)
Article
Gastroenterology & Hepatology
Jilei Zhang, Yongguo Zhang, Callum J. McGrenaghan, Vincent P. Kelly, Yinglin Xia, Jun Sun
Summary: This study found that the expression of QTRT1 was significantly downregulated in patients with inflammatory bowel disease (IBD). The 4 Q-tRNA-related tRNA synthetases were also decreased in IBD patients. These changes were associated with alterations in epithelial cell proliferation and junction formation. Further investigation revealed that queuine treatment enhanced cell proliferation and junction activity, and reduced inflammation in epithelial cells. These findings uncover a novel role for tRNA modifications in the pathogenesis of IBD.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Endocrinology & Metabolism
Tess Holling, Laura Brylka, Tasja Scholz, Tatjana Bierhals, Theresia Herget, Peter Meinecke, Thorsten Schinke, Ralf Oheim, Kerstin Kutsche
Summary: Isolated short stature is a common condition in children. Exome sequencing identified a homozygous TMCO3 variant in two sisters with isolated short stature. TMCO3 variant is associated with reduced skeletal growth in humans and mice.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Immunology
Zhou Zhou, Leonie G. G. Plug, Thiago A. A. Patente, Eveline S. M. de Jonge-Muller, Amir Abou Elmagd, Andrea E. van der Meulen-de Jong, Bart Everts, Marieke C. C. Barnhoorn, Lukas J. A. C. Hawinkels
Summary: Inflammatory bowel disease (IBD) is a chronic relapsing inflammation of the intestinal tract with unclear pathogenesis. This study found that glycolysis was increased in IBD intestinal samples and that PFKFB3 expression was elevated in IBD-derived stromal cells. Inhibition of PFKFB3 reduced the severity of colitis and suppressed inflammatory characteristics of fibroblasts.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Bao-Dong Tang, Xin Xia, Xiao-Fei Lv, Bei-Xin Yu, Jia-Ni Yuan, Xiao-Yi Mai, Jin-Yan Shang, Jia-Guo Zhou, Si-Jia Liang, Rui-Ping Pang
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2017)
Article
Biochemistry & Molecular Biology
Bei-Xin Yu, Jia-Ni Yuan, Fei-Ran Zhang, Ying-Ying Liu, Ting-Ting Zhang, Kai Li, Xiao-Fei Lv, Jia-Guo Zhou, Lin-Yan Huang, Jin-Yan Shang, Si-Jia Liang
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Cell Biology
Xiao-Yun Liu, Fei-Ran Zhang, Jin-Yan Shang, Ying-Ying Liu, Xiao-Fei Lv, Jia-Ni Yuan, Ting-Ting Zhang, Kai Li, Xiao-Chun Lin, Xiu Liu, Qingqing Lei, Xiao-Dong Fu, Jia-Guo Zhou, Jia Liang
CELL DEATH & DISEASE
(2018)
Article
Cell Biology
Yingxue Su, Jiani Yuan, Feiran Zhang, Qingqing Lei, Tingting Zhang, Kai Li, Jiawei Guo, Yu Hong, Guolong Bu, Xiaofei Lv, Sijia Liang, Jingsong Ou, Jiaguo Zhou, Bin Luo, Jinyan Shang
CELL DEATH & DISEASE
(2019)
Article
Chemistry, Multidisciplinary
Jia-Wei Guo, Xiu Liu, Ting-Ting Zhang, Xiao-Chun Lin, Yu Hong, Jie Yu, Qin-Yan Wu, Fei-Ran Zhang, Qian-Qian Wu, Jin-Yan Shang, Xiao-Fei Lv, Jing-Song Ou, Jia-Guo Zhou, Rui-Ping Pang, Bao-Dong Tang, Si-Jia Liang
Article
Chemistry, Multidisciplinary
Ying-ying Liu, Xiu Liu, Jia-guo Zhou, Si-jia Liang
Summary: MiR-302a exacerbates smooth muscle cell proliferation and restenosis by increasing Akt signaling through targeting PHLPP2.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Chemistry, Multidisciplinary
Kai Li, Ying-ying Liu, Xiao-fei Lv, Zhuo-miao Lin, Ting-ting Zhang, Fei-ran Zhang, Jia-wei Guo, Yu Hong, Xiu Liu, Xiao-chun Lin, Jia-guo Zhou, Qian-qian Wu, Si-jia Liang, Jin-yan Shang
Summary: The study demonstrates that reducing intracellular chloride concentration inhibits angiogenesis by suppressing various cellular processes and oxidative stress-mediated VEGFR2 signaling activation. Modulation of chloride levels may offer a novel therapeutic approach for angiogenic dysfunction-associated diseases.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Biochemistry & Molecular Biology
Jie Yu, QianYun Zhang, MengChuan Wang, SiJia Liang, HongYun Huang, Lang Xie, ChunHui Cui, JinLong Yu
Summary: The study investigated the prognostic role of tumor mutation burden (TMB) and its relationship with immune cell infiltration in gastric cancer. Higher TMB was associated with better survival outcome, and patients with high TMB showed increased immune cell infiltration. High macrophage infiltration in high TMB group was correlated with inferior survival outcome of gastric cancer patients.
