Article
Chemistry, Medicinal
Ammar Salehi-Sahlabadi, Hamed Kord-Varkaneh, Betul Kocaadam-Bozkurt, Shaikh Sanjid Seraj, Seyed Moayed Alavian, Azita Hekmatdoost
Summary: This study suggests that wheat germ consumption may have clinical effects on patients with NAFLD. After 12 weeks of intervention, the wheat germ group showed significant improvements in liver enzyme levels, lipid profiles, and hepatic steatosis compared to the placebo group. The wheat germ group also had higher levels of total antioxidant capacity and lower levels of inflammation biomarker hs-CRP.
PHYTOTHERAPY RESEARCH
(2022)
Article
Nutrition & Dietetics
Jinwang Li, Siyu Xie, Wendi Teng
Summary: Sulforaphane (SFA) has the potential to improve lipid metabolism, inhibit lipid accumulation and apoptosis, making it a potential candidate for preventing and treating nonalcoholic fatty liver disease (NAFLD).
Article
Radiology, Nuclear Medicine & Medical Imaging
Amir M. Pirmoazen, Aman Khurana, Andreas M. Loening, Tie Liang, Vijay Shamdasani, Hua Xie, Ahmed El Kaffas, Aya Kamaya
Summary: In this study, we found that AC, Nakagami, SI, SS, MBF, and HRI have the best correlation with MRI-PDFF and show high diagnostic performance for detecting and classifying hepatic steatosis.
INVESTIGATIVE RADIOLOGY
(2022)
Article
Engineering, Biomedical
Sushila Maharjan, Diana Bonilla, Princy Sindurakar, Hongbin Li, Wanlu Li, Sergio Duarte, Ali Zarrinpar, Y. Shrike Zhang
Summary: This study developed a three-dimensional human hepatic tissue model for emulating steatotic and fibrotic conditions, providing a valuable in vitro platform for drug testing and mechanistic studies. The model used photolithography biofabrication with specific inductions to successfully induce hepatic steatosis and fibrosis, and validated drug treatments for inhibiting these conditions.
BIO-DESIGN AND MANUFACTURING
(2021)
Review
Nutrition & Dietetics
Liangyou Rui, Jiandie D. Lin
Summary: Nonalcoholic fatty liver disease (NAFLD), associated with obesity, ranges from benign fat accumulation to more severe nonalcoholic steato-hepatitis (NASH). New research has revealed the role of genetics, epigenetics, diet, and metabolic dysfunctions in driving hepatic fat accumulation and injury. Single-cell RNA sequencing studies have provided unprecedented insights into liver cell heterogeneity, intrahepatic cross talk, and disease-related changes in the liver microenvironment. This review highlights recent advances in understanding NASH pathogenesis and potential therapeutic opportunities.
ANNUAL REVIEW OF NUTRITION
(2022)
Article
Gastroenterology & Hepatology
Rui-Nan Zhang, Feng Shen, Qin Pan, Hai-Xia Cao, Guang-Yu Chen, Jian-Gao Fan
Summary: The study confirmed the association between PPARGC1A rs8192678 and NAFLD, and found that the risk A allele was related to more severe steatosis, higher activity, and NASH in NAFLD patients, independently of PNPLA3 rs738409.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Medicine, General & Internal
Jieun Chung, Hee-Sun Park, Young-Jun Kim, Mi-Hye Yu, Sungeun Park, Sung-Il Jung
Summary: This study investigated the association of hepatic steatosis determined by non-enhanced CT criteria with clinical parameters in a screening population. The presence of hepatic steatosis was significantly associated with levels of serum fasting glucose and triglycerides, the ALT/AST ratio, BMI, and HSI values. Logistic regression analysis revealed significant associations between serum fasting glucose level and HSI with hepatic steatosis using criterion (a), and between ALT/AST ratio and HSI with hepatic steatosis using criteria (b) and (c). Hepatic steatosis on non-enhanced CT should be considered to indicate possible clinical profile abnormalities regarding metabolic syndrome.
