Article
Food Science & Technology
William Crowe, Xiaobei Pan, James Mackle, Adam Harris, Gary Hardiman, Christopher T. Elliott, Brian D. Green
Summary: The consumption of processed meat, particularly those with preservative salts such as sodium nitrite, has been linked to the development of colorectal cancer. This study found that nitrite-containing sausages may exacerbate the development of colorectal cancer in mice, leading to increased tumor growth and higher levels of lipid peroxidation. Additionally, these sausages were associated with alterations in gut microbiota and metabolic profiles.
NPJ SCIENCE OF FOOD
(2022)
Article
Cell Biology
Fuli Li, Tinglei Huang, Yao Tang, Qingli Li, Jianzheng Wang, Xiaojiao Cheng, Wenhui Zhang, Baiwen Zhang, Cong Zhou, Shuiping Tu
Summary: UTD1, a novel microtubule stabilizing agent, has shown significant anti-tumor activity in colorectal cancer by inhibiting cell proliferation, inducing cell cycle arrest in G2/M phase, and triggering apoptosis. Additionally, UTD1 exhibits a stronger apoptosis-inducing effect in ABCB1 high-expression cells.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Soeren Ocvirk, Stephen J. D. O'Keefe
Summary: The risk of colorectal cancer is primarily influenced by environmental factors, particularly diet. High dietary fat intake is associated with the formation of pre-neoplastic lesions and colonic tumorigenesis, mainly due to its effects on gut microbiota composition and metabolism, especially in relation to bile acids. Alterations in bile acid metabolism, linked to fat-mediated changes in gut microbiota, are implicated in CRC risk and tumorigenesis by influencing intestinal and hepatic cross-signaling.
SEMINARS IN CANCER BIOLOGY
(2021)
Review
Oncology
Kevin D. Seely, Amanda D. Morgan, Lauren D. Hagenstein, Garrett M. Florey, James M. Small
Summary: Bacterial infection not only promotes the occurrence of colorectal cancer, but also affects its metastasis and organ selectivity by modifying the microenvironment. Bacteria self-signal and establish a pre-metastatic niche at distant sites, providing a suitable environment for tumor cell survival. Specific bacteria in the gut microbiome may play a significant role in the development and metastasis of colorectal cancer.
Article
Pharmacology & Pharmacy
Aminah G. Alotaibi, Jia Li, Nigel J. Gooderham
Summary: The study revealed that the inflammation mediator TNF-alpha can enhance DNA damage induced by BaP and PhIP in colon cancer epithelial cells, without affecting the gene expression levels of the AhR signaling pathways. Additionally, functional p53 suppresses TNF-alpha-induced DNA damage, while the JNK signaling pathway plays a crucial role in this process.
Article
Cell Biology
Kerui Fan, Kun Chen, Xinyan Zan, Ying Zhi, Xue Zhang, Xinyue Zhang, Jinghuan Qiu, Gang Liu, Longjiang Li, Li Tang, Kai Hu, Jingyuan Wan, Xianqiong Gong, Yongqiang Yang, Li Zhang
Summary: Accumulating evidence suggests that metabolic responses are closely related to signal transduction, providing new opportunities for controlling various disorders. This study investigated the molecular mechanisms of IRG1/itaconate in regulating apoptosis in mice with LPS/D-Gal-induced liver injury. The findings showed that IRG1 deletion increased hepatocyte apoptosis and liver injury, and impaired the Nrf2 signaling and enhanced the activation of the AMPK/JNK pathway. Furthermore, supplementation with 4-octyl itaconate resulted in beneficial outcomes in fulminant liver injury. Therefore, IRG1/itaconate might function as a negative regulator of AMPK-induced hepatocyte apoptosis in LPS/D-Gal-induced liver injury.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Liana C. Arnaud, Thierry Gauthier, Augustin Le Naour, Saleha Hashim, Nathalie Naud, Jerry W. Shay, Fabrice H. Pierre, Elisa Boutet-Robinet, Laurence Huc
Summary: The study found that long-term exposure to food contaminants may have a potential promoting effect on colorectal cancer occurrence and development, affecting cellular mechanisms depending on genetic susceptibility.
