Insulin-likegenes in ascidians: Findings inCionaand hypotheses on the evolutionary origins of the pancreas

Auto and cross regulatory elements control Onecut expression in the ascidian nervous system

(2014) Maria Rosa Pezzotti et al.   DEVELOPMENTAL BIOLOGY

Insulin and insulin-like growth factor receptors in the brain: Physiological and pathological aspects

(2014) Haim Werner et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

An insulin-like growth factor found in hepatopancreas implicates carbohydrate metabolism of the blue crab Callinectes sapidus

(2014) J. Sook Chung   GENERAL AND COMPARATIVE ENDOCRINOLOGY

β-Catenin-Driven Binary Fate Specification Segregates Germ Layers in Ascidian Embryos

(2013) Clare Hudson et al.   CURRENT BIOLOGY

Tbx2/3 is an essential mediator within the Brachyury gene network during Ciona notochord development

(2013) D. S. Jose-Edwards et al.   DEVELOPMENT

Formation of the digestive tract inCiona intestinalisincludes two distinct morphogenic processes between its anterior and posterior parts

(2013) Keiichi Nakazawa et al.   DEVELOPMENTAL DYNAMICS

Development of the Human Pancreas From Foregut to Endocrine Commitment

(2013) R. E. Jennings et al.   DIABETES

Nkx6.1 Is Essential for Maintaining the Functional State of Pancreatic Beta Cells

(2013) Brandon L. Taylor et al.   Cell Reports

Functional Brachyury Binding Sites Establish a Temporal Read-out of Gene Expression in the Ciona Notochord

(2013) Lavanya Katikala et al.   PLOS BIOLOGY

NK4 Antagonizes Tbx1/10 to Promote Cardiac versus Pharyngeal Muscle Fate in the Ascidian Second Heart Field

(2013) Wei Wang et al.   PLOS BIOLOGY

From Notochord Formation to Hereditary Chordoma: The Many Roles ofBrachyury

(2013) Yutaka Nibu et al.   Biomed Research International

The transcriptional co-repressor Grg3/Tle3 promotes pancreatic endocrine progenitor delamination and  -cell differentiation

(2012) D. E. Metzger et al.   DEVELOPMENT

Evolutionary crossroads in developmental biology: cyclostomes (lamprey and hagfish)

(2012) S. M. Shimeld et al.   DEVELOPMENT

Islet  -,  -, and  -Cell Development Is Controlled by the Ldb1 Coregulator, Acting Primarily With the Islet-1 Transcription Factor

(2012) C. S. Hunter et al.   DIABETES

Gata6is required for complete acinar differentiation and maintenance of the exocrine pancreas in adult mice

(2012) Paola Martinelli et al.   GUT

Peptide signaling in Hydra

(2012) Toshitaka Fujisawa et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

GATA4 and GATA6 control mouse pancreas organogenesis

(2012) Manuel Carrasco et al.   JOURNAL OF CLINICAL INVESTIGATION

Dorsoventral patterning of the Drosophila hindgut is determined by interaction of genes under the control of two independent gene regulatory systems, the dorsal and terminal systems

(2012) Takashi Hamaguchi et al.   MECHANISMS OF DEVELOPMENT

Insulin analog with additional disulfide bond has increased stability and preserved activity

(2012) Tine N. Vinther et al.   PROTEIN SCIENCE

Novel functions for insulin in bone

(2011) Keertik Fulzele et al.   BONE

Insulin-producing cells in the brain of adult Drosophila are regulated by the serotonin 5-HT1A receptor

(2011) Jiangnan Luo et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Molecular cloning of IGF-1 and IGF-1 receptor and their expression pattern in the Chilean flounder (Paralichthys adspersus)

(2011) Sebastian Escobar et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

The maternal genes Ci-p53/p73-a and Ci-p53/p73-b regulate zygotic ZicL expression and notochord differentiation in Ciona intestinalis embryos

(2011) Takeshi Noda   DEVELOPMENTAL BIOLOGY

The identification of transcription factors expressed in the notochord of Ciona intestinalis adds new potential players to the brachyury gene regulatory network

(2011) Diana S. José-Edwards et al.   DEVELOPMENTAL DYNAMICS

Peptidomic Analysis of the Central Nervous System of the Protochordate,Ciona intestinalis: Homologs and Prototypes of Vertebrate Peptides and Novel Peptides

(2011) Tsuyoshi Kawada et al.   ENDOCRINOLOGY

Pancreas-Specific Deletion of Prox1 Affects Development and Disrupts Homeostasis of the Exocrine Pancreas