Article
Biochemistry & Molecular Biology
Abraham S. Meijnikman, Mark Davids, Hilde Herrema, Omrum Aydin, Valentina Tremaroli, Melany Rios-Morales, Han Levels, Sjoerd Bruin, Maurits de Brauw, Joanne Verheij, Marleen Kemper, Adriaan G. Holleboom, Maarten E. Tushuizen, Thue W. Schwartz, Jens Nielsen, Dees Brandjes, Eveline Dirinck, Jonas Weyler, An Verrijken, Christophe E. M. De Block, Luisa Vonghia, Sven Francque, Ulrich Beuers, Victor E. A. Gerdes, Fredrik Backhed, Albert K. Groen, Max Nieuwdorp
Summary: This study found that microbial ethanol might contribute to pathogenesis in some patients with nonalcoholic fatty liver disease. The research suggests that microbial ethanol could be considered in the pathogenesis of this highly prevalent liver disease.
Article
Biochemistry & Molecular Biology
Woori Chae, Kyung Jae Lee, Ki Young Huh, Jin Soo Moon, Jae Sung Ko, Joo-Youn Cho
Summary: This study aimed to evaluate the metabolome profile and metabolic pathway changes associated with pediatric NAFLD, successfully developing machine learning-based diagnostic models with excellent performance. Metabolome changes in pediatric NAFLD patients' plasma are associated with disease pathophysiology and can be used for less invasive diagnosis.
Article
Gastroenterology & Hepatology
Peter J. Altshuler, Hien Dang, Adam M. Frank, Ashesh P. Shah, Jaime Glorioso, Tingting Zhan, Arturo Rios Diaz, Osama Shaheen, Carlo B. Ramirez, Warren R. Maley, Adam S. Bodzin
Summary: The study found that in liver transplantation, NASH patients with macrosteatotic allografts had similar survival rates up to 10 years compared to non-NASH patients. However, NASH patients with allografts with >= 30% macrosteatosis may experience reduced early survival rates, but long-term survival rates are similar to other allografts.
LIVER TRANSPLANTATION
(2022)
Article
Medicine, General & Internal
Chang-Hai Liu, Shanshan Zheng, Shisheng Wang, Dongbo Wu, Wei Jiang, Qingmin Zeng, Yi Wei, Yong Zhang, Hong Tang
Summary: Ceruloplasmin and ORM1 may serve as potential biomarkers in distinguishing mild and severe steatosis in MAFLD patients.
Article
Food Science & Technology
Maryam Taghdir, Akram Salehi, Karim Parastouei, Sepideh Abbaszadeh
Summary: This study aimed to assess the association between diet quality and NAFLD predictor indices in patients with MetS. The findings revealed that patients with a higher diet quality had lower FLI and HSI scores. After adjusting for confounding factors, a statistically significant inverse association was found between HEI-2015 and FLI.
FOOD SCIENCE & NUTRITION
(2023)
Article
Medicine, General & Internal
Azizullah Beran, Hazem Ayesh, Mohammed Mhanna, Waseem Wahood, Sami Ghazaleh, Ziad Abuhelwa, Wasef Sayeh, Nameer Aladamat, Rami Musallam, Reem Matar, Saif-Eddin Malhas, Ragheb Assaly
Summary: This study conducted a systematic review and meta-analysis to assess the significance of the triglyceride-glucose (TyG) index in predicting the incidence of nonalcoholic fatty liver disease (NAFLD). The results showed that a higher TyG index is associated with higher odds of NAFLD. The TyG index may serve as an independent predictive tool to screen high-risk NAFLD patients in primary care settings. However, further large-scale prospective cohort studies are needed to validate these findings.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Kasper W. ter Horst, Daniel F. Vatner, Dongyan Zhang, Gary W. Cline, Mariette T. Ackermans, Aart J. Nederveen, Joanne Verheij, Ahmet Demirkiran, Bart A. van Wagensveld, Geesje M. Dallinga-Thie, Max Nieuwdorp, Johannes A. Romijn, Gerald I. Shulman, Mireille J. Serlie
Summary: In obese patients with NAFLD, impaired insulin-mediated suppression of glucose production and no increase in glucose-stimulated/high-insulin lipogenesis were observed, indicating a proximal block in insulin signaling pathways in hepatocytes.
