Biocatalytic strategies for the asymmetric synthesis of profens – recent trends and developments

Dramatically improved catalytic activity of an artificial (S)-selective arylmalonate decarboxylase by structure-guided directed evolution

(2011) Yusuke Miyauchi et al.   CHEMICAL COMMUNICATIONS

Searching for green solvents

(2011) Philip G. Jessop   GREEN CHEMISTRY

Toxicological Assessment of 2-Methyltetrahydrofuran and Cyclopentyl Methyl Ether in Support of Their Use in Pharmaceutical Chemical Process Development

(2011) Vincent Antonucci et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Efficient Production of (S)-Naproxen with (R)-Substrate Recycling Using an Overexpressed Carboxylesterase BsE-NP01

(2010) Xiang Liu et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Structural Basis for Inverting the Enantioselectivity of Arylmalonate Decarboxylase Revealed by the Structural Analysis of the Gly74Cys/Cys188Ser Mutant in the Liganded Form

(2010) Rika Obata et al.   BIOCHEMISTRY

Biocatalytic Redox Reactions for Organic Synthesis: Nonconventional Regeneration Methods

(2010) Frank Hollmann et al.   ChemCatChem

Engineering the Promiscuous Racemase Activity of an Arylmalonate Decarboxylase

(2010) Robert Kourist et al.   CHEMISTRY-A EUROPEAN JOURNAL

Applied Biotransformations in Green Solvents

(2010) María J. Hernáiz et al.   CHEMISTRY-A EUROPEAN JOURNAL

Ionic liquids in biotransformations: from proof-of-concept to emerging deep-eutectic-solvents

(2010) Pablo Domínguez de María et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Hydrolases in Green Solvents

(2010) Maria Perez et al.   CURRENT ORGANIC CHEMISTRY

Protein engineering and discovery of lipases

(2010) Robert Kourist et al.   EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY

Biooxidation of Primary Alcohols to Aldehydes through Hydrogen Transfer Employing Janibacter terrae

(2010) Thomas Orbegozo et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Enzyme-catalyzed C–C bond formation using 2-methyltetrahydrofuran (2-MTHF) as (co)solvent: efficient and bio-based alternative to DMSO and MTBE

(2010) Saravanakumar Shanmuganathan et al.   GREEN CHEMISTRY

Enzyme-mediated oxidations for the chemist

(2010) Frank Hollmann et al.   GREEN CHEMISTRY

Biocatalyzed irreversible esterification in the preparation of S-naproxen

(2010) R. Morrone et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Use of a Robust Dehydrogenase from an Archael Hyperthermophile in Asymmetric Catalysis−Dynamic Reductive Kinetic Resolution Entry into (S)-Profens

(2010) Jacob A. Friest et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Directed Evolution of an Enantioselective Lipase with Broad Substrate Scope for Hydrolysis of α-Substituted Esters

(2010) Karin Engström et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemoenzymatic synthesis of (2S)-2-arylpropanols through a dynamic kinetic resolution of 2-arylpropanals with alcohol dehydrogenases

(2010) Paola Galletti et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Multienzyme-Catalyzed Processes: Next-Generation Biocatalysis

(2010) Paloma A. Santacoloma et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Structure-Guided Directed Evolution of Alkenyl and Arylmalonate Decarboxylases

(2009) Krzysztof Okrasa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

From Ostwald Ripening to Single Chirality

(2009) Wim L. Noorduin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Identification of Amino Acid Residues Responsible for the Enantioselectivity and Amide Formation Capacity of the Arylacetonitrilase from Pseudomonas fluorescens EBC191

(2009) C. Kiziak et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Achievements and new knowledge unraveled by metagenomic approaches

(2009) Carola Simon et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Composite Particles of Novozyme 435 and Silicone: Advancing Technical Applicability of Macroporous Enzyme Carriers

