Review
Biochemistry & Molecular Biology
Niraj Lodhi, Rubi Singh, Satya Prakash Rajput, Quaiser Saquib
Summary: The study highlights the roles of ACE2 and TMPRSS2 genes in host cells and their transcriptional regulation. Furthermore, it discusses the impact of the codon 72 Single Nucleotide Polymorphism (SNP) of p53 gene on the mortality rate of SARS-CoV-2 in different regions, as well as potential emerging therapies using bioengineered bacteriophage, anti-sense, or CRISPR strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
Bartosz Slominski, Maria Skrzypkowska, Monika Ryba-Stanislawowska, Malgorzata Mysliwiec, Piotr Trzonkowski
Summary: The TP53 codon 72 polymorphism is associated with complications and comorbidities in patients with T1D. The Pro/Pro genotype is linked to an increased risk of microvascular complications, dyslipidemia, and celiac disease, while the Arg/Arg variant is associated with a decreased risk of autoimmune thyroiditis and celiac disease. The Pro allele is connected to an increased risk of dyslipidemia, autoimmune thyroiditis, and celiac disease.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Review
Mathematical & Computational Biology
Xia Ma, Xiaoxiao Jin, Xiujuan Shao, Wanjing Hu, Haihong Jin, Yiqun Wang
Summary: The study investigated the relationship between the rs1042522 single nucleotide polymorphism of the p53 gene and the incidence of endometriosis using meta-analysis. The results showed a significant correlation between the decrease of the GG gene frequency and the increase of allele C with the risk of female endometriosis.
COMPUTATIONAL INTELLIGENCE AND NEUROSCIENCE
(2022)
Review
Pharmacology & Pharmacy
Yuanmei Dong, Decong Sun, Juan Li, Sisi Ye, Yanyun Zhu
Summary: This study investigated the association between tumor protein 53 polymorphism and esophageal cancer through a systematic review and meta-analysis. The findings suggest that changes in the tumor protein 53 gene can affect the risk and prognosis of esophageal cancer.
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Bu-Yeo Kim, Seo-Young Lee, Sun-Ku Chung
Summary: This study revealed that the polymorphic p53 codon 72 does not significantly affect growth arrest or apoptosis, but differentially regulates the expression patterns related to metabolism in cells exposed to genotoxic stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Navid Sobhani, Giandomenico Roviello, Alberto D'Angelo, Raheleh Roudi, Praveen Kumar Neeli, Daniele Generali
Summary: The meta-analysis confirms the diagnostic utility of p53 antibodies for cancer patients in predicting poorer outcomes, indicating the potential usefulness of serum p53 values for future theranostics.
Review
Oncology
Maoquan Yang, Mingwei Zhang, Qiong Wang, Xiaojing Guo, Peizhen Geng, Jinhua Gu, Wansheng Ji, Li Zhang
Summary: In this meta-analysis, a significant association was found between H19 gene polymorphisms and cancer susceptibility. Specifically, the rs2107425 variation was related to decreased cancer risk among Caucasians, while the rs217727 polymorphism was associated with increased risk of lung cancer, hepatocellular carcinoma, and oral squamous cell carcinoma. Moreover, the rs2839698 polymorphism was linked to increased cancer risk among Asians and in different cancer types (such as gastric cancer and hepatocellular carcinoma) and larger study populations. Overall, H19 SNPs were found to be significantly correlated with cancer risk.
Article
Pathology
Xiaoling Lu, Meitong Liu, Yuxiao Liao, Chao Huang, Longlong Chai, Yuchen Jin, Qiantao Xiong, Bifeng Chen
Summary: The meta-analysis revealed a significant association between SNPs rs2295080, rs17036508, and rs1034528 in the mTOR gene and cancer risk, while target genetic polymorphisms in the mLST8 gene or RPTOR gene may not be associated with cancer risk. Further large-scale and well-designed studies in different ethnic populations are needed to confirm or strengthen these findings.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Review
Genetics & Heredity
Rong Dai, Yue Chen, Kai Yang, Tao Wu, Changkai Deng
Summary: This meta-analysis investigated the association between Trp64Arg polymorphism in ADRB3 gene and susceptibility to OAB. The results suggest that Trp64Arg polymorphism might be associated with increased risk of OAB in different models and comparisons. However, further well-designed studies with large sample sizes are needed to confirm these findings.
FRONTIERS IN GENETICS
(2022)
Article
Immunology
Dan Si, Yanping Yao, Xu Chen, Jun Qiu
Summary: This meta-analysis found that P53 gene rs1042522 polymorphism contributed to a decreased risk of HPV infection in Brazilian and Arabian populations.
MICROBIAL PATHOGENESIS
(2021)
Article
Geriatrics & Gerontology
Nima Montazeri-Najafabady, Mohammad Hossein Dabbaghmanesh, Nasrin Nasimi, Zahra Sohrabi, Alireza Estedlal, Naeimehossadat Asmarian
Summary: This study found that the Arg/Pro genotype and Arginine-Insertion and Proline-Insertion haplotypes of the TP53 gene may decrease the risk of sarcopenia in older adults in Iran. There were significant differences in muscle mass, body composition, and biochemical parameters between different genotypes and haplotypes.
Article
Oncology
Shiori Nakano, Taiki Yamaji, Ryoko Katagiri, Norie Sawada, Manami Inoue, Shoichiro Tsugane, Motoki Iwasaki
Summary: The p53 Arg72Pro polymorphism has different effects on tumorigenesis based on adiposity status, with Pro homozygous carriers being more susceptible to cancer under normal weight conditions and Arg carriers having a higher cancer risk when overweight.
Review
Oncology
Anthony-Joe Nassour, Anika Jain, Nicholas Hui, George Siopis, James Symons, Henry Woo
Summary: Lynch syndrome (LS) is associated with an increased risk of colorectal, endometrial, genitourinary, and other malignancies. The association between LS and upper tract urothelial carcinoma is well established, but the evidence for bladder and kidney cancer is limited. This study aimed to quantify the relative risk of bladder and kidney cancer, summarize the existing evidence, and provide recommendations for clinicians.
Correction
Oncology
Junjian Chen, Mao Sun, Min Zhou, Renfu Lu
Summary: An amendment to this paper has been published and can be accessed via the original article.
Review
Biochemistry & Molecular Biology
Arnold J. Levine, John D. Carpten, Maureen Murphy, Pierre Hainaut
Summary: Multiple Myeloma shows significant differences between patients of African and European ancestry, possibly due to genetic polymorphisms and somatic mutations in the TP53 gene. African Americans have a higher incidence rate of MM compared to Caucasian Americans, while Caucasian Americans have more somatic TP53 mutations. Polymorphisms in the TP53 gene may lead to a higher risk of acquiring inactivating somatic mutations in a specific region of the gene in Caucasian Americans.
CELL DEATH AND DIFFERENTIATION
(2023)