BIOSCIENCE REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Xiu Liu, Jia-Wei Guo, Xiao-Chun Lin, Yong-Hua Tuo, Wan-Li Peng, Su-Yue He, Zhao-Qiang Li, Yan-Chen Ye, Jie Yu, Fei-Ran Zhang, Ming-Ming Ma, Jin-Yan Shang, Xiao-Fei Lv, An-Dong Zhou, Ying Ouyang, Cheng Wang, Rui-Ping Pang, Jian-Xin Sun, Jing-Song Ou, Jia-Guo Zhou, Si-Jia Liang
Summary: The study showed that macrophage NFATc3 up-regulates miR-204 to reduce SR-A and CD36 levels, thereby preventing foam cell formation and atherosclerosis, indicating a potential therapeutic target against atherosclerosis.
EUROPEAN HEART JOURNAL
(2021)
Article
Cell Biology
Jiawei Guo, Zihao Song, Jie Yu, Chengyi Li, Chenchen Jin, Wei Duan, Xiu Liu, Yingying Liu, Shuai Huang, Yonghua Tuo, Fei Pei, Zhengyang Jian, Pengyu Zhou, Shaoyi Zheng, Zhaowei Zou, Feng Zhang, Quan Gong, Sijia Liang
Summary: TMEM16A exacerbates hepatic I/R injury by promoting GPX4-dependent ferroptosis. TMEM16A-GPX4 interaction and GPX4 ubiquitination are therefore indispensable for TMEM16A-regulated hepatic I/R injury.
CELL DEATH & DISEASE
(2022)
Article
Pharmacology & Pharmacy
Zhuomiao Lin, Xiaochun Lin, Ying Lai, Congcong Han, Xinran Fan, Jie Tang, Shiqi Mo, Jiahui Su, Sijia Liang, Jinyan Shang, Xiaofei Lv, Siwan Guo, Ruiping Pang, Jiaguo Zhou, Tingting Zhang, Feiran Zhang
Summary: This study reveals that ponatinib can significantly improve obesity-related metabolic syndrome, especially insulin sensitivity and hyperlipidemia. Ponatinib achieves its beneficial effects by inhibiting the inflammatory transformation of adipose tissue macrophages, thus maintaining the physiological function of adipose tissue under excessive obesity.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Chengyi Li, Xiusong Zhu, Juxian Chen, Xiaoxi Xie, Sijia Liang, Xiu Liu, Quan Gong, Jiawei Guo
Summary: Ferroptosis is a newly identified form of cell death characterized by iron-dependent lipid peroxidation. Its molecular mechanism is not fully understood, but it appears to involve various biological processes and systems. Cardiovascular diseases are the leading cause of death globally, and ferroptosis plays a significant role in the pathogenesis of cardiac conditions such as cardiomyopathy, myocardial ischemia-reperfusion injury, heart failure, and atherosclerosis. Therefore, the study of ferroptosis is of great importance for the treatment of cardiovascular diseases.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2023)
Article
Biochemistry & Molecular Biology
Chengyi Li, Zihao Song, Pengyue Gao, Wei Duan, Xiu Liu, Sijia Liang, Quan Gong, Jiawei Guo
Summary: This study investigates the role of transaldolase in foam cell formation and atherogenesis in atherosclerosis. The researchers find that transaldolase overexpression attenuates foam cell formation, while transaldolase knockdown accelerates it. Transaldolase regulates cholesterol uptake through the p38 MAPK signaling pathway mediated by CD36. The study suggests that targeting transaldolase-GSH-p38-CD36 axis may be a potential therapeutic strategy for atherosclerosis.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2023)
Article
Pharmacology & Pharmacy
Jia-Hui Su, Yu Hong, Cong-Cong Han, Jie Yu, Xin Guan, Ya-Mei Zhu, Cheng Wang, Ming-Ming Ma, Rui-Ping Pang, Jing-Song Ou, Jia-Guo Zhou, Zi-Yi Zhang, Tao Ban, Si-Jia Liang
Summary: CsA-induced atherosclerosis after organ transplantation is a major concern, but its mechanisms are not well understood. This study found that miR-204 plays an important role in CsA-induced atherosclerosis by inhibiting foam cell formation and reducing plaque lesions. Therefore, miR-204 may be a potential target for the prevention and treatment of CsA-related atherosclerotic side effects.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Xiao-Fei Lv, Ya-Juan Zhang, Xiu Liu, Hua-Qing Zheng, Can-Zhao Liu, Xue-Lin Zeng, Xiang-Yu Li, Xiao-Chun Lin, Cai-Xia Lin, Ming-Ming Ma, Fei-Ran Zhang, Jin-Yan Shang, Jia-Guo Zhou, Si-Jia Liang, Yong-Yuan Guan