Article
Endocrinology & Metabolism
Anna Sophie L. Kjaer, Rikke Beck Jensen, Jorgen H. Petersen, Allan Linneberg, Line Lund Karhus, Louise Scheutz Henriksen, Trine Holm Johannsen, Katharina M. Main, Andrew R. Hoffman, Anders Juul
Summary: This study found that the levels of IGF-I and IGFBP-3 remain stable throughout an individual's lifetime, thus a single measurement of IGF-I can reliably reflect lifetime exposure. GH therapy has only a slight effect on lifetime exposure to IGF-I and remains below the average exposure in the reference population.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Luigi Maione, Cristina Albrici, Solange Grunenwald, Celine Mouly, Vincenzo Cimino, Anne-Lise Lecoq, Jean Claude Souberbielle, Philippe Caron, Philippe Chanson
Summary: This study compared the serum IGF-I dynamics and variability in patients treated with SRLs, surgically cured patients, and healthy controls. The results showed that IGF-I decreased significantly at Day 7 and Day 14 after injection in SRL-treated patients, but remained stable in cured patients and healthy controls. In addition, SRL-treated patients had higher IGF-I variability, especially in nonoptimally controlled patients. The measurement at the farthest distance from SRL injection was the best predictor of optimal disease control.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Cecilia Catellani, Gloria Ravegnini, Chiara Sartori, Sabrina Angelini, Maria E. Street
Summary: Growth hormone and the insulin-like growth factor system play crucial roles in cell proliferation, differentiation, apoptosis, and angiogenesis, while miRNAs and lncRNAs regulate gene expression and have been linked to diseases such as cancer.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Vivian Hwa, Masanobu Fujimoto, Gaohui Zhu, Wen Gao, Corinne Foley, Meenasri Kumbaji, Ron G. Rosenfeld
Summary: Growth hormone insensitivity (GHI) syndrome is linked to monogenic defects in the growth hormone receptor (GHR) gene, causing growth failure. Recognition of other monogenic defects downstream of GHR has greatly expanded understanding of the primary causes of GHI and growth retardation.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2021)
Review
Cell Biology
Marina Caputo, Stella Pigni, Emanuela Agosti, Tommaso Daffara, Alice Ferrero, Nicoletta Filigheddu, Flavia Prodam
Summary: Growth hormone (GH) and insulin-like growth factor-1 (IGF-I) play crucial roles in lifespan, growth, metabolism, and nutrient utilization. Nutrients are essential modifiers of the GH/IGF-I axis, and these hormones also regulate the utilization of nutrients in cells and tissues.
Review
Endocrinology & Metabolism
Concetta Mastromauro, Cosimo Giannini, Francesco Chiarelli
Summary: Linear growth during childhood is the result of various factors, with the growth hormone-insulin-like growth factor axis playing a crucial role. Growth hormone insensitivity (GHI) is a significant disorder characterized by low IGF-1 levels, normal or elevated GH levels, and lack of IGF-1 response after GH administration. Recombinant IGF-1 preparations can be used for treatment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Stefano Cianfarani
Summary: GH therapy has shown excellent short-term safety, but long-term potential side effects remain a concern. Recent observational studies in different cohorts of young adult patients have yielded conflicting results, focusing on the risks of cancer, cardio and cerebrovascular diseases, and diabetes associated with GH therapy.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Anja Apel, Daniel I. Iliev, Christina Urban, Karin Weber, Roland Schweizer, Gunnar Blumenstock, Sarah Pasche, Vanessa Nieratschker, Gerhard Binder
Summary: In patients treated with a normal dose of rhGH, the methylation of IGF1 P2 promoter was not significantly correlated with GH responsiveness, and the methylation of two key sites remained relatively stable during treatment.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Environmental Sciences
Songtao Liu, Yingying Fang, Ying Liu, Xin Li, Fei Sun, Yanling Wu, Zhen Ma, He Ma
Summary: This study explored the effects of different LED spectra on the growth of juvenile Takifugu rubripes. It was found that green light significantly promoted the growth of Takifugu rubripes, while red light significantly inhibited its growth. The expressions of GH/IGF-I growth axis and apoptosis-related genes were analyzed, and significant differences were observed among different LED spectra treatments.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Endocrinology & Metabolism
Martina Romanisio, Rosa Pitino, Alice Ferrero, Francesca Pizzolitto, Samuele Costelli, Valentina Antoniotti, Paolo Marzullo, Gianluca Aimaretti, Flavia Prodam, Marina Caputo
Summary: This study evaluated metabolic comorbidities in surgically treated acromegalic patients and found that the discrepancy between GH and IGF-1 levels does not appear to be a risk factor for their presence or persistence. Further extended studies are needed to confirm these results in the long term.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Vicente Barrios, Laura M. Frago, Sandra Canelles, Santiago Guerra-Cantera, Eduardo Arilla-Ferreiro, Julie A. Chowen, Jesus Argente
Summary: This study found that Leptin levels have a significant impact on the regulation of the GH/IGF-I axis and thermogenesis in BAT. Food restriction reduces GH and IGF-I concentrations, while the presence of Leptin affects signaling pathways and metabolism related to IGF-I in BAT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Manuel H. Aguiar-Oliveira, Roberto Salvatori
Summary: The study of isolated GH deficiency caused by a homozygous inactivating mutation in the GH releasing hormone receptor gene has shown a variety of phenotypic changes in body size and function, with a greater number of beneficial consequences.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2021)
Article
Sport Sciences
Hannah Mortimer, Jean Whitehead, Maria Kavussanu, Bahri Gurpinar, Christopher Ring
Summary: The study found that moral values had the best predictive effect on the likelihood of clean sport, while other values associated with the spirit of sport and sport values also had a positive impact on clean sport likelihood.
JOURNAL OF SPORTS SCIENCES
(2021)
Article
Engineering, Environmental
Junli Zuo, Tangbin Huo, Xue Du, Qing Yang, Qin Wu, Jianzhong Shen, Chunsheng Liu, Tien-Chieh Hung, Wei Yan, Guangyu Li
Summary: The coexposure of PSNPs and MCLR increased the transfer of MCLR to offspring and exacerbated growth inhibition of F1 larvae. This coexposure decreased thyroid hormone levels by altering HPT axis-related gene expression, eventually leading to growth inhibition of F1 larvae. PSNPs and MCLR coexposure also affected key genes of the GH/IGF axis, indicating a potential target for growth inhibition in F1 larvae.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Editorial Material
Endocrinology & Metabolism
Gudmundur Johannsson, John J. Kopchick
Summary: This thematic review provides short reviews on growth hormone deficiency and insensitivity in children and adults, covering from basic science to clinical significance.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2021)