Journal
PLOS ONE
Volume 7, Issue 2, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0030762
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Funding
- Spanish Ministry of Science and Innovation [FIS PI10 02827, SAF 2004 07656 C02-02, SAF 2010 21274, RYC-2010-06729]
- Fundacion Seneca [FS/15329/PI/10]
- CIBERNED (Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas)
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CCL2 is a chemokine involved in brain inflammation, but the way in which it contributes to the entrance of lymphocytes in the parenchyma is unclear. Imaging of the cell type responsible for this task and details on how the process takes place in vivo remain elusive. Herein, we analyze the cell type that overexpresses CCL2 in multiple scenarios of T-cell infiltration in the brain and in three different species. We observe that CCL2(+) astrocytes play a part in the infiltration of T-cells in the brain and our analysis shows that the contact of T-cells with perivascular astrocytes occurs, suggesting that may be an important event for lymphocyte extravasation.
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