Article
Fisheries
Gao Gao, Guoling Liang, Hongling Wei, Xing Li, Yuhao Chen, Huan Wang, Chunlin Wang, Changkao Mu, Shuai Liu
Summary: In this study, the researchers cloned the essential c-fos gene of the JNK signaling pathway and found that the JNK pathway regulates the synthesis of vitellogenin (Vg) in the swimming crab Portunus trituberculatus through the transcription factor activator protein 1. Silencing the JNK signaling pathway target gene c-jun resulted in down-regulation of key JNK signaling pathway genes and decreased accumulation of vitellin in the ovary.
Article
Nutrition & Dietetics
Achraf El Asri, Karim Ouldim, Laila Bouguenouch, Mohammed Sekal, Fatima Zahra Moufid, Ellen Kampman, Inge Huybrechts, Marc J. Gunter, Sanae Abbaoui, Kaoutar Znati, Mehdi Karkouri, Khaoula El Kinany, Zineb Hatime, Meimouna Mint Sidi Deoula, Laila Chbani, Btissame Zarrouq, Karima El Rhazi
Summary: This study aimed to explore the associations between fat intake and KRAS mutations in colorectal cancer (CRC) in the Moroccan population. The results suggest that high polyunsaturated fatty acids (PUFA) consumption may be associated with KRAS mutations, possibly related to the etiology of CRC.
Article
Biochemistry & Molecular Biology
Xiaoli Zhang, Weiwei Li, Yiming Ma, Xinhua Zhao, Longmei He, Peng Sun, Hongying Wang
Summary: A high-fat diet exacerbates colorectal cancer by suppressing lipid peroxidation and iron-dependent cell death, known as ferroptosis. Ferroptosis is negatively correlated with tumor number in colorectal cancer. A lipid mixture can block ferroptosis, offering a new potential approach for colorectal cancer prevention.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Moon-Young Song, Da-Young Lee, Sun-Mi Yun, Eun-Hee Kim
Summary: Glucose transporter 3 (GLUT3) is highly expressed in colorectal cancer (CRC) and promotes epithelial-mesenchymal transition (EMT) through the TGF-beta/JNK/ATF2 signaling pathway, enhancing invasive ability.
Article
Multidisciplinary Sciences
Hong-Chieh Tsai, Han-Hsing Tsou, Chun-Chi Lin, Shao-Chen Chen, Hsiao-Wei Cheng, Tsung-Yun Liu, Wei-Shone Chen, Jeng-Kai Jiang, Shung-Haur Yang, Shih-Ching Chang, Hao-Wei Teng, Hsiang-Tsai Wang
Summary: Colorectal cancer is a well-known malignancy with high prevalence and poor 5-year survival, and a high-fat diet may increase the odds of developing this cancer. Acrolein plays a crucial role in oncogenic transformation through activation of the RAS/MAPK signaling pathway in colon tumorigenesis.
SCIENTIFIC REPORTS
(2021)
Article
Agriculture, Dairy & Animal Science
M. Zhang, W. J. Tu, Q. Zhang, X. L. Wu, X. Y. Zou, S. Jiang
Summary: This study reveals that osteocalcin can prevent fatty liver hemorrhagic syndrome in poultry by inhibiting the ROS-JNK signaling pathway.
Review
Oncology
Kuang He, Wen-Juan Gan
Summary: The Wnt/beta-catenin signaling pathway is closely associated with the carcinogenesis and progression of colorectal cancer (CRC), playing a crucial role in cancer-related processes. Hyperactivation of the pathway is observed in almost all CRC cases and contributes to cancer stem cell propagation, angiogenesis, epithelial-mesenchymal transition (EMT), chemoresistance, and metastasis. This review will discuss the involvement of the Wnt/beta-catenin signaling pathway in CRC and potential therapeutic approaches.
