Article
Immunology
Yunqi Li, Francois Lefebvre, Edith Nakku-Joloba, Allan Ronald, Glenda Gray, Guy de Bruyn, James Kiarie, Connie Celum, Mark J. Cameron, Jairam R. Lingappa, Romel D. Mackelprang
Summary: In individuals exposed to HIV-1, higher expression of PTPRC (CD45 antigen) and interferon-response pathways may indicate an increased risk of acquiring HIV-1.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Clinical Neurology
Leila Asad Samani, Kamran Ghaedi, Ahmad Majd, Maryam Peymani, Masoud Etemadifar
Summary: This study aimed to assess the overlap of PD patients' transcriptomes in the substantia nigra (SN) with peripheral blood mononuclear cells (PBMCs) to discover potential biomarkers for diagnosis. Through the analysis of gene expression differences and validation using RT-qPCR, HSPA1A/B, DGKH, and NOTCH2 were identified as potential biomarkers for PD diagnosis.
NEUROLOGICAL SCIENCES
(2023)
Article
Biochemical Research Methods
Kristina Lietz, Babak Saremi, Lena Wiese
Summary: This study developed a web application that simplifies the analysis of microarray data and allows for the comparison of results from different technologies and organisms. The application provides a convenient and customizable analysis process and allows users to gain further insights from existing study data.
BMC BIOINFORMATICS
(2023)
Article
Cell Biology
Siyang Wen, Yilu Qin, Rui Wang, Liping Yang, Huan Zeng, Pengpeng Zhu, Qiao Li, Yuxiang Qiu, Shanchun Chen, Yongcan Liu, Yixuan Hou, Xi Tang, Manran Liu, Gang Tu
Summary: The novel lncRNA lnc408 functions as an oncogenic factor by inhibiting CBY1 expression and promoting beta-catenin accumulation in the nucleus, contributing to the maintenance of breast cancer stem cells (BCSCs) and tumorigenesis. This lnc408-CBY1-beta-catenin signaling axis may serve as a potential diagnostic and therapeutic target for breast cancer.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Chuan-Lei Dong, Feng Zhu, Ming-Xing Lu, Yu-Zhou Du
Summary: The study identified Cshsp19.0 as a small heat shock protein that plays a significant role in insect development and stress tolerance. Expression of Cshsp19.0 in C. suppressalis is influenced by developmental stage, heat and cold stress, and shows a difference between male and female pupae in response to humidity. Silencing of Cshsp19.0 results in reduced larval survival, confirming its importance in environmental stress tolerance and physiological activities in C. suppressalis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Plant Sciences
Anelita de Jesus Rocha, Julianna Matos da Silva Soares, Fernanda dos Santos Nascimento, Adailson dos Santos Rocha, Vanusia Batista Oliveira de Amorim, Andresa Priscila de Souza Ramos, Claudia Fortes Ferreira, Fernando Haddad, Edson Perito Amorim
Summary: Fusarium wilt caused by Fusarium oxysporum f. sp. cubense (Foc) is a major limiting factor in banana agriculture. This study analyzed the interaction between Musa spp. and Foc, and found that the BRS Platina cultivar has a strong resistance to Foc. These findings are important for breeding programs focused on developing Foc-resistant banana cultivars and understanding the virulence relationships of Foc and the defense responses of banana plants after infection.
Article
Multidisciplinary Sciences
Laetitia Coassolo, Tianyun Liu, Yunshin Jung, Nikki P. Taylor, Meng Zhao, Gregory W. Charville, Silas Boye Nissen, Hannele Yki-Jarvinen, Russ B. Altman, Katrin J. Svensson
Summary: Non-alcoholic fatty liver disease (NAFLD) is a heterogeneous disease with unclear molecular mechanisms. By analyzing single-cell RNA sequencing data, this study identifies previously unknown clusters of hepatocytes with distinct lipid signatures and uncovers high constitutive androstane receptor (CAR) expression as a novel driver of NAFLD. The study further reveals the functional modules associated with CAR and demonstrates the correlation between CAR expression and steatohepatitis in human livers. These findings provide valuable insights into the cellular differences in lipid signatures and the underlying mechanisms of hepatic steatosis.
