Article
Multidisciplinary Sciences
Rie Seyama, Masashi Nishikawa, Yuri Uchiyama, Keisuke Hamada, Yuka Yamamoto, Masahiro Takeda, Takanori Ochi, Monami Kishi, Toshifumi Suzuki, Kohei Hamanaka, Atsushi Fujita, Naomi Tsuchida, Eriko Koshimizu, Kazuharu Misawa, Satoko Miyatake, Takeshi Mizuguchi, Shintaro Makino, Takashi Yao, Hidenori Ito, Atsuo Itakura, Kazuhiro Ogata, Koh-ichi Nagata, Naomichi Matsumoto
Summary: This study identified a rare RAC1 variant in a male patient, resulting in multiple anomalies and respiratory failure leading to death. The variant may deactivate downstream signals and affect normal cellular functions.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Physical
Mainak Chatterjee, Anirban Sain
Summary: Dynamic pattern formations in multicellular systems and embryos at their single-cell stage can be modeled using reaction-diffusion networks.
JOURNAL OF CHEMICAL PHYSICS
(2022)
Review
Oncology
Pontus Aspenstrom
Summary: For many years, the role of RHO GTPases in cancer has been overlooked, but recent studies have shown that they are altered in many cancer types and may have oncogenic effects. This review article summarizes the current knowledge of these mutant RHO GTPases, focusing on how their kinetics can contribute to cancer progression.
Article
Multidisciplinary Sciences
Supriya Ramesha, Sruti Rayaprolu, Christine A. Bowen, Cynthia R. Giver, Sara Bitarafan, Hai M. Nguyen, Tianwen Gao, Michael J. Chen, Ngozi Nwabueze, Eric B. Dammer, Amanda K. Engstrom, Hailian Xiao, Andrea Pennati, Nicholas T. Seyfried, David J. Katz, Jacques Galipeau, Heike Wulff, Edmund K. Waller, Levi B. Wood, Allan Levey, Srikant Rangaraju
Summary: By studying Kv1.3-expressing CNS-MPs in AD mouse models, researchers have identified unique molecular features of these cells and confirmed their microglial origin. Blocking Kv1.3 channels in vivo resulted in reduced Aβ burden, increased anti-inflammatory CNS-MPs, and a prophagocytic phenotype in AD mouse models.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
En Li, Yu-Ling Zhang, Xuelian Shi, Han Li, Xuefeng Yuan, Sha Li, Yan Zhang
Summary: This study identified a positive feedback circuit essential for root hair tip growth, involving ROP proteins, activators, effectors, and AGC1.5 kinases. These components interact through sequential oligomerization and phosphorylation, showing the importance of asymmetric targeting and recruitment of AGC1.5 during plant cell polar growth.
Review
Biochemistry & Molecular Biology
Germana Cocozza, Stefano Garofalo, Riccardo Capitani, Giuseppina D'Alessandro, Cristina Limatola
Summary: The research interest in microglia's role in neurodegenerative diseases is increasing rapidly, with a focus on the importance of potassium channels in modulating microglial functions in diseases like Alzheimer's, Parkinson's, and ALS. The discovery of specific biomarkers of microglia phenotype may have wide applications in human diseases and could lead to tailored therapeutic interventions.
Article
Chemistry, Multidisciplinary
Huiping He, Chengjian Zhou, Xi Chen
Summary: This article introduces a targeted protein degradation method based on the autophagy pathway, which overcomes the limitations of current small-molecule degraders and can degrade unligandable proteins. By designing an intelligent nanobody chimera called ATNC, researchers have successfully achieved selective degradation of intracellular targets and demonstrated its therapeutic potential in suppressing ovarian cancer cell proliferation and migration.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Review
Immunology
Rana El Masri, Jerome Delon
Summary: Ras homology (RHO) GTPases play crucial roles in triggering multiple immune functions through interactions with effectors and kinases, and recent discoveries of new partners and genetic mutations in RHO GTPase signaling hubs offer novel therapeutic opportunities.