(2011) Joby J. Westmoreland et al.   GASTROENTEROLOGY

LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function

(2011) S. R. Holmstrom et al.   GENES & DEVELOPMENT

The liver receptor homolog-1 (LRH-1) is expressed in human islets and protects β-cells against stress-induced apoptosis

(2011) Mathurin Baquié et al.   HUMAN MOLECULAR GENETICS

RFX6 is needed for the development and maintenance of the β-cell phenotype

(2011) Nadine Taleb et al.   Islets

Roles and Regulation of the Transcription Factor CREB in Pancreatic β -Cells

(2011) Stephane Dalle et al.   Current Molecular Pharmacology

Genomic cis-regulatory networks in the early Ciona intestinalis embryo

(2010) A. Kubo et al.   DEVELOPMENT

Brachyury-downstream gene sets in a chordate, Ciona intestinalis: integrating notochord specification, morphogenesis and chordate evolution

(2010) Kohji Hotta et al.   EVOLUTION & DEVELOPMENT

Functional conservation and divergence of duplicated insulin-like growth factor 2 genes in grass carp (Ctenopharyngodon idellus)

(2010) Xiang-Nan Yuan et al.   GENE

Ependymal cells of chordate larvae are stem-like cells that form the adult nervous system

(2010) Takeo Horie et al.   NATURE

The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing

(2010) C. Kenyon   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Early Chordate Origins of the Vertebrate Second Heart Field

(2010) A. Stolfi et al.   SCIENCE

Origin and Genetic Evolution of the Vertebrate Skeleton

(2010) Hiroshi Wada   ZOOLOGICAL SCIENCE

Neurogenin3: A master regulator of pancreatic islet differentiation and regeneration

(2010) J. Michael Rukstalis et al.   Islets

Direct activation of a notochord cis-regulatory module by Brachyury and FoxA in the ascidian Ciona intestinalis

(2009) Y. J. Passamaneck et al.   DEVELOPMENT

The evolutionarily conserved leprecan gene: Its regulation by Brachyury and its role in the developing Ciona notochord

(2009) Matthew P. Dunn et al.   DEVELOPMENTAL BIOLOGY

Unfolding a chordate developmental program, one cell at a time: Invariant cell lineages, short-range inductions and evolutionary plasticity in ascidians

(2009) Patrick Lemaire   DEVELOPMENTAL BIOLOGY

Sox17 Regulates Organ Lineage Segregation of Ventral Foregut Progenitor Cells

(2009) Jason R. Spence et al.   DEVELOPMENTAL CELL

Targeted Gene Knockdown in Zebrafish Reveals Distinct Intraembryonic Functions for Insulin-Like Growth Factor II Signaling

(2009) Yvonne A. R. White et al.   ENDOCRINOLOGY

Methylthioadenosine phosphorylase and activated insulin-like growth factor-1 receptor/insulin receptor: potential therapeutic targets in chordoma

(2009) Josh Sommer et al.   JOURNAL OF PATHOLOGY

The Krüppel-like zinc finger protein Glis3 directly and indirectly activates insulin gene transcription

(2009) Yisheng Yang et al.   NUCLEIC ACIDS RESEARCH

Zebrafish IGF Genes: Gene Duplication, Conservation and Divergence, and Novel Roles in Midline and Notochord Development

(2009) Shuming Zou et al.   PLoS One

Cdx4 is required in the endoderm to localize the pancreas and limit  -cell number

(2008) M. D. Kinkel et al.   DEVELOPMENT

Ephrin signaling establishes asymmetric cell fates in an endomesoderm lineage of the Ciona embryo

(2008) W. Shi et al.   DEVELOPMENT

brachyury null mutant-induced defects in juvenile ascidian endodermal organs

(2008) S. Chiba et al.   DEVELOPMENT

Gene regulatory networks underlying the compartmentalization of the Ciona central nervous system

(2008) K. S. Imai et al.   DEVELOPMENT

Trunk lateral cells are neural crest-like cells in the ascidian Ciona intestinalis: Insights into the ancestry and evolution of the neural crest

(2008) William R. Jeffery et al.   DEVELOPMENTAL BIOLOGY

Delineating metamorphic pathways in the ascidian Ciona intestinalis

(2008) Akie Nakayama-Ishimura et al.   DEVELOPMENTAL BIOLOGY

Role of the Transcription Factor Sox4 in Insulin Secretion and Impaired Glucose Tolerance

(2008) M. Goldsworthy et al.   DIABETES

The amphioxus genome illuminates vertebrate origins and cephalochordate biology

(2008) L. Z. Holland et al.   GENOME RESEARCH

Improved genome assembly and evidence-based global gene model set for the chordate Ciona intestinalis: new insight into intron and operon populations

(2008) Yutaka Satou et al.   GENOME BIOLOGY