CANCER MANAGEMENT AND RESEARCH
(2023)
Article
Chemistry, Medicinal
Ah-Won Kwak, Jin-Young Lee, Seung-On Lee, Ji-hye Seo, Jin Woo Park, Yung Hyun Choi, Seung-Sik Cho, Goo Yoon, Mee-Hyun Lee, Jung-Hyun Shim
Summary: This study elucidates the molecular mechanism of Ech-induced apoptosis in both oxaliplatin-sensitive and -resistant CRC cells, showing that Ech exhibits anticancer activity by inducing ROS-mediated apoptosis through the JNK/p38 MAPK signaling pathway.
PHYTOTHERAPY RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Takashi Sasaki, Rei Ishibashi, Shuntaro Yoshida, Toshio Fujisawa, Hiroki Shinagawa, Chimyon Gon, Yousuke Nakai, Naoki Sasahira, Yoshihisa Saida, Hiroyuki Isayama
Summary: This study evaluated the mechanical properties of colorectal SEMSs and found that the structure and size of each stent influence the radial force and axial force curves. There was a strong correlation between AFs measured by the new and conventional methods. Colorectal SEMSs could be categorized into five subgroups based on their mechanical properties.
DIGESTIVE ENDOSCOPY
(2021)
Article
Gastroenterology & Hepatology
Yusuke Takasaki, Shigeto Ishii, Tomoyoshi Shibuya, Toshio Fujisawa, Mako Ushio, Sho Takahashi, Koichi Ito, Wataru Yamagata, Akinori Suzuki, Koki Okahara, Yoshihiro Okawa, Kazushige Ochiai, Ko Tomishima, Osamu Nomura, Kenichi Haga, Hiroaki Saito, Akihito Nagahara, Hiroyuki Isayama
Summary: This study compared the efficacy and safety of EUS-AG and DB-ERC in removing bile duct stones in patients with surgically altered anatomies, finding that EUS-AG had comparable technical success and complete stone removal rates to DB-ERC, but with a shorter operating time. The adverse event rate was acceptable in both procedures.
DIGESTIVE ENDOSCOPY
(2021)
Article
Surgery
Fumihiro Kawano, Ryuji Yoshioka, Yu Gyoda, Hirofumi Ichida, Tomoya Mizuno, Shigeto Ishii, Toshio Fujisawa, Hiroshi Imamura, Yoshihiro Mise, Hiroyuki Isayama, Akio Saiura
Summary: By comparing the intraoperative and postoperative outcomes of patients with ETGBS and PTGBD, it was found that ETGBS patients had a higher rate of cystic duct thickening, which interfered with duct closure. In contrast, no obstruction occurred in PTGBD patients. Further investigations are needed to validate the results of this pilot study.
Article
Medicine, General & Internal
Ko Tomishima, Shigeto Ishii, Toshio Fujisawa, Muneo Ikemura, Mako Ushio, Sho Takahashi, Wataru Yamagata, Yusuke Takasaki, Akinori Suzuki, Koichi Ito, Keiichi Haga, Kazushige Ochiai, Osamu Nomura, Hiroaki Saito, Tomoyoshi Shibuya, Akihito Nagahara, Hiroyuki Isayama
Summary: The retrospective study showed that using fully covered self-expandable metallic stents (FCSEMS) for refractory BBS was feasible and effective through various insertion routes. Stents should be exchanged every 6 months to ensure stricture resolution, but patients need to be aware of the risks of stent fracture and other complications.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Kazushige Ochiai, Toshio Fujisawa, Shigeto Ishii, Akinori Suzuki, Hiroaki Saito, Yusuke Takasaki, Mako Ushio, Sho Takahashi, Wataru Yamagata, Ko Tomishima, Tadakazu Hisamatsu, Hiroyuki Isayama
Summary: This retrospective study of 48 patients undergoing EUS-HGS found that a longer distance between the stomach and liver increased the risk of stent migration. Ensuring a large proportion of the stent in the stomach is crucial during EUS-HGS procedures.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Yuki Fukumura, Lu Rong, Yifare Maimaitiaili, Toshio Fujisawa, Hiroyuki Isayama, Jun Nakahodo, Masataka Kikuyama, Takashi Yao
Summary: Understanding the pathogenesis and carcinogenesis of gallbladder adenocarcinoma is crucial. This study reviewed and summarized information on three gallbladder neoplastic precursors, PGA, BilIN, and ICPN, as well as gallbladder lesions in patients with PBM.
