The Zic2 gene directs the formation and function of node cilia to control cardiac situs

The ZIC gene family encodes multi-functional proteins essential for patterning and morphogenesis

(2013) Rob Houtmeyers et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A murine Zic3 transcript with a premature termination codon evades nonsense-mediated decay during axis formation

(2013) J. N. Ahmed et al.   Disease Models & Mechanisms

Zic3 is required in the migrating primitive streak for node morphogenesis and left-right patterning

(2013) M. J. Sutherland et al.   HUMAN MOLECULAR GENETICS

Cilia, calcium and the basis of left-right asymmetry

(2012) Dominic P Norris   BMC BIOLOGY

Cilia, KIF3 molecular motor and nodal flow

(2012) Nobutaka Hirokawa et al.   CURRENT OPINION IN CELL BIOLOGY

Differential regulation of node formation, nodal ciliogenesis and cilia positioning by Noto and Foxj1

(2012) L. Alten et al.   DEVELOPMENT

An essential and highly conserved role for Zic3 in left–right patterning, gastrulation and convergent extension morphogenesis

(2012) Ashley E. Cast et al.   DEVELOPMENTAL BIOLOGY

Zinc fingers of the cerebellum (Zic): Transcription factors and co-factors

(2012) Radiya G. Ali et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

High Resolution Melt Analysis (HRMA); a Viable Alternative to Agarose Gel Electrophoresis for Mouse Genotyping

(2012) Nicole Thomsen et al.   PLoS One

Cilia at the Node of Mouse Embryos Sense Fluid Flow for Left-Right Determination via Pkd2

(2012) S. Yoshiba et al.   SCIENCE

Two rotating cilia in the node cavity are sufficient to break left–right symmetry in the mouse embryo

(2012) Kyosuke Shinohara et al.   Nature Communications

Initiating head development in mouse embryos: integrating signalling and transcriptional activity

(2012) R. M. Arkell et al.   Open Biology

Role of the Gut Endoderm in Relaying Left-Right Patterning in Mice

(2012) Manuel Viotti et al.   PLOS BIOLOGY

Pkd1l1 establishes left-right asymmetry and physically interacts with Pkd2

(2011) S. Field et al.   DEVELOPMENT

Transcriptional control of genes involved in ciliogenesis: a first step in making cilia

(2010) Joëlle Thomas et al.   BIOLOGY OF THE CELL

Foxj1 regulates floor plate cilia architecture and modifies the response of cells to sonic hedgehog signalling

(2010) C. Cruz et al.   DEVELOPMENT

Mouse mutagenesis identifies novel roles for left-right patterning genes in pulmonary, craniofacial, ocular, and limb development

(2009) Alexander Ermakov et al.   DEVELOPMENTAL DYNAMICS

The full spectrum of holoprosencephaly-associated mutations within theZIC2gene in humans predicts loss-of-function as the predominant disease mechanism

(2009) Erich Roessler et al.   HUMAN MUTATION

Mutations in ZIC2 in human holoprosencephaly: description of a Novel ZIC2 specific phenotype and comprehensive analysis of 157 individuals

(2009) B. D. Solomon et al.   JOURNAL OF MEDICAL GENETICS

Morphogenesis of the node and notochord: The cellular basis for the establishment and maintenance of left-right asymmetry in the mouse

(2008) Jeffrey D. Lee et al.   DEVELOPMENTAL DYNAMICS

Zic2 -associated holoprosencephaly is caused by a transient defect in the organizer region during gastrulation

(2008) Nicholas Warr et al.   HUMAN MOLECULAR GENETICS