Journal
CLINICA CHIMICA ACTA
Volume 523, Issue -, Pages 120-130Publisher
ELSEVIER
DOI: 10.1016/j.cca.2021.09.013
Keywords
circRNA; miRNA; mRNA; Breast cancer
Categories
Funding
- Natural Science Foundation of Hunan Province [2021JJ30694]
- Hunan Science and Technology Innovation Project [2020SK51703]
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Breast cancer has the highest incidence rate among women and the circRNA-miRNA-mRNA axis plays a crucial role in its progression, serving as a potential marker for early diagnosis and treatment.
Among cancers, breast cancer has the highest incidence rate among women and poses a tremendous threat to women's health. Messenger RNA (mRNA), microRNA (miRNA) and circular RNA (circRNA) play vital roles in the progression of breast cancer through a variety of biological effects and mechanisms. Recently, the regulatory network formed by circRNAs, miRNAs and mRNAs has piqued attention and garnered interest. CircRNAs bind to miRNAs through a regulatory mechanism in which endogenous RNAs compete to indirectly regulate the expression of mRNA corresponding to downstream target genes of miRNAs, contributing to the progression of breast cancer. The circRNA-miRNA-mRNA axis may be a marker for the early diagnosis and prognosis of breast cancer and a potential breast cancer treatment target, providing unlimited possibilities for the development of breast cancer biomarkers and therapeutic strategies. This article reviews recent research progress on the circRNA-miRNA-mRNA axis as a regulatory network of competing endogenous RNAs in breast cancer. Herein, we focus on the mechanism and function of the circRNA-miRNA-mRNA axis in the occurrence and metastasis of breast cancer, and resistance to chemotherapy.
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