Article
Medicine, General & Internal
Toshio Fujisawa, Hiroshi Fukuda, Naoto Sakamoto, Mariko Hojo, Ko Tomishima, Shigeto Ishii, Hirohide Yokokawa, Mizue Saita, Toshio Naito, Akihito Nagahara, Sumio Watanabe, Hiroyuki Isayama
Summary: CO2 insufflation may reduce postprocedural abdominal discomfort from transnasal esophagogastroduodenoscopies without apparent adverse events.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Yusuke Takasaki, Hiroyuki Isayama, Kyoung Sub Shin, Shigeto Ishii, Toshio Fujisawa, Jong Pil Moon, Taito Fukuma, Mako Ushio, Sho Takahashi, Akinori Suzuki, Koichi Ito, Ko Tomishima
Summary: In this study, anchoring force (ACF) of various LAMS and CSEMS was measured and compared using a new phantom model. The AXIOS had the highest ACF among the LAMS, while the Spring Stopper had the highest ACF among the CSEMS. Some ACF values varied with the direction of pull. These findings may influence stent selection for interventional endoscopic ultrasonography, and the model can be utilized for evaluating newly developed stents.
DIGESTIVE ENDOSCOPY
(2023)
Article
Gastroenterology & Hepatology
Sho Takahashi, Toshio Fujisawa, Mako Ushio, Taito Fukuma, Akinori Suzuki, Yusuke Takasaki, Koichi Ito, Ko Tomishima, Shigeto Ishii, Hiroyuki Isayama
Summary: This study retrospectively evaluated the placement of 6mm slim fully covered self-expandable metallic stents (SFCSEMS) for unresectable malignant hilar-biliary obstruction. The results showed that the placement of SFCSEMS was feasible and effective, with a low incidence of segmental cholangitis.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Editorial Material
Medicine, General & Internal
Hiroyuki Isayama, Shigeto Ishii, Ko Tomishima, Toshio Fujisawa
JOURNAL OF CLINICAL MEDICINE
(2022)
Editorial Material
Gastroenterology & Hepatology
Toshio Fujisawa, Hiroyuki Isayama
DIGESTIVE ENDOSCOPY
(2022)
Article
Gastroenterology & Hepatology
Wataru Yamagata, Toshio Fujisawa, Takashi Sasaki, Rei Ishibashi, Tomotaka Saito, Shuntaro Yoshida, Shizuka No, Kouta Inoue, Yousuke Nakai, Naoki Sasahira, Hiroyuki Isayama
Summary: This study investigated the mechanical properties of different self-expandable metallic stents (SEMSs) and their influence on clinical outcomes. The structure of the stents was found to be related to their performance. Hook-and-cross-type SEMSs had low axial force and a high zero border angle, making them the safest option with minimal stress on the bile duct wall.
CLINICAL ENDOSCOPY
(2023)
Editorial Material
Gastroenterology & Hepatology
Sho Takahashi, Toshio Fujisawa, Hiroyuki Isayama
DIGESTIVE ENDOSCOPY
(2023)
Editorial Material
Gastroenterology & Hepatology
Haruka Hagiwara, Ko Tomishima, Yasuhisa Jimbo, Mako Ushio, Akinori Suzuki, Toshio Fujisawa, Hiroyuki Isayama
Editorial Material
Gastroenterology & Hepatology
Sho Takahashi, Shigeto Ishii, Akinori Suzuki, Koichi Ito, Ko Tomishima, Toshio Fujisawa, Hiroyuki Isayama