Review
Pharmacology & Pharmacy
Evangelia S. Makri, Antonis Goulas, Stergios A. Polyzos
Summary: NAFLD is a common liver disease with potentially severe consequences, and pharmacological therapy is still lacking. SGLT-2 inhibitors show promising potential for treating NAFLD, especially in improving liver function.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Engineering, Environmental
Longwei Wang, Xiaowen Tang, Zhongwei Yang, Jiawei Guo, Zhen You, Yu Cai, Xiaochen Niu, Xiaoyu Zhang, Liwei Zhang, Jian Zhang, Aizhu Wang, Jing Liu, Hong Liu, Xin Yu
Summary: Functional group-regulated PDINH/GO has enhanced photocatalytic properties, exhibiting effective antibacterial effect and accelerating wound healing. It establishes a successful example of activating nanomaterials by regulating functional groups.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Mathematics
Jia-Wei Guo, Fu-Tsun Wei
Summary: The purpose of this paper is to investigate the masses over CM points on Drinfeld-Stuhler modular curves and definite Shimura curves over global function fields. By connecting the CM masses with the modified Hurwitz class numbers, it is shown that the generating function of these masses is a particular metaplectic theta series. The application of the Poisson summation formula enables the explicit description of the meromorphic continuation of the Mellin transform of the generating theta series, leading to Gauss-type mean value formula and new class number relations in the positive characteristic world.
MATHEMATISCHE ZEITSCHRIFT
(2023)
Review
Biochemistry & Molecular Biology
Chengyi Li, Xiusong Zhu, Juxian Chen, Xiaoxi Xie, Sijia Liang, Xiu Liu, Quan Gong, Jiawei Guo
Summary: Ferroptosis is a newly identified form of cell death characterized by iron-dependent lipid peroxidation. Its molecular mechanism is not fully understood, but it appears to involve various biological processes and systems. Cardiovascular diseases are the leading cause of death globally, and ferroptosis plays a significant role in the pathogenesis of cardiac conditions such as cardiomyopathy, myocardial ischemia-reperfusion injury, heart failure, and atherosclerosis. Therefore, the study of ferroptosis is of great importance for the treatment of cardiovascular diseases.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2023)
Article
Optics
Xiu He, Zhengxi He, Zengling Ran, Jianxin Cui, Nan Wang, Jiangling Gong, Jiawei Guo, Yanbo Xiao, Dong Sun, Jialiang Zhu, Zhuoyue Li, Yun Yu, Zhiming Sun, Yunjiang Rao
Summary: This paper proposes and demonstrates a temperature-insensitive quasi-distributed fiber-optic high-pressure sensing technique based on cascaded extrinsic Fabry-Perot (EFP) sensing units and an optical carrier based microwave interference system (OCMI). The EFP unit, formed by hollow-core photonic bandgap fiber, has the advantages of low insertion loss and low temperature-pressure cross sensitivity. The OCMI system, based on a tunable single-wavelength light, can simultaneously reconstruct optical interferograms of multiple EFP units. Experimental results show good agreement between the reconstructed optical interferograms of three cascaded EFP units and those obtained using an optical spectrum analyzer. Moreover, the EFP unit has a wide measurement range of 0 to 100 MPa and a low temperature-pressure cross-sensitivity of -0.02 MPa/°C, comparable to that of a point fiber-optic pressure sensor. This technique provides a new idea for high-performance distributed pressure sensing.
