Article
Cell Biology
Mohammad Taheri, Arash Safarzadeh, Bashdar Mahmud Hussen, Soudeh Ghafouri-Fard, Aria Baniahmad
Summary: The construction of ceRNA network in prostate cancer and the identification of its importance in predicting patient survival were investigated in this study. The analysis of microarray data led to the identification of differentially expressed mRNAs, lncRNAs, and miRNAs. A ceRNA network consisting of miRNAs, lncRNAs, and mRNAs was constructed, and 10 hub genes were identified. The expression levels of these hub genes showed high diagnostic value. Overall, this study introduces novel diagnostic biomarkers for prostate cancer.
Article
Biochemistry & Molecular Biology
Giulia Dal Santo, Marco Frasca, Gloria Bertoli, Isabella Castiglioni, Claudia Cava
Summary: This study analyzed miRNA-mRNA interactions and constructed networks for the onset and progression of prostate cancer, identifying potential biomarkers for differential diagnosis. The selected miRNAs showed better performance in predicting the occurrence and progression of prostate cancer compared to the miRNAs selected by the Boruta algorithm.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Oncology
Diego A. Pedroza, Matthew Ramirez, Venkatesh Rajamanickam, Ramadevi Subramani, Victoria Margolis, Tugba Gurbuz, Adriana Estrada, Rajkumar Lakshmanaswamy
Summary: Our study reveals that therapeutic targeting of PGRMC1 in aggressive breast cancers leads to the activation of miRNAs targeting overexpressed genes and deactivation of miRNAs with oncogenic potential.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Amrutha Menon, Noraini Abd-Aziz, Kanwal Khalid, Chit Laa Poh, Rakesh Naidu
Summary: This review focuses on the role of miRNA in cancer, therapeutic approaches with miRNAs, and effective delivery into the system. Patents and ongoing clinical trials for miRNA therapy are also summarized.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medical Laboratory Technology
Meilan Zhang, Xue Bai, Xuemei Zeng, Jiangrong Liu, Feng Liu, Zhiwei Zhang
Summary: Breast cancer has the highest incidence rate among women and the circRNA-miRNA-mRNA axis plays a crucial role in its progression, serving as a potential marker for early diagnosis and treatment.
CLINICA CHIMICA ACTA
(2021)
Article
Genetics & Heredity
Zhiwen Wang, Xi Zhu, Hongyun Zhai, Yanghai Wang, Gangyue Hao
Summary: The study identified and established an mRNA-SNP-miRNA interaction network in prostate cancer, suggesting that hsa-miR-21, hsa-miR-30b, and ITGB8 may serve as new biomarkers. A nomogram model containing four variables was constructed for predicting the risk of prostate cancer.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Xingchen Fan, Xuan Zou, Cheng Liu, Shuang Peng, Shiyu Zhang, Xin Zhou, Tongshan Wang, Wei Zhu
Summary: This study identifies miRNA-mRNA regulation pairs related to bladder cancer pathogenesis through analyzing miRNA and mRNA datasets. One of the miRNA-mRNA regulation pairs was experimentally validated, and the diagnostic performance of these pairs in distinguishing bladder cancer was confirmed through ROC and DCA analysis. Additionally, the study found a correlation between these regulation pairs and tumor immunity.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Himali Gujrati, Siyoung Ha, Azah Mohamed, Bi-Dar Wang
Summary: This study suggests that differential miRNA-mRNA regulatory networks contribute to the disparities in prostate cancer (PCa) between African American (AA) and European American (EA) populations. The study identifies differential expression of miRNAs and mRNA pathways, particularly mTOR and VEGF signaling, in AA PCa compared to EA PCa. Further analysis reveals that certain miRNAs negatively regulate genes involved in PCa progression, providing potential targets for reducing PCa aggressiveness and chemoresistance in AA patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Shuang Peng, Cheng Liu, Xingchen Fan, Jingfeng Zhu, Shiyu Zhang, Xin Zhou, Tongshan Wang, Feng Gao, Wei Zhu
Summary: This study identified negatively regulatory miRNA-mRNA pairs in PRAD by analyzing TCGA RNA-Seq data and GEO mRNA/miRNA expression profiles, and established a diagnostic model that can distinguish PRADs from normal controls.
Article
Plant Sciences
Zhenyi Li, Zongyong Tong, Feng He, Xianglin Li, Juan Sun
Summary: This study investigated the response of alfalfa to phosphate deficiency stress by integrating transcriptional and post-transcriptional data. Differentially expressed genes and miRNAs were identified, and their target genes and regulatory relationships were predicted. The study revealed the post-transcriptional regulation mechanism of phosphate deficiency responses in alfalfa.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Hongyou Zhao, Bin Yi, Zhipin Liang, Ches'Nique Phillips, Hui-Yi Lin, Adam Riker, Yaguang Xi
Summary: Sulindac inhibits colorectal cancer cell cycle progression through up-regulation of Cyclin G2 and down-regulation of MiR-182, in turn enhancing FOXO3a transcriptional activity. The expression levels of MiR-182/FOXO3a/Cyclin G2 could potentially serve as predictive markers for tumor progression in colorectal cancer.
Article
Plant Sciences
Yucui Han, Yiyang Zhang, Guannan Cao, Leilei Shao, Qin Ding, Lingjian Ma
Summary: Thermosensitive cytoplasmic male sterile (TCMS) lines play a crucial role in wheat breeding. MiRNAs can regulate gene expression levels by inhibiting gene translation. YS3038, a wheat TCMS line, was studied for its fertility conversion mechanism through examination of abortion characteristics, miRNA regulation patterns, and target genes.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Biology
Ambritha Balasundaram, C. George Priya Doss
Summary: This study identified differentially expressed genes in non-small cell lung cancer (NSCLC) and constructed a circRNA-miRNA-mRNA regulatory network to explore the potential mechanism of NSCLC.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Cheng Liu, Chun Yu, Guoxin Song, Xingchen Fan, Shuang Peng, Shiyu Zhang, Xin Zhou, Cheng Zhang, Xiangnan Geng, Tongshan Wang, Wenfang Cheng, Wei Zhu
Summary: MicroRNA (miRNA) plays a role as post-transcriptional regulators of mRNAs by base-pairing with complementary sequences within mRNAs, which are involved in the complex interaction between immune system and tumors. In this study, we investigated the expression profiles of miRNAs and target mRNAs and their associations with phenotypic hallmarks of colorectal cancers (CRC). Through integrative analysis of transcriptomic, immunophenotype, methylation, mutation, and survival data, we identified two pivotal regulatory pairs (miR-139-5p/STC1 and miR-20a-5p/FGL2) and validated the diagnostic value of a complex model combining these signatures.
Article
Oncology
Bai Xue, Shupeng Li, Xianyu Jin, Lifeng Liu
Summary: The study identified key signaling pathways and cellular activities related to cisplatin-resistant ovarian cancer through analyzing differentially expressed genes and miRNAs, and established a miRNA-mRNA regulatory pair (mir-454-UBB) as a potential therapeutic target for drug resistance in ovarian cancer.