NATURE REVIEWS IMMUNOLOGY
(2021)
Article
Ophthalmology
Hong Li, Donglong Chen, Wei Sun, Jiansu Chen, Chang Luo, Heping Xu, Jacey Hongjie Ma, Shibo Tang
Summary: The study showed that pinacidil can alleviate diabetes-induced retinal gliosis and microglial activation. In vitro, pinacidil inhibited the expression of proinflammatory factors in microglia and reduced GFAP expression induced by M1 microglia in Muller cells. Pinacidil may have a potential therapeutic effect on diabetes-induced retinal inflammation and gliosis through upregulating Kir6.1 expression.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Multidisciplinary Sciences
Fabio Falleroni, Ulisse Bocchero, Simone Mortal, Yunzhen Li, Zhongjie Ye, Dan Cojoc, Vincent Torre
Summary: There is growing evidence that the mechanical properties of neurons play a crucial role in cellular processes. This study found that neurons are able to distinguish the magnitude of mechanical stimuli and respond with changes in intracellular calcium levels. Mechanically evoked responses require the influx of extracellular calcium through transmembrane ion channels. Furthermore, mechanical stimulation activates certain proteins involved in cellular signaling.
Article
Immunology
Robin Caire, Elisa Dalix, Marwa Chafchafi, Mireille Thomas, Marie-Therese Linossier, Myriam Normand, Alain Guignandon, Laurence Vico, Hubert Marotte
Summary: This study reveals the critical role of transcription co-factors YAP/TAZ in the signaling of pro-inflammatory cytokine TNF, and their involvement in biological effects associated with cancer and inflammatory disorders.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Chao Mei, Chong Liu, Ying Gao, Wen-Ting Dai, Wei Zhang, Xi Li, Zhao-Qian Liu
Summary: This study revealed that eIF3a is overexpressed in colorectal cancer tissues, and its high expression is associated with tumor metastasis and overall survival. Downregulation of eIF3a significantly inhibits the proliferation and migration of malignant cells. Mechanistically, eIF3a regulates Cdc42 and RhoA expression to promote actin cytoskeleton remodeling, facilitating cancer cell migration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Yudai Matsuoka, Hani Al-Shareef, Mikihiko Kogo, Hirokazu Nakahara
Summary: Rac proteins play a crucial role in cancer development, with inhibition inducing apoptosis in oral squamous cell carcinoma cells of varying malignancy grades. Activation of JNK is strongly correlated with apoptosis.
Article
Biochemistry & Molecular Biology
Hiroshi Senoo, Daisuke Murata, May Wai, Kenta Arai, Wakiko Iwata, Hiromi Sesaki, Miho Iijima
Summary: AKT, a serine/threonine kinase, plays a crucial role in metabolism, cell growth, and cytoskeletal dynamics, and is activated by PDK1 and mTORC2. Research has uncovered that insulin activates mTORC2 towards AKT by forming a supercomplex KARATE with KRAS4B and RHOA GTPases, revealing a fundamental mechanism in insulin-regulated glucose homeostasis.