(2009) Lars O. Wiemann et al.   ChemCatChem

Progress of Enantioselective Nitrile Biotransformations in Organic Synthesis

(2009) Mei-Xiang Wang   CHIMIA

Regioselective enzymatic acylation of pharmacologically interesting nucleosides in 2-methyltetrahydrofuran, a greener substitute for THF

(2009) Yolanda Simeó et al.   GREEN CHEMISTRY

Improvements of enzyme activity and enantioselectivity in lipase-catalyzed alcoholysis of (R,S)-azolides

(2009) An-Chi Wu et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Directed Evolution of Enantioselective Enzymes: An Unconventional Approach to Asymmetric Catalysis in Organic Chemistry

(2009) Manfred T. Reetz   JOURNAL OF ORGANIC CHEMISTRY

Finding better protein engineering strategies

(2009) Romas J Kazlauskas et al.   Nature Chemical Biology

Site-selective immobilisation of functional enzymes on to polystyrene nanoparticles

(2009) Lu Shin Wong et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Directed evolution of Candida antarctica lipase A using an episomaly replicating yeast plasmid†

(2009) Anders G. Sandström et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Enzyme engineering for enantioselectivity: from trial-and-error to rational design?

(2009) Linda G. Otten et al.   TRENDS IN BIOTECHNOLOGY

Enantioselective kinetic resolution of phenylalkyl carboxylic acids using metagenome-derived esterases

(2009) Elena Fernández-Álvaro et al.   Microbial Biotechnology

Complete Inversion of Enantioselectivity towards Acetylated Tertiary Alcohols by a Double Mutant of aBacillus Subtilis Esterase

(2008) Sebastian Bartsch et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Screening, cloning, expression, and purification of an acidic arylmalonate decarboxylase from Enterobacter cloacae KU1313

(2008) Yoshito Yatake et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Asymmetric decarboxylation of α-hydroxy- and α-amino-α-phenylmalonate catalyzed by arylmalonate decarboxylase fromAlcaligenes bronchisepticus

(2008) Keisuke Tamura et al.   BIOCATALYSIS AND BIOTRANSFORMATION

Microbial kinetic resolution of 2-substituted-1-propanol

(2008) K. Miyamoto et al.   BIOCATALYSIS AND BIOTRANSFORMATION

A new irreversible enzyme-aided esterification method in organic solvents

(2008) Günter E. Jeromin et al.   BIOTECHNOLOGY LETTERS

Structure and Mechanism of an Unusual Malonate Decarboxylase and Related Racemases

(2008) Krzysztof Okrasa et al.   CHEMISTRY-A EUROPEAN JOURNAL

Microbial nitrilases: versatile, spiral forming, industrial enzymes

(2008) R.N. Thuku et al.   JOURNAL OF APPLIED MICROBIOLOGY

Active-Site Mobility Revealed by the Crystal Structure of Arylmalonate Decarboxylase from Bordetella bronchiseptica

(2008) E. Bartholomeus Kuettner et al.   JOURNAL OF MOLECULAR BIOLOGY

Advances in Recovery of Novel Biocatalysts from Metagenomes

(2008) Helen L. Steele et al.   JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY

Metagenomics for Mining New Genetic Resources of Microbial Communities

(2008) Manuel Ferrer et al.   JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY

Optimisation of stabilised Carboxylesterase NP for enantioselective hydrolysis of naproxen methyl ester

(2008) Lucia Steenkamp et al.   PROCESS BIOCHEMISTRY

The green and effective oxidation of alcohols to carboxylic acids with molecular oxygen via biocatalytic reaction

(2008) Jun-ichiro Hirano et al.   TETRAHEDRON LETTERS

X-ray Structure of Candida antarctica Lipase A Shows a Novel Lid Structure and a Likely Mode of Interfacial Activation

(2007) Daniel J. Ericsson et al.   JOURNAL OF MOLECULAR BIOLOGY

Recent developments in dynamic kinetic resolution

(2007) Hélène Pellissier   TETRAHEDRON