OPTICS AND LASER TECHNOLOGY
(2023)
Article
Optics
Hui Wang, Zhi-Jian Li, Xue-Mei Hu, Hao Hao, Jia-Wei Guo, Yang-Hui Huang, Hao Liu, Chao Wan, Xue-Cou Tu, Xiao-Qing Jia, La -Bao Zhang, Jian Chen, Lin Kang, Tao Yue, Qing-Yuan Zhao, Pei-Heng Wu
Summary: This study focused on the readout ambiguity of a superconducting nanowire single-photon imager and proposed a correction method by extracting multiple-photon detections on idle pixels. This method increased the dynamic range of the imager.
Article
Multidisciplinary Sciences
Shuang Chen, Ke Li, Jiawei Guo, Hai-Ning Chen, Yue Ming, Yang Jin, Fuyan Xu, Tingting Zhang, Yang Yang, Zixia Ye, Wenrong Liu, Hulin Ma, Jian Cheng, Jian-Kang Zhou, Zhang Li, Shu Shen, Lunzhi Dai, Zong-Guang Zhou, Heng Xu, Yong Peng
Summary: This study identified circNEIL3 (hsa_circ_0001460) as a TGF beta-repressive and metastasis-related circRNA, which effectively inhibits tumor metastasis by directly interacting with onco-genic protein YBX1 and promoting its Nedd4L-mediated proteasomal degradation. The findings highlight the significance of circNEIL3 as a potential biomarker and therapeutic option in cancer treatment, and shed light on the molecular mechanism of circRNA in metastasis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Engineering, Environmental
Lixia Yang, Xiaotong Liu, Tianqiao Yang, Zhenglin Chen, Jiawei Guo, Lingyi Zheng, Xiao Xiao, Guisheng Zeng, Xubiao Luo, Shenglian Luo
Summary: Electrochemical reduction and immobilization of Cr(VI) were achieved using a special Fe/Ni-MIL-53 MOF-electrode. The novel Fe/Ni-MIL-53 (Acethydrazide) was grown in situ from a nickel foam through redox reactions and solvothermal treatment. The Fe/Ni-MIL-53 (Acethydrazide) exhibited significantly higher efficiency in reducing and removing Cr(VI) compared to Fe/Ni-MIL-53. This work highlights the potential of MOFs in the removal and recovery of heavy metal ions.
RESOURCES CONSERVATION AND RECYCLING
(2023)
Article
Engineering, Environmental
Wenhao Gao, Jing Zhang, Weizhen Zhang, Dong Sun, Jiawei Guo, Songjiang Zhao, Ying Zeng, Xinze Liu
Summary: The hydrochemical characteristics of surface water were analyzed using mathematical statistics. Piper three line diagram was used to determine the hydrochemical types, and Gibbs diagram and ion correlation analysis were employed to discuss the sources and influencing factors of main ions. Results showed that the surface water had a TDS ranging from 109 to 559 mg/L, with an average of 318.67 mg/L. The pH value ranged from 6.81 to 8.62, with an average of 7.85. Most of the surface water belonged to weakly alkaline water. The dominant cations were Ca2+ and Mg2+, and the dominant anion was HCO3-, resulting in the hydrochemical type of HCO3-Ca. Correlation analysis revealed that TDS had a significant positive correlation with Na+, K+, Mg2+, Ca2+, and HCO3-, with these ions contributing to TDS. HCO3- showed a significant correlation with Na+, K+, and Mg2+, and its source was carbonate rocks. According to the water-rock model analysis, the hydrochemical genesis of surface water in the study area was mainly controlled by rock weathering, where most ions were weathered and dissolved by carbonate rocks and evaporated salt rocks, with a few cations influenced by water ion exchange.