Article
Virology
Serdal Arslan, Mehmet Bakir, Burcu Bayyurt, Eylem Aydemir, Kenan Kinaci, Aynur Engin
Summary: This study investigated the lncRNA gene expression profiles in CCHF using microarray for the first time. Several lncRNAs were found to be significantly regulated in both case and fatal case groups. These lncRNAs could be considered as important therapeutic targets for further studies on CCHF.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Pharmacology & Pharmacy
Sarayut Radapong, Kelvin Chan, Satyajit D. Sarker, Kenneth J. Ritchie
Summary: Oxyresveratrol (OXY) alters key gene expression and biological pathways in MCF-7 breast cancer cells, inducing apoptosis and inhibiting cell cycle control. These changes were validated through quantitative PCR analysis and protein assays.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
Luisa C. Carvalho, Miguel J. N. Ramos, David Faisca-Silva, Pedro Marreiros, Joao C. Fernandes, Ricardo Egipto, Carlos M. M. Lopes, Sara Amancio
Summary: Climate change is causing increased heat and drought in the Mediterranean area. A study on grapevine in Spain and Portugal found that drought reduces yield and quality, leading to economic losses. Deficit irrigation is commonly used due to limited water resources, and this research investigated two deficit irrigation treatments and their effects on grape berries. The study found that water stress significantly regulated the expression of genes related to various functions, with primary metabolism being the most affected. Key genes involved in drought response and anthocyanin biosynthesis were identified.
Article
Clinical Neurology
Delphine Boche, Marcia N. Gordon
Summary: The review explores the diversity of microglial phenotypes in healthy brains, aging, and Alzheimer's disease, identifies knowledge gaps, and suggests areas for further research. Comparisons between human samples and mouse models are made to understand the molecular complexity of microglial response repertoire, which could lead to new therapeutic avenues for Alzheimer's disease.
ALZHEIMERS & DEMENTIA
(2022)
Article
Biochemistry & Molecular Biology
Shuai Wang, Shuying Han, Xiangui Zhou, Changjiang Zhao, Lina Guo, Junqi Zhang, Fei Liu, Qixin Huo, Wensheng Zhao, Zejian Guo, Xujun Chen
Summary: The rice transcription factor gene OsWRKY31 is a key component in the MPK signaling pathway involved in rice disease resistance. OsWRKY31 is phosphorylated and ubiquitinated in the defense signaling pathway mediated by OsMKK10-2.
Article
Psychiatry
Zhijun Li, Xinwei Li, Mengdi Jin, Yang Liu, Yang He, Ningning Jia, Xingyao Cui, Yane Liu, Guoyan Hu, Qiong Yu
Summary: This study identified 15 key genes potentially associated with schizophrenia through analyzing multiple gene expression datasets using various bioinformatics algorithms. The study also found correlations between the expression of these hub genes and immune infiltrating cells. Furthermore, a risk prediction model based on these genes and immune cells achieved high accuracy in early diagnosis of schizophrenia.
PSYCHIATRY RESEARCH
(2022)
Article
Food Science & Technology
Xin Song, Xiaoyu Zhang, Zhiqiang Xiong, Yongjun Xia, Yan Wu, Lianzhong Ai, Hui Xu, Yanjun Tian, Yijin Yang, Guangqiang Wang
Summary: This study identifies an endogenous constitutive promoter library from L. salivarius, which has the potential to serve as a basic toolbox for various lactic acid bacteria applications.
Article
Cell Biology
Qian Zhang, Zihao Wang, Wenfeng Zhang, Qingbo Wen, Xinyu Li, Jun Zhou, Xueying Wu, Yongqing Guo, Yangli Liu, Changshuo Wei, Wenfeng Qian, Ye Tian
Summary: Parental stress memories can be passed on to offspring by elevating mitochondrial DNA levels, inducing UPRmt in the next generation to better cope with challenges.
NATURE CELL BIOLOGY
(2021)