Additional sex combs-likefamily genes are required for normal cardiovascular development

Loss of Asxl1 leads to myelodysplastic syndrome-like disease in mice

(2013) J. Wang et al.   BLOOD

De novoframeshift mutation in ASXL3 in a patient with global developmental delay, microcephaly, and craniofacial anomalies

(2013) Darrell L Dinwiddie et al.   BMC Medical Genomics

Functional and cancer genomics of ASXL family members

(2013) M Katoh   BRITISH JOURNAL OF CANCER

Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo

(2013) Omar Abdel-Wahab et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Additional Sex Combs-Like 2 Is Required for Polycomb Repressive Complex 2 Binding at Select Targets

(2013) Hsiao-Lei Lai et al.   PLoS One

De novo truncating mutations in ASXL3 are associated with a novel clinical phenotype with similarities to Bohring-Opitz syndrome

(2013) Matthew N Bainbridge et al.   Genome Medicine

The prevalence of adult congenital heart disease, results from a systematic review and evidence based calculation

(2012) Teun van der Bom et al.   AMERICAN HEART JOURNAL

Two novel patients with Bohring-Opitz syndrome caused by de novo ASXL1 mutations

(2012) Pamela Magini et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

ASXL1 Mutations Promote Myeloid Transformation through Loss of PRC2-Mediated Gene Repression

(2012) Omar Abdel-Wahab et al.   CANCER CELL

Epigenetic regulation of cardiac development and function by polycomb group and trithorax group proteins

(2012) Q. Tian Wang   DEVELOPMENTAL DYNAMICS

Maintenance of adult cardiac function requires the chromatin factor Asxl2

(2012) Hsiao-Lei Lai et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Trials with ‘epigenetic’ drugs: An update

(2012) Angela Nebbioso et al.   Molecular Oncology

Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis

(2012) Paul Delgado-Olguín et al.   NATURE GENETICS

Loss of the Tumor Suppressor BAP1 Causes Myeloid Transformation

(2012) A. Dey et al.   SCIENCE

Modifier Genes and the Plasticity of Genetic Networks in Mice

(2012) Bruce A. Hamilton et al.   PLoS Genetics

Epigenetic mechanisms in cardiac development and disease

(2011) Marcus Vallaster et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Epigenetics and Cardiovascular Development

(2011) Ching-Pin Chang et al.   Annual Review of Physiology

Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A

(2011) A. M. Jankowska et al.   BLOOD

Epigenetic factors and cardiac development

(2011) J. H. van Weerd et al.   CARDIOVASCULAR RESEARCH

Epigenetic Modifications of Stem Cells

(2011) Yonggang Zhou et al.   CIRCULATION RESEARCH

Polycomb Repressive Complex 2 Regulates Normal Development of the Mouse Heart

(2011) Aibin He et al.   CIRCULATION RESEARCH

Mesenchymal Nuclear factor I B regulates cell proliferation and epithelial differentiation during lung maturation

(2011) Yu-Chih Hsu et al.   DEVELOPMENTAL BIOLOGY

Bohring–Opitz (Oberklaid–Danks) syndrome: clinical study, review of the literature, and discussion of possible pathogenesis

(2011) Rob Hastings et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

SWI/SNF Complexes Containing Brahma or Brahma-Related Gene 1 Play Distinct Roles in Smooth Muscle Development

(2011) M. Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY

De novo nonsense mutations in ASXL1 cause Bohring-Opitz syndrome

(2011) Alexander Hoischen et al.   NATURE GENETICS

Clinical Effect of Point Mutations in Myelodysplastic Syndromes

(2011) Rafael Bejar et al.   NEW ENGLAND JOURNAL OF MEDICINE

Fetal Programming of Adult Disease

(2011) Christopher Lau et al.   OBSTETRICS AND GYNECOLOGY

Critical Congenital Heart Disease-Utility of Routine Screening for Chromosomal and Other Extracardiac Malformations

(2011) Kimberly Baker et al.   Congenital Heart Disease

Combined Mutation Screening of NKX2-5, GATA4, and TBX5 in Congenital Heart Disease: Multiple Heterozygosity and Novel Mutations

(2011) Javier T. Granados-Riveron et al.   Congenital Heart Disease

Failure of Postnatal Ductus Arteriosus Closure in Prostaglandin Transporter–Deficient Mice

(2010) Hee-Yoon Chang et al.   CIRCULATION

Heterogeneity of Genetic Modifiers Ensures Normal Cardiac Development

(2010) Julia B. Winston et al.   CIRCULATION

Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB

(2010) Johanna C. Scheuermann et al.   NATURE

Epigenetic modifications as therapeutic targets

(2010) Theresa K Kelly et al.   NATURE BIOTECHNOLOGY

Epigenetics and cardiovascular disease

(2010) José M. Ordovás et al.   Nature Reviews Cardiology

Lunatic Fringe-mediated Notch signaling is required for lung alveogenesis

(2009) Keli Xu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Loss-of-function Additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia

(2009) C. L. Fisher et al.   BLOOD

Mutations of polycomb-associated geneASXL1in myelodysplastic syndromes and chronic myelomonocytic leukaemia

(2009) Véronique Gelsi-Boyer et al.   BRITISH JOURNAL OF HAEMATOLOGY

Heart Malformation

(2009) Joseph T.C. Shieh et al.   CIRCULATION

Recurrence of Congenital Heart Defects in Families

(2009) Nina Øyen et al.   CIRCULATION

Additional sex combs-like 1 belongs to the enhancer of trithorax and polycomb group and genetically interacts with Cbx2 in mice

(2009) C.L. Fisher et al.   DEVELOPMENTAL BIOLOGY

Cardiac Fibroblasts Regulate Myocardial Proliferation through β1 Integrin Signaling

(2009) Masaki Ieda et al.   DEVELOPMENTAL CELL

Platelets contribute to postnatal occlusion of the ductus arteriosus

(2009) Katrin Echtler et al.   NATURE MEDICINE

Interpreting Neonatal Lethal Phenotypes in Mouse Mutants: Insights Into Gene Function and Human Diseases

(2009) Benjamin Turgeon et al.   PHYSIOLOGICAL REVIEWS

Functional Conservation of Asxl2, a Murine Homolog for the Drosophila Enhancer of Trithorax and Polycomb Group Gene Asx

(2009) Heather A. Baskind et al.   PLoS One

Identification of a Cardiac Disease Modifier Gene Using Forward Genetics in the Mouse

(2009) William T. Pu   PLoS Genetics

Tnni3k Modifies Disease Progression in Murine Models of Cardiomyopathy

(2009) Ferrin C. Wheeler et al.   PLoS Genetics

ACC/AHA 2008 Guidelines for the Management of Adults With Congenital Heart Disease

(2008) Carole A. Warnes et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

An optimized procedure for whole-mount in situ hybridization on mouse embryos and embryoid bodies

(2008) Denis Piette et al.   Nature Protocols

A chemical method for fast and sensitive detection of DNA synthesis in vivo

(2008) A. Salic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic insights into normal and abnormal heart development

(2007) Mona Nemer   CARDIOVASCULAR PATHOLOGY