WATER SCIENCE AND TECHNOLOGY
(2023)
Review
Multidisciplinary Sciences
Jiawei Guo, Jieming Ma, Angel F. Garcia-Fernandez, Yungang Zhang, Haining Liang
Summary: This paper focuses on the combination of traditional algorithms and machine learning algorithms in the field of image enhancement. Traditional methods, including gray level transformation, histogram equalization, and Retinex methods, are introduced, and machine learning based algorithms are categorized. Finally, comprehensive comparisons are made using multiple image quality assessment methods.
Article
Biochemistry & Molecular Biology
Chengyi Li, Zihao Song, Pengyue Gao, Wei Duan, Xiu Liu, Sijia Liang, Quan Gong, Jiawei Guo
Summary: This study investigates the role of transaldolase in foam cell formation and atherogenesis in atherosclerosis. The researchers find that transaldolase overexpression attenuates foam cell formation, while transaldolase knockdown accelerates it. Transaldolase regulates cholesterol uptake through the p38 MAPK signaling pathway mediated by CD36. The study suggests that targeting transaldolase-GSH-p38-CD36 axis may be a potential therapeutic strategy for atherosclerosis.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2023)
Article
Pharmacology & Pharmacy
Jia-Hui Su, Yu Hong, Cong-Cong Han, Jie Yu, Xin Guan, Ya-Mei Zhu, Cheng Wang, Ming-Ming Ma, Rui-Ping Pang, Jing-Song Ou, Jia-Guo Zhou, Zi-Yi Zhang, Tao Ban, Si-Jia Liang
Summary: CsA-induced atherosclerosis after organ transplantation is a major concern, but its mechanisms are not well understood. This study found that miR-204 plays an important role in CsA-induced atherosclerosis by inhibiting foam cell formation and reducing plaque lesions. Therefore, miR-204 may be a potential target for the prevention and treatment of CsA-related atherosclerotic side effects.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Mathematics
Jia-Wei Guo, Yifan Yang, Hwajong Yoo, Myungjun Yu
Summary: We prove that the rational cuspidal subgroup of J(0)(N) is equal to the rational cuspidal divisor class group of X-0(N) when N=p(2)M for any prime p and any squarefree integer M.
MATHEMATISCHE NACHRICHTEN
(2023)
Article
Water Resources
Wenhao Gao, Jing Zhang, Weizhen Zhang, Dong Sun, Jiawei Guo, Songjiang Zhao, Ying Zeng, Xinze Liu
Summary: Groundwater from Huanglong was analyzed for hydrochemical characteristics using mathematical and statistical methods. Piper's trilinear diagram, Gibbs diagram, and ion correlation analysis were employed to identify the sources of major ions and factors affecting groundwater quality. Phreeqc Interactive was used to calculate mineral saturation indices and predict trends in caliche deposition. The results indicated that the majority of groundwater in the study area was weakly alkaline, with Ca2+ as the predominant cation and HCO3- as the main anion, resulting in a HCO3-Ca hydrochemical type. Further analysis revealed strong positive correlations between total dissolved solids (TDS) and Ca2+, SO42-, and HCO3-, with these ions contributing significantly to TDS. The water-rock model analysis suggested that rock weathering predominantly controls the hydrochemical genesis of groundwater in the area, with carbonate rocks exerting a strong influence on most ions and minimal ion-exchange action. The findings can provide valuable insights for water resources planning and allocation in the study area.
Article
Chemistry, Multidisciplinary
Jie Lin, Kaixin Chen, Jixin Wang, Jiawei Guo, Siheng Dai, Ying Hu, Jie Li
Summary: The construction of Csp(3)-Csp(3) bonds using alkylzinc reagents through Negishi-type reactions is highly important for the synthesis of pharmaceuticals and agrochemicals. However, the conventional alkylzinc halides have limitations in terms of reactivity and generality. In this study, we successfully prepared solid and salt-stabilized alkylzinc pivalates by OPiv-coordination, which exhibited enhanced stability and excellent reactivity in a cobalt-catalyzed difluoroalkylation-alkylation of dienoates, allowing for the selective installation of CF2- and Csp(3)-groups across double bonds.