Article
Multidisciplinary Sciences
Rocio G. Sampayo, Mason Sakamoto, Madeline Wang, Sanjay Kumar, David V. Schaffer
Summary: During the process of cell differentiation into tissues, cells are influenced by mechanical signals from the extracellular matrix (ECM), which regulate their fate. The activation of Rho GTPases plays a key role in sensing these cues, but the regulation and integration of the activation dynamics is still unclear. This study found that ECM stiffness cues not only alter the magnitude but also the temporal frequency of RhoA and Cdc42 activation in adult neural stem cells (NSCs). Further experiments using optogenetics showed that the frequency of RhoA and Cdc42 activation drives astrocytic versus neuronal differentiation, highlighting the functional significance of these dynamics.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Pharmacology & Pharmacy
Ruben Orihuela, Christopher A. McPherson, Gaylia Jean Harry
BRITISH JOURNAL OF PHARMACOLOGY
(2016)
Article
Toxicology
Steven T. Szabo, G. Jean Harry, Kathleen M. Hayden, David T. Szabo, Linda Birnbaum
TOXICOLOGICAL SCIENCES
(2016)
Article
Neurosciences
Andrew D. Kraft, Christopher A. McPherson, G. Jean Harry
NEUROTOXICITY RESEARCH
(2016)
Article
Biochemistry & Molecular Biology
Valeria Avdoshina, Seamus P. Caragher, Erin D. Wenzel, Francesca Taraballi, Italo Mocchetti, Gaylia Jean Harry
JOURNAL OF NEUROCHEMISTRY
(2017)
Retraction
Immunology
Jagadeesh Sridhara Rao, Hyung-Wook Kim, Matthew Kellom, Dede Greenstein, Mei Chen, Andrew David Kraft, Gaylia Jean Harry, Stanley Isaac Rapoport, Mireille Basselin
JOURNAL OF NEUROINFLAMMATION
(2017)
Article
Neurosciences
David R. Goulding, Sally S. White, Sandra J. McBride, Suzanne E. Fenton, G. Jean Harry
Article
Behavioral Sciences
David R. Goulding, Viktoriya D. Nikolova, Lopa Mishra, Lisheng Zhuo, Koji Kimata, Sandra J. McBride, Sheryl S. Moy, G. J. Harry, Stavros Garantziotis
GENES BRAIN AND BEHAVIOR
(2019)
Article
Neurosciences
Christopher A. McPherson, Guozhu Zhang, Richard Gilliam, Sukhdev S. Brar, Ralph Wilson, Amy Brix, Catherine Picut, G. Jean Harry
NEUROTOXICITY RESEARCH
(2018)
Article
Multidisciplinary Sciences
Kelvin Yen, Junxiang Wan, Hemal H. Mehta, Brendan Miller, Amy Christensen, Morgan E. Levine, Matthew P. Salomon, Sebastian Brandhorst, Jialin Xiao, Su-Jeong Kim, Gerardo Navarrete, Daniel Campo, G. Jean Harry, Valter Longo, Christian J. Pike, Wendy J. Mack, Howard N. Hodis, Eileen M. Crimmins, Pinches Cohen
SCIENTIFIC REPORTS
(2018)
Article
Neurosciences
David R. Goulding, Andrew Kraft, Peter R. Mouton, Christopher A. McPherson, Valeria Avdoshina, Italo Mocchetti, G. Jean Harry
NEUROTOXICITY RESEARCH
(2019)
Article
Environmental Sciences
Christine Bowen, Gabrielle Childers, Caroline Perry, Negin Martin, Christopher A. McPherson, Tatlock Lauten, Janine Santos, G. Jean Harry
Review
Biochemistry & Molecular Biology
Gaylia Jean Harry
Summary: Changes in microglia are commonly associated with neurodegeneration, but it is not clear if they initiate the process. Communication between microglia and neurons helps maintain the cells in a surveillance state, suggesting a partnership role rather than an initiating one in neurodegeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Gabrielle M. Childers, Caroline A. Perry, Barbara Blachut, Negin Martin, Carl D. Bortner, Stella Sieber, Jian-Liang Li, Michael B. Fessler, G. Jean Harry
Summary: The study investigated the role of mitochondrial toxicants in inflammasome activation and IL-1β processing in murine macrophages. Results showed that mitochondrial toxicants induced inflammasome activation, suppressed mitochondrial bioenergetics and ROS production, and impacted the transcriptional response of macrophages, potentially leading to suppressed host defense.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2021)
Meeting Abstract
Neurosciences
G. J. Harry
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2019)
Meeting Abstract
Biochemistry & Molecular Biology
G. J. Harry, C. Perry, C. McPherson
JOURNAL OF NEUROCHEMISTRY
(2017)